Anti-LAG-3 antibody LBL-007 plus anti-PD-1 antibody toripalimab in advanced nasopharyngeal carcinoma and other solid tumors: an open-label, multicenter, phase Ib/II trial by Gang Chen, Dong-Chen Sun, Yi Ba, Ya-Xiong Zhang, Ting Zhou, Yuan-Yuan Zhao, Hong-Yun Zhao, Wen-Feng Fang, Yan Huang, Zhen Wang, Chao Deng, De-Sheng Hu, Wei Wang, Jin-Guan Lin, Gui-Ling Li, Su-Xia Luo, Zhi-Chao Fu, Hai-Sheng Zhu, Hui-Li Wang, Sheng-Li Cai, Xiao-Qiang Kang, Li Zhang, Yun-Peng Yang

“…Methods Patients with advanced tumors refractory to prior standard therapies were enrolled. In phase Ib, patients received LBL-007 200 mg or 400 mg and toripalimab 240 mg intravenously once every 3 weeks. …”
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SO₂ emissions derived from TROPOMI observations over India using a flux-divergence method with variable lifetimes by Y. Chen, Y. Chen, R. J. van der A, J. Ding, H. Eskes, J. E. Williams, N. Theys, A. Tsikerdekis, P. F. Levelt, P. F. Levelt, P. F. Levelt

“…Our improved flux-divergence method reduced the spreading of the point-source emissions compared to the standard flux-divergence method. Our derived averaged SO<span class="inline-formula">₂</span> emissions covering the recent 5 years are about 5.2 Tg yr<span class="inline-formula">⁻¹</span> with a monthly mean uncertainty of 40 %, which is lower than the bottom-up emissions of 11.0 Tg yr<span class="inline-formula">⁻¹</span> from CAMS-GLOB-ANT v5.3. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Using a large real-world dataset with validated survival endpoint data, we evaluated clinical validity of TMB measurement by the test in over 8000 patients across 24 cancer types who received single-agent immune checkpoint inhibitor (ICI).Methods Patients with advanced-stage cancers from 24 cancer types treated with single-agent anti-PD(L)1 therapy in standard-of-care settings were included. Deidentified data from electronic health records from approximately 280 cancer treatment facilities were captured into a clinico-genomic database. …”
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Evaluation of clinical, laboratory, radiographical and histopathological characteristics in patients with spinal tuberculosis in the context of HIV infection: An analysis of 52 pat... by J Scherer, M Locketz, S Castelein, R Dunn, M Held, F Thienemann

“…We assessed 52 patients with STB (mean (standard deviation (SD) age 38 (15.2) years, range 17 - 80 years), of whom 55.8% were female, and 59.6% HIV infected. …”
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Modeling Factors Influencing Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…These risks, if not effectively managed, can exert considerable influence on project outcomes, impacting crucial objectives such as project timelines, cost management, safety protocols, quality standards, and long-term sustainability goals. Understanding these risk factors and their interplay is paramount for stakeholders involved in project financing endeavors. …”
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Determining dry oak lumber consumption for the production of solid edge-glued panels by Volodymyr Mayevskyy, Rostislav Moroz, Serhiy Kopynets, Oleh Ferents, Roman Shchupakivskyy, Yevstakhii Myskiv

“…The determined operating consumption of oak dry edged lumber is an important prerequisite for developing scienсе-based wood consumption standards in the production of glued panels, which can be used for rational planning of the process of manufacturing glued panels.…”
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Kombinasi Intent Classification dan Named Entity Recognition pada Data Berbahasa Indonesia dengan Metode Dual Intent and Entity Transformer by Zahra Asma Annisa, Rizal Setya Perdana, Putra Pandu Adikara

“…Abstract   Customer service is a way to fulfill the wants and needs of customers accompanied by the accuracy of delivery according to company standards in order to meet customer expectations. In some cases such as banking services, customer service is needed that can be accessed at any time with high accuracy and responsiveness. …”
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The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022 by Yinsong Luo, Liqin Sun, Yun He, Fang Zhao, Duo Shan, Fan Bu, Lingyun Ge, Xiaorui Li, Yiyao Hu, Xi Xiao, Hongzhou Lu, Jiaye Liu

“…Results During a median follow-up of 70 months, 214 PLWH developed CVD. Each 1-standard deviation (SD) increase in the baseline TyG index was associated with a 39% higher risk of CVD (HR 1.39, 95% CI 1.22, 1.59) after adjusting for covariates. …”
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Perbandingan Metode Supervised Machine Learning untuk Prediksi Prevalensi Stunting di Provinsi Jawa Timur by M Syauqi Haris, Ahsanun Naseh Khudori, Wahyu Teja Kusuma

“…This value is still relatively high because the minimum standard set by the World Health Organization (WHO) is 20%. …”
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CAMELS-IND: hydrometeorological time series and catchment attributes for 228 catchments in Peninsular India by N. K. Mangukiya, K. B. Kumar, P. Dey, S. Sharma, V. Bejagam, P. P. Mujumdar, P. P. Mujumdar, A. Sharma, A. Sharma

“…CAMELS-IND follows the same standards of the previously developed CAMELS datasets for the USA, Chile, Brazil, Great Britain, Australia, Switzerland, and Germany to facilitate comparisons with catchments of those countries and inclusion in global hydrological studies. …”
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Treatment of chronic hepatitis C by cepeginterferon alpha-2b in combination to ribavirin by M. V. Mayevskaya, O. O. Znoyko, Ye. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, Yu. N. Linkova

“…The adverse events were registered during treatment by Algeron, in dose-dependent manner, however their frequency had did not exceed that in patients receiving standard PegIntron dozes.Conclusions. Study results prove high efficacy and safety of Algeron in suppression of hepatitis C virus replication and allow to recommend its application at previously untreated patients with CHC in a doze of 1,5 mkg/kg/wk for 24-48 wks in relation to genotype HCV.…”
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Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease by E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin

“…Group 1 comprised patients with coronary heart disease receiving standard treatment. Group 2 comprised patients with coronary heart disease receiving additionally a probiotic (Bifidobacterium bifidum no less than 1x109 CFU; Bifidobacterium longum no less than 1x109 CFU; Bifidobacterium infantis no less than 1x109 CFU; Lactobacillus rhamnosus no less than 1x109 CFU) within 28 days. …”
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Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…Abstract Background Despite the existence of promising outcomes from standard 2D culture systems, these data are not completely akin to in vivo tumor parenchyma. …”
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Ultrasound investigation at examination of gastro-intestinal tract at combined trauma by A. S. Yermolov, O. A. Alekseyechkina, Ye. S. Vladimirova, G. P. Titova, V. M. Abuchina

“…Abdominal organs were examined according to the standard protocol for signs of traumatic damage, presence of free fluid, retroperitoneum was examined as well. …”
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Les techniques de construction du second forum de Bavay (Nord) : utilisation, origine et datation des matériaux en terre cuite by Xavier Deru, Christine Louvion

“…Starting from an in-depth observation of the remains, and a comparison with the standards of Roman architecture enable us to present an architectural proposal; From the analysis of the materials, an origin and supply circuits are defined; in the end, their combination serves an economic discourse that similar studies will be able to refine.…”
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Evaluasi Usability dan Perbaikan Antarmuka untuk Meningkatkan User Experience Menggunakan Metode Usability Testing (Studi Kasus: Aplikasi Warga Bali) by I Made Sukarsa, I Putu Wira Buana, I Putu Juliarta Arya Utama, Ni Wayan Wisswani

“…The test results of respondents in the adolescent and adult categories show that the usability level of the effectiveness variable obtained is 96% and 93% which means it is quite high, the efficiency variable has an average of 30 seconds and 38 seconds, the user satisfaction variable from the SUS questionnaire is 46 and 51 which meaning that it is still below the standard SUS score of 68 points. The analysis using the Think Aloud technique resulted in 49 recommendations for improvement from the Warga Bali Application. …”
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Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…They also play a crucial role in fundamental physics research, including testing Lorentz symmetry and charge–parity–time (CPT) symmetry, which are essential for understanding potential deviations from standard physical theories. A significant challenge in the SERF comagnetometers performance is power errors in optical pumping systems, which affect two critical operational aspects: scale factor and zero-bias stability. …”
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Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…We found that higher body mass was associated with higher risk of musculoskeletal (risk ratio [RR] per 1 standard deviation [SD] 1.12 [95% confidence interval, CI 1.09, 1.16]), cardiovascular (RR 1.22 [95% CI 1.17, 1.27] per 1 SD) and respiratory diseases (RR 1.14 [95% CI 1.05, 1.23] per 1 SD). …”
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Pengukuran Kapabilitas Tata Kelola TI Sistem Informasi Tiras dan Transaksi Bahan Ajar Universitas Terbuka Menggunakan Cobit 5 by Denisha Trihapningsari, Dewi Agushinta R., Lintang Yuniar Banowosari

“…It can be shown that the organization has not fully implemented some best practices for the process being evaluated, even there are already IT governance service standards but it has not been implemented optimally. …”
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