Phantom motor execution as a treatment for phantom limb pain: protocol of an international, double-blind, randomised controlled clinical trial by Brian E McGuire, Lina Bunketorp-Käll, Eva Lendaro, Liselotte Hermansson, Helena Burger, Corry K Van der Sluis, Monika Pilch, Katarzyna Kulbacka-Ortiz, Ingrid Rignér, Anita Stockselius, Lena Gudmundson, Cathrine Widehammar, Wendy Hill, Sybille Geers, Max Ortiz-Catalan

“…The results will be published according to the Consolidated Standards of Reporting Trials guidelines in a peer-reviewed journal.Trial registration number NCT03112928; Pre-results.…”
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Saturated hydraulic conductivity and steady-state infiltration rate database for Brazilian soils by Marta Vasconcelos Ottoni, Wenceslau Geraldes Teixeira, Aline Mari Huf dos Reis, Letícia Guimarães Pimentel, Luciana Rodrigues Souza, Jackson Adriano Albuquerque, Valdinar Ferreira Melo, Karina Maria Vieira Cavalieri-Polizeli, José Miguel Reichert, João Herbert Moreira Viana, Ademir Fontana, Lucas de Castro Medrado, Glenio Guimarães Santos, Luís Gustavo Henriques do Amaral, Lúcia Helena Cunha dos Anjos, José Coelho de Araújo Filho, Silvio Barge Bhering, Gabrielle Fernandes de Brito, Pedro Gomes de Campos do Valle, Pablo Nieto Campos, Adriana Monteiro da Costa, Jean Dalmo de Oliveira Marques, Alba Leonor da Silva Martins, Michele Bruna de Souza do Nascimento, Norberto Cornejo Noronha, Ricardo Duarte de Oliveira, Jeane Cruz Portela, Milson Evaldo Serafim, Marlen Barros e Silva, Sueli Rodrigues, Wilk Sampaio de Almeida, Margareth Lopes de Moraes, Nilton Curi

“…The two groupings that presented the lowest variability in terms of Ksat standard deviation values were the combination of textural classes with soil classes at the second category level of SiBCS (Brazilian Soil Classification System), and porosity classes with soil classes at the second category level of SiBCS. …”
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Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Refer... by Huaying WANG, Yang CHEN, Peng HUANG, Yue LI, Gang ZHANG, Zhongsheng ZHANG, Haixia JI, Hao GUO, Heng MA

“…CAG was used as the reference standard for detecting the presence of stenoses. Vessel length and diameter were compared between sequences using paired t-tests. …”
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Comparison of specialist ataxia centres with non-specialist services in terms of care access and organisation, health services resource utilisation and costs in Germany using patie... by Julie Vallortigara, Julie Greenfield, Barry Hunt, Holm Graessner, Carola Reinhard, Andreas Nadke, Bart-Jan Schuman, Deborah Hoffman, Steve Morris, Paola Giunti

“…For patients who visited both a SAC and a standard neurology clinic, 67.2 % reported that the care received at a SAC was better. …”
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Effects of ambient air pollutants on cardiovascular disease hospitalization admission by L. Salvaraji, R. Avoi, M.S. Jeffree, S. Saupin, H.R. Toha, S.B. Shamsudin

“…The nitrogen dioxide (<0.04 ppm), carbon monoxide (<9 ppm), ozone (<0.05 ppm) and PM10 (<100 µg/m3) gases detected are below the national standard limit levels. In the later years of the series, the ozone and fine particulate gases intensify. …”
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Traditional herbal medicine for Guillain-Barré syndrome: A systematic review and meta-analysis by Somin Jung, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko

“…Background: Guillain-Barré syndrome (GBS) is a rapid-onset disease caused by the immune system damaging the peripheral nervous system. Since most standardized treatments for GBS focus on acute phase treatment, there are limitations to the rehabilitation and management of general conditions. …”
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Evaluation of three diagnostic algorithms to reduce normal scan rates, radiation exposure and costs in patients with suspected chronic coronary syndrome referred for 82Rb-Positron... by Christian Müller, Damian Wild, Philip Haaf, Felix Mahfoud, Michael J Zellweger, Simon M Frey, Gabrielle Huré, Jan-Philipp Leibfarth, Kathrin Thommen, Melissa L Amrein, Ibrahim Schaefer, Klara Rumora, Igor G Schneider, Federico Caobelli

“…The proportion of missed ischemia, number of scans and reduction of normal scan results, radiation exposure and costs were compared with the current gold standard (CACS+PET in every patient). Endpoints were defined as small ischemia (SDS ≥2) and relevant ischemia (≥10% of myocardium).Results The mean age of the patients was 65±11 years, and 43% were female. …”
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Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study by Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas

“…No statistically significant difference could be observed for the incidence of relapse.Conclusions The results of this study provide a prospectively validated standard laboratory biomarker index to estimate the transplant-related mortality risk after alloSCT. …”
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Global burden of ischemic heart disease in older adult populations linked to non-optimal temperatures: past (1990–2021) and future (2022–2050) analysis by Lihui Liu, Lihui Liu, Yisong He, Yisong He, Gang Huang, Yangxi Zeng, Yangxi Zeng, Jiaan Lu, Ru He, Haiqing Chen, Yuheng Gu, Qingwen Hu, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan

“…With the ongoing global climate change, understanding the impact of non-optimal temperatures on IHD burden becomes increasingly important, especially in vulnerable populations such as the older adult.MethodsThis study used data from the Global Burden of Disease Study 2021 (GBD 2021) to analyze the spatiotemporal trends of low and high temperatures on IHD burden in the older adult population (aged 60 and above) from 1990 to 2021. We used age-standardized rates (ASR), annual percentage change (EAPC), and the Bayesian age-period-cohort (BAPC) model to forecast 2050. …”
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Xpert Bladder Cancer Detection in Emergency Setting Assessment (XESA Project): A Prospective, Single-centre Trial by Federica Sordelli, Antonio Desai, Filippo Dagnino, Roberto Contieri, Sofia Giuriolo, Marco Paciotti, Vittorio Fasulo, Stefano Mancon, Davide Maffei, Pier Paolo Avolio, Giorgio Da Rin, Federica Maura, Elena Vanni, Davide Federico, Piergiuseppe Colombo, Giovanni Lughezzani, Nicolò Maria Buffi, Paolo Casale, Alberto Saita, Massiomo Lazzeri, Rodolfo Hurle, Antonio Voza

“…The primary outcomes were sensitivity, specificity, and a cost analysis for the Xpert BCD test in comparison to standard diagnostic methods such as urine cytology (UC) and white-light cystoscopy (WLC). …”
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Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator’s Consortium Registry Analysis by Margaret Stalker, MD, Connor B. Grady, MPH, Alex Watts, MS, Wei-Ting Hwang, PhD, Krishna Chandrasekhara, MS, Fangdi Sun, MD, Geoffrey Liu, MD, Devalben Patel, MD, Jorge Nieva, MD, Amanda Herrmann, MD, Kristen Marrone, MD, Vincent K. Lam, MD, Vamsidhar Velcheti, MD, Stephen V. Liu, MD, Gabriela Liliana Bravo Montenegro, MD, William Tompkins, MD, Tejas Patil, MD, Jared Weiss, MD, Kelsey Leigh Miller, MD, William Schwartzman, MD, Jonathan E. Dowell, MD, Khvaramze Shaverdashvili, MD, PhD, Liza Villaruz, MD, Amanda Cass, PharmD, Wade Iams, MD, Dara Aisner, MD, PhD, Charu Aggarwal, MD, MD, D. Ross Camidge, MD, PhD, Lova Sun, MD, Melina E. Marmarelis, MD

“…Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. …”
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Measured Resection as Gap Balance Method in Mobile‐Bearing Medial Unicompartmental Knee Arthroplasty: A Randomized Controlled Trial by Qian Liu, Jianhua Ren, Wenhui Zhang, Tangzhao Liang, Zhe Wang, Siwei Xie, Yuhang Li, Jianfeng Hou, Kun Wang, Ronghan He

“…However, this process commonly depends on the surgeon's experience and lacks specific unified standards. This study aimed to propose and evaluate a novel “measured resection” method for gap balance in MB‐UKA. …”
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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…This study provides new evidence that preoperative CT scans should be considered a non-invasive gold standard for analyzing nasal subtypes as they significantly influence surgical success, with concha bullosa associated with worse pain relief. …”
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Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea by Nanfang Li, Mulalibieke Heizhati, Chao Sun, Suofeiya Abulikemu, Liang Shao, Xiaoguang Yao, Yingchun Wang, Jing Hong, Ling Zhou, Lei Wang, Yu Zhang, Weiwei Zhang

“…OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). …”
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Characteristic of the active substance of the Saccharomyces cerevisiae preparation having radioprotective properties by G. S. Ritter, V. P. Nikolin, N. A. Popova, A. S. Proskurina, P. E. Kisaretova, O. S. Taranov, T. D. Dubatolova, E. V. Dolgova, E. A. Potter, S. S. Kirikovich, Y. R. Efremov, S. I. Bayborodin, M. V. Romanenko, M. I. Meschaninova, A. G. Venyaminova, N. A. Kolchanov, S. S. Bogachev

“…A comparison of the radioprotective effect of the standard radioprotector B-190 and the RNA preparation was made in one experiment. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Future directions include strategies to reduce MSC heterogeneity, standardized protocols for isolation and expansion of those cells, and the development of well-designed large-scale trials to show significant efficacy during a long follow-up, mainly in individuals with DKD.…”
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Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis by Jian Zhang, Xiaomei Li, Ying Hu, Bin Dong, Yongning Jia, Ziyu Li, Xiaojing Cheng, Jinyao Shi, Jiafu Ji, Zhongwu Li, Hong Du, Ting Guo, Shuqin Jia, Xiaofang Xing, Yunsheng Dou

“…CD8+ cytotoxic T lymphocytes levels were elevated after chemotherapy, which was more significant in the group treated with XELOX regimen and in patients with better response, consistent with the TCR diversity elevation.Conclusions These findings have deepened our understanding of the immune modulating effect of chemotherapy and suggest that the immune profile of specimens after standard chemotherapy should be considered for the personalized immunotherapy to ultimately improve clinical outcome in patients with GC.…”
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Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, resp... by Fei Wang, Yongjiu Wang, Bin Xiong, Zhenlin Yang, Jingfen Wang, Yumin Yao, Lixiang Yu, Qinye Fu, Liang Li, Qiang Zhang, Chao Zheng, Shuya Huang, Liyuan Liu, Chun Liu, Huaibo Sun, Beibei Mao, Dong-Xu Liu, Zhigang Yu

“…Patients showing poor response, as defined by RECIST 1.1, could opt to receive additional pyrotinib or continue standard therapy. The primary endpoint was the total pathological complete response (tpCR; ypT0/isN0) rate. …”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Socazolimab combined with standard EC regimen chemotherapy for first-line treatment of ES-SCLC significantly prolonged overall survival and did not increase the safety risk of treatment.…”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Background: Tumor molecular profiling (TMP) for pancreatic cancer (PC) is recommended by current international guidelines, yet no testing standards exist. Moreover, the magnitude of benefit and the cost-effectiveness of comprehensive next-generation sequencing panels for PC are under debate. …”
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