PMA Induces Vaccine Adjuvant Activity by the Modulation of TLR Signaling Pathway by Dool-Ri Oh, Hu Won Kang, Jong-Ro Kim, Sunoh Kim, In-Kyu Park, Joon Haeng Rhee, Won Keun Oh, Young Ran Kim

“…In in vivo mouse vaccination model, PMA induced antigen-specific IgG and IgA antibody responses and increased IL-12 production corresponding to T cell responses in spleen lymphocytes. These results suggest that PMA would serve as an efficacious mucosal vaccine adjuvant.…”
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Does perioperative electroacupuncture reduce postoperative pain in dogs undergoing ovariohysterectomy? by Celine Iwe, Anika Schiele, Vanessa Passenegg, Daniele Corona, Regula Bettschart-Wolfensberger, Vanessa Heitzmann

“…IntroductionThis study aimed to investigate the analgesic efficacy of perioperative electroacupuncture in fifty-six healthy female dogs undergoing ovariohysterectomy as part of a catch-neuter-release project.Materials and methodsTen minutes after sedation with 20 μg/kg medetomidine combined with 0.3 mg/kg butorphanol intramuscularly, the dogs were randomly allocated into two groups and received either electroacupuncture (EA, n = 27) or sham acupuncture (C, n = 29) treatment for 10 min (after sedation until the end of the surgery) at 6 different acupuncture points LI-4 (Large intestine 4), LIV-3 (Liver 3), ST-36 (Stomach 36), SP-6 (Spleen 6) bilateral. After administration of 0.2 mg/kg meloxicam and anesthesia induction with 2 mg/kg ketamine intravenously, ovariohysterectomy was performed by the same experienced surgeon using a midline surgical approach in dorsal recumbency. …”
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Influence of Dietary Chromium and Vitamin E Supplementation on Performance, Metabolism, and Physiology of Broilers Subjected to Cyclic Heat Stress by ML X Júnior, RD Bernardes, CH Oliveira, KMM Dias, BF Almeida, SO Borges, FS Dalólio, KM Gomes, CJ Rodrigues, AA Calderano

“…VitE at 300 mg/kg increased spleen relative weight (p ≤ 0.05). Cr supplementation reduced MDA concentrations (p ≤ 0.05). …”
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Ultrasound Presentation of a Disseminated Fetal and Neonatal Rhabdoid Tumor by Yolaine Joueidi, Aline Rousselin, Céline Rozel, Philippe Loget, Dominique Ranchere Vince, Sylvie Odent, Franck Bourdeaut, Vincent Lavoue, Maela Le Lous

“…Fetal ultrasound showed signs of a disseminated tumor affecting the left armpit, liver, spleen, and limbs. A caesarian section was performed because of signs of fetal distress. …”
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Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study by Chunran Xue, Haojun Yu, Xuzhong Pei, Xiaoying Yao, Jie Ding, Xiying Wang, Yi Chen, Yangtai Guan

“…Results hUC-MSCs alleviated NMOSD progression in vivo with improved motor function, reduced inflammatory infiltration, myelin loss, and preservation of astrocytes and neurons. hUC-MSC treatment did not affect autoimmune reactions in the spleen, however, decreased cytokine release in the spinal cord and mitigated blood–brain barrier disruption. …”
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Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice by Xiaoxie Xu, Jun Huang, Mei Zhao, Huanpeng Chen, Jinhua Mo, Xiaoqing Zhou, Qiao Su, Bolan Yu, Zhaofeng Huang

“…Meanwhile, stabilized β-catenin obviously decreased the numbers of spleen TCRβ+CD4−CD8− T (DNT) cells, and the levels of some serum proinflammatory factors also were lowered in β-catTglpr/lpr mice. …”
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Evaluation of Hydatid Cyst Cases: A Single-center Retrospective Study by Suzan Şahin, Bülent Kaya

“…Single cases of brain, spinal cord, spleen, kidney, and bone involvement were observed. …”
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Identification of a new fish trypanosome from the large yellow croaker (Larimichthys crocea) and description of its impact on host pathology, blood biochemical parameters and immun... by Yang Xiaoao, Qi Pengzhi, Tao Zhen, Zhang Qingwei, Wang Yanjie, Zhu Denghui, Yan Xiaojun, Fu Peipei, Guo Baoying

“…Trypanosome infection had no effect on the growth of L. crocea, but significantly increased the concentration of blood urea nitrogen (BUN), and induced pathological changes in the gills, liver, spleen and kidney. The pro-inflammatory immune genes, including TNF-α, IFN-γ, IL-1β, CXCL8 and iNOS, were significantly upregulated in the L. crocea infected with trypanosomes. …”
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Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques by Yaning Li, Yan Wang, Yang Yao, Brian B. Griffiths, Liangshu Feng, Tao Tao, Feng Wang, Baohui Xu, Creed M. Stary, Heng Zhao

“…We detected these immune cells from the ischemic brain, peripheral blood, spleen, and bone marrow at different time courses after stroke. …”
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A new vaccination approach for Salmonellosis employing a multi-epitope vaccine based on live microbial cell factory from Lactococcus lactis by Reyhaneh Sadat Moosavi-Kohnehsari, Mahnaz Jafari-Sohi, Tohid Piri-Gharaghie, Shakiba Tolou-Shikhzadeh-Yazdi, Mona Aghassizadeh-Sherbaf, Romina Hosseinzadeh

“…Salmonella infection is a severe health and economic burden in the poultry industry, according to spleen sections from the L. lactis/pNZ8121-Multi epitope. …”
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Visceral Leishmaniasis Clinical Management in Endemic Districts of India, Nepal, and Bangladesh by Megha Raj Banjara, Siddhivinayak Hirve, Niyamat Ali Siddiqui, Narendra Kumar, Sangeeta Kansal, M. Mamun Huda, Pradeep Das, Suman Rijal, Chitra Kumar Gurung, Paritosh Malaviya, Byron Arana, Axel Kroeger, Dinesh Mondal

“…Fever measurement or spleen palpation was infrequently done in Bangladesh but improved after intervention (from 23% to 47%). …”
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Effects of Algal-Derived β-Glucan on the Growth Performance, Intestinal Health, and Aeromonas veronii Resistance of Ricefield Eel (Monopterus albus) by Yu Guo, Zijing Yuan, Yueyun Han, Daiqin Yang, Hanwen Yuan, Fuxian Zhang

“…Moreover, the addition of 0.05%–0.2% β-glucan significantly improved the relative survival rate (SR) of A. veronii-infected eels and significantly decreased the bacterial load of the liver, spleen, and kidney (p<0.05). In comparison to eels that did not receive β-glucan supplementation, eels supplemented with 0.2% β-glucan exhibited decreased intestinal structural damage. …”
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Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis by Fengfan Yang, Xing Luo, Wenxiao Zhu, Jia Li, Zhaohui Zheng, Ping Zhu

“…Multiplex immunofluorescence staining described the distribution of ILCs in spleen tissues. Our results indicate that dysregulation of ILCs occurs during the pathogenesis of RA and CIA.…”
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Integrated omics profiling of individual variations in intestinal damage to the soybean allergen in piglets by Mengmeng Mi, Yaqing Zheng, Xin Fu, Nan Bao, Li Pan, Guixin Qin, Yuan Zhao

“…Whole genome re-sequencing analysis revealed specific mutations in the exons and URT5 of TRAPPC2, PIR, CFP, and SOWAHD genes and showed significantly higher expression levels of related genes in the spleen of allergic piglets (P &lt; 0.05). Transcriptome analysis identified IL17REL, CCL19, CD1E, CD1.1, etc. immune differential genes, metabolomics results showed that soybean antigen affected the utilization and metabolism of intestinal nutrients in piglets, mainly the digestion and absorption of protein and the synthesis and metabolism of amino acids. …”
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Comparative study of PCR test kits for ASFV DNA detection by M. S. Krasnikova, S. P. Yatsentyuk, M. B. Bryusova, A. D. Kozlova, М. А. Gergel

“…When the specificity was assessed, all the kits showed absence of non-specific reactions and acceptable sensitivity when testing various types of ASFV-containing material (blood, suspensions of pork spleen and pork casings used in sausage production). …”
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Application of warm acupuncture combined with scraping therapy in relief of symptoms of diabetic peripheral neuropathy and related nursing measures (温灸刮痧缓解1例糖尿病周围神经病变患者下肢症状的护理体会)... by SHANG Zhihua (尚志花), LI Xin (李欣), WANG Chunhong (王春红), ZHAO Xin (赵欣), LIU Huan (刘欢), XU Weihong (徐卫红), TANG Ling (唐玲)

“…A special scraping device was used to wipe smoothly along the meridians such as Liver Channel of Foot Jueyin, Kidney Channel of Foot Shaoyin, Spleen Channel of Foot Taiyang and Stomach Channel of Foot Yangming. …”
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Effects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly Mice by Heng-Xiao Wang, Shuang-Qin Yi, Jun Li, Hayato Terayama, Munekazu Naito, Shuichi Hirai, Ning Qu, Nozomi Yi, Masahiro Itoh

“…Mice with alymphoplasia (aly/aly) mutation characterized by a lack of lymph nodes, Peyer's patches, and well-defined lymphoid follicles in the spleen were found. In this study, we used splenectomized aly/aly mice to elucidate the effects of secondary lymphoid organs in the development of aly/aly autoimmune pancreatitis. …”
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Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…We also tested the changes of TME through flow cytometry of spleen of mice in each group, as well as the IHC of cytokines.ResultsThe co-therapy of PO and anti-PD-1 showed admirable anti-tumor effect compared with the control group and the single drug groups. …”
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Comparative Exploration of Antioxidant Properties of Alcalase- and Trypsin-Hydrolyzed Porcine By-Products and Their Classification for Industrial Use by Jun Hwang, Woo-Young Son, Eun Ju Jeong, Kyeong-Soo Kim, Eui-Cheol Shin, Dong-Heon Song, Kyung-Woo Lee, Hyun-Wook Kim

“…In this study, we compared the antioxidant properties of protein hydrolyzates derived from major porcine organs (heart, kidney, spleen, liver, and lung) and performed classification based on their antioxidative potential. …”
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Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model by Nadine Lanzke, Mario Menk, Clarissa von Haefen, Lilit Sargsyan, Bianca Scharf, Klaus-Dieter Wernecke, Claudia D. Spies

“…T helper cell subpopulations and the released cytokines were assessed in lungs, spleens, and plasma. Key transcription factors of T cell differentiation were evaluated. …”
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