Oral Administration of Piperine as Curative and Prophylaxis Reduces Parasitaemia in Plasmodium berghei ANKA-Infected Mice by Shafia Khairani, Nisa Fauziah, Hesti Lina Wiraswati, Ramdan Panigoro, Endang Yuni Setyowati, Afiat Berbudi

“…Additionally, piperine showed an ability to protect organs (lungs, liver, spleen, and kidneys) from some damage in a dose-dependent manner. …”
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Study of cultural properties of canine enteric coronavirus isolate in different cell cultures by A. A. Komarova, T. S. Galkina

“…It was established that such cell linesas fel in espleen cells (FS) and primary trypsinized kitten spleen cells (KS) are also sensitive to the CCoV isolate but less than CRFK cells. …”
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Infiltration of the liver by cells of innate and adaptive immunity and their destruction in development of experimental immune concanavalin-A-induced hepatitis by S. I. Pavlovich, T. M. Bryzgina, N. V. Makogon, L. I. Aleksyuk, T. V. Martynova, R. I. Yanchy, I. N. Alekseyeva

“…In the early terms after ConA injection destruction of thymic cells was amplified mainly by apoptotic pathway, and spleen cells – by necrotic pathway.Conclusions. Obtained data assume, that infiltration of the liver by leukocytes, in particular neutrophiles, in combination to ascending necrotic destruction of peripheral cells of innate and adaptive immunity can be the essential pathogenic mechanism at inflammatory liver diseases of T-cell origin.…”
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The effect of nuclear transcriptional factor κВ activation inhibitor – curcumine on the experimental immune liver disease by I. N. Alekseyeva, N. V. Makogon, S. I. Pavlovich, T. M. Bryzgina, L. I. Aleksyuk, T. V. Martynova, V. S. Sukhina

“…To study at two models of immune hepatitis (Т-cellular and antibody origin) in mice damage of the liver, activity and destruction of its immunocompetent cells, thymus gland and the spleen, as well as the effect of curcumine — inhibitor of NF-κB activation on development of pathological process.Material and methods. …”
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Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model by Maitham Ahmed Al-Sammak, Douglas G. Rogers, Kyle D. Hoagland

“…There were no histopathologic lesions in brain, liver, heart, kidney, lung, or spleen in any of the mice during the 14-day study. …”
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Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion by Rasika Singh, Charles Edward Keen, Christopher Stone, Patrick Sarsfield

“…Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells which can occur in skin, bone marrow, lymph nodes, spleen, liver, and lung. LCS can present with multiple cutaneous and systemic lesions. …”
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Mechanisms of reduced sensitization by extensive hydrolysis of milk protein concentrate: Impact on the immune response of Th1/Th2 and Treg/Th17 cells in mice by Qiang Cui, Jianjun Cheng, Mingruo Guo

“…This indicated an imbalance of Th1/Th2 in the MPC group, which was confirmed by the results of cytokines and transcription factors in the spleen. The mice in the control MPC group highly expressed FcεRI+CD117+ mast cells (22.25%), peripheral blood B cells (2.91%), and CD3+CD8+ T cells (8.65%). …”
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Sex-Related Differences in Hematological Parameters and Organosomatic Indices of Oreochromis niloticus Exposed to Aflatoxin B1 Diet by Esther Marijani, Johnson Nasimolo, Emmanuel Kigadye, Gbemenou Joselin Benoit Gnonlonfin, Sheila Okoth

“…Organosomatic indices showed that the relative liver, kidney, and spleen weights were significantly higher (P<0.05) in the AFB1 supplemented group than in the control group. …”
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Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis by Varun Mamidi, Manikantan Shekar, Jaiju James Chakola, Vamsi Krishna Makkena, Jayakumar Matcha

“…Whole body Flourine-18-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT) showed increased metabolic uptake with ill-defined lesions in the liver, spleen, and pelvic lymph nodes. Biopsy of the ill-defined lesions in the liver showed necrotizing granulomatous lesions without angiitis. …”
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The Effects of Laurencia caspica Algae Extract on Hemato-Immunological Parameters, Antioxidant Defense, and Resistance against Streptococcus agalactiae in Nile tilapia (Oreochromis... by Majid Khanzadeh, Babak Beikzadeh, Seyed Hossein Hoseinifar

“…In addition, feeding with L. caspica significantly increased the antioxidant enzyme activities on the 25th day (L. caspica 1% and 2% in peroxidase [POD] and superoxide dismutase [SOD] in all groups) and 50th day (catalase [CAT], SOD and L. caspica 1% and 2% in POD) in the spleen. The survival rate of fish challenged with Streptococcus agalactiae was considerably greater than the control group. …”
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Common variable immunodeficiency: An uncommon cause of bronchiectasis, granulomatous disease, chronic liver disease, and enteropathy – Case report and review of literature by Veena Shamsudeen, Arun Hegde, Uday Bhanu Kovilapu, Nisha Verma, Anurag Jain

“…Some patients develop a granulomatous disease manifesting with noncaseating granulomas, especially of lymph nodes, skin, lung, spleen, and liver. Nearly 20%–25% of cases develop autoimmune complications such as autoimmune hemolytic anemia and immune thrombocytopenia. …”
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Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis by Yu-Chen Hou, Jin-Ming Wu, Ming-Yang Wang, Ming-Hsun Wu, Kuen-Yuan Chen, Sung-Ling Yeh, Ming-Tsan Lin

“…APS treatment reversed the sepsis-induced decrement in the T helper (Th) cell population, and the percentage of activated Th cells also increased in the spleen and Peyer’s patches. APS administration downregulated the percentages of circulating Th2 cells and regulatory T cells (Treg), and the percentage of Th17 cells in blood was upregulated in the A400 group. …”
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Fipronil in sub-lethal doses leads to immuno-toxicological effects in broiler birds. by Shafia Tehseen Gul, Muhammad Zergham Tahir, Latif Ahmad, Aisha Khatoon, Muhammad Kashif Saleemi, Farid Shokry Ataya, Riaz Hussain, Bakhtawar Maqbool, Dalia Fouad, Ahrar Khan

“…Results also revealed that the bursa of Fabricius thymus and spleen were also affected due to the toxic effect of fipronil, even at sub-lethal doses.…”
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A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. These effects might be elucidated by the upregulated inflammation-associated proteins in ΔarrS. …”
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Protective effect of exercise on animals with sepsis: a systematic review of the existing literature by Na Yang, Nan Jiang, Chunming Shen, Ming Gao, Qian Tong, Jian Sun

“…Our comprehensive descriptive analysis showed that exercise could improve the general condition, lung injury, liver injury, kidney injury, heart and aortic injury, spleen and thymus injury, and other injuries in animals with sepsis. …”
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Quantitative Evaluation of Display Contrast of Gd-EOB-DTPA-Enhanced Magnetic Resonance Images: Effects of the Flip Angle and Grayscale Gamma Value by Yusuke Inoue, Hirofumi Hata, Ai Nakajima, Keiji Matsunaga, Yusuke Ohzeki, Tetsuya Hashimoto, Hiroki Haradome

“…To assess image contrast, the liver-to-muscle signal ratio (LMR), liver-to-spleen signal ratio (LSR), contrast ratio (CR), liver signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were calculated. …”
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Sex-Biased Immune Responses to Antibiotics during Anti-PD-L1 Treatment in Mice with Colon Cancer by Nan Jing, Luoyang Wang, Huiren Zhuang, Chao Ai, Guoqiang Jiang, Zheng Liu

“…We observed that two narrow-spectrum antibiotics, neomycin and metronidazole, were more effective in alleviating colitis, as evidenced by the remission of loss of the body weight, enlargement of the spleen, shortening of the colon, secretion of proinflammatory cytokines, and histological score of the colon tissue. …”
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The Current Status of Atmospheric Micro/Nanoplastics Research: Characterization, Analytical Methods, Fate, and Human Health Risk by Hsin-Chieh Kung, Chien-Hsing Wu, Nicholas Kiprotich Cheruiyot, Justus Kavita Mutuku, Bo-Wun Huang, Guo-Ping Chang-Chien

“…Since most polymers are inert, the adverse health risks include endocytosis and accumulation in the liver and spleen. However, most of the toxic effects of these contaminants are related to surface-bound compounds, including heavy metals and persistent organic pollutants. …”
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Nomogram for Predicting Postoperative Portal Venous Systemic Thrombosis in Patients with Cirrhosis Undergoing Splenectomy and Esophagogastric Devascularization by Miao Chen, Jian-Bo Han, Jia-Kang Zhang, Qing-Hua Shu, Yu-Feng Zhang, Yong-Xiang Yi

“…The results of the multivariate logistic regression suggested that a higher RDW on POD3 (RDW3) (odds ratio (OR): 1.188, 95% confidence interval (CI): 1.073–1.326), wider portal vein diameter (OR: 1.387, 95% CI: 1.203–1.642), history of variceal hemorrhage (OR: 3.407, 95% CI: 1.670–7.220), and longer spleen length (OR: 1.015, 95% CI: 1.001–1.029) were independent risk parameters for postoperative PVST. …”
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Glycogen Storage Disease Type IX due to a Novel Mutation in PHKA2 Gene by Hamza Hassan Khan, Lauren Parr, Allison Jay, Saleem Raza, Hernando Lyons, Sanjay Kumar

“…Ultrasound of abdomen revealed hepatomegaly with a liver span of 13 cm, homogeneous parenchyma, and normal spleen size. Liver and muscle biopsies were obtained: the liver biopsy revealed distended hepatocytes with excessive glycogen accumulation and fine septate fibrosis. …”
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