The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomize... by Kinga Kovács, Rita Nagy, Lilla Andréka, Brigitta Teutsch, Miklós Szabó, Péter Varga, Péter Hegyi, Péter Hársfalvi, Nándor Ács, Ágnes Harmath, Csaba Nádor, Ákos Gasparics

“…Preterm infants in the control group will receive the standard dosing regimen. The primary outcome will be reintubation within 48 hours.…”
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Heavy Metals in Water and Sediments and Their Impact on Water Quality in Andean Micro-watersheds: A Study of the Colorado and Alajua Rivers in the Ambato River Watershed, Tungurahu... by Rodny Peñafiel, Fabián Rodrigo Morales-Fiallos, Bolivar Paredes-Beltran, Dilon Moya, Adriana Jacqueline Frias Carrion and Belén Moreano

“…While most parameters met the Ecuadorian quality standards for water sources intended for human consumption, concerns emerged regarding elevated levels of total and fecal coliforms along both rivers, which could limit the suitability of these rivers as a water source for human use and consumption. …”
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Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019 by Xinyue Yang, Zhiqiang Zhang, Jiayi Sun, Wenjuan Zhang

“…The corresponding age-standardized mortality rates (ASMR) and age-standardized DALYs rates (ASDR) were both in a decreasing trend with estimate of the annual percentage change (EAPC) of -1.38 (-1.42 – -1.34) and -1.43 (-1.47 – -1.38). …”
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A prospective, cross-sectional study to establish age-specific reference intervals for neonates and children in the setting of clinical biochemistry, immunology and haematology: th... by Susan M Donath, Monsurul Hoq, Vicky Karlaftis, Susan Mathews, Janet Burgess, John Carlin, Paul Monagle, Vera Ignjatovic

“…Analytical testing is performed according to the standard operating procedures used for clinical samples. …”
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Role of outer membrane vesicles of hypervirulent Klebsiella pneumoniae isolated from bovine uterine discharge in pro-inflammatory dysregulation by A. F. Daham, A. H. Jaber, A. Neamah, H. Al-Karagoly

“…The standard PCR test showed that 27 out of the 47 isolates (57.45%) tested positive for the 16S rRNA gene, with all 27 of these isolates also testing positive for the rmpA and traT genes. …”

Change in seed viability of commercial maize hybrids during storage by Perić Sanja, Stevanović Milan, Mladenović Marko, Popović Aleksandar, Kovačević Aleksandar, Grčić Nikola

“…In the Republic of Serbia, certified corn seeds must adhere to specific germination standards as outlined by regulatory guidelines. Given that germination rates decline during storage, routine germination testing at accredited laboratories is imperative. …”
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Automated post-run analysis of arrayed quantitative PCR amplification curves using machine learning [version 1; peer review: awaiting peer review] by David Garrett Brown, Darwin J. Operario, Lan Wang, Shanrui Wu, Daniel T. Leung, Eric R. Houpt, James A. Platts-Mills, Jie Liu, Ben J. Brintz

“…Previous manual analyses of the amplification curves by experts in qPCR analysis were used as the gold standard. First, a classification model predicted whether amplification occurred or not, and if so, a second model predicted the cycle threshold (Ct) value. …”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…The CH2Cl2 : CH3OH (1 : 1) extract (IC50 : 1.51 µg/mL) and β-sitosteryl-3β-glucopyranoside-6′-O-palmitate (4) (IC50 : 5.41 µg/mL) also exhibited auspicious DPPH scavenging activities, followed by stigmasterol (5) (IC50 : 6.88 µg/mL) compared to the ascorbic acid standard (IC50 : 0.46 µg/mL). The molecular docking analyses unveiled the highest binding affinity by β-sitosteryl-3β-glucopyranoside-6′-O-palmitate (4) (−8.0 kcal/mol) against P. aeruginosa PqsA relative to the ciprofloxacin standard (−8.2 kcal/mol). …”
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The Influence of Rice Types and Boiling Time on Glycemic Index: An In Vivo Evaluation Using the ISO 2010 Method by Anna Vîrlan, Lidia Coșciug, Dinu Țurcanu, Rodica Siminiuc

“…This study investigated the impact of rice type and boiling duration on the GI in healthy adults using an in vivo approach aligned with ISO 2010 standards. The glycemic response to four rice types (white round-grain, parboiled medium-grain, white long-grain, and whole-grain long-grain) was measured through postprandial blood glucose levels under both standard and extended boiling conditions to assess their implications for dietary glycemic control. …”
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Prognostic relevance of Ki-67 and P16/INK4a markers in histological diagnosis of cervical dysplasia by T. A. Dimitriadi, D. V. Burtsev, E. A. Dzhenkova, T. N. Gudtskova, K. V. Dvadnenko

“…According to the results of a standard histological examination, the distribution of patientsinto groups occurred as follows: CIN 1–18, in CIN 2–39, in CIN 3–14 patients. …”
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Assessment of Antidepressant Activity of Ethanolic Extract of Hibiscus rosa sinensis Linn. Petals in Comparison with Fluoxetine and its Toxicity in Swiss Albino Mice: A Preclinical... by Sneha Ray, Swanand S Pathak

“…The study procedure will involve procuring standard drugs, screening animals, preparing a solution for the test drugs and determining the LD50. …”
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Assessment Of Heavy Metals Concentration and Pollution Indices Of Surface Water In Enerhen River, Warri South LGA, Delta State, Nigeria by A. O. Egai, M. Paaru

“… The objective of this paper is to assess heavy metal concentrations and pollution indices of surface water in Enerhen River, Warri South, Delta State, Nigeria using appropriate standard method.   Data obtained show that the result indicated the concentration of Zinc 0.065mg/l - 0.190mg/l, Pb (0.003mg/l -0.142mg/l), Cu (0.081mg/l - 0.213mg/l), Cd (0.02mg/l - 0.282mg/l, Cr (0.041mg/l - 0.171mg/l), Fe (0.162mg/l - 0.278mg/l) and Ni (0.104mg/l - 0.762mg/l)  comparison with WHO 2012 permissible limit the probed water sample falls within the allowable concentration of the standard except the  concentration of lead (Pb) in SW1, SW2, SW4 and SW5 which is a  concern because it exceeded the allowable limit, lead is considered toxic to human at higher concentrations . …”
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The Global, Regional, and National Burden of Tracheal, Bronchus, and Lung Cancer Caused by Smoking: An Analysis Based on the Global Burden of Disease Study 2021 by Jingting Zhang, Jincheng Tang, Renyi Yang, Siqin Chen, Huiying Jian, Puhua Zeng

“…Estimated annual percentage changes (EAPCs) were calculated to evaluate trends in age-standardized mortality rates (ASMRs) and age-standardized DALY rates (ASDRs). …”
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PropAngio study protocol: a neoadjuvant trial on the efficacy of propranolol monotherapy in cutaneous angiosarcoma—a proof of principle study by Neeltje Steeghs, Jos H Beijnen, Kimberley M Heinhuis, Nikki S IJzerman, Anne Miek Koenen, Winette T A van der Graaf, Rick L Haas, Alwin D R Huitema, Winan J van Houdt

“…The neoadjuvant setting provides a good opportunity to rapidly evaluate both the clinical response and histological response, without a significant delay in standard anticancer treatment. Fourteen patients with primary, recurrent or metastatic cutaneous angiosarcoma will be included. …”
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Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review by Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang

“…Even though surgical resection is the primary treatment to relieve clinical symptoms, prevent recurrence, and confirm diagnosis, no standard surgical protocol is available. The therapeutic effect of postoperative adjuvant therapies remains unclear. …”
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Protocol for the development of a reporting guideline for causal and counterfactual prediction models in biomedicine by Yi Guo, Hua Xu, Fei Wang, Jie Xu, Jiang Bian, Robert Lucero, Mattia Prosperi

“…In stage 3, a computer-based, real-time Delphi survey will be performed to consolidate the PRECOG checklist, involving experts in causal inference, epidemiology, statistics, machine learning, informatics and protocols/standards. Stage 4 will involve the write-up of the PRECOG guideline based on the results from the prior stages. …”
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Assessment of Nutritional Status in Patients with Head and Neck Cancer Before Radiotherapy: A Single-center, Cross-sectional Study by Susetyowati SUSETYOWATI, Fuadiyah Nila KURNIASARI, Amalia Sarah SHOLIKHATI, Mardiah HARDIANTI, Ericko EKAPUTRA

“…Conclusions: The method for nutritional status assessment in HNC patients undergoing radiotherapy can be performed by measuring body weight, weight loss, upper arm circumference, visceral fat, hemoglobin, and RMR in addition to PG-SGA as the gold standard.…”
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Dietary Diversity among Children Aged 6–23 Months in Aleta Wondo District, Southern Ethiopia by Karisa Dafursa, Samson Gebremedhin

“…However, in many developing countries, meeting the minimum standards of DD is challenging and information concerning its determinants is limited. …”
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Interpretable machine learning models for predicting skip metastasis in cN0 papillary thyroid cancer based on clinicopathological and elastography radiomics features by Xiaohua Yao, Mingming Tang, Min Lu, Jie Zhou, Debin Yang

“…We collected preoperative clinicopathological data and extracted, standardized radiomics features from elastography imaging to develop various ML models. …”
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Diagnoses of postpartum urinary retention using next-generation non-piezo ultrasound technology: assessing the accuracy and benefits by Ruben Plöger, Charlotte Behning, Adeline Walter, Ulrich Gembruch, Brigitte Strizek, Florian Recker

“…To simplify the diagnosis and establish a screening tool we analyzed the application of portable handheld-ultrasound devices  (PUD) as used in Point-of-care diagnostics in comparison to established standard ultrasound devices (SUD). This prospective study aimed to evaluate the reliability of non-piezo, chip-based PUD in comparison to the measurement withSUD, containing a piezo transducer, as golden standard for the ultrasound diagnosis of postpartum urinary retention. …”
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