Comprehensive chemical and bioactive investigation of Chinese peony flower: a case of valorization of by-products as a new food ingredient from Chinese herb by Meng-ling Peng, Ming-Jiong Gong, Jing Zhang, Anastassiya V. Gadetskaya, Qian-Wen Liang, Pei-Wen He, Xiao-Hui Qiu, Zhi-Hai Huang, Wen Xu, Wen Xu

“…The anti-inflammatory and antioxidant activities were analyzed using RAW264.7 cells, and DPPH, ABTS, FRAP, and ORAC antioxidant assays.ResultsA total of 150 chemical components were identified in CPF, among them, more than 50 components were reported from this species for the first time, with potential new chemicals reported. 67 quantified or semi-quantified targeted metabolomics analysis indicated a clear distinction between flower parts and four cultivars. …”
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HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease by Khang-Yen Pham, Shristi Khanal, Ganesh Bohara, Nikesh Rimal, Sang-Hoon Song, Thoa Thi Kim Nguyen, In-Sun Hong, Jinkyung Cho, Jong-Sun Kang, Sooyeun Lee, Dong-Young Choi, Simmyung Yook

“…Notably, CAY released from PLGA@CAY@Lf NPs restored the disrupted acetylation balance in PD, resulting in neuroprotection by reversing mitochondrial dysfunction, suppressing reactive oxygen species, and inhibiting α-syn accumulation. Additionally, PLGA@CAY@Lf NPs treatment normalized dopamine and tyrosine hydroxylase levels, reduced neuroinflammation, and improved behavioral impairments. …”
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The Effect of Buriti Oil (Mauritia flexuosa L.) as Feed Additive on the Organic and Inorganic Materials Digestibility on Heat Stress Exposed Broilers by Burhanudin, Sunaryo Hadi Warsito, Bodhi Agustono, Nusdianto Triakoso, Ragil Angga Prastiya, Faisal Fikri

“…Buriti oil (Mauritia flexuosa L.) contains antioxidants that can suppress Reactive Oxygen Species (ROS) thereby reducing the negative effects of heat stress. …”
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CTX-M, SHV, TEM and VEB β-lactamases, and MCR-1 among multidrug-resistant Escherichia coli and Klebsiella isolates from environment near animal farms in Thailand by Arpasiri Srisrattakarn, Bhanubong Saiboonjan, Patcharaporn Tippayawat, Sunpetch Angkititrakul, Aroonwadee Chanawong, Chanakan Pornchoo, Chokdee Smithkittipol, Aroonlug Lulitanond

“…Results: A total of 123 E. coli (n = 59) and Klebsiella species (n = 64) were identified and 25 isolates of them were MDR; 21 and 4 isolates from the downstream and upstream areas respectively. …”
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USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells by Vignesh Srinivasan, Rabah Soliymani, Larisa Ivanova, Ove Eriksson, Nina Peitsaro, Maciej Lalowski, Mati Karelson, Dan Lindholm

“…There was an increase in reactive oxidative species (ROS) and elongated mitochondria in USP14 deficient cells and counteracting oxidative stress decreased α-syn levels. …”
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Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia by Anastasia A. Zabolotneva, Katerina E. Popruga, Valentin V. Makarov, Sergei M. Yudin, Andrei M. Gaponov, Sergei A. Roumiantsev, Aleksandr V. Shestopalov

“…In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as <i>Akkermansia muciniphila</i> and <i>Bacteroides acidifaciens</i> and depleting the representation of pathobionts such as <i>Prevotella</i>, although olivetol supplementation did not influence the diversity or richness of the communities. …”
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Advances in Molecular Genetics of Reproductive Isolation in Rice by Shunmei LI, Zihan ZHENG, Ruiying LIU, Hongze GUO, Lin ZHENG, Yongyao XIE

“…It plays an important role in speciation and maintaining species stability, and is the core scientific issue of evolutionary biology. …”
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Water hyacinth [Eichhornia Crassipes (Mart.)] invasion: implications for livelihoods in the central Rift Valley of Ethiopia by Assefa Gudina, Dagne Getachew Woldemedhin, Aseffa Seyoum, Feyera Senbeta, Engdawork Assefa, Afework Alemayehu

“…Further research is suggested to investigate the fish species favored and affected by this invasive weed. …”
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First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls by Danuta Dudzik, Vangeliya Atanasova, Coral Barbas, Jose Luis Bartha

“…Using advanced analytical techniques, including liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS), we profiled over 150 lipid species and central carbon metabolism intermediates.ResultsSignificant metabolic alterations were observed in both early- and late-onset GDM groups compared to healthy controls, with a specific focus on glycerolipids, fatty acids, and glucose metabolism. …”
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Molecular cytogenetic characteristics of new spring bread wheat introgressive lines resistant to stem rust by O. A. Baranova, I. G. Adonina, S. N. Sibikeev

“…In this regard, the transfer of effective resistance genes from related species to the bread wheat breeding material followed by the chromosomal localization of the introgressions and a marker analysis to identify known resistance genes is of great importance. …”
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Dexmedetomidine pretreatment enhances protective effect efficacy of pericytes agaist acute lung injury in septic mice by LUO Xi, ZHANG Zisen, YANG Ao

“…After PCs and Dex-PCs were exposed to 10 μg/mL LPS， the level of intracellular reactive oxygen species （ROS） was measured.　‍Results　‍Compared with the Sham group， the ALI group had increased permeability of pulmonary vascular endothelial cells， extensive extravasation of Evans blue， severely destructed of lung tissue structure and massive inflammatory cell infiltration， higher lung wet/dry weight ratio， elevated serum TNF-α and IL-6 levels， and declined lung function， and no mice survived for 72 h after modeling （P<0.05）. …”
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What motivates West African cocoa farmers to value trees? Taking the 4 W approach to the heart of the field by Marie Ruth Dago, Irié Casimir Zo‐Bi, Isaac Kouamé Konan, Aimé Kouadio Kouassi, Stéphane Guei, Patrick Jagoret, Anny Estelle N'Guessan, Elsa Sanial, Chloé Tankam, Soulemane Traoré, Bruno Hérault

“…The level of specialization or diversification in cocoa farmers' motivations is significantly influenced by their knowledge of tree species and cocoa tree density, with knowledgeable farmers exhibiting greater diversification, while higher cocoa tree density and the presence of remnant trees lead to more specialized strategies that hinder agroforestry adoption. …”
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Utilizing Invasive <i>Pterygoplichthys pardalis</i> as a Sustainable Fish Meal Substitute and <i>Euphorbia hirta</i> Extract Supplement: Effects on Growth Performance, Organosomati... by Sontaya Sookying, Phanit Srisuttha, Vipada Rodprasert, Chanthima Chaodon, Wikit Phinrub, Nantaporn Sutthi, Paiboon Panase

“…This investigation offers valuable perspectives on the development of sustainable aquaculture feed and the potential application of invasive fish species in aquatic animal nutrition.…”
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Unveiling the Texture Secrets of <i>Morchella</i> Germplasm: Advanced Grading and Quality Assessment Through Texture Profile Analysis (TPA) by Jialiang Li, Ying Chen, Xuelian Cao, Jie Tang, Liyuan Xie, Lixu Liu, Yan Wan, Rongping Hu

“…Furthermore, the coefficient of variation for the characteristics of <i>Morchella sextalata</i> was higher than those of other species. Principal component analysis simplified the texture evaluation indices of <i>Morchella</i> pileus into a palatable factor and cohesive factor, and arranged the texture evaluation indexes of <i>Morchella</i> stipe into toughness–hardness factor and cohesive factor. …”
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Effects of dietary bile acid on the growth performance, intestinal health, blood biochemistry, and antioxidative response of Nile tilapia (Oreochromus niloticus) fed high-fat diets by Mahmoud A.O. Dawood, Sameh El-Dahan, Samy Elsaadawy, Ahmed E. Noreldin, Hani Sewilam

“…However, high-fat diets have a deleterious influence on aquatic species' metabolic and immunological functioning. …”
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Camel milk is a neglected source of brucellosis among rural Arab communities by Peter Holloway, Matthew Gibson, Tanja Holloway, Iain Pickett, Brittany Crook, Jacqueline M. Cardwell, Stephen Nash, Imadidden Musallam, Bilal Al-Omari, Ahmad Al-Majali, Wail Hayajneh, Ehab Abu-Basha, Punam Mangtani, Javier Guitian

“…Due to sociocultural and religious influences camel milk (camelus dromedarius) is widely consumed raw, while milk from other livestock species is largely boiled. To investigate the potential public health impact of Brucella in camels we conduct a cross-sectional study in southern Jordan including 227 herds and 202 livestock-owning households. …”
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Differences in Metabolites of Different Varieties from Xinjiang Large-fruit Sea Buckthorn as Analyzed by Non-targeted Metabolomics by Rong HAN, Yan MA, Shengjie LI, Xintao MENG, Mingqiang XU, Ting ZHANG, Yan PAN

“…This experiment aimed to investigate the differences in metabolites of different varieties from Xinjiang large-fruit sea buckthorn, ultra high performance liquid chromatography-mass spectrometry (UPLC-QTOF-MS) coupled with multivariate statistical analysis and pathway enrichment analysis were used to characterize the metabolites of six Xinjiang large-fruit sea buckthorn species ('Mixed Fruit', 'Giant', 'Shenqunhon', 'Wucifeng', 'Xiangyang' and 'Zhuangyuan Yellow') were subjected to non-targeted metabolomics study. …”
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The Effect of Lithium on Inflammation-Associated Genes in Lipopolysaccharide-Activated Raw 264.7 Macrophages by Raymond T. Makola, Vusi G. Mbazima, Matlou P. Mokgotho, Vincent S. Gallicchio, Thabe M. Matsebatlela

“…A reduced internal H2DCFDA fluorescence intensity, indicative of reduced reactive oxygen species (ROS) production, was observed in LPS-activated Raw 264.7 macrophages treated with lithium. …”
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The stability of soil aggregates in sweet cherry (Prunus avium L.) orchards of different ages and varieties by Muhao Chen, Shu Feng, Jun Wang, Mingyu Gao, Min Liu, Kaibo Wang, Zhou-ping Shangguan, Yongwang Zhang

“…The management mode and species characteristics in the tillage process lead to a decrease in soil quality, and the stability of soil aggregates and decrease in soil nutrients indicate this. …”
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Transcriptomic analysis of Andrias davidianus meat and experimental validation for exploring its bioactive components as functional foods by Changge Guan, Zhenglin Tan, Shucheng Li, Yi Wang, Naoyuki Yamamoto, Chong Zhang, Songjun Wang, Junjie Chen, Xin-Hui Xing

“…Andrias davidianus (Chinese giant salamander, CGS) is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China. …”
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