The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease by Farshad Amirkhizi, Mahdiyeh Taghizadeh, Banafshe Khalese-Ranjbar, Soudabeh Hamedi-Shahraki, Somayyeh Asghari

Subjects: Get full text

Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from Trypanosoma brucei by Renan A. Gomes, Marcelo D. Polêto, Hugo Verli, Vitor M. Almeida, Sandro R. Marana, Andreas Bender, Bruna F. Godoi, Vinícius T. L. Rodrigues, Flavio da S. Emery, Gustavo H. G. Trossini

Get full text

Understanding the Impact of the Sirtuin 1 (SIRT1) Gene on Age-related Macular Degeneration: A Comprehensive Study by Saranya Velmurugan, Rashmi Pauline, Gurudeva Chandrashekar, Langeswaran Kulanthaivel, Gowtham Kumar Subbaraj

“…SIRT1, a key member of the sirtuin family, influences cellular processes such as ageing, metabolism, DNA repair and stress response. …”
Get full text

In silico approach in the development of structural analogues of resveratrol with improved distribution in the central nervous system by Mitrović Darko, Pavlović Nebojša

Subjects: Get full text

Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats by S. Rossi, C. Di Filippo, C. Gesualdo, F. Testa, M. C. Trotta, R. Maisto, B. Ferraro, F. Ferraraccio, M. Accardo, F. Simonelli, M. D’Amico

“…RvD1 dose-dependently increased the expression of sirtuin-1 (SIRT1) within the eye, while it decreased the expression of acetyl-p53 and acetyl-FOXO1. …”
Get full text

Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer by Havina Nurul Aizah, Amel Yanis, Hirowati Ali, Tofrizal Tofrizal, Cimi Ilmiawati, Dessy Arisanty

“…Keywords:  Alzheimer, MSC-WJ, Sirtuin-1…”
Get full text

Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development by G. F. Korytina, L. Z. Akhmadishina, V. A. Markelov, Y. G. Aznabaeva, O. V. Kochetova, T. R. Nasibullin, A. P. Larkina, N. N. Khusnutdinova, N. Sh. Zagidullin, T. V. Victorova

Subjects: Get full text

The effect of caloric restriction on genetical pathways by Mustafa Fevzi Karagöz, A. Gülçin Sağdıçoğlu Celep

Subjects: Get full text

Loss of Sirtuin 7 impairs cell motility and proliferation and enhances S-phase cell arrest after 5-fluorouracil treatment in head and neck cancer by Marta Halasa, Syeda Afshan, Anna Wawruszak, Agata Borkowska, Klaudia Brodaczewska, Alicja Przybyszewska-Podstawka, Joanna Kalafut, Marzena Baran, Adolfo Rivero-Müller, Andrzej Stepulak, Matthias Nees

“…Abstract Sirtuin 7 (SIRT7), a member of the sirtuin family of NAD+-dependent deacetylases, plays a vital role in cancer, exhibiting context-dependent functions across various malignancies. …”
Get full text

Alleviating the IL-1β-stimulated extracellular matrix degradation in osteoarthritis, and chondrocyte inflammation by Morinda officinalis polysaccharide via the SIRT6/NF-κB pathway... by Dongfang Zhao, Shuqin Xing, Jiao Qi, Zhiqiang Wei, Jianghai Huang, Jigao Sun, Xinzhu Wen, Yafei Wang

Subjects: Get full text

Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia by Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran

Subjects: Get full text

N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 by Toru Miwa, Toru Miwa, Akihito Tarui, Akihito Tarui, Teppei Kouga, Yasunori Asai, Yasunori Asai, Hideaki Ogita, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba, Nobuhiro Hakuba

Subjects: Get full text

Editorial: Challenges in pediatric endocrinology regarding alterations in glucose metabolism, growth disorders, disorders of sex development, and puberty in adolescents by Giulio Maltoni, Egidio Candela, Egidio Candela, Gianluca Tornese, Gianluca Tornese

Subjects: Get full text

Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction by Changhui Zhu, Xue Dong, Xiwei Wang, Yingying Zheng, Juanjuan Qiu, Yanling Peng, Jiajun Xu, Zhengbin Chai, Chunyan Liu

“…Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. …”
Get full text

The Effect of Smoking on SIRT3 and Selected Biochemical Variables in Patients with Parkinson’s Disease by Noor Abdulsatar Majeed, Mohammed Bahry Hassin

“…Objectives: This study aimed to examine the impact of smoking on sirtuin 3 (SIRT3), a mitochondrial sirtuin, and selected biochemical variables in individuals with Parkinson’s disease (PD). …”
Get full text

Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives by Ricardo P. Garay

“…Five families of investigational products are in clinical investigation to slow or reverse normal aging processes [longevity candidates, mesenchymal stem cells, senolytics drugs, sirtuin activators, and nicotinamide adenine dinucleotide (NAD)+ precursors]. …”
Get full text

Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. …”
Get full text

Effects of the New Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m on High Glucose Induced Prolongation of Cardiac QT Interval and Increase of Coronary Perfusion Pressure by C. Di Filippo, B. Ferraro, R. Maisto, M. C. Trotta, N. Di Carluccio, S. Sartini, C. La Motta, F. Ferraraccio, F. Rossi, M. D’Amico

“…BF-5m also increased the expression levels of sirtuin 1, MnSOD, eNOS, and FOXO-1, into the heart. …”
Get full text

Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells by Lulli Daniela, Potapovich Alla, Riccardo Maurelli, Dellambra Elena, Pressi Giovanna, Kostyuk Vladimir, Dal Toso Roberto, De Luca Chiara, Pastore Saveria, Korkina Liudmila

“…Inflammatory responses were induced by UVA+UVB, lipopolysaccharide (LPS), oxidized low-density lipoprotein (oxLDL), and a mixture of proinflammatory cytokines. Trichostatin A, a sirtuin inhibitor, was used to induce keratinocyte inflammatory senescence. …”
Get full text

Chemical Profiling Ethyl Acetate Extract of <i>Basilicum polystachyon</i> Leaves and Exploration of Anticancer SIRT1 Inhibitors Using <i>In Silico</i> Approach by Tukiran Tukiran, Muhammad Raihan

“…Through an in silico approach, this research studied the anticancer mechanism against the sirtuin1 (SIRT1) at the molecular level. Molecular docking simulations were performed to understand the interaction behavior of potential compounds as SIRT1 inhibitors. …”
Get full text