Comparative analysis of 2 approaches to monitor countries' progress towards full and equal access to sexual and reproductive health care, information, and education in 75 countries... by Jewel Gausman, Richard Adanu, Delia A B Bandoh, Neena R Kapoor, Ernest Kenu, Ana Langer, Magdalene A Odikro, Thomas Pullum, R Rima Jolivet

“…The main limitation of our methodology is that there is no gold standard for measurement of the phenomenon under study, and thus we are unable to specify with total certainty which indicator performs better.…”
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Combination Treatment with Thread-Embedding Acupuncture and Electroacupuncture for Knee Osteoarthritis Patients with Postoperative Pain: A Randomized Controlled Feasibility Study by Lee YJ, Han CH, Jeon JH, Kim E, Park KH, Kim AR, Kim YI

“…The TG received TEA once a week for four sessions and EA twice a week for eight sessions while continuing usual care, defined as standard conventional treatments. The CG received only usual care for four weeks. …”
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Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer’s disease pathology by Maxime Van Egroo, Elise Beckers, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Heidi I. L. Jacobs

“…Methods Ninety-two cognitively unimpaired adults (mean age = 59.85 ± 13.77 years, range = 30–85, 47 females) underwent 10 days of actigraphic recordings, and blood drawing. Standard non-parametric indices of 24-h rest-activity rhythm fragmentation (intradaily variability, IV) and stability (interdaily stability, IS) were extracted from actigraphy data using the GGIR package. …”
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New Option for Antibiotic Susceptibility Testing in Clinical Practice: Performance Evaluation of AutoMic-i600 Automatic System Based on Broth Microdilution Method by Lin C, Zhang H, Wu Q, Qiu X, Li Q, Wu G

“…Broth microdilution (BMD) is the gold standard but is impractical for routine application. …”
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Venous thromboembolism incidence and risk factors associated with immune checkpoint inhibitors among patients with advanced non-small cell lung cancer by Chi Nguyen, Alok A Khorana, John Barron, Jennell Palaia, Lisa Rosenblatt, Radhika Pisupati, Ning Huang, Kerrin Gallagher, T Christopher Bond

“…Immune checkpoint inhibitors (ICIs) are a new standard of care for the treatment of lung cancer, but their association with VTE is not fully understood. …”
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Development of a Comprehensive Fall Risk Assessment Tool for Older People in Elderly Care Institutions and Its Test by LUO Yuan, ZHANG Hua, WANG Sanxiang, ZHANG Mengxi, DENG Yuqian, RAN Haiye, LIU Jiaxin, ZHANG Yi, CHEN Xi, WU Yibo, ZHAO Liping

“…The total Cronbach's alpha coefficient for sub-instrument (i) was 0.73 and the scorer reliability coefficient was 0.85; the exploratory factor analysis extracted three common factors with a cumulative variance contribution of 57.95%; the fit indices of the confirmatory factor model: Chi-square degrees of freedom ratio (χ2/df), Goodness of fit index (GFI), adjusted goodness of fit index (AGFI), standardized moderate index (NFI), comparative fit index (CFI), Tucker-Lewis coefficient (TLI), approximation error (RMSEA) were 2.43, 0.95, 0.91, 0.89, 0.93, 0.91, and 0.07, and discriminant validity is statistically significant (P<0.001). …”
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Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Two Kenyan Facilities: A... by Sylvia M. Maveke, Gabriel O. Aboge, Laetitia W. Kanja, Alfred O. Mainga, Naftaly Gachau, Beatrice W. Muchira, Gervason A. Moriasi

“…The isolates’ ESBL production and antibiotic susceptibility were phenotypically confirmed using a standard procedure. Molecular analysis was done through conventional polymerase chain reaction (PCR) with appropriate primers for gadA, rpoB, blaTEM, blaSHV, blaOXA, blaCTX-M-group-1, blaCTX-M-group-2, blaCTX-M-group-9, and blaCTX-M-group-8/25 genes, sequencing and BLASTn analysis. …”
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Development and Application of Quadruple Luminex xTAG Method for Simultaneous Detection of Japanese Encephalitis Virus, West Nile Virus, Yellow Fever Virus and Zika Virus by Junying SUN, Qiwen WU, Jichu LI, Chunhong LI, Pengju GUO, Yi HUANG, Feifei YIN

“…Multiplex PCR amplification was carried out with standard virus strains as model. Then, PCR products were hybridized with magnetic beads with complementary TAG sequences and streptavidin-phycoerythrin, and the fluorescence signals of magnetic beads and phycoerythrin were detected by Luminex 200 instrument to indicate the classification and quantification of the pathogens of the arbovirus samples.…”
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Simultaneous Liver Venous Deprivation Following Hepatic Arterial Chemoembolization Before Major Hepatectomy for Hepatocellular Carcinoma: A New Methods to Achieve Hypertrophy Liver... by Zhang S, Song R, Hou C, Yao H, Xu J, Zhou H, Li S, Cai W, Fei Y, Meng F, Yin D, Wang J, Zhang S, Liu Y, Wang J, Liu L

“…The ratio of FLR to standardized liver volume increased from 35.9% (interquartile range [IQR], 8.6) to 46.4% (IQR, 8.2), with a mean degree of hypertrophy and kinetic growth rate of 13.2% (IQR, 5.4) and 4.4% (IQR, 1.8) per week, respectively. …”
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Effects of MyBFF@school, a multifaceted obesity intervention program, on anthropometry and body composition of overweight and obese primary schoolchildren by Ruziana Mona Wan Mohd Zin, Abdul Halim Mokhtar, Abqariyah Yahya, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…A total of 1,397 primary-school students aged 9–11 with a body mass index (BMI) $$z$$ z -score (corrected for age) greater than + 1 standard deviation based on the World Health Organization 2007 Growth Reference were assigned to intervention ( $$n=647$$ n = 647 ) and control ( $$n=750$$ n = 750 ) groups. …”
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Exploring the clinical value of procalcitonin, c-reactive protein, white blood cell count, and neutrophil-to-lymphocyte ratio in the early diagnosis of bloodstream infections in ch... by Yadong Li, Mingjie Li, Chenye Lin, Wentao Tang, Qiuyu Tang, Feng Cheng

“…Abstract Backgroud In the diagnosis of bloodstream infections (BSI) in children, compared to the gold standard of blood culture, markers in the blood offer advantages such as rapid results and cost-effectiveness. …”
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy st... by Fu Zhao, Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li

“…BackgroundHigh-grade serous ovarian cancer (HGSOC), the predominant subtype of epithelial ovarian cancer, is frequently diagnosed at an advanced stage due to its nonspecific early symptoms. Despite standard treatments, including cytoreductive surgery and platinum-based chemotherapy, significant improvements in survival have been limited. …”
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Call to Action: Lead Pharmacy into the Next Decade by Gregory Zumach, Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks, Anthony Olson, Andrew Bartlett, Nilushi Karunaratne, Betty Exintaris

“…Pharmacy leaders feel that leadership is needed to make decisions, take accountability and, especially in an area as highly regulated as healthcare, ensure regulations and procedures are followed and standards are upheld. At the same time, our current environment requires attention to new challenges such as a multigenerational workforce and artificial intelligence. …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…The control group will receive standard of care programming and will be offered participation in the intervention following completion. …”
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Novel Procedures for Evaluating Autism Online in a Culturally Diverse Population of Children: Protocol for a Mixed Methods Pathway Development Study by Venus Mirzaei, Jeanne Wolstencroft, Georgia Lockwood Estrin, Eleanor Buckley, Shermina Sayani, Panos Katakis, Reena Anand, Tessa Squire, Eleanor Short, Paige Frankson, David Skuse, Michelle Heys

“…CHATA comprises 2 key elements: online self-completed standardized autism questionnaires and a structured online interview and observation by a trained clinician. …”
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Performance of antiretroviral drugs supply chain management and related challenges in Amhara National Regional State, Ethiopia. In the case of public health facilities found in the... by Meseret Tilahun Zeleke, Berhanemeskel Weldegerima Atsbeha, Belachew Yebeyin Melaku, Yesuneh Tefera Mekasha, Abibo Wondie Mekonen, Shimelis Dagnachew Nigatu

“…Therefore, to improve the performance of ARV drug supply chain management, all the concerned bodies should work cooperatively in maintaining quality data and be dedicated to updating inventory recording tools, creating standard storage conditions, as well as recruiting pharmacy professionals, facilitating capacity-building training, and offering ongoing mentorship and supervision. …”
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Evaluación de la capacidad de resistencia al fuego de una estructura de hormigón armado tras un terremoto = Post-earthquake fire capacity assesment of a reinforced concrete frame by Ismail Haouach, Belkacem Lamri, Abdelhak Kada

“…The current building standards do not take this double action into account, which acts in a sequential manner and neglects the probability of fires occurring after an earthquake. …”
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Botulinum toxin type A for the treatment of patients with post-stroke spasticity in Thailand: cost-utility and budget impact analysis by Phorntida Hadnorntun, Pattara Leelahavarong, Tanawan Kongmalai, Varalak Srinonprasert, Juthamas Prawjaeng, Phakamas Tanvijit, Chuenchom Chueluecha, Nawarat Jintakul, Tipyarat Saringcarinkul, Witsanu Kumthornthip

“…Objectives To evaluate the cost-utility of botulinum toxin A (BoNT-A) for treating upper limb (UL) and lower limb (LL) post-stroke spasticity.Design Using a Markov model, adopting a societal perspective and a lifetime horizon with a 3% annual discount rate, the cost-utility analysis was conducted to compare BoNT-A combined with standard of care (SoC) with SoC alone. Costs, utilities, transitional probabilities and treatment efficacy were derived from 5-year retrospective data from tertiary hospitals and meta-analysis. …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…There was also a significant difference between sarcosine-aniline hybrid and standard drugs used to treat malaria including artesunate and chloroquine (p<0.05). …”
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Potential drug targets for asthma identified through mendelian randomization analysis by Xingxuan Chen, Yu Shang, Danting Shen, Si Shi, Zhe Wen, Lijuan Li, Hong Chen

“…In plasma, we observed that an increase of one standard deviation in IL1R1[1.30 (95% CI 1.20–1.42)], IL7R[1.07 (95% CI 1.04–1.11)], ECM1[1.03 (95% CI 1.02–1.05)], and CD200R1[1.18 (95% CI 1.09–1.27)] were associated with an increased risk of asthma, while an increase in ADAM19 [0.87 (95% CI 0.82–0.92)] was found to be protective. …”
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