Solid lipid nanoparticles for increased oral bioavailability of acalabrutinib in chronic lymphocytic leukaemia by Swagata Sinha, Punna Rao Ravi, Makarand Somvanshi, S. R. Rashmi

“…Abstract Acalabrutinib (ACP) is a first-line treatment for chronic lymphocytic leukemia but suffers from poor and variable oral bioavailability due to its pH-dependent solubility, CYP3A4 metabolism, and P-gp efflux. Thus, the objective of this study was to improve the solubility and dissolution behaviour, in turn enhancing bioavailability, by formulating solid lipid nanoparticles (SLNs). …”
Get full text

4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation by Ying Gu, Hsi-Ming Lee, Nicole Napolitano, McKenzie Clemens, Yazhou Zhang, Timo Sorsa, Yu Zhang, Francis Johnson, Lorne M. Golub

“…Curcumin is the principal dyestuff in the popular Indian spice turmeric and has significant regulatory effects on inflammatory mediators but is characterized by poor solubility and low bioactivity. Recently, we developed a series of chemically modified curcumins (CMCs) with increased solubility and zinc-binding activity, while retaining, or further enhancing, their therapeutic effects. …”
Get full text

On the phase behavior of sorbitol/water/H2/CO2 mixtures at high pressures and temperatures by in situ infrared spectroscopy by Bonnin, Isaline, Mereau, Raphaël, De Oliveira Vigier, Karine, Tassaing, Thierry 

“…Presence of sorbitol in the water-rich phase and H2 in the CO2-rich phase has a limited impact on the mutual solubility of water and CO2. Furthermore, sorbitol is not soluble in the CO2-rich phase and instead remains in the water-rich liquid phase over the thermodynamic range investigated.…”
Get full text

Ultrasonication modifies the structural, thermal and functional properties of pumpkin seed protein isolate (PSPI) by Mehvish Habib, Sakshi Singh, Sameer Ahmad, Shumaila Jan, Ankit Gupta, Kulsum Jan, Khalid Bashir

“…Alterations in the SDS-PAGE profile and reduced weight loss were associated with improved solubility and enhanced thermal and functional properties in the treated pumpkin seed protein isolates. …”
Get full text

Interplay Role of Heat-Moisture Treatment and Lipid from Egg yolk and Margarine on Functional and Pasting Properties of Banana Flour by Yana Cahyana, Tomi Nugraha, Nabila Aprilira, Karina Ayuningtias, Giffary Pramafisi Soeherman, Herlina Marta, Tensiska Tensiska

“…The reducing effect of lipid addition on egg yolk complex solubility predominated the increasing impact of HMT. …”
Get full text

Optimization of Agave tequilana Weber var. Azul Juice Spray Drying Process by Alejandra Chávez-Rodríguez, Irma G. López-Muraira, Juan F. Goméz-Leyva, Guadalupe Luna-Solano, Rosa I. Ortíz-Basurto, Isaac Andrade-González

“…The process was optimized to obtain maximum powder yield with the best solubility time, hygroscopicity, bulk density, water activity, and reducing sugars. …”
Get full text

Effect of ultrasound on the functional properties and structural changes of chicken liver insoluble proteins isolated by isoelectric solubilization/precipitation by Rongrong Mao, Guoyuan Xiong, Haibo Zheng, Jun Qi, Chunhui Zhang

“…The highest solubility was observed at pH 11.0 and 360 W ultrasound treatment, reaching 77.26 %. …”
Get full text

Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements by Sanshita, Taneja Ayushi, Sangnim Tanikan, Huanbutta Kampanart, Sindhu Rakesh K., Singh Inderbir

“…Liquorice is enclosed in different novel carriers and encapsulated liquorice displayed enhanced stability, solubility, high encapsulation efficiency, controlled drug release and extended circulation time period.…”
Get full text

Physicochemical Characterization, Storage Stability Behavior, and Intestinal Bioaccessibility of Clove Extract Encapsulated Using Varying Combinations of Gum Arabic and Maltodextri... by Farhad Ahmadi, Hafiz A. R. Suleria, Frank R. Dunshea

“…Clove (<i>Syzygium aromaticum</i>, L.) is a rich source of polyphenols and antioxidants, but its intense flavor, poor solubility, and instability may limit its widespread and efficient use in industrial applications. …”
Get full text

Phosphorus recovery from domestic sewage sludge in the presence of waste grape pruning biochar by M. Piri, E. Sepehr

“…Increasing the remove and recovery of phosphorus from sewage sludge by application of grape-biochar decreased the incidence of eutrophication, as an environmental dilemma, and provided the requirement for phosphorus-fertilizers by solid waste management. The solubility of the samples was 0.5 mole per liter hydrochloric acid > in 20 gram per liter citric acid > water. …”
Get full text

Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations by Diana-Andreea Blaj, Catalina A. Peptu, Mihaela Balan-Porcarasu, Cristian Peptu, Cristina Gabriela Tuchilus, Lacramioara Ochiuz

“…However, their poor water solubility and low bioavailability limit the therapeutic potential. …”
Get full text

Novel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application by Wallace Cordeiro de Morais, Gustavo Henrique Oliveira Costa, Vinícius Leal Pitcella, João Victor Vanolli Protti, Carolina Paula de Souza Moreira, José Eduardo Gonçalves, Susana Johann, Renata Barbosa de Oliveira

“…RW3 showed favorable solubility and high intestinal permeability, indicating potential for oral administration. …”
Get full text

Comparative Evaluation of Structural Characteristics and in Vitro Biological Activities of Polysaccharides from Common Bean (Phaseolus vulgaris L.) and Those from Shiitake Mushroom... by XU Mengyue, TIAN Xin, WANG Junke, WU Aoxue, ZOU Zhiyi, WU Jiahui, WANG Hongbo

“…Fourier transform infrared spectroscopy (FTIR), high performance liquid chromatography (HPLC), high performance gel permeation chromatography (HPGPC), scanning electron microscopy (SEM) and Congo red assay were used to characterize the structures, monosaccharide compositions, molecular masses, and microstructures of the two kinds of polysaccharides. Their water solubility and water-holding capacity were compared, and their antioxidant, hypoglycemic and hypolipidemic activities in vitro were evaluated comprehensively. …”
Get full text

Absorption mechanism, structural and electronic properties of MC19 (M = B and Si) fullerenes with 1-acetylpiperazine by Özgür Alver, Cemal Parlak, Mohamed I Elzagheid, Ponnadurai Ramasami

“…Stability, electronic properties, influence of water on the solubility and stability, molecular parameters, descriptive vibrational bands and nuclear magnetic resonance shielding values are reported. …”
Get full text

Methods for Measuring Nitrogen Release from Controlled-Release Fertilizer Used for Vegetable Production by Monica Ozores-Hampton, Luther C. Carson

“…This increase may be accomplished through maintaining nutrients in the root zone by physical barriers, reduced solubility, or retaining nutrients in a less leachable form. …”
Get full text

Methods for Measuring Nitrogen Release from Controlled-Release Fertilizer Used for Vegetable Production by Monica Ozores-Hampton, Luther C. Carson

“…This increase may be accomplished through maintaining nutrients in the root zone by physical barriers, reduced solubility, or retaining nutrients in a less leachable form. …”
Get full text

Physicochemical and Antioxidant Properties of Chitosan Films Incorporated with Cinnamon Oil by Marco A. López-Mata, Saul Ruiz-Cruz, Norma Patricia Silva-Beltrán, José de Jesús Ornelas-Paz, Víctor Manuel Ocaño-Higuera, Francisco Rodríguez-Félix, Luis A. Cira-Chávez, C. L. Del-Toro-Sánchez, Keiko Shirai

“…The films were characterized based on their physical properties (solubility, water vapor permeability, optical property, and microstructure) and antioxidant properties (DPPH, ABTS, and its protective effects on human erythrocytes). …”
Get full text

Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties by Yan Wu, Hong Liu, Zhihua Li, Dongye Huang, Lizheng Nong, Zhengxing Ning, Zhizhong Hu, Chunping Xu, Jing‐Kun Yan

“…After encapsulation was completed, pectin‐SeNPs@Cur showed enhanced water solubility (∼500‐fold), dispersibility, and storage stability compared with those of free Cur. …”
Get full text

Optimization of Black Garlic Protein Extraction Process and Exploration of Its Properties and Functions with Enzymatic Hydrolysis Products by Jian Liu, Yuanyuan Wang, Bo Wang, Wei Zhang, Xiaoyu Ren, Youchuang Zhang, Lijun Jiang, Chunming Dong, Guihong Zhao

“…Compared to BGP, the hydrolysates demonstrated significantly improved solubility, water-holding capacity, and foaming ability (<i>p</i> < 0.05), while their emulsifying activity, emulsion stability, DPPH radical scavenging capacity, and hypoglycemic activity decreased. …”
Get full text

Carbon Dioxide Micro-Nano Bubbles Aeration Improves Carbon Fixation Efficiency for Succinic Acid Synthesis by <i>Escherichia coli</i> by Ying Chen, Hao Wu, Qianqian Huang, Jingwen Liao, Liuqing Wang, Yue Pan, Anming Xu, Wenming Zhang, Min Jiang

“…The low solubility of CO₂ in water leads to massive CO₂ emission and extremely low CO₂ utilization in succinic acid (SA) biosynthesis. …”
Get full text