Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison tri... by Andrea Benedetti, Cecilia T Costiniuk, Kosar Khwaja, Andrew Johnson, Barret Rush, Darrell Tan, Ranjani Somayaji, Salman Qureshi, Michaeline McGuinty, Nicole Ezer, Sara Belga, Emily G. McDonald, Zahra N. Sohani, Guillaume Butler-Laporte, Andrew Aw, Alex Carignan, Matthew P. Cheng, Bryan Coburn, Dan Gregson, Alexander Lawandi, Victor Leung, Sylvain Lother, Derek MacFadden, Leighanne Parkes, Valerie Roy, Ilan Schwartz, Miranda So, Emilie Trinh, Todd C. Lee

“…Introduction Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection of immunocompromised hosts with significant morbidity and mortality. The current standard of care, trimethoprim-sulfamethoxazole (TMP-SMX) at a dose of 15–20 mg/kg/day, is associated with serious adverse drug events (ADE) in 20%–60% of patients. …”
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A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A... by Rindra Vatosoa Randremanana, Mathurin Tejiokem, Niaina Rakotosamimanana, Valérie Donkeng Donfack, Verlaine Bolyse Mbouchong, Mirella Randrianarisoa, Aina Harimanana, Jean Voisin Taguebue, Suzie Tetang Ndiang, Valère Itchy, Annick Robinson, Lovaniaina Ravelomanana, Mbola Rakotomahefa, Dina Ranoharison, Man-Koumba Soumahoro, Brigitte Gicquel, Raymond N'Guessan, Sara Eyangoh, Voahangy Rasolofo, Emery Flavien Akpafi, Marius Irie Bi Irie, Anabelle Bai-Orsot, Jaudel Francis Yuya Septoh, Serge Abogo, Mamy Serge Raherison, Andrianantenaina Rakotoson, Vaomalala Raharimanga, Patrice Piola, Paulo Ranaivomanana, Jean-Marc Collard, Gabrielle Prisca Emmylou Andrianah, Turibio Razafindranaivo, Reziky Tiandraza Mangahasimbola, Kathleen Victoir

“…We used a composite reference standard to estimate the accuracy of the Xpert MTB/RIF test with alternative samples. …”
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Daily Performance of Adolescents with Executive Function Deficits: An Empirical Study Using a Complex-Cooking Task by Yael Fogel, Sara Rosenblum, Renana Hirsh, Mathilde Chevignard, Naomi Josman

“…Participants in both groups performed the CCT, an ecological standardized complex task. Results. Significant group differences were found for all CCT outcome measures (total number of errors, task duration, and all qualitative rating variables). …”
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Low-Level Social Demand Is Associated with Anxiety-Related Gamma Wave Responses in Autistic Male Youth by Vicki Bitsika, Christopher F. Sharpley, Ian D. Evans, Christopher B. Watson, Rebecca J. Williams, Kirstan A. Vessey

“…Methods: To compare data from both of these indicators of mental effort and anxiety, a two-stage study was conducted using (1) standardized test data and (2) in vivo EEG data in a low-demand social setting. …”
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The impact of digital training and mentoring on early childhood education teachers’ knowledge and practices related to nutrition and health by Herawati Netti, B Nuraeni, R Efendi, Y Herlina, N Kusumaningtyas, Zam R Zam, Rudianto, Y Natakusuma, AM Ramadhan

“…A paired-sample t-test revealed a significant increase in teachers' scores, from 61 to 71 (p = 0.019), exceeding the minimum standard (score ≥70). The proportion of ECE teachers with scores according to minimum standards (≥70) before intervention was 39% and significantly increased to 57%. …”
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Modeling a Telemedicine Screening Program for Diabetic Retinopathy in Iran and Implementing a Pilot Project in Tehran Suburb by Sare Safi, Hamid Ahmadieh, Marzieh Katibeh, Mehdi Yaseri, Homayoun Nikkhah, Saeed Karimi, Ramin Nourinia, Ali Tivay, Mohammad Zareinejad, Mohsen Azarmina, Alireza Ramezani, Siamak Moradian, Mohammad Hossein Dehghan, Narsis Daftarian, Davood Abbasi, Afshin Eshghi Fallah, Bahareh Kheiri

“…All images were independently reviewed by a retina specialist as the gold standard. Patients who required further assessment were referred to an eye hospital. …”
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Preparation of Cathode-Anode Integrated Ceramic Filler and Application in a Coupled ME-EGSB-SBR System for Chlortetracycline Industrial Wastewater Systematic Treatment by Yuanfeng Qi, Suqing Wu, Fei Xi, Shengbing He, Chunzhen Fan, Bibo Dai, Jungchen Huang, Meng Meng, Xiangguo Zhu, Lei Wang

“…The coupled ME-EGSB-SBR system removed about 98.0% of CODcr and 95.0% of NH3-N and the final effluent met the national discharged standard (C standard of CJ 343-2010, China). Therefore, the CTC industrial wastewater could be effectively treated by the coupled ME-EGSB-SBR system, which has significant implications for a cost-efficient system in CTC industrial systematic treatment and solid wastes (DSS and SI) treatment.…”
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Factors to Improve the Management of Hepatitis C in Drug Users: An Observational Study in an Addiction Centre by Joseph Moussalli, Helene Delaquaize, Dominique Boubilley, Jean Pierre Lhomme, Jules Merleau Ponty, David Sabot, Anne Kerever, Marc Valleur, Thierry Poynard

“…In a primary care drug user's addiction centre we studied access to HCV standard of care before and after using an onsite total care concept provided by a multidisciplinary team and noninvasive liver fibrosis evaluation. …”
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Impact of nutritional screening on mortality and intensive care unit length of stay by Blanca Cecilia Díaz Chavarro, Blanca Cecilia Díaz Chavarro, Manuel Romero-Saldaña, Manuel Romero-Saldaña, Jorge Karim Assis Reveiz, Guillermo Molina-Recio, Guillermo Molina-Recio

“…This study aims to test the impact of the incorporation of nutritional screening and assessment on mortality and length of stay in patients hospitalized in an Intensive Care Unit in Cali, Colombia, during the years 2019 and 2021–2022.MethodsThis is a historical cohort epidemiological study where one cohort consisted of 114 patients who received a standard nutritional screening (interpretation of body mass index and its clinical impression). …”
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A lightweight prosthetic hand with 19-DOF dexterity and human-level functions by Hao Yang, Zhe Tao, Jian Yang, Wenpeng Ma, Haoyu Zhang, Min Xu, Ming Wu, Shuaishuai Sun, Hu Jin, Weihua Li, Liu Wang, Shiwu Zhang

“…We also integrate an onboard power management module that provides electricity for operating the entire system. In addition to 33 standard grasping modes, this prosthetic hand supports 6 advanced grasping modes designed for enhanced dexterity evaluation, expanding the range of achievable ADLs for amputees while facilitating standard prosthesis function tests and validation in real-world scenarios. …”
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Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021 by Junqing Liang, Jun Shen, Yankai Guo, Manzeremu Rejiepu, Xiuwen Ling, Xiaoyan Wang, Yi Jian, Xing Zhang, Shijie Shao, Baopeng Tang, Ling Zhang

“…The Bayesian Age-Period-Cohort model was utilized to predict future trends in ASDR and age-standardized mortality rate (ASMR) for AF/AFL 2030. Between 1990 and 2021, ASDR rose from 34.22 to 34.94, whereas ASMR increased from 1.46 to 1.50 per 100,000 people. …”
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LotusSQL: SQL Engine for High-Performance Big Data Systems by Xiaohan Li, Bowen Yu, Guanyu Feng, Haojie Wang, Wenguang Chen

“…In recent years, Apache Spark has become the de facto standard for big data processing. SparkSQL is a module offering support for relational analysis on Spark with Structured Query Language (SQL). …”
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Artificial intelligence as a transforming factor in motility disorders–automatic detection of motility patterns in high-resolution anorectal manometry by Miguel Mascarenhas, Francisco Mendes, Joana Mota, Tiago Ribeiro, Pedro Cardoso, Miguel Martins, Maria João Almeida, João Rala Cordeiro, João Ferreira, Guilherme Macedo, Cecilio Santander

“…The London Protocol and Classification were developed to standardize anorectal motility patterns classification. …”
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Hybrid Push-Pull Endoscopic and Laparoscopic Full Thickness Resection for the Minimally Invasive Management of Gastrointestinal Stromal Tumors: A Pilot Clinical Study by Field F. Willingham, Paul Reynolds, Melinda Lewis, Andrew Ross, Shishir K. Maithel, Flavio G. Rocha

“…This novel, minimally invasive, hybrid laparoscopic and endoscopic push-pull technique is a safe and feasible alternative in the management of select GISTs that are not amenable to standard laparoscopic resection.…”
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Repeated exposure to low doses of light induces retinal damage in vivo in a wavelength-dependent manner by Anaïs Françon, Laurent Jonet, Francine Behar-Cohen, Alicia Torriglia

“…The exposure of the general population to artificial light at night has dramatically increased in recent decades. Current standards for domestic lighting are based on acute exposure to light and consider blue wavelengths to be responsible for phototoxicity. …”
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Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? by Priti Gros, Victoria P. Mery, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R. John Kimoff, Marta Kaminska

“…PM accuracy was calculated compared with PSG for standard apnea hypopnea index (AHI) thresholds. Results. …”
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Commissioning and analysis of new desulfurization wastewater treatment system in a coal-fired power plant by LIU Guidong, HU Yangyang, WANG Jing, CHEN Yang, WANG Zhiyong, DANG Yulu, XU Hao

“…The effluent quality could meet the relevant indicators of the Discharge Standard of Wastewater from Limestone-Gypsum Flue Gas Desulfurization System in Fossil Fuel Power Plants (DL/T 997-2020). …”
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Improving Perinatal Care in the Rural Regions Worldwide by Wireless Enabled Antepartum Fetal Monitoring: A Demonstration Project by Roberto Tapia-Conyer, Shelley Lyford, Rodrigo Saucedo, Michael Casale, Hector Gallardo, Karen Becerra, Jonathan Mack, Ricardo Mujica, Daniel Estrada, Antonio Sanchez, Ramon Sabido, Carlos Meier, Joseph Smith

“…Data were collected from 153 high-risk pregnant indigenous Mayan women receiving either remote monitoring (n=74) or usual standard-of-care (n=79). Remote monitoring resulted in markedly increased adherence (94.3% versus 45.1%). …”
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Optimizing Antipsychotic Therapy in Acute Alcoholic Hallucinosis through Pharmacogenetic Testing by Valentin Skryabin, Anton Masyakin, Sergei Pozdniakov, Igor Shatokhin, Svetlana Sokolova, Valentina Ivanchenko

“…Psychotic disorders triggered by alcohol consumption, such as hallucinations and delusions, require antipsychotic treatment, though standard therapy often results in adverse drug reactions and variable efficacy. …”
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Triggering thresholds and influential factors in the propagation of meteorological drought to hydrological drought by Na Zhen, Rui Yao, Peng Sun, Qiang Zhang, Chenhao Ge, Han Shen

“…This study employs the non-stationary Normalized Standardized Precipitation Evapotranspiration Index (NSPEI) and the Standardized Runoff Index (SRI) from 1980 to 2019 to delineate MD and HD. …”
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