Prevalence and clinical profile of hepatitis C virus infections in multitransfused thalassemic patients in the capital twin cities of Pakistan by Z. Z. Piracha, U. Saeed, R. Uppal, M. R. Uppal, A. Ahmad Khan, M. Abdullah, K. Mari, A. Basra, S. S. Gilani, M. N. Tariq, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…Splenomegaly was evident in 67.12% of HCV-positive thalassemic patients, with an average spleen size augmentation of 4.46 cm. Splenectomy was identified in 15.75% of cases. …”
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Characterizing cell-type spatial relationships across length scales in spatially resolved omics data by Rafael dos Santos Peixoto, Brendan F. Miller, Maigan A. Brusko, Gohta Aihara, Lyla Atta, Manjari Anant, Mark A. Atkinson, Todd M. Brusko, Clive H. Wasserfall, Jean Fan

“…Finally, we apply CRAWDAD to SRO datasets of the human spleen to identify consistent as well as patient and sample-specific cell-type spatial relationships. …”
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Fermented Lentinus edodes extract containing α-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice by Xin Hu, Dan Cheng, Yingxia Zhang, Po Li, Xiaoping Wu, Junsheng Fu

“…The results showed that compared with the model group, the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased, and the degree of inflammatory cell infiltration in liver, thymus and spleen was significantly reduced. Quantitative polymerase chain reaction, immunohistochemistry, and Western blotting showed that FLA pre-treatment inhibited the ConA-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of BCL-2. …”
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TIM-3 and TIM-1 Could Regulate Decidual γδTCR Bright T Cells during Murine Pregnancy by Jasper Nörenberg, Matyas Meggyes, Pal Jakso, Eva Miko, Aliz Barakonyi

“…Gamma/delta T cells from the uterus and spleen of pregnant and nonpregnant mice were analyzed by flow cytometry. …”
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Differential Immune Response against Recombinant Leishmania donovani Peroxidoxin 1 and Peroxidoxin 2 Proteins in BALB/c Mice by Nada S. Daifalla, Abebe Genetu Bayih, Lashitew Gedamu

“…Immunization with recombinant LdPxn1 alone induced a predominantly Th2 type immune response that is associated with the production of high level of IgG1 and no IgG2a isotype while rLdPxn2 resulted in a mixed Th1/Th2 response characterized by the production of antigen-specific IgG2a in addition to IgG1 isotype. Antigen-stimulated spleen cells from mice that were immunized with rLdPxn1 produced low level of IL-10 and IL-4 and no IFN-γ, whereas cells from mice immunized with rLdPxn2 secreted high level of IFN-γ, low IL-4, and no IL-10. …”
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Common Variable Immunodeficiency Associated with Hepatosplenic T-Cell Lymphoma Mimicking Juvenile Systemic Lupus Erythematosus by A. A. Jesus, C. M. A. Jacob, C. A. Silva, M. Dorna, A. C. Pastorino, M. Carneiro-Sampaio

“…The necropsy showed hepatosplenic T-cell lymphoma with diffuse involvement of bone marrow, spleen, liver, and lungs. The lymphoma cells were positive for CD3 immunostaining and negative for CD20 and lysozyme. …”
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Adult Intra-Thoracic Kidney: A Case Report of Bochdalek Hernia by Valeria Fiaschetti, Luca Velari, Eleonora Gaspari, Roberta Mastrangeli, Giovanni Simonetti

“…Magnetic Resonance (MR) confirmed a defect in left hemidiaphragm with herniation of left kidney, omento, spleen and colon flexure, and intrarotation with posterior hilum on sagittal plane. …”
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Structural and Functional Characterization of Recombinant Interleukin-10 from Indian Major Carp Labeo rohita by Sweta Karan, Pujarini Dash, Himani Kaushik, Pramoda K. Sahoo, Lalit C. Garg, Aparna Dixit

“…The rLrIL-10 was biologically active and its administration significantly reduced serum proinflammatory cytokines, namely, interleukin 1β, TNFα, and IL-8, and augmented the NKEF transcript levels in spleen of L. rohita. Anti-inflammatory role of the rLrIL-10 was further established by inhibition of phagocytosis using NBT reduction assay in vitro. …”
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Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review by Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

“…At the time of diagnosis, the PET scan demonstrated hypermetabolic neoplastic cells involving the left axilla, bilateral internal jugular areas, mediastinum, right hilum, bilateral lungs, and spleen. However, bone marrow biopsy performed for hemolytic anemia revealed normocellular bone marrow with trilineage maturation. …”
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Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs by R. Frandoloso, S. Martínez-Martínez, E. F. Rodríguez-Ferri, S. Yubero, D. Rodríguez-Lázaro, M. Hernández, C. B. Gutiérrez-Martín

“…However, overexpression of all proinflammatory molecules was observed in CHG group, mainly in the target infection tissues (brain, lungs, and spleen). High expression of CCL-2, CXCL-8, IL-1α, IL-1β, and IL-6 can be considered one of the characteristics of H. parasuis infection by serovar 5.…”
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Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies by Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye, Eric Woode

“…Sections of tissues from liver, kidney, spleen, brain, and stomach were also used for histopathological examination. …”
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Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities by Bassma H. Elwakil, Mohab H. Elsabrouty, Areej Eskandrani, Keshav Raj Paudel, Esraa Abdelhamid Moneer

“…On top of that, the synthesized nanoparticles reduced the parasitic tachyzoites’ count by 37, 43, and 49 % in the spleen, brain, and liver, respectively.…”
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Melittin ameliorates schistosomiasis-induced liver fibrosis by suppressing signal transducer and activator of transcription 3 and nuclear factor kappa B by Ola I. Rozik, Manal M. Hussein, Ahmed S. El-elebiarie, Soad Nady

“…Moreover, histopathology of the liver and spleen were also investigated. Results S. mansoni-infected mice showed significant (P<0.05) increases in the pro-inflammatory mediators and upregulate expression of STAT3, and NF-κB compared with the healthy group. …”
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EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by Xue Bing, Liu Xuelei, Dong Wanwei, Liang Linlang, Chen Keyan

“…Flow cytometry was used to measure the percentage of CD4+IFN-γ+ and CD4+IL-4+ in the spleen and colon. TLR4 antagonist E5564 was given in each group. …”
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Development of an Enzyme-Linked Immunosorbent Assay Method for the Detection of Rhein in Rheum officinale by Min Chen, Tie-Gui Nan, Jie Xin, Li Cui, Bo Zhang, Xiao Wang, Bao-Min Wang

“…First, a specific and sensitive monoclonal antibody (mAb) against rhein was produced from a stable hybridoma cell line, 1F8, generated by the fusion of mouse myeloma sp2/0 with spleen cells obtained from a Bal b/c mouse immunized with rhein-BSA. …”
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Antimicrobial susceptibility patterns of bacillus anthracis isolates obtained from different origins by Elif ÇELİK, Aliye GÜLMEZ SAĞLAM, Fatih BÜYÜK, Salih OTLU, Mitat ŞAHİN, Özgür ÇELEBİ, Mustafa Reha COŞKUN, Seda GÖKDEMİR, Yaren ERSOY, Eray BÜYÜK, Bengisu ERŞAHİN

“…In this retrospective study, it was evaluated the antimicrobial susceptibility profiles of Bacillus anthracis isolates obtained from human, various samples (blood, spleen, lung, liver, meat) of dead animals (cattle, sheep, dog, horse) that died from anthrax and soil samples from the animal burial areas between 2012 and 2023 from Kars province of Türkiye. …”
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The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…Organ weights, including brain, spleen, liver, and kidney, varied significantly among the lines and sexes in response to HFD. …”
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Cryoablation plus chemotherapy regimen enhance anti-tumor immune response in a mouse model of Lewis lung cancer by Hua Duan, Li Yang, Xueni Fang, Shaohua Yan, Yang Cao, Bingli Qiao, Tian Zhou, Kaiwen Hu

“…Cryo + chemo could increase the number of CD4+ T cells both in spleen and tumor microenvironment, decrease the infiltration of Treg cells in the tumor microenvironment. …”
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The immunohistochemical combination of low SGLT2 expression and high PRDX4 expression independently predicts shortened survival in patients undergoing surgical resection for hepato... by Yao Liu, Jia Han, Akihiro Shioya, Yang-Xian Zhang, Vu Anh Dung, Takeru Oyama, Xin Guo, Qian Yang, Tohru Ito, Sohsuke Yamada

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Understanding hospital length of stay in trauma laparotomy patients: a National Trauma Database Study by Jeremy Grushka, Kosar Khwaja, Hayaki Uchino, Evan G Wong

“…Additionally, isolated abdominal trauma, splenic injuries or spleen-related procedure were more likely to result in a short HLOS. …”
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