Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty by Ting Chen, Linqi Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Fei Xiao

“…We identified four novel missense variants of MKRN3, c.1138G > A (p.Glu380Lys), c.1420T > A (p.Leu474Met), c.673C > G (p.Leu225Val), and c.1071C > G (p.Ile357Met) in two sporadic cases and three familial cases. According to ACMG standards, two MKRN3 variant (p.Glu380Lys and p.Ile357Met) are likely pathogenic, and two others are of uncertain significance. …”
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Efficacy and safety of transanal endoscopic microsurgery for early rectal cancer: a meta-analysis by Chunqiang Wang, Tianye Huang, Xuebing Wang

“…BackgroundThe gold standard for the treatment of rectal cancer is radical surgery with total mesorectal excision (TME). …”
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Unanchored simulated treatment comparison on survival outcomes using parametric and Royston-Parmar models with application to lenvatinib plus pembrolizumab in renal cell carcinoma by Christopher G. Fawsitt, Janice Pan, Philip Orishaba, Christopher H. Jackson, Howard Thom

“…Methods We fit covariate-adjusted survival models to individual patient data from phase 3 trial of LEN + PEM, including standard parametric distributions and Royston-Parmar spline models with up to 3 knots. …”
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Short-term and long-term effect of non-pharmacotherapy for adults with ADHD: a systematic review and network meta-analysis by Xinyue Yang, Lin Zhang, Jing Yu, Meng Wang

“…Cochrane Risk of Bias tool version 2 (ROB2) and Confidence in Network Meta-Analysis (CINeMA) were used to assess the risk of bias and the certainty of the evidence. Standardized mean differences were estimated using network meta-analyses with random effects.ResultsA total of 37 RCTs involving 2,289 participants and 10 non-pharmacological therapies were included. …”
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Phosphorus transitions driven by cyclone biparjoy linked middle east North Africa (MENA) and Indian Thar Desert dust storm pathways in Asia’s largest grassland by Rupak Dey, Seema B. Sharma, Mahesh G. Thakkar, Ranjit Kumar Sarangi, Abhiroop Chowdhury, Aliya Naz

“…Spatial and temporal variations in dust emissions were assessed using satellite remote sensing data, while ground truthing was performed for phosphorus content analysis using standard protocols. The aerosol data from MERRA-2 for the past 40 years were used to examine the relationships between aerosol concentrations and wind direction and speed. …”
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Alloplasmic recombinant lines (H. vulgare)-T. aestivum with 1RS.1BL translocation: initial genotypes for production of common wheat varieties by L. A. Pershina, L. I. Belova, N. V. Trubacheeva, T. S. Osadсhaya, V. K. Shumny, I. A. Belan, L. P. Rosseeva, V. V. Nemchenko, S. N. Abakumov

“…Alloplasmic lines L-311(1)–L-311(6) showed their advantage in comparison with the standard varieties for resistance to leaf and stem rust, yield, and grain quality. …”
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Experiences of midwifery students and graduates in Somalia: evidence from qualitative data by Hawa Abdullahi, Asia Mohamed Mohamud, Maryan Abdulkadir Ahmed, Mohamed Ahmed Omar, Abdirisak A. Dalmar, Hannah Tappis, Shatha Elnakib

“…Somalia ranks among the countries with the highest maternal mortality rate, with an estimated shortage of 20,000 midwives compared to the WHO recommended standard. Yet, limited research has explored the lived experience of midwives in conflict. …”
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Tratamento Farmacológico das Dimensões Sintomáticas da Perturbação de Personalidade Borderline: Recomendações Baseadas na Evidência by Carlos Siopa, Francisco Silva, Inês Souto Braz

“…Embora a psicoterapia seja o tratamento gold‑standard, o tratamento farmacológico torna‑se necessário em vários casos. …”
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Comprehensive metabolite profiling and evaluation of anti-nociceptive and anti-inflammatory potencies of Nypa fruticans (Wurmb.) leaves: Experimental and in-silico approaches by Farhana Islam, Md. Aktaruzzaman, Md. Tarikul Islam, Fariya Islam Rodru, Saquiba Yesmine

“…Two phytochemicals, (−) Epicatechin (CID 72276) and Quercetin (CID 5280343), outperformed the standard anti-inflammatory drug, diclofenac sodium, in MDS studies. …”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…However, we encountered challenges that complicated pleural infection interpretation, including: (i) uncertainties regarding microbial pathogenicity and the impact of prior antibiotic therapy on diagnostic performance; (ii) lack of a clinical diagnostic gold-standard for molecular performance comparisons; (iii) potential microbial contamination during specimen collection or processing; and (iv) difficulties distinguishing background microbial noise from true microbial signal in low-biomass specimens. …”
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Efficiency of the data generated by the robotic milking system for comprehensive diagnosis of mastitis in cows by M. N. Isakova, M. V. Ryaposova

“…Milking time for the majority of the cows (67.2%) complied with the standards and equaled to 4–7 min, mean milking time for 32.7% of the animals was 8 minutes. …”
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New strategies in management of severe alcoholic hepatitis by P. Ye. Tkachenko, I. I. Komkova, M. V. Mayevskaya, V. T. Ivashkin

“…Prescription of prednisolone and Adomet combination at severe alcohol-induced hepatitis increases the treatment response rate to corticosteroids, promotes decrease of short-term mortality and results in significantly less frequent development of hepatorenal syndrome as compared to standard therapy.…”
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OCT Biometry (B-OCT): A New Method for Measuring Ocular Axial Dimensions by Bartosz L. Sikorski, Pawel Suchon

“…The presented method is the first spectral domain OCT-based biometry technique and the only one integrated into a standard OCT device. Thus, it brings novel functionality to OCT technology.…”
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Comparing the Technological and Intraoperative Performances of Da Vinci xi and DaVinci 5 Robotic Platforms in Patients Undergoing Robotic-Assisted Radical Prostatectomy by Ahmed Gamal, Marcio Covas Moschovas, Shady Saikali, Sumeet Reddy, Yu Ozawa, Rohan Sharma, Avaneesh Kunta, Travis Rogers, Vipul Patel

“…Surgical technique: We performed our RARP technique with our standard approach in all patients (6–8). With this new platform, we maintained our conventional technique without any modifications or adaptions from the trocar placement until anastomosis. …”
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Good soil management can reduce dietary zinc deficiency in Zimbabwe by Muneta G. Manzeke-Kangara, Edward J. M. Joy, Florence Mtambanengwe, Prosper Chopera, Michael J. Watts, Martin R. Broadley, Paul Mapfumo

“…Potential monetized yield gains from adopting improved soil fertility management range from 49- to 158-fold larger than the potential reduction in DALYs, if the latter are monetized using standard methods. Conclusion Farmers should be incentivized to adopt improved soil fertility management to improve both crop yield and quality.…”
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Association between controlling nutritional status score and the prognosis of patients with acute myocardial infarction: a systematic review and meta-analysis by Lei Peng, Jian Tang, Ningjun Zhang, Zhongnan Zhang, Deqi Wang, Youfu He

“…The statistical analyses on both categorical and continuous variables unraveled that a high CONUT score was markedly linked to an elevated risk of MACE [categorical variable: odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.42–2.15; continuous variable: standardized mean difference (SMD) = 1.02, 95% CI = 0.78–1.26], mortality (categorical variable: OR = 2.08, 95% CI = 1.70–2.55; continuous variable: SMD = 1.16, 95% CI = 0.57–1.74), cardiac death (categorical variable: OR = 2.81, 95% CI = 1.67–4.73), myocardial reinfarction (categorical variable: OR = 2.21, 95% CI = 1.28–3.83), and atrioventricular block (categorical variable: OR = 5.21, 95% CI = 1.83–14.89) in AMI patients. …”
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The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin by Lan Min Lai, Qing-gen Chen, Yang Liu, Rui Zhao, Mei Ling Cao, Lei Yuan

“…The sensitivity and specificity of culture and mNGS were analyzed based on the final clinical diagnosis as the gold standard to assess the diagnostic value of mNGS in FUO cases. …”
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Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis by Hongxi Guo, Juan Luo, Hu Yang, Jun Yang, Hongqiang Bian, Xufei Duan, Xin Wang

“…Body mass index (BMI) also showed a significant improvement post-treatment compared to pre-treatment (P < 0.05).ConclusionsERP performed by trained endoscopists utilizing standard adult endoscopes and accessories proved a safe and effective treatment option for pediatric CP, with complication rates comparable to those reported in adult cases.…”
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The development of winter wheat lines with several genes for resistance to Puccinia graminis Pers. f. sp. tritici for use in breeding programs in Russia by I. F. Lapochkina, O. A. Baranova, N. R. Gainullin, G. V.  Volkova, E. V. Gladkova, E. O. Kovaleva, A. V.  Osipova

“…The genotypes with a set of economically valuable features approximating or surpassing the standard cultivar of winter wheat Moskov skaya 39 were selected for further testing in breeding nurseries of the Moscow region. …”
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Risk Index Model of Property and Cargo Insurance Claims Based on Precipitation in Hunan by Peng Weiying, Li Yueyong, Tan Shiqi, Li Hao, Guan Jianwen, Liao Chunhua, Zhou Wei, Xie Ruiheng

“…Importantly, the model proves effective even in scenarios where meteorological rainstorm standards are not met, showcasing its reliability in preemptively identifying potential insurance claim risks.Presently, the developed risk index model has been implemented in Hunan Insurance Meteorological Disaster Risk Control Service Platform Version 2.0. …”
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