Diversity and Multiple Infections of <i>Bartonella</i> in Red Deer and Deer Keds by Iva Hammerbauerová, Eva Richtrová, Kateřina Kybicová, Petr Pajer, Jan Votýpka

“…One-third of the deer and 70% of the deer keds were <i>Bartonella</i> positive; within the tested animal tissues, usually the spleen was positive. The most prevalent <i>Bartonella</i> represents an undescribed species related to isolates from Japanese sika deer and <i>L. fortisetosa</i>. …”
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Detection and Genetic Analysis of Porcine Bocavirus in Different Swine Herds in North Central China by Mengmeng Liu, Yi Li, Dong Sun, Yihe Xia, Jinhai Huang, Lili Guo

“…The positive rates of spleen (20.75%) and inguinal lymph node (27.18%) are higher than those of other organs. …”
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Achievement of Therapeutic Goals with Low-Dose Imiglucerase in Gaucher Disease: A Single-Center Experience by Irina Tukan, Irith Hadas-Halpern, Gheona Altarescu, Ayala Abrahamov, Deborah Elstein, Ari Zimran

“…Among 164 patients at baseline, values for spleen and liver volumes, hemoglobin and platelet counts, and Z-scores for lumbar spine and femoral were significantly different from the goal. …”
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Characterization of patients with chronic liver disease of alcoholic etiology by Doppler ultrasound. Cienfuegos, 2020 by Masleidy Valladares Valle, Lariagna Moya Cardoso, Dianarelys Villafuerte Delgado, Rubén Daniel Fernández Azpiri, Liam Lain Pérez Valladares, Claudia Vasallo López

“…<br /><strong>Results</strong>: male patients were more representative and the age group from 42 to 51 years old was more numerous. The liver and spleen were of normal size in most cases (44.5% and 58.4%, respectively). …”
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Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp (Penaeus vannamei) proteins in BALB/c mice by Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Wang Li, Na Sun

“…As compared with the SPS groups, the GDS/GIDS groups caused lower specific immunoglobulins (IgE/IgG1) levels (P < 0.05), but higher than the control groups, indicating that the digestion products sensitized the mice. Meanwhile, spleen index, mouse mast cell protease-1 (mMCP-1) concentration and proportion of degranulated mast cells were significantly reduced in the GDS/GIDS groups (P < 0.05); simultaneously, allergic symptoms, vascular permeability and histopathological changes of tissues were alleviated. …”
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The Role of IL-17 Promotes Spinal Cord Neuroinflammation via Activation of the Transcription Factor STAT3 after Spinal Cord Injury in the Rat by Shaohui Zong, Gaofeng Zeng, Ye Fang, Jinzhen Peng, Yong Tao, Keke Li, Jingmin Zhao

“…RT-PCR was used to analyze the mRNA expression of IL-17 and IL-23p19 in the spleen tissue. ELISA was used to determine the peripheral blood serum levels of IL-6, IL-21, and IL-23. …”
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Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice by Yifan Wang, Shanjun Chen, Chong Wang, Yi Zhang, Hongliang Zeng, Linglin Fu, Yanbo Wang

“…Treatment with B. coagulans, in the high-dose group, signif icantly reduced IgE and IgG1 levels and modulated the balance of T helper type 1 cell (Th1) and Th2 and the expression of relevant genes in the spleen. 16S rRNA analysis showed that probiotics improved the structure of the microbiota, in particular by boosting the percentage of Clostridia, Bacteroides vulgatus and Enterococcus faecium, and by increasing the abundance of microbial species, thereby modulating the immune system. …”
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Prenatal diagnosis of mucopolysaccharidosis type I on hepatosplenomegaly and coarse features: a case-report by Maxime Agranier, Florence Demurger, Christele Dubourg, Jerome Fromageot, Anne-Sophie Cabaret Dufour, Erika Launay, Magalie Gournay, Charles Lefèvre, Roseline Froissart, Magali Pettazzoni, Paul Rollier

“…Case presentation A pregnant woman at 26.5 gestational weeks was referred to our center for fetal ultrasound findings of hepatosplenomegaly, distinct facial features, and liver, spleen and thymus echogenic spots. Whole exome sequencing after amniocentesis identified two likely pathogenic IDUA gene variants (in trans), raising suspicion of a diagnosis of MPS I. …”
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DETECTION OF PORCINE CIRCOVIRUS TYPE 3 IN RUSSIAN PIG HOLDINGS by M. V. Biryuchenkova, A. M. Timina, A. V. Shcherbakov

“…Porcine circovirus type 3 was detected in lung, bronchial and mediastinal lymph node, spleen tissues from grower and fattening piglets, adult pigs and aborted fetuses. …”
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Cloning and expression analysis of the glucocorticoid receptors and the effects of cortisol in sex differentiation in protogynous hermaphroditic swamp eel, Monopterus albus by Jialin Su, Lei Sun, Jiaqi Yang, Weizhi Yao, Hongyan Xu, Ke Feng

“…Real-time PCR indicated that swamp eel gr1a mainly expressed in the brain; gr1b mainly in the spleen, head kidney, kidney and muscle; gr2 mainly in the muscle. …”
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Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia by Ke Zhang, Zhenfeng Dai, Runzhe Liu, Fang Tian, Xi Liu, Yi Sun, Xin Zhao, Xiaoping Pu

“…The present study shows that icaritin can significantly increase peripheral blood platelet counts and thrombocytocrit, increase the TPO level in serum, attenuate splenomegaly, and reduce the abnormal proliferation of megakaryocytes in the spleen and bone marrow. Icaritin can also downregulate the expression of bone marrow TPO, myeloproliferative leukemia virus oncogene (MPL), and p-Stat3. …”
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Effect of Moringa oleifera, Bacillus amyloliquefaciens, and Their Combination on Growth Performance, Digestive Enzymes, Immunity, and Microbiota in Nile Tilapia (Oreochromis niloti... by Mingxuan Guan, Junfeng Guan, Haotian Zhang, Dikuang Peng, Xiaotong Wen, Xiaoyong Zhang, Qing Pan

“…MO significantly upregulated the gene expression of TNF-α, IL-6, IL-10, and C3 in the spleen of Nile tilapia (P<0.05), while Ba significantly upregulated the gene expression of IL-6 and C3 (P<0.05). …”
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γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation by Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li

“…GSI also significantly suppressed Th17-cell responses in spleen and reduced IL-17 levels in serum. These findings suggest that GSI directly regulates Th17 responses through a Notch signaling-dependent pathway in mouse model of allergic asthma, supporting the notion that GSI is a potential therapeutic agent for the treatment of allergic asthma.…”
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Efficacy of Zingibain phyto-protease on growth performance, litter quality and gut microbiota in broilers fed high animal protein concentrates by Muhammad Shahkar Uzair, Asad Sultan, Ziaul Islam, Muqadar Shah, Muhammad Tahir, Shabana Naz, Abdulwahed Fahad Alrefaei, Sheikh Adil, Naseer Khan Momand, Rifat Ullah Khan

“…Immune organ weights of spleen and bursa of fabricius were significantly increased in groups having 4 and 6% APC with GPZ (p = 0.02). …”
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Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice by Hao Liu, Yiwen Li, Yujiao Zhu, Lei Ma, Haibo Xue

“…Additionally, the Th17 cell percentages and IL-17A concentrations in spleen mononuclear cells (SMCs) from EAT-A mice decreased in a dose-dependent manner after DAPT treatment in vitro (all P<0.01). …”
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Music-guided imagination technology combined with acupoint application therapy and Traditional Chinese Medicine nursing measures for preoperative blood pressure control in a patien... by HOU Xuemin (侯雪敏), HUANG Yanping (黄砚萍), FANG Xiaomei (方晓梅)

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Induced pathomorphism and manifestations of residual focal lesions in parenchymatous organs of patients after noninvasive procedures by Z. A. Lemeshko, A. V. Borsukov, A. V. Mamoshin, T. G. Morozova

“…Overall 365 patients with focal lesions: metastases and cysts of the liver, residual foci in gallbladder area after endoscopic obliteration of organ cavity, malignant tumors and pseudo-cysts of the pancreas, chronic pancreatitis, abscesses of abdominal cavity of various localization, cysts and tumors of the spleen, cysts and tumors of kidneys, focal goiter, fibrous adenoma of breast gland were studied. …”
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Listeria monocytogenes use multiple mechanisms to disseminate from the intestinal lamina propria to the mesenteric lymph nodes by Joshua S. Nowacki, Grant S. Jones, Sarah E. F. D'Orazio

“…However, increasing the number of circulating dendritic cells by treating mice with rFlt3L resulted in a significant increase in L. monocytogenes in the lymph nodes that drain the small intestine and the spleen. Whole-mount fluorescent microscopy of lymphatic vessels following ligated loop infection revealed both free-floating L. monocytogenes and cell-associated bacteria within lymphatic vessels. …”
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Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells by Melanie Giesen, Erika Fleck, Jürgen Scheele, Tanja Nicole Hartmann, Reinhard Henschler

“…In a competitive murine short-term homing model with i.v. co-injection of Rap1A+B siRNA-treated and control MSCs that were labeled with PKH 26 and PKH 67 fluorescent dyes, the Rap1A+B siRNA-treated MSCs were detected at increased frequencies in blood, liver, and spleen compared to control MSCs. Thus, Rap1 GTPase modulates the adhesion and migration of MSCs in vitro and may increase the bio-availability of i.v.…”
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Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens by Jan Lukas Kleiner, Odilia Köpke, Anton Faron, Yunyang Zhang, Jan Cornelssen, Mark Coburn, Stilla Frede, Lars Eichhorn, Christina Katharina Weisheit

“…It was determined whether TAC induces a characteristic leukocyte-driven immune response in the myocardium, aorta ascendens and descendens, spleen, blood, and draining lymph nodes supported by cytokine-driven chemotaxis in mice at 3, 6, and 21 days following surgery. …”
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