Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer by Haowei Wang, Lei Cheng, Jian Chen, Peixin Chen, Zhuoran Tang, Qianyi Wang, Ying Ma, Chao Zhao, Xuefei Li, Tao Jiang, Fei Zhou, Xiaoxia Chen, Caicun Zhou

“…Abstract Background PD-1 blockade plus chemotherapy has become the first-line standard of care for patients with advanced non-small-cell lung cancer (NSCLC) without oncogenic drivers. …”
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New Insights on Keller–Osserman Conditions for Semilinear Systems by Dragos-Patru Covei

“…In this article, we consider a semilinear elliptic system involving gradient terms of the form <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mfenced separators="" open="{" close=""><mtable><mtr><mtd columnalign="left"><mrow><mo>Δ</mo><mi>y</mi><mfenced open="(" close=")"><mi>x</mi></mfenced><mo>+</mo><msub><mi>λ</mi><mn>1</mn></msub><mfenced separators="" open="|" close="|"><mo>∇</mo><mi>y</mi><mfenced open="(" close=")"><mi>x</mi></mfenced></mfenced><mo>=</mo><mi>p</mi><mfenced open="(" close=")"><mfenced open="|" close="|"><mi>x</mi></mfenced></mfenced><mi>f</mi><mfenced separators="" open="(" close=")"><mi>y</mi><mfenced open="(" close=")"><mi>x</mi></mfenced><mo>,</mo><mi>z</mi><mfenced open="(" close=")"><mi>x</mi></mfenced></mfenced></mrow></mtd><mtd columnalign="left"><mrow><mi>i</mi><mi>f</mi></mrow></mtd><mtd columnalign="left"><mrow><mi>x</mi><mo>∈</mo><mo>Ω</mo><mo>,</mo></mrow></mtd></mtr><mtr><mtd columnalign="left"><mrow><mo>Δ</mo><mi>z</mi><mfenced open="(" close=")"><mi>x</mi></mfenced><mo>+</mo><msub><mi>λ</mi><mn>2</mn></msub><mfenced separators="" open="|" close="|"><mo>∇</mo><mi>z</mi><mfenced open="(" close=")"><mi>x</mi></mfenced></mfenced><mo>=</mo><mi>q</mi><mfenced open="(" close=")"><mfenced open="|" close="|"><mi>x</mi></mfenced></mfenced><mi>g</mi><mfenced separators="" open="(" close=")"><mi>y</mi><mfenced open="(" close=")"><mi>x</mi></mfenced></mfenced></mrow></mtd><mtd columnalign="left"><mrow><mi>i</mi><mi>f</mi></mrow></mtd><mtd columnalign="left"><mrow><mi>x</mi><mo>∈</mo><mo>Ω</mo><mo>,</mo></mrow></mtd></mtr></mtable></mfenced></semantics></math></inline-formula> where <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>λ</mi><mn>1</mn></msub></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>λ</mi><mn>2</mn></msub><mo>∈</mo><mfenced separators="" open="[" close=")"><mn>0</mn><mo>,</mo><mo>∞</mo></mfenced></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mo>Ω</mo></semantics></math></inline-formula> is either a ball of radius <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>R</mi><mo>></mo><mn>0</mn></mrow></semantics></math></inline-formula> or the entire space <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi mathvariant="double-struck">R</mi><mi>N</mi></msup></semantics></math></inline-formula>. Based on certain standard assumptions regarding the potential functions <i>p</i> and <i>q</i>, we introduce new conditions on the nonlinearities <i>f</i> and <i>g</i> to investigate the existence of entire large solutions for the given system. …”
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Phenotypes of primary sclerosing cholangitis in children by M.B. Dyba, V.S. Berezenko

“…Research aimed at studying the clinical course of PSC in children and improving early diagnosis is relevant, especially given the limited access to modern diagnostic methods, such as magnetic resonance cholangiopancreatography, the need for invasive studies, and the lack of standardized diagnostic criteria adapted to childhood, which complicates the diagnosis and treatment of these patients. …”
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Application of “One Syndrome and One Product” nursing model in nursing care of patients with optic atrophy (“一证一品”护理模式在青盲患者中的应用探讨) by LI Xianglu (李享璐), ZHANG Shuai (张帅), WANG Wei (王玮), WANG Qiao (王俏), HUANG Shaolan (黄少兰)

“…The control group received routine nursing intervention and the experimental group accepted the nursing pattern based on “one syndrome and one product” nursing model , including integrated nursing ward round, humanistic care based on Traditional Chinese Medicine (TCM) nursing, standardized TCM measures for different syndrome types, TCM nursing path management and quality control. …”
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Hospital and physician-based mental healthcare during 12 months of opioid agonist treatment for opioid use disorder: Exploring costs and factors associated with acute care. by Tea Rosic, Glenda Babe, Myanca Rodrigues, Brittany B Dennis, Richard Perez, Claire de Oliveira, Andrew Worster, Lehana Thabane, Zainab Samaan

“…For participants with at least one visit, we determined the mean number of ED visits (1.93, standard deviation [SD] = 2.15), hospitalizations (1.46, SD = 1.05), primary care visits (3.51, SD = 4.31), and psychiatry visits (4.04, SD = 4.73). …”
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CBCT Analysis of Mandibular Ramus as a Donor Site for Cortical Bone Graft: A Retrospective Analytical Study by Pallabi Das, Samiran Ghosh, Kaushik Dutta, Richi Burman, Amit Ray, Debolina Pramanick, Siddhartha Chatterjee, Somak Saha

“…Continuous variables (Mean, Median and Standard Deviation) were compared using Mann-Whitney U test or Kruskal Wallis Test as appropriate. …”
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Analysis of the focal relationship of level five leadership with school organizational excellence by Hosein Majooni, Siroos Ghanbari

“…Frequency distribution tables, central indices (mean, median and mean), and dispersion indices (standard deviation and variance) were used in the descriptive analysis of the data, and the statistical techniques of Pearson correlation coefficient, focal correlation coefficient, and multivariate regression were used in testing the research hypotheses. …”
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Evolving trends in lung cancer risk factors in the ten most populous countries: an analysis of data from the 2019 Global Burden of Disease StudyResearch in context by Chinmay T. Jani, Samuel A. Kareff, Dan Morgenstern-Kaplan, Ana S. Salazar, Georgina Hanbury, Justin D. Salciccioli, Dominic C. Marshall, Joseph Shalhoub, Harpreet Singh, Estelamari Rodriguez, Gilberto Lopes

“…This study compares trends in tobacco, air pollution, and asbestos-associated Age-Standardized Mortality Rates (ASMR) from Trachea, Bronchus, and Lung (TBL) Cancer across the top ten most populated countries (2023 censuses) and globally. …”
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A Meta analysis on effect of auricular point sticking and pressing therapy in the treatment of hyperemesis gravidarum (耳穴贴压法治疗妊娠恶阻临床疗效的Meta分析) by TIAN Tian (田恬), XIE Wei (谢薇), DENG Yunyan (邓云燕), LI zhongqing (李忠琴), ZHANG yang (张杨), ZHAO Su (赵苏)

“…Methods Use of computer to search Cochrane, PubMed, China Knowledge Network Full Text Database (CNKI), VIP Database and Wanfang Database, to collect Randomized Controlled Trials (RCTs) about auricular point sticking and pressing therapy in the treatment of hyperemesis gravidarum were collected, and the quality of the included studies was evaluated according to the randomly hidden quality standard in Jadad scale. Meta analysis was performed by Rev man 5. 3 software. …”
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Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems by Frank S. C. Tenywa, Ummi A. Kibondo, Julian Entwistle, Osward Dogan, Mapipi Haruna, Restuta P. Phisoo, Jason Moore, Jane J. Machange, Haji Makame, Frederic Tripet, Pie Müller, Mathias Mondy, Derric Nimmo, Jennifer C. Stevenson, Sarah J. Moore

“…The findings indicate that future bioassays to evaluate ATSBs should use mosquitoes of both sexes, aged 3–5 days, include multiple species in the same cage or chamber, and utilize both non-choice and choice tests with a standard comparator.…”
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Effects of external ankle support on balance control outcomes following muscle fatigue in individuals with ankle instability: A systematic review and meta-analysis by Hanieh KHALILIYAN, Mahmood BAHRAMIZADEH, Amirhossein ZARE, Kavita BATRA, Gabriella NUCERA, Aldo SITIBONDO, Aanuoluwapo AFOLABI, Majid ANSARI, Olayinka ILESANMI, Lukasz SZARPAK, Alireza KHAGHANI, Shahla MOHAJERI, Farhad GHAFFARI, Arash SHARAFATVAZIRI

“…A meta-analysis was performed using Review Manager 5.3 software, calculating standardized mean differences with 95% confidence intervals (CI) for each outcome. …”
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Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets by Carlotta De Filippo, Sofia Chioccioli, Niccolò Meriggi, Antonio Dario Troise, Francesco Vitali, Mariela Mejia Monroy, Serdar Özsezen, Katia Tortora, Aurélie Balvay, Claire Maudet, Nathalie Naud, Edwin Fouché, Charline Buisson, Jacques Dupuy, Valérie Bézirard, Sylvie Chevolleau, Valérie Tondereau, Vassilia Theodorou, Claire Maslo, Perrine Aubry, Camille Etienne, Lisa Giovannelli, Vincenzo Longo, Andrea Scaloni, Duccio Cavalieri, Jildau Bouwman, Fabrice Pierre, Philippe Gérard, Françoise Guéraud, Giovanna Caderni

“…We then conducted faecal microbiota transplantation (FMT) from PIRC rats to germ-free rats treated with AOM and fed a standard diet for 3 months. We analysed multiple tumour markers and assessed the variations in the faecal microbiota using 16S rRNA gene sequencing together with targeted- and untargeted-metabolomics analyses. …”
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The impact of preliminary patient hydration on physiological [18F]PSMA-1007 uptake in the urinary bladder on PET/CT by T. L. Antonevskaya, A. I. Khalimon, O. V. Mukhortova, M. M. Khodzhibekova, A. I. Nikiforuk, D. D. Zubkov, G. F. Khamadeeva, D. Yu. Khodakova, T. N. Lazutina, I. V. Pylova, A. V. Leontyev, I. P. Aslanidi

“…All patients were divided into two groups: the group with hydration (n = 95, 53 %), which included the subgroups of patients with oral (n = 76, 80 %) and intravenous (n = 19, 20 %) routes of hydration, and the control group with no hydration (n = 85, 47 %). [18F]PSMA‑1007 uptake in the urinary bladder was quantified using SUVmean (Mean Standardized Uptake value), measured within a spherical VOI with a fixed volume of 2.5 cm3 delineating the bladder boundaries. …”
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SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort studyResearch in context by Tesleem K. Babalola, Sean A.P. Clouston, Zennur Sekendiz, Devi Chowdhury, Nicola Soriolo, Joseph Kawuki, Jaymie Meliker, Melissa Carr, Bruno R. Valenti, Ashley Fontana, Onix A. Melendez, Olga Morozova, Benjamin J. Luft

“…Findings: A total of 475 (prevalence = 18.9%, [95% confidence interval] = [17.4–20.5]) PASC patients were identified. The mean (standard deviation (SD)) age of participants who experienced PASC (54.8 (7.2) years) was similar to those who did not (54.2 (7.4) years). …”
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Anti-LAG-3 antibody LBL-007 plus anti-PD-1 antibody toripalimab in advanced nasopharyngeal carcinoma and other solid tumors: an open-label, multicenter, phase Ib/II trial by Gang Chen, Dong-Chen Sun, Yi Ba, Ya-Xiong Zhang, Ting Zhou, Yuan-Yuan Zhao, Hong-Yun Zhao, Wen-Feng Fang, Yan Huang, Zhen Wang, Chao Deng, De-Sheng Hu, Wei Wang, Jin-Guan Lin, Gui-Ling Li, Su-Xia Luo, Zhi-Chao Fu, Hai-Sheng Zhu, Hui-Li Wang, Sheng-Li Cai, Xiao-Qiang Kang, Li Zhang, Yun-Peng Yang

“…Methods Patients with advanced tumors refractory to prior standard therapies were enrolled. In phase Ib, patients received LBL-007 200 mg or 400 mg and toripalimab 240 mg intravenously once every 3 weeks. …”
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Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models by Marcelo Simonsen, Marcelo Simonsen, Rossana Verónica Mendoza López, Simone Maistro, Lucas Takeshi Ikeoka, Glaucia Fernanda de Lima Pereira, Ademar Benévolo Lugão, José Carlos Sadalla, Maria Lúcia Hirata Katayama, Maria Aparecida Azevedo Koike Folgueira

“…There was a small benefit in overall tumor reduction in animals treated with intraperitoneal chemotherapy applied through the slow release device compared with animals treated with intraperitoneal free chemotherapy, as evaluated through tumor weight - results in standardized mean difference. (-1.06; 95% CI: -1.34, -0.78) and tumor volume (-3.72; 95% CI: -4.47, -2.97), a benefit that was seen in most weekly evaluations and for most chemotherapy drugs, such as carboplatin (tumor weight: -5.60; 95% CI: -7.83, -3.37), paclitaxel (tumor weight: -1.18; 95% CI: -1.52, -0.83), and cisplatin (tumor volume: -2.85; 95% CI: -3.66, -2.04) carboplatin (tumor volume: -12.71; 95% CI: -17.35, -8.07); cisplatin (tumor volume: -7.76; 95% CI: -9.88, -5.65); paclitaxel (tumor volume: -2.85; 95% CI: -3.66, -2.04). …”
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A clinical study on head meridian massage to relieve tension type headache in patients with anxiety disorders (头部经穴推拿缓解焦虑障碍患者紧张性头痛的临床研究)... by WEI Hongmei (韦红梅), CHEN Yanfen (陈燕芬), LUO Tianyun (罗添云), YE Junrong (叶君荣), XIONG Linghui (熊令辉), LONG Xuxing (龙绪星), ZHOU Peilin (周沛林), ZHANG Xin (张辛)

“…The visual analogue scale (VAS), Hamilton Anxiety Scale (HAMA) and self-made efficacy standards were used to compare the headache degree, anxiety and clinical efficacy of the two groups before and after treatment. …”
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Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…Methods We conducted a secondary analysis of the Broadening the Reach, Impact, and Delivery of Genetic Services (BRIDGE) trial at University of Utah Health and NYU Langone Health, involving 2,760 unaffected patients meeting genetic testing criteria for inherited cancer susceptibility and who were initially randomized to either an automated chatbot or an enhanced standard of care (SOC) genetic services delivery model. …”
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Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits by YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai

“…Furthermore, we explored the relationships between rs7305526 and rs11615756 with clinical quantitative traits of OSA, such as respiratory events, oxygen levels, and sleep traits, using clinical monitoring data from the Shanghai Sleep Health Study Cohort (SSHS) based on standard polysomnography (PSG).Results·The NOS1 gene demonstrated elevated levels of expression in various brain regions crucial for regulating sleep, namely the amygdala, basal forebrain, striatum, and thalamus, as well as in the respiratory center, including the mesencephalon and pontine tegmentum. …”
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Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

“…BackgroundHigh-dose glucocorticoids are the standard treatment for acute relapses in patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). …”
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