The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods by Zhiwei Zhou, Dan Wang, Wei Liu, Lang He, Pengkuan Liang, Junli Hao, Qun Sun

“…Mice model experiment revealed that compared with the control, the PPH treatment significantly improved the spleen index (P < 0.05) by increasing the phagocytic rate of macrophages from 20 % to 60 % and the conversion rate of T lymphocytes from 8 % to 60 %. …”
Get full text

A distinct metabolomic pattern revealed intestinal microenvironment factor-mediated food allergy in a BALB/c mouse model by Qiang Xie, Chenglong Liu, Wenhui Fu, Chen Chen, Dan Luo, Shimin Gu, Wentong Xue

“…In response to GA, T-cell balance was disrupted, with aberrant production of interleukin (IL)-4, interferon (IFN)-γ, IL-10, and IL-2 in the spleen. GA led to a disrupted intestinal microenvironment homeostasis, including increased pH and water content, impaired intestinal antioxidant capacity and epithelial barrier function, decreased short-chain fatty acid production, and microbial dysbiosis, which was strongly correlated with GA severity. …”
Get full text

A retrospective Study on Intestinal Injury from Blunt Abdominal Trauma by Muralidharan Kannaian, Bhaskara Rao Bezawada, Vinod K, Subash Chandra Bose

“…The liver, small bowel, and spleen are the most frequently injured organs. …”
Get full text

Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes by Narcís Saubi, Eung-Jun Im, Raquel Fernández-Lloris, Olga Gil, Pere-Joan Cardona, Josep Maria Gatell, Tomáš Hanke, Joan Joseph

“…The specific HIV-1 cellular immune responses were analyzed in spleen cells. The body weight of the newborn mice was weekly recorded. …”
Get full text

Atypical Presentation of Cat-Scratch Disease in an Immunocompetent Child with Serological and Pathological Evidence by Serkan Atıcı, Eda Kepenekli Kadayıfcı, Ayşe Karaaslan, Muhammed Hasan Toper, Cigdem Ataizi Celikel, Ahmet Soysal, Mustafa Bakır

“…An atypical presentation which includes liver and/or spleen lesions is rarely reported in an immunocompetent child. …”
Get full text

Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model by Yannick Carlos Tcheutchoua, Danielle Claude Bilanda, Yolande Sandrine Mengue Ngadena, Paul Désiré Djomeni Dzeufiet, Pascal Emmanuel Owona, Ronald Bidingha á Goufani, Rodrigue Ngapout Fifen, Lohik Mbolang Nguegan, Michel Noubom, Théophile Dimo, Pierre Kamtchouing

“…The study showed that the aqueous extract of the mixture of B. pilosa and C. citratus has a low toxicity and does not cause any injury to the liver, kidney, lungs, or spleen.…”
Get full text

Immunomodulatory effect of ethanol-soluble oligopeptides from Atlantic cod (Gadus morhua) by Zhen Yuan, Meilian Yang, Dongyang Zhu, Di Wu, Shuzhen Cheng, Chao Wu, Hesham R. El-Seedi, Ming Du

“…CP-ES could promote the proliferation of spleen lymphocytes and T lymphocytes in mice, suggesting that CP-ES may regulate adaptive immunity. …”
Get full text

The Effect of IFN-γ, Alum and Complete Freund Adjuvant on TNP-KLH Induced Ig.G1, IgE and IgG2a Responses in Mice by R. van Ommen, A. E. C. M. Vredendaal, M. de Gooyer, A. van Oudenaren, H. F. J. Savelkoul

“…IFN-γ treatment resulted in an increased IL-6 and decreased IFN-γ production by spleen cells upon Con A stimulation, whereas it did not change the IL-4 production in similar conditions. …”
Get full text

Development and validation of highly sensitive multiplex real-time RT-PCR assay for detection of classical swine fever virus genome by A. S. Sadchikova, A. S. Igolkin, R. S. Chernyshev, A. A. Kozlov, I. S. Kolbin, A. V. Sprygin, D. A. Biryuchenkov, I. A. Chvala, A. Mazloum

“…For comparative analysis of the developed as say sensitivity, swabs, samples of organs and tissues collected from pigs experimentally infected with an epizootic strain of the classical swine fever virus (spleen, kidney, liver, blood, lymph nodes, rectal and oral smears), animal-contaminated feed and virus-containing material with known virus titres were also tested in parallel with coded test systems No. x1 andx2. …”
Get full text

Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin by Shuai Wang, Shuo Huang, Qianhong Ye, Xiangfang Zeng, Haitao Yu, Desheng Qi, Shiyan Qiao

“…Furthermore, sublancin restored the mRNA levels of IL-2, IL-4, and IL-6 in the spleen. Finally, the intestinal absorption of sublancin was poor as detected in the Caco-2 transwell system. …”
Get full text

Interactions of Self-Assembled <i>Bletilla Striata</i> Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles by Guangyuan Zhang, Jin Qiao, Xin Liu, Yuran Liu, Ji Wu, Long Huang, Danyang Ji, Qingxiang Guan

“…Docetaxel levels of DTX-loaded BSPs-SA nanoparticles in some organs changed, and more docetaxel accumulated in the liver, spleen, and the tumor compared with Duopafei^®. …”
Get full text

β-Glucan induced plasma B cells differentiation to enhance antitumor immune responses by Dectin-1 by Yu Bai, Jun Ding, Liuyang He, Zhichao Zhu, Jie Pan, Chunjian Qi

“…In mouse models of Lewis lung cancer (LLC) tumors, combining β-glucan with programmed death-1(PD-1) blocking antibodies led to increase recruitment of CD19+ B cells in the tumor microenvironment (TME), higher numbers of germinal centers B cells (GC B) in the spleen and draining lymph node (DLN), elevate Ig production, and delay tumor progression. …”
Get full text

Fucoidan alleviated colitis aggravated by fiber deficiency through protecting the gut barrier, suppressing the MAPK/NF-κB pathway, and modulating gut microbiota and metabolites by Weiyun Zheng, Shuangru Tang, Xiaomeng Ren, Xiaomeng Ren, Shuang Song, Shuang Song, Chunqing Ai, Chunqing Ai

“…Undaria pinnatifida fucoidan (UPF) alleviated colitis symptoms in mice that fed with a fiber deficient diet (FD), characterized by increased weight gain and reduced disease activity index, liver and spleen indexes, and histological score. The protective effect of UPF against FD-exacerbated colitis can be attributed to the alleviation of oxidative stress, the preservation of the gut barrier integrity, and inhibition of the MAPK/NF-κB pathway. …”
Get full text

Serotype distribution and antimicrobial susceptibility of Streptococcus suis isolates from porcine diagnostic samples in Hungary, 2020–2023 by Ervin Albert, István Emil Kis, Krisztián Kiss, Katalin K-Jánosi, Tamás Révész, Imre Biksi

“…The most frequently detected cps-types during the four years of this passive survey were 9 (19.6%), 2 (19.3%), 1/2 (18.9%) and 7 (14.5%). The brain, spleen, endocardial valve thrombus and lung proved to be the most frequent site of S. suis strain isolation, and animals 29–75 days of age were affected in the highest proportion. …”
Get full text

Activin A promoted the anti‐tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma by Liangchang Hu, Yu Zhao, Xuguang Zhang, Chunhui Ma

“…The tumor contained more ActRIIA high CD8+ T cells compared to the peripheral blood and spleen. ActRIIA high CD8+ T cells highly express cytotoxic molecules and cytokines. …”
Get full text

Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice by Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F

“…This beneficial effect was associated with a decrease in circulating B cell and spleen follicular B cell numbers. Regarding its mode of action, we demonstrated that the 6F7 antibody is not a depleting antibody and does not block HVEM binding to BTLA, but instead induces BTLA down modulation and exhibits in vivo agonist activity.Conclusion: Overall, our data confirm the involvement of BTLA in lupus pathogenesis and provide the first evidence that BTLA is a potential therapeutic target for the treatment of lupus.Keywords: systemic lupus erythematosus, BTLA, lupus mice, inhibitory receptors…”
Get full text

NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula by Yingbin Luo, Jianchun Wu, Xiaowen Zhu, Chenyuan Gong, Chao Yao, Zhongya Ni, Lixin Wang, Lulu Ni, Yan Li, Shiguo Zhu

“…Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased the population of NK cells in spleen, and enhanced NK cell-mediated killing activity. …”
Get full text

LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation by Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Deming Zhu, Wenhu Zhao, Chao Xu, Xiangyu Ling, Qingpeng Lv, Xiaoming Ai, Lianbao Kong, Wenzhou Ding

Get full text

TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…The indirect and direct effects of the TGFβ vaccine on these cell subsets were evaluated by culturing M2 macrophages or fibroblasts with tumor-conditioned media or with T cells isolated from the spleen of mice treated with the TGFβ vaccine or a control vaccine, respectively. …”
Get full text

Clinical phenotype and trio whole exome sequencing data from a patient with glycogen storage disease IV in Indonesia(NCBI) by Ivan William Harsono, Yulia Ariani, Beben Benyamin, Fadilah Fadilah, Dwi Ari Pujianto, Cut Nurul Hafifah, Titis Prawitasari

“…Early diagnosis of GSD IV is challenging due to non-specific symptoms, such as liver and spleen enlargement, which can overlap with other hematologic and hepatobiliary disorders. …”
Get full text