Smallpox vaccination in a mouse model by S. N. Shchelkunov, A. A. Sergeev, S. A. Pyankov, K. A. Titova, S. N. Yakubitskiy

Subjects: “…smallpox…”
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Recombinant short TNF-BD protein from smallpox virus is pharmacologically active in an experimental septic shock model by I. P. Gileva, S. N. Yakubitskiy, I. V. Kolosova, S. N. Shchelkunov

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Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy by K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev

“…At present, there is no animal model for smallpox that reflects the weakened immune system in people and can therefore help assess the prophylactic (highly preventive) efficiency of antiviral drugs. …”
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Tecovirimat in the management of poxviruses: a narrative review of available evidence by Olalekan John Okesanya, Jerico Bautista Ogaya, Ikponmwosa Jude Ogieuhi, Mohamed Mustaf Ahmed, Bonaventure Michael Ukoaka, Ojoisimi Franca Jamgbadi, Deborah Oluwaseun Shomuyiwa, Don Lucero-Prisno Eliseo, Blessing Olawunmi Amisu, Olakulehin Adebusuyi, William K. Chung, Emery Manirambona, Nimat Bola Idris, Janet Alexis A. De los Santos

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Investigations sur une crise de mortalité à Boulogne-sur-Mer (Pas-de-Calais, XVIIIe s.). Hypothèses d’interprétation by Dominique Castex, Hélène Réveillas

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A Case Report of Monkeypox in a 4-Year-Old Boy from the DR Congo: Challenges of Diagnosis and Management by Anna Korsgaard Eltvedt, Michael Christiansen, Anja Poulsen

“…With the eradication of smallpox in 1980, vaccination against smallpox has ceased. …”
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Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus by S. N. Shchelkunov, T. V. Bauer, S. N. Yakubitskiy, A. A. Sergeev, A. S. Kabanov, S. A. Pyankov

“…The most effective agents are live vaccines, usually low-virulence organisms for humans and closely related to pathogenic viruses or attenuated as a result of mutations/deletions in the genome of pathogenic virus. Smallpox vaccination with live vaccinia virus (VACV) closely related to smallpox virus played a key role in the success of the global smallpox eradication program carried out under the World Health Organization auspices. …”
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Immunogenicity of recombinant fragment of orthopoxvirus p35 protein in mice by Ya. A. Khlusevich, A. L. Matveev, E. P. Goncharova, I. K. Baykov, N. V. Tikunova

“…Despite the elimination of smallpox, orthopoxviruses continue to be a source of biological danger for humans, as cowpox and monkey pox viruses circulate in nature and the last virus can cause both sporadic cases of human diseases and outbreaks of smallpox-like infection. …”
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Mathematical models of contact patterns between age groups for predicting the spread of infectious diseases by Sara Y. Del Valle, J. M. Hyman, Nakul Chitnis

“…We apply the analysis to the spread of a smallpox-like disease, derive the formula for the reproduction number, $\Re_{0}$, and based on this threshold parameter, show the level of human behavioral change required to control the epidemic.We analyze how different mixing patterns can affect the disease prevalence, the cumulative number of new infections, and the final epidemic size.Our analysis indicates that the combination of residual immunity and behavioral changes during a smallpox-like disease outbreak can play a key role in halting infectious disease spread; and that realistic mixing patterns must be included in the epidemic model for the predictions to accurately reflect reality.…”
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Monkeypox and other orthopoxvirus zoonoses by K. N. Gruzdev

“…Despite the elimination of the historically infamous smallpox, orthopoxviruses remain a serious veterinary and health problem. …”
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Monkeypox: Origin, Transmission, Clinical Manifestations, Prevention, and Therapeutic Options by Sajal Kumar Halder, Arafin Sultana, Mahbubul Kabir Himel, Aparna Shil

“…Antiviral drugs such as tecovirimat, cidofovir, and brincidofovir, which were initially developed to treat smallpox, were found to have been effective in treating MPXV cases. …”
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Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies by Suresh Kumar, Dhanyashri Guruparan, Kalimuthu Karuppanan, K. J. Senthil Kumar

“…Monkeypox (mpox) is a viral infection closely related to smallpox, manifesting as a milder febrile rash in affected individuals. …”
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The Basic Reproduction Number for the Markovian SIR-Type Epidemic Models: Comparison and Consistency by Muteb Faraj Alharthi

“…For illustration, numerical simulation studies are performed. Abakaliki smallpox data are examined as a real data application.…”
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Improved Estimation of the Initial Number of Susceptible Individuals in the General Stochastic Epidemic Model Using Penalized Likelihood by Changhyuck Oh

“…We applied the proposed method to the Abakaliki smallpox data.…”
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Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism by Sergei N. Shchelkunov

“…Here, study of the orthopoxviruses pathogenic for humans, such as variola (smallpox), monkeypox, cowpox, and vaccinia viruses, may be most important. …”
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Genome stability of the vaccine strain VAC∆6 by R. A. Maksyutov, S. N. Yakubitskiy, I. V. Kolosova, T. V. Tregubchak, A. N. Shvalov, E. V. Gavrilova, S. N. Shchelkunov

“…Due to cessation of mass smallpox vaccination in 1980, the collective immunity of humans against orthopoxvirus infections has virtually been lost. …”
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Current advances and challenges in mpox vaccine development: a global landscape by Maryam Shafaati, Shayan Forghani, Amirhossein Shahsavand Davoudi, Reza Samiee, Keyhan Mohammadi, Samaneh Akbarpour, Arash Seifi, Mohammadreza Salehi, Maryam Zare

“…Given the surge in mpox outbreaks in 2022 and the advancements in domestic and international vaccine research, the effectiveness of smallpox vaccines in providing cross-protection against mpox remains crucial. …”
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The Dietary Use of Pigeon Pea for Human and Animal Diets by Belete Kuraz Abebe

“…PP’s green leaves, roots, seeds, and pods are high in phenolic compounds, which have anti-inflammation, antibacterial, antioxidant, anticarcinogenic, and antidiabetic properties, as well as the ability to cure diseases like measles, smallpox, chicken pox, sickle cell anemia, fever, dysentery, hepatitis, and antimalarial medications for the body. …”
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Enhancing Monkeypox Detection through Data Analytics: A Comparative Study of Machine and Deep Learning Techniques by Kinjal A. Patel, Asadi Srinivasulu, Kuntesh Jani, Goddindla Sreenivasulu

“…Monkeypox detection is a challenging task due to the disease's resemblance to other viral infections such as smallpox and chickenpox. This paper presents a comprehensive study that investigates the efficacy of machine and deep learning techniques in detecting monkeypox. …”
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In-silico formulation of a next-generation polyvalent vaccine against multiple strains of monkeypox virus and other related poxviruses. by Abu Tayab Moin, Nurul Amin Rani, Rajesh B Patil, Tanjin Barketullah Robin, Md Asad Ullah, Zahidur Rahim, Md Foyzur Rahman, Talha Zubair, Mohabbat Hossain, A K M Moniruzzaman Mollah, Nurul Absar, Mahboob Hossain, Mohammed Abul Manchur, Nazneen Naher Islam

“…Mpox (formerly known as monkeypox) virus and some related poxviruses including smallpox virus pose a significant threat to public health, and effective prevention and treatment strategies are needed. …”
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