MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…This regulation led to the survival of vascular and neuronal cells, a reduction in the production of reactive oxygen species (ROS), activation of the PI3K/AKT/eNOS signaling pathway, increased expression of neurotrophic factors, and ultimately alleviation of ED in diabetic mice. …”
Get full text

Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

“…Moreover, fibrosis and pyroptosis in HK-2 cells induced by NLRP3 overexpression were reduced by treatment with BSHX.Conclusions BSHX significantly reduced renal fibrosis and pyroptosis, and its mechanism was mainly associated with the inhibition of reactive oxygen species (ROS)/NLRP3-mediated inflammasome activation.…”
Get full text

A note on the global existence and boundedness of an N-dimensional parabolic-elliptic predator-prey system with indirect pursuit-evasion interaction by Liu Ling

“…We investigate the two-species chemotaxis predator-prey system given by the following system: ut=Δu−χ∇⋅(u∇w)+u(λ1−μ1ur1−1+av),x∈Ω,t>0,vt=Δv+ξ∇⋅(v∇z)+v(λ2−μ2vr2−1−bu),x∈Ω,t>0,0=Δw−w+v,x∈Ω,t>0,0=Δz−z+u,x∈Ω,t>0,\left\{\begin{array}{ll}{u}_{t}=\Delta u-\chi \nabla \cdot \left(u\nabla w)+u\left({\lambda }_{1}-{\mu }_{1}{u}^{{r}_{1}-1}+av),& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ {v}_{t}=\Delta v+\xi \nabla \cdot \left(v\nabla z)+v\left({\lambda }_{2}-{\mu }_{2}{v}^{{r}_{2}-1}-bu),& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ 0=\Delta w-w+v,& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ 0=\Delta z-z+u,& x\in \Omega ,\hspace{0.33em}t\gt 0,\end{array}\right. in a bounded domain Ω⊂RN(N≥1)\Omega \subset {{\mathbb{R}}}^{N}\left(N\ge 1) with smooth boundary, where parameters χ,ξ,λi,μi>0\chi ,\xi ,{\lambda }_{i},{\mu }_{i}\gt 0, and ri>1(i=1,2){r}_{i}\gt 1\hspace{0.33em}\left(i=1,2). …”
Get full text

Synthesis, Characterization, and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells by Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah

“…To demonstrate the nanocomposite’s anticancer effects, MTT assay, morphological analysis, apoptosis studies using acridine orange/ethidium bromide (AO/EtBr) dual staining, reactive oxygen species (ROS) analysis, and levels of antioxidant enzymes were analyzed using the MOLT4 blood cancer cell line. …”
Get full text

Changes in the hematology and blood metabolites of guinea pigs (Cavia porcellus) under intensive rearing system in humid tropical conditions by Daniel Paredes-López, Rizal Robles-Huaynate, Uriel Aldava-Pardave, Miguel Morales-Cauti

“… Guinea pigs in intensive production generates an imperative necessity of physio-pathological bases for diagnosing their state of welfare, health, and production; those which are available for this species are referred to as laboratory or companion animal. …”
Get full text

Nest site selection during the second breeding attempt in Japanese tits (Parus minor): effects of nest site characteristics by Xudong Li, Jiangping Yu, Li Zhang, Dake Yin, Keqin Zhang, Mingju E, Haitao Wang

“…Abstract Numerous investigations focusing on nest site selection among multiple-brooded bird species have revealed a common trend: breeders frequently return to their first nest sites for another brood during the same breeding season. …”
Get full text

Phylogenetic analysis and detection of positive selection in the SIRT gene family across vertebrates by Qiuxi Zhou, Xiongtao Yang, Da Li, Jing Li, Ling Peng, Wenwu He

“…Seventy-three amino acid sequences and full-length mRNA sequences from 22 vertebrate species and one invertebrate were retrieved from public databases. …”
Get full text

The protective effects of peptides from Chinese baijiu on AAPH-induced oxidative stress in HepG2 cells via Nrf2-mediated signaling pathway by Jiaying Huo, Yuezhang Ming, Huifeng Li, Anjun Li, Jiwen Zhao, Mingquan Huang, Weizheng Sun, Jihong Wu, Jinglin Zhang

“…The results showed that these peptides exerted protective effects by suppressing reactive oxygen species (ROS) generation, preventing malondialdehyde (MDA) formation, and upregulating cellular antioxidant enzyme activities (SOD, CAT, and GSH-Px) in a dose-dependent manner. …”
Get full text

Modulation of the Microstructure and Enhancement of the Photocatalytic Performance of g-C3N4 by Thermal Exfoliation by Xinshan Zhao, Junwei Yu, Tingyu Meng, Yuanyuan Luo, Yanzhen Fu, Zhao Li, Lin Tian, Limei Sun, Jing Li

“…The photocatalytic mechanism for reducing Cr(VI) by CN-540 was elucidated based on the active species •OH and •O2– and Mott-Schottky (M-S) tests. …”
Get full text

Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…Depending on timing, before hBM-MSC transplantation into patients, after detaching them from the culture dish, cell viability, deformability, cell size, and membrane fluidity are decreased, whereas reactive oxygen species generation, lipid peroxidation, and cytosolic vacuoles are increased. …”
Get full text

Effects of hydrogen enrichment in Methane/Air combustion with different inlet arrangements: A numerical approach by Arithra Debnath Prithu, Kazi Mostafijur Rahman, Md.Rhyhanul Islam, Didarul Hasan Saharaj, Md Sabbir Hossain

“…A reduced version of GRI-Mech 3.0 methane chemistry reaction including 19 species was used in the study. Hydrogen was added to methane fuel (CH4) at the inlet within the range 0∼50 % by mass while the mass flow rate of fuel is constant. …”
Get full text

Synergistic effects of chemical and biochemical fertilization on yield enhancement and oil quality optimization in ‘Zard’ olive cultivars by Mohammad Saeed Tadayon, Ahmad Asgharzadeh, Seyed Majid Mousavi, Kobra Saghafi

“…The second factor, biological fertilizer application (BF), also comprised three levels: BF0 (control), soil-applied organic fertilizer without biological agents; BF1, which included a soil application of an organic fertilizer mix, mycorrhizal fungi, and the beneficial bacteria Bacillus subtilis and Pseudomonas fluorescens, supplemented with fulvic acid and amino acids; and BF1+BFF, where trees were treated with both soil and foliar applications of the aforementioned bacterial species, fulvic acid, and amino acids.ResultsThe CF100+BF1+BFF treatment significantly increased fruit length (31.14%), diameter (41.61%), flesh thickness (30.48%), fresh weight (38.76%), dry weight (55.68%), and yield per tree (27.00%) compared to the control (CF100+BF0). …”
Get full text

RETRACTED ARTICLE: LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells by Ziyi Zhao, Yingwei Sun, Jing Tang, Yuting Yang, Xiaochao Xu

“…Consistent with a previous report, LRPPRC knockdown decreased the expression levels of FOXM1 and its downstream target genes, including PRDX3, MnSOD and catalase, which are responsible for scavenging reactive oxygen species (ROS). Expectedly, LRPPRC knockdown increased the accumulation of ROS in osteosarcoma and osteosarcoma-derived CSCs under hypoxic conditions due to the decrease in ROS scavenging proteins. …”
Get full text

Evaluating Remote Sensing Metrics for Land Surface Phenology in Peatlands by Michal Antala, Anshu Rastogi, Marcin Stróżecki, Mar Albert-Saiz, Subhajit Bandopadhyay, Radosław Juszczak

“…However, the monitoring of vegetation generative phenology through remote sensing techniques does not allow for species-specific retrieval in mixed ecosystems; hence, land surface phenology (LSP) is used instead of traditional plant phenology based on plant organ emergence and development observations. …”
Get full text

Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture by Cuixia Chen, Yangyang Ge, Qilong Gu, Tianling Wang, Yanyan Yang, Jinpeng Hu, Kang Gao, Xing Zhou, Hui Li

“…Bacterial diseases mainly caused by Vibrio species pose a serious threat to shrimp aquaculture and lead to the sudden mass mortalities and huge economics losses. …”
Get full text

Impact of commercial gut health interventions on caecal metagenome and broiler performance by Gladys Maria Pangga, Banaz Star-Shirko, Androniki Psifidi, Dong Xia, Nicolae Corcionivoschi, Carmel Kelly, Callie Hughes, Ursula Lavery, Anne Richmond, Umer Zeeshan Ijaz, Ozan Gundogdu

“…These shifts are hypothesised to differentiate performance among groups and cycles, highlighting the beneficial role of several bacteria, including Rikenella microfusus and UBA7160 species. Conclusions All GHIs are shown to be effective methods for gut microbial modulation, with varying influences on MAG diversity, composition, and microbial functions. …”
Get full text

The Bacterial and pathogenic landscape of African buffalo (Syncerus caffer) whole blood and serum from Kenya by Richard Nyamota, Earl A. Middlebrook, Hussein M. Abkallo, James Akoko, Francis Gakuya, Lillian Wambua, Bernard Ronoh, Isaac Lekolool, Athman Mwatondo, Mathew Muturi, Bernard Bett, Jeanne M. Fair, Andrew W. Bartlow

“…The bacteria operational taxonomic units (OTU) were identified to species levels by mapping the generated V12 and V45 regions of 16 S rRNA gene to the SILVA database. …”
Get full text

A systematic review of interventions targeting Anopheles stephensi [version 1; peer review: 2 approved] by Alison M Reynolds, Patricia Doumbe Belisse, Martin J Donnelly, Anne L Wilson, David Weetman

“…The invasion of this species into sub-Saharan Africa is of particular concern given its potential to increase malaria burden, especially in urban environments where An. stephensi thrives. …”
Get full text

Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug by Deysiane Oliveira Brandão, Geovani Pereira Guimarães, Ravely Lucena Santos, Fernando José de Lima Ramos Júnior, Karla Monik Alves da Silva, Fabio Santos de Souza, Rui Oliveira Macêdo

“…Momordica charantia is a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. …”
Get full text

Modulated Light Elicitation and Associated Physiological and Molecular Processes in Phenolic Compounds Production in <i>Ocimum basilicum</i> L. Microgreens by Gabriel-Ciprian Teliban, Naomi-Eunicia Pavăl, Gabriela Mihalache, Marian Burducea, Vasile Stoleru, Andrei Lobiuc

“…<i>Ocimum basilicum</i> L. species naturally synthesize valuable, phenolic compounds, among which rosmarinic acid is most prominent. …”
Get full text