Differences in HIV infection trends in two regions of Cameroon with a longstanding HIV epidemic: insights from 2012 and 2022 by Yannick F. Ngoume, Urmes C. Teagho, Brice Eselacha, Oumarou H. Goni, Dell-Dylan Kenfack, Mérimé Tchakoute, Georges Nguefack-Tsague, Marcel Tongo, Marcel Tongo

“…In this regard, we determined the HIV prevalence in remote communities of the East and South administrative regions of Cameroon where the four cross-species SIV transmissions that gave rise to the four HIV-1 groups likely happened.MethodsWe did this in two different periods: 2012/2013 (Period 1; 4,435 participants enrolled in the East and 2,347 in the South) and 2021/2022 (Period 2; 2,203 participant enrolled in the East and 2,347 in the South) using HIV1/2 rapid assays and standard ELISAs and according to the WHO testing strategy.ResultsDuring Period 1, the HIV seroprevalence in the East was 6.9%. …”
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Efficacy of Shear-Wave Elastography for Detecting Postoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma by Hye Jeong Kim, In Ho Choi, So-Young Jin, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo

“…The mean (EMean), minimum (EMin), maximum (EMax), and standard deviation (ESD) of SWE elasticity indices were measured. …”
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Time Series Classification of Raw Voice Waveforms for Parkinson's Disease Detection Using Generative Adversarial Network-Driven Data Augmentation by Marta Rey-Paredes, Carlos J. Perez, Alfonso Mateos-Caballero

“…Despite its prevalence, the detection of PD remains a complicated task, as no gold standard test has yet been developed to provide an accurate diagnosis. …”
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Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Vardenafil and Its Application of Bioequivalence by Kok Zheng Gan, Riyanto Teguh Widodo, Zamri Chik, Lay Kek Teh, Mohd Salleh Rofiee, Mohd Izwan Mohamad Yusof

“…The mass transitions m/z 489⟶151 and m/z 390⟶169 were used to measure vardenafil and tadalafil (internal standard), respectively, with a total assay run time of 6 min. …”
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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Eligible participants are those who are at least 18 years old, have a diagnosis of active moderate to severe CD and have failed to respond to or tolerate at least two prior lines of standard medication. Participants receive a single dose of autologous ex vivo-expanded Tregs and will be followed up to week 21 to collect safety and exploratory efficacy data. …”
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Implications of Implementing Promulgated and Prospective Emission Regulations on Air Quality and Health in India during 2030 by Sreyashi Debnath, Rama Krishna Karumuri, Gaurav Govardhan, Rajmal Jat, Himadri Saini, Akash Vispute, Santosh H. Kulkarni, Chinmay Jena, Rajesh Kumar, D. M. Chate, Sachin D. Ghude

“…Throughout India, under the S2 and S3 scenarios, 38% and 62% of states would meet the annual National Ambient Air Quality Standard (NAAQS) of 40 µg m−3, respectively. We projected that the S2 emission regulation scenario would prevent 274,000 (8.3%) premature mortalities and improve mean life expectancy by about 0.6 ± 0.2 years in 2030 relative to the BAU scenario. …”
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Does the transfer of knowledge from the pioneer generation to the second‐generation speed‐up the learning curve of robot‐assisted partial nephrectomies? TRANSFER trial (UroCCR n°83... by Louis Vignot, Zine‐Eddine Khene, Adil Mellouki, Arnoult Morrone, Jean‐Christophe Bernhard, Karim Bensalah, Daniel Chevallier, Nicolas Doumerc, Morgan Roupret, Francois‐Xavier Nouhaud, Cédric Lebacle, Jean‐Alexandre Long, Pierre Pillot, Xavier Tillou, Brannwel Tibi, Matthieu Durand, Younes Ahallal, Imad Bentellis

“…Conclusions Learning curve patterns would reflect a transfer of knowledge to the second‐generation, as opposed to the establishment of standards by the pioneers.…”
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Gas Displacement Engineering Test by Combination of Low and Medium Pressure Injection with Liquid CO2 in High Gas and Low Permeability Coal Seam by Hu Wen, Mingyang Liu, Gaoming Wei, Xiaowei Zhai, Shixing Fan, Xiaojiao Cheng, Hu Wang, Jianchi Hao

“…Taking the liquid CO2 low-medium-pressure displacement gas test area as the calculation unit, from the comprehensive benefit analysis, compared with the original drainage mode, the liquid CO2-combined pressure injection process can save 34.7% of the engineering cost and shorten the gas drainage standard time by 45.9%. Therefore, the application of this technology has important technical support and reference significance for the efficient management of gas in the same type of mine.…”
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Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention by Shuyan Liu, Matthias Haucke, Rika Groß, Kay Schneider, Jaekyung Shin, Fabian Arntz, Patrick Bach, Tobias Banaschewski, Christian Beste, Lorenz Deserno, Ulrich Ebner-Priemer, Tanja Endrass, Marvin Ganz, Ali Ghadami, Marco Giurgiu, Andreas Heinz, Falk Kiefer, Reinhold Kliegl, Bernd Lenz, Marta Anna Marciniak, Andreas Meyer-Lindenberg, Andreas B. Neubauer, Michael Rapp, Michael N. Smolka, Jens Strehle, Rainer Spanagel, Gianna Spitta, Heike Tost, Henrik Walter, Hilmar Zech, Dominic Reichert, Markus Reichert

“…Methods We will target 180 individuals aged 18 to 70 in Germany who report loneliness, alcohol cravings, and meet risk or binge drinking criteria (over 14 standard drinks per week or five drinks in a single day for males, and over seven drinks per week or four drinks in a single day for females). …”
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In-flight Electrocardiography Monitoring in a Pilot During Cross Country Flight by William D. Kim, Sang-Wook Kim, Seong-Kyu Cho, Ju Hyeon Byeon, GunYoung Lee, WooSeok Hyun, JoungSoon Jang

“…Landing phase showed the highest values in standard deviation of NN interval (59.3 ms), triangular index (11.7), and triangular interpolation of NN interval (195 ms), while the postflight phase had highest root mean square of successive difference (20.5 ms) and proportion of successive RR interval (3.4 ms). …”

High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients by Annabella Di Mauro, Mariachiara Santorsola, Giovanni Savarese, Roberto Sirica, Monica Ianniello, Alessia Maria Cossu, Anna Ceccarelli, Francesco Sabbatino, Marco Bocchetti, Anna Chiara Carratù, Francesca Pentimalli, Gerardo Ferrara, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano

“…Methods We evaluated the prognostic significance of TMB levels in MSS metastatic colon cancer patients undergoing standard treatments. Tumor responses were assessed using RECIST v1.1 criteria. …”
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Exploring the Therapeutic Role of Physical Activity in Psychotic Disorders: Cognitive, Somatic, and Mental Health Impacts by Klaudia Fikas, Kamil Chwaliszewski, Dorota Waz, Michał Mazur, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Sebastian Samuła

“…Integrating physical activity into standard treatment regimens could significantly improve patient outcomes in this population. …”
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Optimization Techniques for Physician Scheduling Problem: A Systematic Review of Recent Advancements and Future Directions by Norizal Abdullah, Masri Ayob, Meng Chun Lam, Nasser R. Sabar, Graham Kendall, Mohamad Khairulamirin Md Razali

“…This review also analyzes the datasets used in PSP research, noting the lack of standardized benchmarks. Key findings reveal the prevalence of mathematical optimization methods, the growing importance of multi-objective optimization and robustness, as well as the potential of machine learning and data-driven approaches. …”
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Real world data on outcomes of anti-CD38 antibody treated, including triple class refractory, patients with multiple myeloma: a multi-institutional report from the Canadian Myeloma... by A. Visram, A. De La Torre, D. White, J. Su, E. Masih-Khan, M. Chu, V. Jimenez-Zepeda, A. McCurdy, R. LeBlanc, K. Song, H. Mian, M. Louzada, M. Sebag, D. Bergstrom, J. Stakiw, A. Reiman, R. Kotb, M. Aslam, C. Venner, R. Kaedbey, E. Gul, D. Reece

“…This multi-center retrospective cohort study used the Canadian Myeloma Research Group Database to describe real-world outcomes of patients withanti-CD38 monoclonal antibody (mAb) refractory MM subsequently treated with standard of care (SoC) regimens. Patients with triple class refractory (TCR) disease (refractory to a proteasome inhibitor, immunomodulatory drug, and anti-CD38 mAb) were examined as a distinct cohort. …”
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Simulation of interferometric imaging with EISCAT_3D for fine-scale in-beam incoherent scatter spectra measurements by D. Huyghebaert, D. Huyghebaert, B. Gustavsson, J. Vierinen, A. Kvammen, M. Zettergren, J. Swoboda, I. Virtanen, S. M. Hatch, K. M. Laundal

“…Using singular value decomposition (SVD) with Tikhonov regularization, it is possible to pre-calculate the inversion matrix for a given range and look direction, with the regularization value scaled based on the signal-to-noise standard deviation ratio (SNSDR). The pre-calculation of the inversion matrix can reduce computational overhead in the imaging solution. …”
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Pattern of Bacterial Pathogens and Their Susceptibility Isolated from Surgical Site Infections at Selected Referral Hospitals, Addis Ababa, Ethiopia by Walelign Dessie, Gebru Mulugeta, Surafael Fentaw, Amete Mihret, Mulu Hassen, Engida Abebe

“…Wound specimens were collected using sterile cotton swab and processed as per standard operative procedures in appropriate culture media; and susceptibility testing was done using Kirby-Bauer disc diffusion technique. …”
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Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site by Maria Paula Roberti, Pornpimol Charoentong, Yanhong Lyu, Marten Meyer, Stefan B. Eichmüller, Patrick Schmidt, Frank Momburg, Miray Cetin, Felix Hartmann, Nektarios A. Valous, Albrecht Stenzinger, Laura Michel, Peter Lichter, Andreas Schneeweiss, Verena Thewes, Carlo Fremd, Inka Zörnig, Dirk Jäger

“…Our study shows, for the first time, that tumor mutation – specific T cells are generated at high frequencies in the vaccination site and can be isolated with standard methods for TCR screening. The easy and safe accessibility of skin biopsies overcomes the major hurdles of current TCR screening approaches and present exciting opportunities for the development of innovative immunotherapeutic strategies.…”
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Controls on the geotechnical properties of plastic-bonded pavement blocks produced by artisanal means in Bamenda, Cameroon by Bertrand Tatoh Aziwo, Moses Kuma Mbuh, Irene Bongsiysi Bame, Paul Venyite, Moyouwou Amadou Njoya, Fidelis Toke Ntam, M.V. Nsongka, Ndigui Billong

“…An average compressive strength of 32.97 MPa, water absorption of 2.27 % and an abrasion index of 0.07 was obtained at 27.5 % PET for 50WS50QS, which meets the recommended requirements of pavement blocks for pedestrian and light vehicular traffic according to ASTM C-902-22, NF EN 1338:2004 and SNI 03-0691-1996 standards. From the results, the geotechnical properties are influenced by nature and size of aggregate, type and amount of plastic-binder and production method. …”
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A Multimodal Workshop to Improve Medical Student Self-Assessment of Knowledge and Comfort Managing Patients With Suicidality by Paige C. Chardavoyne, Amanda Liewen, Paige McKenzie, Jill Sorby, Ana Navarro, Julie R. Owen

“…Methods This was a 2.5-hour multimodal workshop developed for formal third-year medical student suicide education that included: flipped learning with a preworkshop presentation; experiential learning, scaffolding, reflection, and feedback with two standardized patient encounters; think-pair-share with small- and large-group discussion; and a facilitator-led large-group didactic. …”
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Optimizing winged-bean meal through oven and autoclave heating as viable alternative for plant-based aquafeed by Shobrina Silmi Qori Tartila, Tholibah Mujtahidah, Muh. Azril, Anjali Apta Pramudita, Lusi Septiani, Bagas Putra Satria, Ignatius Abel Cristanto, Muhammad Abizar Sakti Oktavian, Sultan Jibran Risqulloh, Santika Dewi Astuti

“…Additionally, the O treatment met the standards for aquafeed protein content (27-45%) and potentially fulfilled the protein requirements for catfish (25-40%), Nile tilapia (30-35%), and Java barb (30-32%). …”
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