Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Using a large real-world dataset with validated survival endpoint data, we evaluated clinical validity of TMB measurement by the test in over 8000 patients across 24 cancer types who received single-agent immune checkpoint inhibitor (ICI).Methods Patients with advanced-stage cancers from 24 cancer types treated with single-agent anti-PD(L)1 therapy in standard-of-care settings were included. Deidentified data from electronic health records from approximately 280 cancer treatment facilities were captured into a clinico-genomic database. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Methods SSADHD subjects underwent clinical evaluations, neuropsychological assessments, biochemical quantification of γ-aminobutyrate (GABA) and related metabolites, electroencephalography (standard and high density), magnetoencephalography, transcranial magnetic stimulation, magnetic resonance imaging and spectroscopy, and genetic tests. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…Our investigation determined clinical significance based on minimally important difference (MID) calculated as 0.5 times the baseline standard deviation.ResultsAmong the 87 patients, average age was 71 years, 42% were non-white, and 24% were considered obese (BMI ≥30 kg/m²). …”
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Outcomes and risk factors of transported patients with extracorporeal membrane oxygenation: An ECMO center experience by Lingjuan Liu, Dingji Hu, Tong Hao, Shanshan Chen, Lei Chen, Yike Zhu, Chenhui Jin, Jing Wu, Haoya Fu, Haibo Qiu, Yi Yang, Songqiao Liu

“…Method: To assess the safety of ECMO patient transport, this study conducted a retrospective analysis on critically ill adults who required ECMO support and transport at the intensive care unit (ICU) center between 2017 and 2023. The study utilized standard ECMO transport protocols and conducted a comprehensive statistical analysis of the collected clinical data and transport processes. …”
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Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-to-decision (EtD) frameworks provide a structure to support standardized and transparent consideration of relevant criteria to inform health decisions. …”
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Evaluation of Learners’ Satisfaction with Open Flexible and Distance Learning Services at the University of Lagos Distance Learning Institute by Adenike Oladipo, Esther O. Oladele, Oladipupo Ajeyalemi, Folashade Afolabi, Peter O. Olayiwola, Johnson A. Adewara, Andrew Akala, Uchenna Udeani

“…Descriptive statistics such as frequencies, percentages, mean and standard deviation were used in analysing the data. …”
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Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data by Zhihao Li, Daniel Aliseda, Owen Jones, Luckshi Rajendran, Christian Magyar, Robert Grant, Grainne M. O’Kane, Anna Saborowski, Gonzalo Sapisochin, Arndt Vogel

“…Following positive results from the TOPAZ-01 and KEYNOTE-966 trials, immune checkpoint inhibitors (ICIs) combined with chemotherapy are now the standard of care. We aim to compare the efficacy of first-line therapies for advanced BTCs. …”
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Evaluation of Learners’ Satisfaction with Open Flexible and Distance Learning Services at the University of Lagos Distance Learning Institute by Adenike Oladipo, Esther O. Oladele, Oladipupo Ajeyalemi, Folashade Afolabi, Peter O. Olayiwola, Johnson A. Adewara, Andrew Akala, Uchenna Udeani

“…Descriptive statistics such as frequencies, percentages, mean and standard deviation were used in analysing the data. …”
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Design and application of inter-hospital transfer form based on SBAR communication mode for transferring critically ill patients in the Psychiatric Department (基于SBAR沟通模式的院内转科交接单在精... by GU Liqin (顾丽琴), KONG Fanzhen (孔凡贞), JI Caifang (季彩芳), ZHU Xiaolan (朱晓岚)

“…The control group used the conventional inter-hospital transfer form for nursing handover, while the observation group used the self-designed standardized transfer sheet based on SBAR communication mode to assist the transfer. …”
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European Beech (Fagus sylvatica L.): Quasi-Virgin Forest Stand of the Gorgany Mts.: Structure, Vascular Plants Diversity, Health Conditions by Yuriy Shparyk, Ivan Danylyk, Oleksandr Kuzyarin, Ivan Senchak, Nazar Kruk

“…(Ukrainian Carpathians), all PZF institutions are located in the forest fund, and the virgin and quasi-virgin forests are standards of the natural structure, condition and vascular plants diversity for local ecosystems. …”
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Diagnosis of Columnar Metaplasia of the Esophageal Mucosa in Patients with Complicated Gastroesophageal Reflux Disease by E. D. Fedorov, A. V. Shidii-Zakrua, L. M. Mikhaleva, K. S. Maslenkina, A. A. Lindenberg, D. E. Seleznev, V. O. Kaybysheva, T. A. Partenadze

“…The biopsy material was stained with hematoxylin and eosin, and periodic acid Schiff reaction was performed in combination with alcyanine blue according to the standard technique.Results. Endoscopic examination in white light and evaluation of metaplasia extent revealed ultrashort segment (<1 cm) in 26/131 (19.9 %) patients; short segment (1–3 cm) — in 47/131 (35.9 %); long segment (> 3 cm) — in 58/131 (44.3 %) patients. …”
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The comparative analysis of the influence of bisoprolol and carvedilol on the course of heart failure of ischemic origin in patients with concomitant atrial fibrillation and diabet... by N.M. Kulaiets, V.M. Kulaiets

“…ECG registration, daily ECG monitoring, standardized echocardiographic exami­nation during hospitalization were carried out. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…The KABC-II mental processing index was 45.2 (standard deviation (SD) 10.5) in CBHF and 48.3 (11.3) in CHU (mean difference 3.3 points [95% confidence interval (95% CI) 2.0, 4.5]; p < 0.001). …”
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Applicazione del Workload Indicators of Staffing Need (WISN) per la stima del fabbisogno di Tecnici Sanitari di Radiologia Medica in una Struttura di Diagnostica per Immagini itali... by Domenico Riccardo Cammisa, Francesca Fortunato, Antonio Alemanno, Rosetta D'Andria, Federica Guglielmi

“…Attraverso questi dati, è stato stabilito il carico di lavoro annuo e il numero di TSRM necessari per le attività professionali standard, applicando un fattore correttivo per considerare anche le attività aggiuntive di categoria ed individuali. …”
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Integrating 16S rDNA and metabolomics to uncover the therapeutic mechanism of electroacupuncture in type 2 diabetic rats by Zhang Yue, Wang Xiang, Deng Duping, Gong Yuanyuan, Chen Xuanyi, Li Juan, Li Juan, Hong Xiaojuan

“…The normal rats received a standard diet and saline gavage, while the other groups were fed a high-fat diet and emulsion. …”
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Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021 by Weiqiu Jin, Kaichen Huang, Ziyin Ding, Mengwei Zhang, Chongwu Li, Zheng Yuan, Ke Ma, Xiaodan Ye

“…Methods Data about age-standardized rates (ASRs) of incidence (ASIR), mortality (ASDR), probability of death (ASPoD) and DALYs (ASDALYRs) of EC were obtained from the 2021 Global Burden of Disease (GBD) study. …”
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Human Capital, Economic Growth and Environmental Quality with Special Emphasis on Public Education Expenditures: An Application of DSGE Models by Yahya Mohaghegh, hashem zare, Mehrzad Ebrahimi

“…Findings The results indicate that an increase in public education expenses by one standard deviation increases the marginal efficiency of private education expenses. …”
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The effect of the MyBFF@school program on cardiorespiratory fitness in overweight and obese primary schoolchildren: a cluster randomized controlled trial by Abdul Halim Mokhtar, Muhammad Ashaari Kamarudin, Alston Choong, Lakvinder Singh, Vinotha Genisan, Abqariyah Yahya, Ruziana Mona Wan Mohd Zin, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…The intervention group participated in the MyBFF@school program while the control followed the existing standard curriculum. The primary outcome was cardiorespiratory fitness using physical fitness score (PFS) measured by the modified Harvard step test. …”
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Topological Analysis of Brain Glucose Metabolic Connectivity Networks of Patients with Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment by LIANG Shengxiang, YANG Junchao, ZHANG Yusi, YIN Xiaolong, HUANG Li, LI Zuanfang

“…Using the cerebellum as reference area, standardized uptake value ratio (SUVR) of the anatomical automatic labeling (AAL) module brain regions of each subject was extracted to construct the glucose metabolism connectivity brain network. …”
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Household transmission of SARS-CoV-2 in a rural area in South Africa by G Maimela, C E Martin, M Chersich, B Bello, J Mauti, T Bäernighausen, S Kohler, A Almuedo-Riera, S Luchters, S Sawry

“…Associations between outcomes and HC characteristics were adjusted for intra‐cluster correlation using robust standard errors. The secondary infection rate (SIR) was the proportion of new COVID‐19 infections among susceptible HCs. …”
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