Valine potentiates cefoperazone-sulbactam to kill methicillin-resistant Staphylococcus aureus by Shao-hua Li, Yuan Tao, Zhi-cheng Yang, Huan-zhe Fu, Hui-yin Lin, Xuan-xian Peng, Hui Li

“…In mouse models, lower bacterial load in liver, spleen, kidney, thigh, and higher survival were determined in the SCF + valine than valine or SCF alone. …”
Get full text

Meta-analysis of Therapeutic Effect of Warm Acupuncture and Moxibustion on Knee Osteoarthritis of Yang Deficiency and Cold Coagulation and Research on Regularity of Acupoint Select... by Zeling HUANG, Shanni SHI, Junjun HE, Hongjian GAO, Haiya GE, Zhenqiang HONG

“…The selected points of warm acupuncture and moxibustion treatment mainly concentrated on the stomach meridian of Foot-Yangming, the extraordinary points, the gallbladder meridian of Foot-Shaoyang, the spleen meridian of Foot-Taiyin and Ren meridian.Conclusion:Warming acupuncture and moxibustion can effectively improve the symptoms of joint pain, morning stiffness, dysfunction and limb chills in KOA patients of Yang deficiency and cold coagulation, the clinical effective rate is good. …”
Get full text

The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…Additionally, ΔmcpC demonstrated significantly decreased colonization in the liver, spleen, and cecum of mice, indicating attenuated virulence. …”
Get full text

Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro by Da Xu, Yujie Gu, Guilian Li, Ruihuan Wang, Shiqi Xiao, Hongyang Duan, Jingwei Jiang, Xiuqin Zhao, Kanglin Wan, Xinyue He, Haican Liu, Yongliang Lou

“…Furthermore, there was no significant difference in the proliferation of Mycobacterium tuberculosis between the immunized group and the PBS group in spleen cells. These data indicate that proteins from Mycobacterium abscessus are highly immunogenic in mice. …”
Get full text

Investigation of natural infection of BALB C mice by Bartonella henselae by Luciene Silva dos Santos, Sayros Akyro Soares Martins, Francine Ramos Scheffer, Alexandre Seiji Maekawa, Rafaela de Paula Silva, Gabriel Rabelo de Araújo, Paulo Eduardo Neves Ferreira Velho, Marina Rovani Drummond

“…To achieve this, ten immunocompetent BALB/c mice were obtained directly from the bioterium and euthanized for collection of samples, including blood, skin, spleen, liver, heart, eye, kidney, intestine, esophagus, and brain. …”
Get full text

PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…This suggestion is proven by structural equivalents of functional involution of lymphoid organs, such as thymus, spleen, and lymph nodes.We speculate that the death of treated animals resulted from multiple organ dysfunctions caused by accidental involution of lymphoid organs and the systemic inflammatory response syndrome, both associated with injections of fragmented exogenous DNA into experimental animals within the «death window», which corresponds to the final step in the repair of the majority of CP-induced double-strand breaks.…”
Get full text

Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity by Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang

“…Compared to CUR and GDNV, CG was superior in improving disease activity, colon length, liver and spleen coefficients, myeloperoxidase activity, and biochemical factor levels in ulcerative colitis (UC) mice. …”
Get full text

Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway by Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu

“…We verified our in silico prediction results with an in vivo/vitro antibacterial effect test, mouse phagocytic index test, proliferation, transformation, and migration of mouse spleen lymphocytes. Alteration of NF-κB pathway was determined by Western blotting, immunofluorescence, and PCR. …”
Get full text

Enhancement of systemic and lung-localized CD4⁺ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain by Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak

“…Seven days after the second immunization, cells were isolated from spleen and lung tissues and stimulated with whole wild-type H1N1 influenza virus. …”
Get full text

Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks by Yufei Wang, Siyi Xu, Xia Chen, Yunlong Dou, Xingzhu Yang, Zenglei Hu, Shuang Wu, Xiaoquan Wang, Jiao Hu, Xiufan Liu

“…Protective efficacy results revealed that, compared with the whole virus inactivated vaccine, a single dose of 160 ng σB or σC protein showed advantages in inducing serum antibodies, elevating weight, alleviating liver and spleen injury, restraining viral shedding and viral replication in ducklings. …”
Get full text

Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles by Galindo-Padrón AG, Lorenzo-Anota HY, Rueda-Munguía M, García-Carrasco A, Gaitán López M, Vázquez-Garza E, Campos-González E, Lozano O, Cholula-Díaz JL

“…In particular, whether they could cause an exacerbated cytotoxic response in susceptible tissues due to damage or disease, such as the heart, liver, spleen, or kidneys. In this regard, this study aims to evaluate the cytotoxicity of mono- and bimetallic nanoparticles of gold and silver (Au:Ag NPs) on healthy and hypertrophic cardiac H9c2 cells, and on healthy and metabolically activated macrophages derived from U937 cells. …”
Get full text

Efficacy of Fetal Wharton’s Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome by Illayaraja Krishnan, Magdalene Tan Mei Ling, Min Hwei Ng, Jia Xian Law, Mohd Rafizul Mohd Yusof, Thavachelvi Thangarajah, Zalina Mahmood, Nurul Izzati Uda Zahli, Shathiya Rajamanickam, Baskar Subramani, Yogeswaran Lokanathan

“…Necropsy evaluation was performed on the lungs, liver, spleen, and kidney. Results: Significant reductions in FBG, triglycerides, BP, and increased HDL levels were observed in the treated groups compared to the control group. …”
Get full text

Synergistic impact of Salmonella typhimurium and Eimeria spp. coinfection on turkey poults: Growth performance, salmonella colonization, and ceca microbiota insights by Hamid Reza Rafieian-Naeini, Hanseo Ko, Doyun Goo, Venkata Sesha Reddy Choppa, Seshidhar Reddy Gudidoddi, Hemanth Reddy Katha, Woo Kyun Kim

“…The coinfected groups (T4 and T5) had higher salmonella colonization in the spleen compared to the ST-infected group (T3, P < 0.05). …”
Get full text

Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle by Zhida Zhao, Qunhao Niu, Jiayuan Wu, Tianyi Wu, Xueyuan Xie, Zezhao Wang, Lupei Zhang, Huijiang Gao, Xue Gao, Lingyang Xu, Bo Zhu, Junya Li

“…Notably, the greatest increase of 31.52% was obtained for spleen weight (SW) using BayesB. Also, we found that the top 10% of variants show strong enrichment with weight related QTLs based on the Cattle QTL database. …”
Get full text

Effects of in-ovo injection of Yu ping feng polysaccharides on growth performance, intestinal development, and immunity in broiler chickens by Li-Gang Xue, Tian-Kui Guo, Juan Wang, Yu-Quan Shan, Li Guo, Dong-Xing Zhang, Zhong Wei, Dan Wang

“…Moreover, the analysis of immune development revealed that their serum levels in the polysaccharide-injected groups were also increased, with the YPF groups exhibiting superior performance than the APS and ATR groups and encouraging the development of T and B lymphocytes in the spleen and peripheral blood mononuclear cells. Altogether, the findings of this study demonstrate that the in-ovo injection of YPF can improve the growth performance, intestinal tissue development, and immune system of the broiler chicks.…”
Get full text

Biodistribution of intravenously delivered PEGylated carbon nanotubes to the rat brain cortex by Gisele Eva Bruch, Gisele Eva Bruch, Lidiane Dal Bosco, Lidiane Dal Bosco, Arthur P. Cordeiro, Marcos F. Cordeiro, Sangram K. Sahoo, Carolina Peixoto, Marta C. Klosterhoff, Luis Alberto Romano, Cristiano Fantini, Adelina P. Santos, Daniela M. Barros

“…SWCNT-PEG were identified in the brain cortex, blood, spleen, and liver of rats. Biochemical and histological analyses did not reveal toxic effects in rats 24 h after SWCNT-PEG injection. …”
Get full text

Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…The studied organs (liver, kidney and spleen) exhibited significant damage, with the most severe alterations observed in the Mix1 and Mix2-treated group in comparison with the groups receiving individual treatment. …”
Get full text

ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway by Xiaofei Huang, Xiaofei Huang, Yuqun Zeng, Jingru Lin, Huazhen Liu, Huazhen Liu, Chun-Ling Liang, Chun-Ling Liang, Yuchao Chen, Yuchao Chen, Feifei Qiu, Feifei Qiu, Jonathan S. Bromberg, Zhenhua Dai, Zhenhua Dai

“…ESAT-6 augmented the percentage of CD4+Foxp3+ Tregs, whereas it decreased the frequency of Th1 and CD4+/CD8+ effector T cells in spleen and lymph nodes (LNs) posttransplantation. …”
Get full text

Dehydrothyrsiferol Against Cutaneous Leishmaniasis: Treatment Outcome in a Murine Model by Atteneri López-Arencibia, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Rubén L. Rodríguez-Expósito, Angélica Domínguez-de-Barros, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Francisco Cen-Pacheco, Ana R. Díaz-Marrero, José J. Fernández, Elizabeth Córdoba-Lanús, Jacob Lorenzo-Morales, José E. Piñero

“…Treatment with DT significantly reduced the parasite load in skin, liver and spleen compared with the untreated group. In addition, DT-Sepigel at the lowest concentration (0.5%) showed the best results, reducing lesion size by 87% at 3 weeks post-treatment. …”
Get full text

Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants by REN Yixuan, CHEN Cheng, CAI Mingci, CHEN Jiamin, YANG Xinxin, WANG Chao, LIN Xiaozhu, CHENG Shu, JIANG Xufeng, CHEN Dongxu

“…The most common extra-nodal sites were the spleen, Waldeyer's ring, bone marrow, and gastrointestinal tract. …”
Get full text