A Unique Case of Relapsed B-Acute Lymphoblastic Leukemia/Lymphoma as an Isolated Omental Mass by Kanchan Kantekure, Furha Cossor, Kenneth B. Miller, Monika E. Pilichowska

“…Extramedullary involvement is frequent, with particular predilection for the central nervous system, lymph nodes, spleen, liver, and testis. We report an unusual case of B-ALL relapsing as an isolated omental mass along with bone marrow involvement.…”
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Iatrogenic Severe Splenic Injury after Colonoscopy by Ikponmwosa Enofe, Jacob Burch, Julie Yam, Manoj Rai

“…About 15 million colonoscopies were carried out in the United States in 2012 with this number projected to increase. Injury to the spleen as a complication of colonoscopy is still a rather rare occurrence. …”
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Isolated Splenic Cold Abscesses with Perisplenic Extension: Treated Successfully without Splenectomy by Mohan Khadka, Ravi Pradhan

“…On physical examination, he had tenderness in the left lower infra-axillary region and Traube’s space dullness without palpable spleen. Ultrasound-guided aspiration of the abscess fluid revealed Mycobacterium tuberculosis (MTB) by polymerase chain reaction (PCR). …”
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Spontaneous Splenic Rupture Complicating Severe P. falciparum Infection: A Case Report and Literature Review by Eltaib Saad, Elamin Elsamani, Walid Abdelrahman

“…Spontaneous rupture of the spleen in malarial infection or malarial splenic rupture (MSR) is a rare but life-threatening condition complicating severe malarial infection in tropics and subtropics, and hence it deserves special attention. …”
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Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver by Ľudmila Pašková, Viera Kuncírová, Silvester Poništ, Danica Mihálová, Radomír Nosáľ, Juraj Harmatha, Iveta Hrádková, Tomáš Čavojský, František Bilka, Katarína Šišková, Ingrid Paulíková, Lýdia Bezáková, Katarína Bauerová

“…Interestingly, in contrast to MTX, N-f-5HT significantly lowered the level of IL-1β in plasma and IL-1β mRNA expression in the liver and spleen of arthritic rats. This speaks for future investigations of N-f-5HT as an agent in the treatment of RA in combination therapy with MTX.…”
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IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis by Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee

“…Peripheral blood count, cytokine level, lymphocyte apoptosis in the spleen, neutrophil infiltration in the lungs and liver, and survival rate were measured. …”
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Severe fever with thrombocytopenia syndrome complicated with aspergillus endocarditis and multiple organ infarctions after glucocorticoid treatment in an immunocompetent man: a cas... by Yuxi Zhao, Xiaoxin Wu, Xinyu Wang, Lanjuan Li

“…His consciousness improved during the treatment of glucocorticoids, intravenous immunoglobulin, and ribavirin, but he developed embolisms in the spleen and right kidney, initially attributed to atrial fibrillation, and the anticoagulant agent was not administered due to the high risk of bleeding. …”
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Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-𝛼 Antibody in Mice by Masaji Okada, Yoko Kita, Noriko Kanamaru, Satomi Hashimoto, Yasushi Uchiyama, Masahiko Mihara, Yoshikazu Inoue, Yoshiyuki Ohsugi, Tadamitsu Kishimoto, Mitsunori Sakatani

“…The results in anti-IL-6R Ab-treated mice suggest that spleen cell responses were decreased to a lesser degree. …”
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An overview of hereditary spherocytosis and the curative effects of splenectomy by Kyril Turpaev, Elizaveta Bovt, Elizaveta Bovt, Soslan Shakhidzhanov, Soslan Shakhidzhanov, Elena Sinauridze, Elena Sinauridze, Nataliya Smetanina, Larisa Koleva, Larisa Koleva, Nikita Kushnir, Nikita Kushnir, Anna Suvorova, Fazoil Ataullakhanov, Fazoil Ataullakhanov, Fazoil Ataullakhanov

“…Eventually, this leads to the trapping the abnormal RBCs (spherocytes) in the spleen. In most severe cases, splenectomy may be necessary to prevent general RBC collapse during the passage of RBCs through the narrow slits of venous sinuses in the spleen. …”
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Sarcoidosis Presenting as Massive Splenic Infarction by Ishita Patel, Mediola Ismajli, Alan Steuer

“…Granulomatous inflammation involving the spleen is common and associated with splenomegaly. …”
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Radiological diagnostic methods in gastroenterology by Z. A. Lemeshko

“…Modern advances of elastometry at diseases of the liver, spleen and pancreas are reflected. Radiological features at medical emergencies with involvement of digestive organs (thrombosis, ileus, circulatory intestinal disorders, closed diaphragmatic trauma) are demonstrated. …”
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Ruptured Large Gastrointestinal Stromal Tumor: A Case Report and Review of Literature by Javereeya Abdul Jabbar, Amr Elmekresh, Yousif Eltayeb

“…The patient was taken for exploratory laparotomy, which revealed a ruptured large cystic mass (21 cm×15 cm×24 cm) occupying the upper abdomen and encompassing the greater curvature of the stomach, body, and tail of the pancreas, as well as part of the spleen.…”
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Dermoid Cyst of the Pancreas: A Report of an Unusual Case and a Review of the Literature by Aynur Albayrak, Umran Yildirim, Metin Aydin

“…Ultrasonography and computed tomography showed a smooth borders, solid, hyperechoic tumor within midline abdomen, without any connection to the stomach or spleen. At surgery, the entire mass was excised off of the head and inferior part of pancreas. …”
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Mixed Germ Cell Testicular Cancer with Left Ventricular Metastasis Presenting with Embolic Stroke and Small Bowel Tumor Seeding by Srinath Sundararajan, Beth Braunhut, Frederick Ahmann, Amit Agarwal

“…We have summarized here a unique case of nonseminomatous germ cell tumor (NSGCT) with intracardiac metastasis resulting in systemic macroembolization to liver, spleen, brain, bowel and musculoskeletal tissues. …”
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Multiple Extramedullary Plasmacytoma with Lytic Bony Lesions: A Rare Case Report by Akhlak Hussain, Mohinder Singh, Kuldip Singh, Harjot Bagga

“…Multiple extramedullary plasmacytoma lesions involving subcutaneous tissue, breast, mediastinal tissue, spleen, and soft tissue of pelvic region along with multiple bones plasmacytomas without marrow plasmacytosis are a very rare presentation. …”
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Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction by Joselle Cook, Steven Song, Anthony Ventimiglia, Carol Luhrs

“…Through incidental discovery during a delayed hemolytic transfusion reaction workup, EMPs were found in the liver, spleen, and possibly the lung. Though rare at presentation, this case emphasizes that the presence of EMPs should be considered at the outset as it not only impacts the treatment regimen for such patients but also considerably affects prognosis.…”
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Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells by Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland

“…Moreover, the panel identified alloreactive CD8+ T cells within the graft infiltrate, spleen and draining lymph node during rejection of a Kd-bearing heart graft. …”
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The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences by Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao

“…IFN-γ production was significantly elevated in spleen lymphocytes upon stimulation with the vaccine. …”
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Extranodal Lymphomas as an Unusual Presentation in Usual Sites: A Potential Clinicoradiological Mimicker of Infection by R. Aruna Geethanjali, Brindha Prabhakaran, S. K. Sridevi, L. Priyadharshini, Vishalli Dinesh, V. Archana

“…Lymphomas encompass a group of malignancies involving the lymphoreticular system, while extranodal non-Hodgkin’s lymphomas affect any organ or tissue excluding lymph nodes and the spleen. Extranodal lymphomas (ENLs) have different characteristics and often have distinct pathogenic mechanisms and clinical behavior, which has a significant impact in their diagnosis and treatment. …”
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Comparison of immune response in broiler chickens after experimental inoculation with isolates of avian metapneumovirus subtypes A and B by P. S. Yaroslavtseva, M. A. Volkova, Z. B. Nikonova, N. S. Mudrak, Ir. A. Chvala

“…The increase of relative number of cytotoxic T lymphocytes in blood and in spleen, specific antibody response in 50-70% of chickens and activation of local immune response in 50% of chickens were observed in inoculated chickens.…”
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