Prevalence and density of Elaphostrongylus rangiferi larvae in faecal samples of semi-domestic reindeer (Rangifer tarandus tarandus) in Norway 2013-16 by Terje Domaas Josefsen, Torill Mørk, Ingebjørg Helena Nymo, Javier Sanchez Romano, Morten Tryland

“…Prevalence did not show statistically significant difference between males and females. LPG showed a highly skewed distribution, total median LPG being 38, range 2-700. …”
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Emergency Medicine Clerkship Grading Scheme, Grade, and Rank-List Distribution as Reported on Standardized Letters of Evaluation by Alexandra Mannix, Thomas Beardsley, Thomas Alcorn, Morgan Sweere, Michael Gottlieb

“…Both grades and rank list demonstrated evidence of a skewed distribution toward higher grades and rank-list position.…”
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Multimorbidity patterns and function among adults in low- and middle-income countries: a scoping review by Karina Berner, Quinette A Louw, Eugene Nizeyimana, Diribsa Tsegaye Bedada

“…Mobility limitations, instrumental activities of daily living, self-care and bowel/bladder problems were consistently linked to all pattern domains.Conclusions The limited and geographically skewed body of literature, along with methodological inconsistencies, hampers a comprehensive understanding of multimorbidity patterns and associations with functioning in LMICs. …”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…Mechanistically, we demonstrated that inhibition of TYRO3-driven CCN1 secretion fosters macrophages into M1-skewing phenotypes, thereby triggering antitumor T-cell responses. …”
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Molecular mapping of the grain iron and zinc concentration, protein content and thousand kernel weight in wheat (Triticum aestivum L.). by Gopalareddy Krishnappa, Anju Mahendru Singh, Swati Chaudhary, Arvind Kumar Ahlawat, Santosh Kumar Singh, Ram Bihari Shukla, Jai Prakash Jaiswal, Gyanendra Pratap Singh, Ishwar Singh Solanki

“…The population showed the continuous distribution for all the four traits, that for pooled Fe and PC was near normal, whereas, for pooled Zn, RILs exhibited positively skewed distribution. A genetic map spanning 2155.3cM was constructed using microsatellite markers covering the 21 chromosomes and used for QTL analysis. 16 quantitative trait loci (QTL) were identified in this study. …”
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Genetic parameters and parental and early-life effects of boar semen traits by Pedro Sá, Rodrigo M. Godinho, Marta Gòdia, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis

“…Semen quality traits showed a skewed distribution, and their transformation significantly reduced their repeatability estimates. …”
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Water woes: the institutional challenges in achieving SDG 6 by Jaivime Evaristo, Yusuf Jameel, Cecilia Tortajada, Raymond Yu Wang, James Horne, Howard Neukrug, Carlos Primo David, Angela Maria Fasnacht, Alan D. Ziegler, Asit Biswas

“…Knowledge transfer is often skewed, favoring dominant nations while sidelining voices from the Global South. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…Patients with partial clinical responses had more diverse T and B cell receptor repertoires prior to therapy initiation.Conclusion Ibrutinib monotherapy skewed the immune landscape both in the circulation and TME towards activated T cells, monocytes and DCs. …”
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Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders by Gisela Chelimsky, Pippa Simpson, Liyun Zhang, Doug Bierer, Steve Komas, Balaraman Kalyanaraman, Thomas Chelimsky

“…Findings and clinical data were compared to healthy control subjects using a Mann–Whitney test for skewed variables, Fisher’s exact test for dichotomous variables, and regression tree for association with functional outcome (functional disability inventory, FDI). …”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…One key mechanism for ICI resistance is the skewing of the immune response from a cytotoxic (Th1) to a chronic inflammatory (Th2) profile. …”
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Central venous oxygen saturation changes as a reliable predictor of the change of CI in septic shock: To explore potential influencing factors by Ran An, Xi-Xi Wan, Yan Chen, Run Dong, Chun-Yao Wang, Wei Jiang, Li Weng, Bin Du

“…Paired t-tests were used for normally distributed data, while the Wilcoxon signed-rank test was used for skewed data, to compare data before and after fluid challenge. …”
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Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals by Najwa D. Aljehani, Levi Tamming, Muhammad Yasir Khan, Rwaa H. Abdulal, Mohamed A. Alfaleh, Aishah Ghazwani, Asalah Helal, Reem M. Alsulaiman, Mohammad A. Sanki, Khalid Alluhaybi, Farah Ayman Sukareh, Rahaf H. Alharbi, Faris H. Alyami, M-Zaki ElAssouli, Salima Shebbo, Wesam H. Abdulaal, Abdullah Algaissi, Ahmad Bakur Mahmoud, Mohammad Basabrain, Diana Duque, Jegarubee Bavananthasivam, Wangxue Chen, Lisheng Wang, Simon Sauve, Turki S. Abujamel, Tarfa Altorki, Rowa Alhabbab, Anh Tran, Xuguang Li, Anwar M. Hashem

“…Two IM or IN doses of rAd5-SARS2-S1 elicited robust and sustained Th1-skewed S1-specific serum IgG, neutralizing antibodies (nAbs) against several SARS-CoV-2 variants and systemic antigen-specific memory T cell responses in mice. …”
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KDM6A facilitates Xist upregulation at the onset of X inactivation by Josephine Lin, Jinli Zhang, Li Ma, He Fang, Rui Ma, Camille Groneck, Galina N. Filippova, Xinxian Deng, Chizuru Kinoshita, Jessica E. Young, Wenxiu Ma, Christine M. Disteche, Joel B. Berletch

“…In one of the lines a transcriptional stop signal inserted in Tsix results in completely skewed X silencing upon differentiation. The effects of both homozygous and heterozygous Kdm6a KO on Xist expression during the onset of XCI were measured by RT-PCR and RNA-FISH. …”
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Study on applicability of Death Attitude Profile-Revised in medical students (死亡态度描绘量表在医学生中的适用性研究) by CHEN Qiannan (陈倩楠), ZHANG Jing (张静), QIAN Zhigang (钱志刚)

“…Results The response distribution of each item was not skewed. Except for items related to natural acceptance dimensions, CR values of other items were all greater than 3 and P was less than 0. 05, and correlation coefficient (r value) between items and total scale was greater than 0. 3. …”
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Dynamics of CO₂ and CH₄ fluxes in Red Sea mangrove soils by J. Breavington, A. Steckbauer, C. Fu, M. Ennasri, C. M. Duarte

“…Mean fluxes offset 94.5 % of carbon burial, with a median of 4.9 % skewed by extreme variability. However, reported CO<span class="inline-formula">₂</span> removal by total alkalinity emission from carbonate dissolution greatly exceeded both processes and drives the role of these ecosystems as intense CO<span class="inline-formula">₂</span> sinks.…”
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Call for Papers: How attractive are political parties and trade unions to young people? by IF and FRFG

“…Younger people are confronted with the rapidly changing nature of the workplace as well as the rise in temporary work and zero-hour contracts, and are probably more interested in salaries, entry requirements and work contracts, rather than in end-of-career matters such as pensions and retirement ages. The skewed age profile of trade unions could shift the discussion more towards the latter concerns, deterring younger generations and reinforcing existing age problems. …”
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