CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study by Yangyang Li, Li Jin, Jing Yan, Hong Zhang, Rong Zhang, Cheng Hu

“…A subset of 227 T2DM patients (118 patients with DKD and 109 patients without DKD) from the total population above were selected to assess serum soluble CD28 (sCD28) levels. Then, we performed a candidate gene association study to identify single-nucleotide polymorphisms (SNPs) associated with DKD susceptibility and further used those SNPs to perform Mendelian randomization analyses of serum sCD28 level and DKD susceptibility. …”
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Impact of microwave processing on phytochemicals, antioxidant status, anti-nutritional factors and metabolite profile of maize flour by Alla Yaswanth Naveen Kumar, Alonkrita Chowdhury, Rajesh Kumar, Vivek Kumar Maurya, Subhasis Batabyal, Mayukh Ghosh

“…Total phenolics (947.95–1304.77 µg GAE/g) and flavonoids (482.73–916.82 µg QE/g) varied, with flavonol content increasing (6.59–43.35 µg CE/g) and soluble sugar content decreasing (6563.13–15,578.75 µg DE/g) compared to the control. …”
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Modulating the fatty acid composition of black soldier fly larvae via substrate fermentation by F. IJdema, S. Lievens, R. Smets, G. Poma, M. Van Der Borght, B. Lievens, J. De Smet

“…Fermentation of two agricultural side streams (wheat bran (WB) and WB with distiller’s dried grains with solubles (DDGS)) increased substrate total crude fat concentration by 2.1 – 4.6%, as well as the concentration of several essential FAs, including the ω-6 FAs arachidonic acid (from less than 0.2 mg/g fat to a maximum of 44.2 mg/g fat) and gamma-linolenic acid (from less than 1.2 mg/g fat to a maximum of 45.8 mg/g fat and the ω-3 FA eicosapentaenoic acid (EPA) (from less than 0.7 mg/g fat to a maximum of 49.9 mg/g fat). …”
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A study on the effect of biostimulant application on yield and quality of tomato under long-lasting water stress conditions by Cristina Patanè, Alessandra Pellegrino, Alessandro Saita, Silvio Calcagno, Salvatore L. Cosentino, Alessio Scandurra, Valeria Cafaro

“…Biostimulants, across cultivars and water regimes, had no effect or even declined fruit quality in terms of total solids (TS), soluble solids (SS), titratable acidity (TA), reducing sugars (RS). …”
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Physiological and productivity responses of Tahiti acid lime grafted onto dwarfing rootstocks under different planting and mulching practices by Ana Júlia Borim de Souza, Mariângela Cristofani-Yaly, Patrícia Marluci da Conceição, Fernando Trevizan Devite, Marinês Bastianel, Paulo Vitor Sanches Romero, Pedro Henrique Barrio Padilha, Fernando Alves de Azevedo

“…They also showed greater photosynthetic efficiency, leading to higher yields and improved fruit quality, particularly in juice yield and soluble solids/acidity ratio. The IAC 3152 Itajobi rootstock demonstrated remarkable resilience to drought stress, outperforming Flying Dragon in root development and physiological metrics. …”
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Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol by Meghedi Vartanian, Konrad Jakob Endres, Yee Teng Lee, Silke Friedrich, Marie-Theres Meemken, Imke Schamarek, Kerstin Rohde-Zimmermann, Robin Schürfeld, Lina Eisenberg, Anja Hilbert, Frauke Beyer, Michael Stumvoll, Julia Sacher, Arno Villringer, Julia F. Christensen, A. Veronica Witte

“…The interventions comprise either a daily supplementary intake of 30 g soluble fiber (inulin), or weekly neurocognitive behavioral group sessions, compared to placebo (equicaloric maltodextrin). …”
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The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer by Vesna Ćeriman Krstić, Dragana Jovanović, Natalija Samardžić, Milija Gajić, Jelena Kotur Stevuljević, Aleksandra Klisic, Ivan Soldatović, Damir Radončić, Marina Roksandić Milenković, Biljana Šeha, Nikola Čolić, Katarina Lukić, Milan Savić

“…The aim of this study was to investigate whether soluble programmed cell death-ligand 1 (sPD-L1) could be a predictive biomarker in patients with epidermal growth factor receptor (EGFR)-positive NSCLC. …”
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Investigation of the Effects and Degradation Mechanism of Low-oxygen on the Stability of Blueberry Anthocyanins in Juice Simulation system by Zhouyang SHENG, Gengsheng XIAO, Lijuan ZHANG, Yujuan XU, Jijun WU, Yuanshan YU, Tenggen HU, Bo ZOU

“…【Objective】Anthocyanins are a class of natural water-soluble pigment, which is easy to be oxidized and degraded during processing and storage. …”
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sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction by Maëlle Plawecki, Marion Morena, Nils Kuster, Leila Chenine, Hélène Leray-Moragues, Bernard Jover, Pierre Fesler, Manuela Lotierzo, Anne-Marie Dupuy, Kada Klouche, Jean-Paul Cristol

“…Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression of tumorigenicity 2 (sST2) biomarker is well identified in risk stratification of cardiovascular (CV) events in heart failure. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Similarly, little is known on the differential effects of dual, compared with single, checkpoint inhibition.Methods We here performed in-depth characterization, including multicolor flow cytometry, single cell RNA sequencing and multiplex supernatant analysis, using tumor single cell suspensions from patients with cancer treated ex vivo with novel bispecific antibodies targeting programmed cell death protein 1 (PD-1) and TIM-3 (PD1-TIM3), PD-1 and LAG-3 (PD1-LAG3), or with anti-PD-1.Results We identified patient samples which were responsive to PD1-TIM3, PD1-LAG3 or anti-PD-1 using an in vitro approach, validated by the analysis of 659 soluble proteins and enrichment for an anti-PD-1 responder signature. …”
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Effect of Experimental Warming on Forage Nutritive Value and Storage in Alpine Meadows at Three Different Altitudes of Nianqing Tanggula Mountain, Northern Tibet: A Long-Term Exper... by Fusong Han, Wei Sun, Shaowei Li, Chengqun Yu, Jun Xu, Tianyu Li, Yujie Deng, Dorblha, Chuhong Chen, Dawaqiongda, Luobu, Gang Fu

“…Forage nutrition quality included crude protein (CP), acid detergent fiber (ADF), neutral detergent fiber (NDF), ether extract (EE), crude ash (Ash), and water-soluble carbohydrate (WSC) content. Warming did not affect community aboveground biomass (AGB) at the three elevations. …”
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Variations in Sources, Composition, and Exposure Risks of PM2.5 in both Pre-Heating and Heating Seasons by Dingyuan Yang, Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Zelin Li, Minglei Gao, Ailian Hu, Wenjia Zhu, Ning Ding, Zhenxin Li, Songtao Guo, Xiangxue Wang, Lei Wang, Jihong Wei

“…PM2.5 concentrations (in µg m−3) increased from 69.1 in the PHS to 129 in the HS, reflecting the impacts of heating activities. Water-soluble ions dominated in terms of PM2.5, accounting for 32.0% in the PHS and 42.3% in the HS, respectively. …”
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint pr... by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein.Methods A wide range of human cancer cell lines derived from solid tumours, keratinocytes and primary embryonic cells were employed, together with helper and cytotoxic T cell lines and human as well as mouse primary T cells. …”
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Genomic strategies to facilitate breeding for increased β-Glucan content in oat (Avena sativa L.) by Sumandeep Kaur Bazzer, Guilherme Oliveira, Jason D. Fiedler, Raja Sekhar Nandety, Jean-Luc Jannink, Melanie Caffe

“…Abstract Background Hexaploid oat (Avena sativa L.) is a commercially important cereal crop due to its soluble dietary fiber β-glucan, a hemicellulose known to prevent cardio-vascular diseases. …”
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Response of Tree Seedlings to a Combined Treatment of Particulate Matter, Ground-Level Ozone, and Carbon Dioxide: Primary Effects by Valentinas Černiauskas, Iveta Varnagirytė-Kabašinskienė, Ieva Čėsnienė, Emilis Armoška, Valda Araminienė

“…Scots pine and Norway maple showed no changes in growth (stem height and diameter) and biochemical parameters (photosynthetic pigments, total polyphenol content (TPC), total flavonoids content (TFC), and total soluble sugars (TSS)), indicating a neutral response to the combined PM, O₃, and CO₂ treatment. …”
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Agronomic characteristics, mineral nutrient content, antioxidant capacity, biochemical composition, and fatty acid profile of Iranian pistachio (Pistacia vera L.) cultivars by Ali Khadivi, Mohammadali Nikoogoftar-Sedghi, Yazgan Tunç

“…Total phenolic content, antioxidant capacity, fruit mineral elements, soluble protein content, kernel-oil content, and fatty-acid composition were determined in 60 fruits (20 fruits per replication). …”
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The Relationship Between Serum 25 hydroxy Vitamin D Deficiency and Dietary Pattern in Baxshin Hospital, Sulaimani City by Mohammed I M Gubari, Jeza Muhamad Abdul Aziz, Fadhil Ahmed Mohialdeen, Khalid Anwar Hama-Ghareeb, Bakhtyar Kamal Muhamed, Hemn Abdalla Omer

“…Vitamin D is one of the fat-soluble vitamins that have a great role in phosphate and calcium balance and bone structure. …”
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Room temperature self-assembly and nonenzymatic electrochemical sensing performance of transition metal-embedded wheel-shaped tungstophosphates by Wen-Da Liu, Hao-Tian Zhu, Xue Zhang, Fang Su, Xiao-Jing Sang, Xiao-Lan Zhang, Lan-Cui Zhang

“…The study findings show that the combination of CS and 1–3 provides an alternative to soluble TM-{P8W48} compounds, which are not reusable in H2O2 detection systems.…”
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Fruit Quality and Production Parameters of Some Bitter Cherry Cultivars by Ionel Perju, Iulia Mineață, Sorina Sîrbu, Iuliana Elena Golache, Ionuț Vasile Ungureanu, Carmen Doina Jităreanu

“…Regarding the chemical attributes, antioxidant activity was relatively higher in fruits with a more intense bitter taste (89.3 μg Trolox·g⁻¹ f.w for C₂ and 89.1 μg Trolox·g⁻¹ f.w. for C₄ and C₅), a fact also found in the content total of polyphenols (with a maximum value of 743.2 mg GAE·100 g⁻¹ f.w at C₂). Total soluble solids content had an average value of 20.51°Brix and titratable acidity of 0.85 g malic acid·100 g⁻¹ f.w. …”
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Adjuvant-free, self−assembling ferritin nanoparticle vaccine coupled with influenza virus hemagglutinin protein carrying M1 and PADRE epitopes elicits cross-protective immune respo... by Yongqiang Zhao, Shuangshuang Guo, Jia Liu, Yating Wang, Bo Wang, Chun Peng, Enqi Du, Enqi Du, Enqi Du

“…HMP-NPs were expressed in a soluble form in the baculovirus-insect cell system and self-assembled into homogeneous nanoparticles. …”
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