Snake venom and cerebrovascular events: insights and public health implications by Jorge Vasconez-Gonzalez, María de Lourdes Noboa-Lasso, Esteban Ortiz-Prado

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Murine model evaluation of biochemical and tissue-damage induced by Bothrops asper (Nauyaca) snake venom by Dr. Carlos Gallardo-Casas Ángel Gallardo-Casas, María Teresa Valadez-Omaña, Emmanuel Correa Solís, María del Carmen Castillo-Hernández, Rocio Ortiz-Butron

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Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment by Sandra H. P. Farsky, Luís Roberto C. Gonçalves, José M. Gutiérrez, Adriana P. Correa, Alexandra Rucavado, Philippe Gasque, Denise V. Tambourgi

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Snake Venom Pharmacokinetics and Acute Toxic Outcomes Following <i>Daboia siamensis</i> Envenoming: Experimental and Clinical Correlations by Sethapong Lertsakulbunlue, Wipapan Khimmaktong, Orawan Khow, Wittawat Chantkran, Jureeporn Noiphrom, Kanyanat Promruangreang, Lawan Chanhome, Janeyuth Chaisakul

“…An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes of envenoming and developing therapeutic approaches to the treatment of envenoming, especially regarding the timing and optimal dosage of antivenom administration. …”
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Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions by Diva F. Cardoso, Monica Lopes-Ferreira, Eliana L. Faquim-Mauro, Mahasti S. Macedo, Sandra H. P. Farsky

“…Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2. …”
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory processes. …”
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Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

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Bp-13 PLA2: Purification and Neuromuscular Activity of a New Asp49 Toxin Isolated from Bothrops pauloensis Snake Venom by Georgina Sucasaca-Monzón, Priscila Randazzo-Moura, Thalita Rocha, Frank Denis Torres-Huaco, Augusto Vilca-Quispe, Luis Alberto Ponce-Soto, Sérgio Marangoni, Maria Alice da Cruz-Höfling, Léa Rodrigues-Simioni

“…A new PLA2 (Bp-13) was purified from Bothrops pauloensis snake venom after a single chromatographic step of RP-HPLC on μ-Bondapak C-18. …”
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Crotalus durissus ruruima Snake Venom and a Phospholipase A2 Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators by Ana Eduarda Zulim de Carvalho, Karina Giannotti, Elbio Leiguez Junior, Márcio Matsubara, Maria Cristina Dos Santos, Consuelo Latorre Fortes-Dias, Catarina Teixeira

“…Among the snakes of Crotalus genus subspecies, the venom of Cdr presents highest level of crotoxin, which is the major component of Crotalus snake venoms, formed by two subunits (crotapotin and a phospholipase A2 named CBr) and presents potent neurotoxic activity. …”
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21st century Latin American synthetic peptides for their application in antivenom production by Jésica A. Rodríguez, Gabriela R. Barredo-Vacchelli, Joaquin A. Eloy, Silvia A. Camperi

“…Epitopes have been identified from many clinically important toxins in Latin American snakes (snake venom metalloproteinases, snake venom serine proteases, crotamine, phospholipases A2, and three-finger toxins), scorpions (beta-mammal/insect toxin Ts1, alpha-mammal toxin Ts2, alpha-mammal toxin Ts3, toxin Ts4, and beta-mammal Tt1g neurotoxin), and spiders (dermonecrotic toxin and delta-ctenitoxin-Pn2a). …”
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Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca by Stella R. Zamuner, Catarina F. P. Teixeira

“…This is the first in vivo evidence that snake venom is able to up-regulate the expression of adhesion molecules by both leukocytes and endothelial cells. …”
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Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair by Natalia Perussi Biscola, Luciana Politti Cartarozzi, Rui Seabra Ferreira Junior, Benedito Barraviera, Alexandre Leite Rodrigues de Oliveira

“…Thus, P2 neonatal Lewis rats were divided into three groups: AX: sciatic nerve axotomy (SNA) without treatment; AX+FS: SNA followed by end-to-end coaptation with fibrin sealant derived from snake venom; AX+CFS: SNA followed by end-to-end coaptation with commercial fibrin sealant. …”
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Autoimmune Factor V Deficiency That Took 16 Years to Diagnose due to Pseudodeficiency of Multiple Coagulation Factors by Takaaki Kato, Takaya Hanawa, Mea Asou, Tomohiko Asakawa, Hisashi Sakamaki, Makoto Araki

“…Anti-factor VIII and IX antibodies which were measured by the Bethesda method, lupus anti-coagulant (diluted Russell snake venom time method) and anti-cardiolipin antibody were also positive. …”
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Antitumor effect of Bothrops jararaca venom by Reinaldo J. da Silva, Márcia G. da Silva, Lízia C. Vilela, Denise Fecchio

“…Many experimental studies have been carried out using snake venoms for the treatment of animal tumors, with controversial results. …”
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First Look at the Venoms of Two <i>Sinomicrurus</i> Snakes: Differences in Yield, Proteomic Profiles, and Immunorecognition by Commercial Antivenoms by Xiang-Yu Li, Ya-Qi Zhang, Xin-Ru Qian, Hong-Yan Zhao, Hong-Liang Lu, Jian-Fang Gao

“…While both the commercial <i>Naja atra</i> and <i>Bungarus multicinctus</i> antivenoms could immunorecognize these two Chinese coral snake venoms, the <i>N. atra</i> antivenom possessed a higher neutralization capability than the <i>B. multicinctus</i> antivenom for both species of coral snakes. …”
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