Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection by Thais F. C. Fraga-Silva, Luiza A. N. Mimura, Camila M. Marchetti, Fernanda Chiuso-Minicucci, Thais G. D. França, Sofia F. G. Zorzella-Pezavento, James Venturini, Maria S. P. Arruda, Alexandrina Sartori

“…EAE aggravation was associated with expansion of peripheral CD4+ T cells and production of high levels of TNF-α, IFN-γ IL-6, and IL-17 by spleen and CNS cells. In addition to yeast and hyphae, fungus specific T cells were found in the CNS. …”
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The Role of CD40 in Allergic Rhinitis and Airway Remodelling by Ke-Jia Cheng, Min-Li Zhou, Yong-Cai Liu, Chen Wang, Ying-Ying Xu

“…The IFN-γ, IL-10, and TGF-β levels in AR mice were significantly lower than that in control and were increased by administration of CD40 siRNA. (2) AR mice had significantly fewer Foxp3+ Tregs in the spleen than control mice. After treated with CD40 siRNA, AR mice had significantly more Foxp3+ Tregs. (3) AR mice exhibited a significantly higher CD40 mRNA levels than control. …”
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Structure and immunomodulatory activity of Lentinus edodes polysaccharides modified by probiotic fermentation by Jingjing Liang, Meina Zhang, Xiaohan Li, Yuan Yue, Xiaowei Wang, Mengzhen Han, Tianli Yue, Zhouli Wang, Zhenpeng Gao

“…F-LEP displayed better moderating effects on the spleen index, immunoglobulin, cytokines and the diversity of gut microbiota than NF-LEP (200, 400 mg/kg). …”
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Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study by Du-Bois Asante, Emmanuel Effah-Yeboah, Precious Barnes, Heckel Amoabeng Abban, Elvis Ofori Ameyaw, Johnson Nyarko Boampong, Eric Gyamerah Ofori, Joseph Budu Dadzie

“…Moreover histopathological analysis revealed ameliorative effect of pathological insults induced by the STZ in the pancreas, liver, and spleen, most significantly the regeneration of the beta cells of the islets of Langerhans in treated rats.…”
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Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs by Felipe Beccaria Casagrande, Sabrina de Souza Ferreira, Fernanda Peixoto Barbosa Nunes, Lavínia Maria Dal’Mas Romera, Suelen Silvana dos Santos, Fernando Henrique Galvão Tessaro, Paula Regina Knox de Souza, Sandro Rogério Almeida, Joilson Oliveira Martins

“…The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection.…”
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Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway by Yuanyang Chen, Sihao Zheng, Zhiwei Wang, Xin Cai, Yanjia Che, Qi Wu, Shun Yuan, Xiaohan Zhong

“…The proportion of multiple lymphocytes in spleen and lymph nodes was then determined using flow cytometry. …”
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Epidemiological and molecular characteristics of extraintestinal pathogenic escherichia coli isolated from diseased cattle and sheep in Xinjiang, China from 2015 to 2019 by Xiaoxiao Gu, Qin Wu, Yingjin Chai, Xin Huang, Xia Zhou, Mengli Han, Tongzhong Wu, Xingxing Zhang, Fagang Zhong

“…Herein we isolated Extraintestinal pathogenic Escherichia coli (ExPEC) from the liver, spleen, lung, heart, and lymph nodes of infected cattle and sheep (Xinjiang, China), and phylogenetic grouping, serotyping, and multilocus sequence typing were performed to determine epidemic and molecular characteristics. …”
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Immune modulation effects of curcumin in pristane-induced lupus mice by Handono Kalim, Kusworini Handono, Takhta Khalasha, Mirza Zaka Pratama, Tri Wahyudi Iman Dantara, Ayu Pramitha Wulandari, Fahimma Albinsaid, Sofi Nur Fitria, Muhammad Vardian Mahardika

“…At 32 weeks after injection, all of mice were assessed for arthritis score, proteinuria level, body weights, adaptive immune system components (Th1, Th2, Th17, and Treg percentages) from spleen using flow cytometry; proinflammatory cytokines and autoantibody production, including interleukin-6 (IL-6), interferon-alpha (IFN-α), and antinuclear antibody (ANA) from serum using enzyme-linked immunosorbent assay. …”
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CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway. by Shuaini Yang, Jinxi Yu, Xue Dong, Jiajia Zeng, Lu Tan, Hong Zhang, Ruoyuan Sun, Yuqing Tuo, Jing Yang, Chunxiao Wan, Hong Bai

“…As a result, there is a significant decrease in CD3+CD4+IFN-γ+ T cells in the lung and spleen, accompanied by reduced levels of IFN-γ protein and mRNA, as well as downregulated mRNA expression of Th1-promoting cytokines (il-12p35, il-12p40) and transcription factors (stat4, T-bet), which play crucial roles in Th1 differentiation. …”
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Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…The levels of Th1/Th2 cytokines (IFN-γ/IL-4) secreted from spleen, mesenteric lymph nodes and Peyer's patches were distinctly increased at 6 weeks following vaccination (P < 0.05). …”
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Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics by Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie

“…Disappointingly, no tumor uptake was observed in EGFR-positive tumor-bearing mice, with most activity being accumulated predominantly in the liver, gall bladder, kidneys, and spleen. Some bone uptake was also observed, suggesting in vivo dissociation of ⁵⁷Co from the complex. …”
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pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…MOG35–55 immunization also determined less inflammation in lumbar spinal cord but did not change CD4+CD25+Foxp3+ T cells frequency in spleen and CNS. Infiltrating cells from the CNS stimulated with rhsp65 produced significantly higher levels of IL-10. …”
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Experimental Study of Thoracoabdominal Injuries Suffered from Caudocephalad Impacts Using Pigs by Sishu Guan, Zhikang Liao, Hongyi Xiang, Xiyan Zhu, Zhong Wang, Hui Zhao, Peng Liu, Xinan Lai

“…The subjects in group I and group II experienced the caudocephalad loading at the peak pelvic accelerations of 108.92 ± 58.87 g and 139.13 g ± 78.54 g, with the peak abdomen pressures, 41.24 ± 16.89 kPa and 63.61 ± 65.83 kPa, respectively. The injuries of the spleen, lung, heart, and spine were detected frequently among the tested subjects. …”
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Contrast-Enhanced CT May Be a Diagnostic Alternative for Gastroesophageal Varices in Cirrhosis with and without Previous Endoscopic Variceal Therapy by Qianqian Li, Ran Wang, Xiaozhong Guo, Hongyu Li, Xiaodong Shao, Kexin Zheng, Xiaolong Qi, Yingying Li, Xingshun Qi

“…Liver fibrosis blood tests, platelet count/spleen diameter ratio (PSR), and contrast-enhanced CT are diagnostic alternatives for gastroesophageal varices, but they have heterogeneous diagnostic performance among different study populations. …”
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Nanotechnological Plastic Flooring: Implications for Broiler Chicken Performance, Health, and Carcass Quality by Bruna Barreto Przybulinski, Rodrigo Garófallo Garcia, Maria Fernanda de Castro Burbarelli, Irenilza de Alencar Naas, Claudia Marie Komiyama, Fabiana Ribeiro Caldara, Vivian Aparecida Rios de Castilho Heiss, Kelly Mari Pires de Oliveira, Renata Pires de Araújo, Jean Kaique Valentim

“…This study evaluated organ biometrics (liver, heart, spleen, and gizzard), the severity of <i>Eimeria</i> lesions, microbiological profiles, performance indices, and meat quality. …”
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Protein quality of four indigenous edible insect species in Nigeria by Florence Inje Oibiokpa, Helmina Olufunmilayo Akanya, Ali Audu Jigam, Abubakar Ndaman Abubakar, Evans Chidi Egwim

“…The organ body weight ratios of the liver, spleen, lung and heart of rats placed on the insect supplemented diets were not significantly different (p > 0.05) from those fed with casein and basal diets. …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…Naïve CD4+ T cells were isolated from spleen lymphocytes and stimulated to differentiate into Th1, Th2, and Th17 cells. …”
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Neo-BCV: A Novel Bacterial Liquid Complex Vaccine for Enhancing Dendritic Cell-Mediated Immune Responses Against Lung Cancer by Zilong Zhu, Zhuze Chu, Fei Fei, Chenxi Wu, Zhengyue Fei, Yuxia Sun, Yun Chen, Peihua Lu

“…Moreover, Neo-BCV significantly improved the immune microenvironment in both tumor and spleen tissues without inducing notable toxic effects in major organs. …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…VirG53 – 353 evoked the production of Th2-type cytokines by spleen cells from vaccinated mice. A new universal Shigella vaccine based on VirG53 – 353 meets the World Health Organization’s preferred product specifications. …”
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Nursing of a patient with gout of damp-heat stagnation syndrome combined with erosive gastritis treated with auricular acupoint therapy combine with pricking and cupping therapy (耳... by ZHU Jianmei (朱建妹), CHEN Hui (陈慧), ZHANG Xiaolin (张小林), LIAO Xuefeng (廖雪锋)

“…In addition to routine nursing, individualized auricular acupoint treatment including auricular bloodletting and pressing combined with pricking and cupping therapy were carried out, aiming at relieving heat and detoxification at early stage of disease, promoting blood circulation, dredging collaterals and regulating qi at midterm and invigorating spleen and warming kidney Yang and end stage of treatment. …”
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