Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…Wistar rats were divided into control (standard diet) and obese (CAF diet) groups. After 75 days, half of each group received oral CoQ10 (5 mg/kg) for 13 days, while the rest received a vehicle. …”
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Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Here, we aim to investigate the expression, cellular biological functions, and the potential underlying mechanism of CES4A in nasopharyngeal carcinoma (NPC). Method A standardized mean difference (SMD) analysis was used to analyze the dysregulation of CES4A based on the gene expression omnibus (GEO) database. qRT-PCR and immunohistochemical staining (IHC) were used to identify the mRNA and protein levels of CES4A in NPC cell lines and tissues, respectively. …”
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Alleviating small sample problem in continuous forest monitoring with remote sensing-assisted Copulas by Xinjie Cheng, Zhengyang Hou, Annika Kangas, Jean-Pierre Renaud, Hao Tang, Weisheng Zeng, Qing Xu

“…However, model-assisted estimation is largely reliant on a sample resulting from costly field surveys to meet the precision standard mandated by these instruments. While a large sample is more likely to represent the population in question and ensure meeting the prescribed precision, it is crucial to reduce costs by finding a balance between precision and sample size. …”
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Novel combination therapy for platinum-eligible patients with locally advanced or metastatic urothelial carcinoma: a systematic review and network meta-analysis by Takafumi Yanagisawa, Keiichiro Mori, Akihiro Matsukawa, Tatsushi Kawada, Satoshi Katayama, Ekaterina Laukhtina, Pawel Rajwa, Fahad Quhal, Benjamin Pradere, Wataru Fukuokaya, Kosuke Iwatani, Renate Pichler, Jeremy Yuen-Chun Teoh, Marco Moschini, Wojciech Krajewski, Jun Miki, Shahrokh F. Shariat, Takahiro Kimura, European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

“…Thus, EV + pembrolizumab may become a guideline-changing standard treatment.…”
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Integrated Lung, Diaphragm and Lower Limb Muscular Ultrasound: Clinical Correlations in Geriatric Patients with Acute Respiratory Illness by Nicoletta Cerundolo, Carmine Siniscalchi, Chukwuma Okoye, Simone Scarlata, Alberto Parise, Martina Rendo, Angela Guerra, Tiziana Meschi, Antonio Nouvenne, Andrea Ticinesi

“…Diaphragm excursion, thickness, RVL thickness and CSA were measured following a standardized protocol. Frailty was assessed with the PC-FI (Primary Care-Frailty Index). …”
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An evaluation of financial losses due to lumpy skin disease outbreaks in dairy farms of northern Thailand by Wittawat Modethed, Khwanchai Kreausukon, Tawatchai Singhla, Kittikorn Boonsri, Kidsadagon Pringproa, Nattawooti Sthitmatee, Nattawooti Sthitmatee, Paramintra Vinitchaikul, Supitchaya Srisawang, Roderick Salvador, Simon Gubbins, Georgina Limon, Veerasak Punyapornwithaya, Veerasak Punyapornwithaya

“…Based on a retrospective study, data was collected using a standardized questionnaire from 100 farms affected by LSD outbreaks (outbreak farms) and 33 farms that did not experience LSD outbreaks (non-LSD outbreak farms) in two dairy farming areas that experienced LSD outbreaks between June and December 2021. …”
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Antibacterial, Antibiofilm, and Efflux Pump Inhibitory Properties of the Crude Extract and Fractions from Acacia macrostachya Stem Bark by Akua Frema Barfour, Abraham Yeboah Mensah, Evelyn Asante-Kwatia, Cynthia Amaning Danquah, Daniel Anokwah, Silas Adjei, Michael Kwesi Baah, Merlin L. K. Mensah

“…At ½ MIC, the methanol fraction demonstrated significant accumulation of EtBr in E. coli having superior efflux inhibition over the standard EPIs: chlorpromazine and verapamil. Tannins, flavonoids, triterpenoids, phytosterols, coumarins, and saponins were identified in preliminary phytochemical studies. …”
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Opening up Corpus FinSL: enriching corpus analysis with linguistic ethnography in a study of constructed action by Puupponen Anna, Hodge Gabrielle, Anible Benjamin, Salonen Juhana, Wainio Tuija, Keränen Jarkko, Hernández Doris, Jantunen Tommi

“…This article outlines a novel interview method developed to enrich the original Corpus of Finnish Sign Language (Corpus FinSL) with additional ethnographic information eight years after it was first documented and archived with standard IMDI corpus metadata. We interviewed 22 Corpus FinSL signers about their family and social networks, as well as their lifelong language, geographical, educational, and employment trajectories. …”
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Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults by Farwa Ali, Jeremy A. Syrjanen, Dan J. Figdore, Walter K. Kremers, Michelle M. Mielke, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, B. Gwen Windham, Leland R. Barnard, Ronald C. Petersen, Alicia Algeciras-Schimnich

“…Results In this study multiple statistically significant relationships are observed for GFAP, NfL, and P-Tau181 with gait parameters. Each standard deviation increase in GFAP, NfL, and P-Tau181 is associated with a reduction in velocity of 2.100 (95% CI: −3.004, −1.196; p = 5.4 × 10−6), 4.400 (−5.292, -3.507; p = 9.5 × 10−22), and 2.617 (−3.414, −1.819; p = 1.5 × 10−10) cm/sec, respectively. …”
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Management of Canine Leishmaniasis and the Treatment Trends of Veterinarians in Aegean Region of Türkiye: A Questionnaire-based Survey by Metin Pekağırbaş, Mehmet Karakuş, Elif Dönmez, Hüseyin Gökhan Özdemir, Yusuf Özbel, Seray Töz

“…Although CanL and vector sandflies are widespread in the study area, there are no standardized diagnostic and treatment methods followed by private clinics. …”
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MRI and FDG PET/CT Findings for Borderline Brenner Tumor of the Ovary: A Case Report and Literature Review by Hiroki Matsutani, Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Masahide Ohmichi, Keigo Osuga

“…Furthermore, ADC values and maximum standardized uptake value (SUV max) in the present case were compared with those of an additional 7 cases of benign BT in this institution in addition to literature reviews. …”
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Groundwater vulnerability and, risk assessment of seawater intrusion for the development of a strategy plan towards sustainability: Case of the Souss-Massa coastal area, Morocco by Yassine Ez-zaouy, Lhoussaine Bouchaou, Mohammed Hssaisoune, Abdelhaq Aangri, Gianluigi Busico, Saadou Oumarou Danni, Oumaima Attar, Mohamed Nehmadou, Aicha Saad, Yassine Ait Brahim

“…Our results show that improved GALDIT provides a better overview on groundwater vulnerability to seawater intrusion in comparison to the standard approach. The study area has five levels of vulnerability, very low, low, moderate, high, and very high, which present 15 %, 1.3 %, 19.8 %, 5.5 %, and 58.4 %, respectively. …”
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Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis by Omran Davarinejad, Saeid Komasi, Mohammad-Taher Moradi, Farzaneh Golmohammadi, Maryam Bahrami, Hamed Esmaeil Lashgarian, Masumeh Jalalvand, Sara Hookari, Fatemeh Kazemisafa

“…Subgroup analyses indicated that the standardized mean difference of GDNF was larger in European samples (d = –1.01, p ≤ 0.001) than in the Asian population (d = –0.61, p = 0.011). …”
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Intracardiac Echocardiography as a Guide for Transcatheter Closure of Patent Ductus Arteriosus by Hironaga Yoshimoto, Maeda Yasuto, Tadashi Inoue, Yoshiyuki Kagiyama, Yozo Teramachi, Ryuta Takase, Yusuke Koteda, Yoshihiro Fukumoto, Motofumi Iemura, Kenji Suda

“…Transcatheter closure of patent ductus arteriosus (TC-PDA), conventionally guided by aortography, has become the standard treatment of this disease. The purposes of this study were to evaluate whether intracardiac echocardiography (ICE) may be used for measuring PDA size and be used as a guide for TC-PDA. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…The refractory form of disease (lack of conclusive clinical and endoscopic remission during 4-8 weeks of standard-dose PPI therapy), presence of strictures and Barrett's esophagus require EGDS with esophageal biopsy and bioptic histological examination. …”
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Comprehensive characterization and identification of chemical constituents of Pingwei Powder by ultra high performance liquid chromatography tandem quadrupole-time-of-flight tandem... by Tongyan Zhu, Na Li, Chunying Zhao, Jianwei Liu, Yuling Liu, Jianhui Chen, Yuxin Dong, Yuxuan Tian, Xia Hong, Hui Xiong

“…Subsequently, the chemical substances in Pingwei Powder were identified by comparison with reference standards, literatures, and the built-in database of SCIEX OS 2.2 software. …”
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PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury by Hui Liu PhD, MD, Hongjun Jin PhD, Xuyi Yue PhD, Junbin Han PhD, Pamela Baum SRS, Dana R. Abendschein PhD, Zhude Tu PhD

“…Three-dimensional (3D) reconstruction of the first 100-second microPET/computed tomography (CT) image indicated the location of bilateral common carotid arteries. [ 11 C]TZ3321 displayed significantly higher accumulation (standardized uptake values: 0.93 ± 0.07 vs 0.78 ± 0.09, n = 6, P = .001) in the injured carotid artery than in the contralateral side. …”
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Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study by Xin Zhang, Caopei Zheng, Ling Zhang, Yuqing Sun, Ying Liang, Xue Chen, Lijun Pang, Yulin Zhang

“…Among the three subgroups of voriconazole monotherapy, no-loading dose regime demonstrated a superior response to IPA therapy compared to the standard-dose regimen (OR 0.264, 95%CI 0.068–0.845, p = 0.035). …”
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Neurological history both twinned and queried by generative artificial intelligence by Jung-Hyun Lee, Jung-Hyun Lee, Jung-Hyun Lee, Eunhee Choi, Sergio L. Angulo, Sergio L. Angulo, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, William W. Lytton, William W. Lytton, William W. Lytton

“…A large language model (LLM) could be utilized as a digital twin which could enhance queryable electronic medical record (EMR) systems and provide healthcare conversational agents (HCAs) to replace waiting-room questionnaires.MethodsIn this observational pilot study, we presented verbatim history of present illness (HPI) narratives from published case reports of headache, stroke, and neurodegenerative diseases. Three standard GPT-4 models were designated Models P: patient digital twin; N: neurologist to query Model P; and S: supervisor to synthesize the N-P dialogue into a derived HPI and formulate the differential diagnosis. …”
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The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…While the amount of GWAS summary statistics collected by the scientific community is rapidly increasing, the use of this data is limited by the lack of generally accepted standards. In particular, the researchers who would like to use GWAS summary statistics in their studies have to become aware that the data are scattered across multiple websites, are presented in a variety of formats, and, often, were not quality controlled. …”
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