Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics by Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer

“…Compared to LNPs with benchmark composition (b‐LNPs), n‐LNPs containing 30% distearoylphosphatidylcholine (DSPC) are well tolerated following intravenous administration and display natural targeting toward the inflamed colon in dextran sodium sulfate (DSS)‐colitis bearing mice, while de‐targeting clearing organs such as the liver and spleen. Using interleukin‐10‐encoding mRNA as therapeutic cargo, n‐LNPs demonstrated a reduction of pathological burden in colitis‐bearing mice. n‐LNPs represent a starting point to further investigate the influence of LNPs composition on systemic biodistribution, ultimately opening new therapeutic modalities in different pathologies.…”
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Biological, cytomorphological and karyological heterogeneity of transformed cell lines derived from domestic pig (Sus scrofa L.) organs by B. L. Manin, E. A. Trofimova, V. L. Gavrilova, O. S. Puzankova

“…Also, a procedure for preparation of new diploid cell culture from porcine spleen (SSs – Splеen Sus scrofa) is described. Based on the obtained data analysis it was concluded that the epithelial cells derived from trypsinized porcine spleens could be successfully immortalized. …”
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Frequency and persistency of DNA vaccine encoding GP25 by oral on common carp by Sri Nuryati, , Yuliyanti, , Alimuddin

“…Feeding fish with diet supplemented with 1 mL E. coli DH5α containing DNA vaccine for each fish and two times a week allowed persistence of DNA vaccine in kindney and spleen.   Keywords: common carp, KHV, DNA vaccine, GP25, persistance     ABSTRAK   Koi herpesvirus (KHV) adalah virus patogen utama yang menginfeksi ikan mas dan ikan koi. …”
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The effect of using Echinacea extract as an immune system stimulant and antioxidant on blood indicators, growth efficiency, and carcass characteristics in broiler chickens to produ... by Elwy A. Ashour, Ahmed K. Aldhalmi, Ismail E. Ismail, Mahmoud Kamal, Ahmed A. Elolimy, Ayman A. Swelum, Mohamed E. Abd El-Hack

“…Our results showed no significant changes in carcass features, except for spleen, gizzard, and abdominal fat, with the 3.0 cm3 EPE group having weight-higher organs and lower abdominal fat. …”
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A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice by Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia

“…The results shown that RLP (100 and 300 mg/kg) could inhibit tumor growth of H22 cells from 23.59 % to 45.52 % and protect thymuses and spleen without damage. In addition, according to cell cycle, AV-FITC/PI and JC-1, RLP could induce dose-dependent apoptosis of H22 cells via S phase arrested which was through a mitochondrial related pathway. …”
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Murine DX5+NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4+CD62Lhigh T Cells through Fas Ligand by Jens M. Werner, Michael Damian, Stefan A. Farkas, Hans J. Schlitt, Edward K. Geissler, Matthias Hornung

“…CD4+CD62Lhigh and DX5+NKT cells from the spleen of Balb/c mice were isolated first by MACS, followed by FACS sorting and cocultured for up to 96 h. …”
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Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination by Yue Zhang, Xia Lei, Hongdan Xu, Guoliang Liu, Yeqiu Wang, Huifeng Sun, Fang Geng, Ning Zhang

“…A rapid and validated UPLC-MS/MS method for simultaneous determination of the seven analytes including neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, eriodictyol, naringenin, and kaempferol in rats’ various tissues (heart, liver, spleen, lung, kidney, stomach, brain, uterus, ovary, and small intestine) using quercetin as the internal standard (IS) was developed after oral administration of TFDR to rats. …”
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Detection of Bartonella spp. in foxes' populations in Piedmont and Aosta Valley (NW Italy) coupling geospatially-based techniques by Annalisa Viani, Tommaso Orusa, Sara Divari, Stella Lovisolo, Stefania Zanet, Riccardo Orusa, Enrico Borgogno-Mondino, Enrico Bollo

“…The objective of this study was to investigate the presence of Bartonella spp. in red foxes (Vulpes vulpes) from Piedmont and Aosta Valley (NW Italy) and to explore the potential association between environmental humidity and Bartonella infection using remote sensing data. A total of 114 spleen samples were collected from hunted red foxes and screened for Bartonella spp. …”
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The role of partial splenic artery embolization in the management of refractory esophageal variceal bleeding due to portal vein thrombosis by Büşra Tetik Dinçer, Nafiye Urgancı, Aylin Hasanefendioğlu Bayrak, Özlem Durmaz, İlgin Özden

“…The liver was palpable 2 cm, and the spleen was palpable 6 cm below the costal margin. …”
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Non-invasive methods for diagnosing portal hypertension and variceal bleeding due to liver cirrhosis secondary to NAFLD/MASLD: systematic review by Nebyu Yonas Shanka, Nebyu Yonas Shanka, Chavdar S. Pavlov, Nigatu Leul Mekonnen

“…Combining LSM with platelet count resulted in a sensitivity of 97% but lower specificity (41%) for CSPH. Spleen stiffness measurement (SSM) also showed good diagnostic performance with a sensitivity of 89% and specificity of 75% for CSPH.ConclusionNon-invasive tests, particularly LSM and SSM, show promise in diagnosing portal hypertension and variceal bleeding in NAFLD/MASLD cirrhosis. …”
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Periplanta americana extract regulates the Th17/Treg cell balance via Notch1 in ulcerative colitis by Yanqiu Zheng, Yanqiu Zheng, Huibiao Li, Shiyu Qi, Fan Xiao, Jinbin Song, Shiyin Liu, Xinlin Chen, Yanwu Li, Muyuan Chen

“…The proportion and the markers of Th17 and Treg cells in the spleen and colon were examined. The signal transduction was detected in vivo. …”
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Bian-stone ironing and rubbing therapy combined with Traditional Chinese Medicine penetration therapy for postoperative constipation in a lung cancer patient undergoing chemotherap... by GAO Yaqian (高雅倩), GUO Huanli (郭换利), HUANG Yanping (黄砚萍), FENG Wenying (冯文英), ZHANG Guohong (张国红), ZHANG Xuelian (张雪莲)

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Nonlinear associations of the hs-CRP/HDL-C index with metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis in US adults: insights from NHANES 2017–2... by Bin Liang, Xue Qiu, Jiansheng Huang, Yequan Lu, Hairong Shen, Jianchao Ma, Yongyu Chen

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Harmful impacts of microplastic pollution on poultry and biodegradation techniques using microorganisms for consumer health protection: A review by Mohamed E. Abd El-Hack, Elwy A. Ashour, Fatemah AlMalki, Asmaa F. Khafaga, Mahmoud Moustafa, Mohammed O. Alshaharni, Islam M. Youssef, Ahmed A. Elolimy, Sylwester Świątkiewicz

“…In poultry, microplastics negatively affect production and harm vital organs such as the kidneys, spleen, and lungs. In humans, exposure to microplastics can lead to inflammation, immune responses, metabolic disturbances, DNA damage, neurological damage, and even cancer upon contact with mucosal membranes or absorption into the body. …”
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Correction of Thrombocytopenia before Elective Surgery / Invasive Procedures in Patients with Liver Cirrhosis (Experts’ Agreement) by M. V. Maevskaya, M. Yu. Nadinskaia, E. N. Bessonova, N. I. Geyvandova, M. S. Zharkova, E. A. Kitsenko, N. V. Korochanskaya, I. A. Kurkina, A. L. Melikyan, V. G. Morozov, Yu. V. Khoronko, T. A. Deeva, K. A. Gulyaeva, V. T. Ivashkin

“…As a result of portal hypertension (sequestration of platelets in an enlarged spleen) and liver failure (decreased production of thrombopoietin in the liver) in liver cirrhosis, thrombocytopenia develops, which is associated with the risk of periprocedural/perioperative bleeding complications. …”
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Preliminary ultrasonography study of the pancreas in the dromedary camel (Camelus dromedarius) by El Hassania Lakhel, Khalid El Allali, Mohamed Rachid Achaâban, Rahma Azrib

“…The pancreatic major duct was seen as an anechoic circle with a hyperechoic wall, with a maximum diameter of 1 cm, and the left lobe scanned beneath the cranial extremity of the spleen; its ultrasonographic pattern showed an irregular hypoechoic band with a mean thickness of 2.32 ± 0.32 cm (n = 14) in young camels and 3.08 ± 0.52 cm (n = 8) in the adults, including a small splenic vein.ConclusionUltrasonography combined with Doppler techniques provides valuable information on pancreatic health, blood flow, and tissue perfusion, aiding early detection of pancreatic diseases and, consequently, minimizing economic losses in camel husbandry.…”
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Scoring System for Lesions Induced by Different Strains of Newcastle Disease Virus in Chicken by Elawad A. Hussein, M. Hair-Bejo, Lawan Adamu, A. R. Omar, Siti S. Arshad, Elmutaz A. Awad, I. Aini

“…In all previous experiments, tissues of brain, trachea, lung, caecal tonsil, liver, kidney, spleen, heart, proventriculus, intestine, and thymus were collected, fixed in 10% buffered formalin, embedded in paraffin, and sectioned. …”
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The active roles of Rhodotorula mucilaginosa ZTHY2 in regulating antioxidant capacity and immune function of Leizhou black ducks by Jiang Wu, Yingxin Hu, Namula Zhao, Wei Yang, Zhibao Chen, Zhibao Chen

“…Moreover, ZTHY2 modulated the mRNA expression profiles of these cytokines in the thymus, spleen, and bursa, thereby sustaining the balance of immune dynamics. …”
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Noninvasive diagnostic methods of liver fibrosis in patients with primary biliary cirrhosis and primary sclerosing cholangitis: role of indirect serological markers by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…According to routine laboratory test data and abdominal ultrasound, indexes of AST to ALT ratio (AAR); AST to platelet count ratio (APRI); platelet count to the spleen diameter ratio - PLT/ SPD and Fibrosis-4 score index (FIB-4) were calculated. …”
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Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model by Zhuo-ma Dawa, Zhuo-ma Dawa, Ting Zhai, Ting Zhai, Chuan-chuan Liu, Chuan-chuan Liu, Hai-ning Fan, Hai-ning Fan

“…After PAB treatment, the levels of CD4+ T lymphocytes increased and the levels of CD8+ T lymphocytes decreased in the host tissue surrounding the metacestodes and the spleen. The proportions of the Th1 and Th17 cell subpopulations were increased and the proportion of Th2 cell and Treg cell subpopulations was decreased in the host tissue surrounding the metacestodes. …”
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