An Optimized Liquid Chromatography–Mass Spectrometry Method for Ganglioside Analysis in Cell Lines by Akeem Sanni, Andrew I. Bennett, Yifan Huang, Isabella Gidi, Moyinoluwa Adeniyi, Judith Nwaiwu, Min H. Kang, Michelle E. Keyel, ChongFeng Gao, C. Patrick Reynolds, Brian Haab, Yehia Mechref

“…Percent recovery and the number of identified sphingolipids were used to evaluate the analytical merits of these methods. …”
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TLR Specific Immune Responses against Helminth Infections by Sivaprakasam Rajasekaran, Rajamanickam Anuradha, Ramalingam Bethunaickan

“…In this review, we discuss the unique and shared host effector mechanisms elicited by systemic helminth parasites and their derived products, including the role of TLRs and sphingolipids. Understanding and exploiting the interactions between these parasites and the host regulatory network are likely to highlight new strategies to control both infectious and immunological diseases.…”
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Specialized contact sites regulate the fusion of chlamydial inclusion membranes by Christine Linton, Jordan Wesolowski, Anna Lobley, Toshiyuki Yamaji, Kentaro Hanada, Fabienne Paumet

“…Fusion depends on IncA clustering within ICSs and is regulated by PI(3,4)P2 and sphingolipids. As IncA concentrates within ICSs, its C-terminus likely interacts in trans with IncA on the apposing membrane, securing a high concentration of IncA at fusion sites. …”
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Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques? by Sara Anselmo, Elisa Bonaccorso, Chiara Gangemi, Giuseppe Sancataldo, Valeria Conti Nibali, Giovanna D’Angelo

“…Lipid rafts are dynamic microdomains in the membrane, rich in cholesterol and sphingolipids, that are critical for biological processes like cell signalling, membrane trafficking, and protein organization. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Niemann-Pick type C disease is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol within the late endolysosomal compartment of cells and accumulation of gangliosides and other sphingolipids. Progressive neurological deterioration and insurgence of symptoms like ataxia, seizure, and cognitive decline until severe dementia are pathognomonic features of the disease. …”
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Effects of different processing methods on the lipid composition of hazelnut oil: A lipidomics analysis by Jiayang Sun, Xiaonuo Feng, Chunmao Lyu, Shuang Zhou, Zixuan Liu

“…A total of 10 subclasses of 98 lipids were identified, including 35 glycerolipids (GLs), 56 glycerophospholipids (GPs) and 7 sphingolipids (SPs). The total lipid and GL content were the highest in CPO, GP content was the highest in UHO and the ceramide content in SPs was most abundant in EAO. …”
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Fecal metabolomics reveals the positive effect of ethanol extract of propolis on T2DM mice by Chunmei Wang, Huiting Zhao, Kai Xu, Yali Du, Jinjia Liu, Jinfei Wang, Yusuo Jiang

“…EEP effectively regulated the dysfunction in the metabolic pathways of glycerophospholipids, sphingolipids, riboflavins, and sterol lipids caused by T2DM. …”
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Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice by Timothy M. Griffin, Ravi K. Komaravolu, Erika Barboza Prado Lopes, Padmaja Mehta-D’souza, Taylor Conner, Tessa Kovats, Susan Kovats, Madeline Allen, Peyton Harris, Mary Beth Humphrey, Hope D. Welhaven, Priyanka Brahmachary, Ronald K. June

“…Exercise acutely altered synovial fluid metabolites, characterized by increased amino acids, peptides, bile acids, sphingolipids, dicarboxylic acids, and straight medium chain fatty acids and decreased hydroxy fatty acids and diacylglycerols. …”
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Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus by Jian Ji, Yongli Ye, Lina Sheng, Jiadi Sun, Qianqian Hong, Chang Liu, Jun Ding, Shuxiang Geng, Deping Xu, Yinzhi Zhang, Xiulan Sun

“…Our data reveal that HIBA can regulate the metabolism of basal ganglia (sphingolipids, acylcarnitines, etc.), possibly in relation to HIBA’s influence on the gut microbiome (Muribaculum, Bacteroides, Lactobacillus, etc.). …”
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Comprehensive Metabolomics in Mouse Mast Cell Model of Allergic Rhinitis for Profiling, Modulation, Semiquantitative Analysis, and Pathway Analysis by Akshay Suresh Patil, Yan Xu

“…Triprolidine primarily modulated histidine and sphingolipid metabolism, while zileuton targeted arachidonic acid and sphingolipid metabolism. …”
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Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment by Karsten Buschard, Laurits J. Holm, Ulla Feldt-Rasmussen

“…Fenofibrate reverses and prevents autoimmune diabetes in nonobese diabetic (NOD) mice by increasing the amount of the sphingolipid sulfatide in islets. Sphingolipid metabolism is otherwise abnormal in the islets at diagnosis of type 1 diabetes. …”
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The Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research by Fanming Kong, Miaomiao Zhu, Xinliang Pan, Li Zhao, Sanjun Yang, Jinyuan Zhuo, Cheng Peng, Dongkai Li, Jing Mi

“…Nine unique differential metabolites were identified in the THR group, mainly enriched in pyruvate metabolism, glycine, serine, and threonine metabolism, glutathione metabolism, and sphingolipid metabolism. A total of 14 unique differential metabolites were identified in the POL group, predominantly enriched in sphingolipid metabolism, glycine, serine, and threonine metabolism, aminoacyl-tRNA biosynthesis, and glutathione metabolism. …”
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Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue by Jiahui Chang, Jiahui Chang, Jiahui Chang, Wanyu Wu, Wanyu Wu, Wanyu Wu, Ping Qian, Zhaoxu Lu, Xuejia He, Fang Wang, Ting Zhang, Ting Zhang, Ting Zhang

“…Further exploration is needed into the 2-oxocarboxylic acid metabolism pathway and the sphingolipid signaling pathway.…”
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Effects of GABA Supplementation on Intestinal SIgA Secretion and Gut Microbiota in the Healthy and ETEC-Infected Weanling Piglets by Yuanyuan Zhao, Jing Wang, Hao Wang, Yonggang Huang, Ming Qi, Simeng Liao, Peng Bin, Yulong Yin

“…KEGG enrichment analysis revealed that the nitrogen metabolism, sphingolipid signaling pathway, sphingolipid metabolism, and microbial metabolism in diverse environments were enriched in the GABA1 group. …”
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Association of Influenza Virus Proteins with Membrane Rafts by Michael Veit, Bastian Thaa

“…Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol/sphingolipid-rich membrane rafts. The viral transmembrane glycoproteins hemagglutinin (HA) and neuraminidase (NA) are intrinsically targeted to these domains, while M2 is seemingly targeted to the edge of the budozone. …”
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Role of dietary and nutritional interventions in ceramide-associated diseases by Shengnan Wang, Zihui Jin, Biyu Wu, Andrew J. Morris, Pan Deng

“…Ceramides are important intermediates in sphingolipid metabolism and serve as signaling molecules with independent biological significance. …”
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The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection by Fabio Gherlone, Katarina Jojić, Ying Huang, Sandra Hoefgen, Vito Valiante, Slavica Janevska

“…ABSTRACT Fusarium verticillioides produces the mycotoxin fumonisin B1 (FB1), which disrupts sphingolipid biosynthesis by inhibiting ceramide synthase and affects the health of plants, animals, and humans. …”
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Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes by Yuting Wei, Huirong Mao, Qiuhong Liu, Wenjie Fang, Tianxiang Zhang, Yongtao Xu, Weiwei Zhang, Biao Chen, Yunlin Zheng, Xiaolong Hu

“…Here we show the active snakes have more vigorous lipid metabolism, whereas snakes in hibernation groups have higher sphingolipid metabolism. Furthermore, the results indicate that the potential energy supply pathway was gluconeogenesis. …”
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Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis by Xiaofan Sun, Yue Li, Juan Du, Fangshu Liu, Caiping Wu, Weihao Xiao, Guopan Yu, Xiaowei Chen, Robert Peter Gale, Hui Zeng

“…Abstract Sphingolipid, ceramide for example, plays an essential role in regulating cancer cell death. …”
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Study on the Characteristics of Traditional Chinese Medicine Syndromes in Patients with Erosive Gastritis Based on Metabolomics by Zhang Shixiong, Liu Shaowei, Yang Zeqi, Xu Miaochan, Zhou Pingping, Bai Haiyan, Lv Jingjing, Wang Yangang

“…The top five pathways were the TCA cycle, sphingolipid metabolism, fatty acid biosynthesis, pantothenate and CoA biosynthesis, and the pentose phosphate pathway. …”
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