Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery by Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko

“…The top 20 gene sets enriched from DEGs shared between CP and CPR are relevant to extracellular matrix and cancer biology, whereas the top 10 gene sets enriched from DEGs specific to CPR are pertinent to DNA methylation and specific signaling pathways. In conclusion, we identified a distinct set of DEGs in association with extracellular matrix and cancer cell activities to contrast CP and CPR. …”
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Emerging targeted therapies in oral oncology: Focus on EGFR inhibition by Vishnu Priya Veeraraghavan, Shikhar Daniel, Arun Kumar Dasari, Kaladhar Reddy Aileni, Chaitra patil, Santosh R. Patil

“…This comprehensive study explored the role of epidermal growth factor receptor (EGFR)-targeted therapies in oral cancer, focusing on emerging strategies, challenges, and future directions. The EGFR signalling pathway plays a critical role in the development and progression of oral cancer, making it an attractive therapeutic target. …”
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Targeting Adult Neurogenesis for Poststroke Therapy by Jianfei Lu, Anatol Manaenko, Qin Hu

“…This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery. …”
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Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect by Yuhan Wang, Junsha An, Jianbo Zhou, Liming Chang, Quan Zhang, Quan Zhang, Quan Zhang, Fu Peng

“…This can serve as a theoretical basis for further research and development of HSYA, with insights into the mechanisms of anticancer signaling pathways.…”
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Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker by Katarzyna Szymulewska-Konopko, Joanna Reszeć-Giełażyn, Monika Małeczek

“…Oxidative stress, which can cause cellular damage, is induced by reactive oxygen species generated during the Fenton reaction, activating signaling pathways associated with tumor growth and proliferation. …”
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Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases by Longxiao Zhang, Yunfei Zhou, Zhongbo Yang, Liangchao Jiang, Xinyang Yan, Wenkai Zhu, Yi Shen, Bolong Wang, Jiaxi Li, Jinning Song

“…Abstract Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. …”
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An overview of the human immune system and the role of interferon regulatory factors (IRFs) by Ashwinder Kaur, Chee-Mun Fang

“…To deploy effective immune responses, immune systems comprise various cells and molecules that communicate with each other via signaling pathways coordinated by gene regulatory networks. …”
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Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus by Masako Isokawa

“…Additionally, I will discuss functional significance of these two systems and their signaling pathways for its relevance to maladaptive reward learning leading to addiction.…”
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The Bioactivities of Phycocyanobilin from Spirulina by Yi Li

“…In addition, PCB can also be used as an excellent anti-inflammatory agent to reduce the proinflammatory factors IL-6 and IFN-γ and to up-regulate the production of anti-inflammatory cytokine IL-10 by inhibiting the inflammatory signal pathways NF-κB and mitogen-activated protein kinase (MAPK). …”
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Genomic Profiling of Liver Cancer by Ju-Seog Lee

“…Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. …”
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PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis by Wen Bao, Rui Kong, Nan Wang, Wei Han, Jie Lu

“…Therefore, through clinical research and analysis, we reported for the first time that fenofibrate combined with octreotide acetate has a more excellent effect in the treatment of patients with acute hypertriglyceridemia pancreatitis, and from the perspective of signal pathways, we revealed that the combination of the two drugs has an effect on NF-κB P65. …”
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Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons by Kedong Zhu, Lanxia Meng, Jiaying Luo, Tingting Wen, Liang Dan, Zhihao Wang, Xuebing Cao, Zhaohui Zhang, Guiqin Chen

“…In this study, a variety of in vivo and in vitro methods, including transcriptomic analysis, were employed to elucidate the effects of Taltirelin on cellular composition and signaling pathways in the striatum of hemi-PD rats. We demonstrated that Taltirelin upregulates the expression of TRHR on striatal GABAergic neurons, which is accompanied by activation of the TRHR-MAPK-RARα-DRD2 pathway. …”
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Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown by Susan Yung, Tak Mao Chan

“…Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. …”
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The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion by Simón Quetzalcóatl Rodríguez-Lara, Leonel García-Benavides, Alejandra Guillermina Miranda-Díaz

“…One of the survival systems of the cells, to the assault caused by ischemia, is the activation of the renin-angiotensin-aldosterone system (also known as an axis), which is focused on activating diverse signaling pathways to favor adaptation to the decrease in metabolic supports caused by the hypoxia. …”
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The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review by Mori Tommaso, Nagaraj Nareshkumar Ragavachetty, Surico Pier Luigi, Zhou Wenjing, Parmar Uday Pratap Singh, D’Esposito Fabiana, Gagliano Caterina, Musa Mutali, Zeppieri Marco

“…The review also examines current research on OSM’s interaction with key signaling pathways and discusses the potential of OSM and the IL-6 family as potential therapeutic targets. …”
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Ibrutinib-Associated Cardiac Tamponade with Concurrent Antiplatelet Therapy by Jennifer L. Miatech, John H. Hughes, Dillon K. McCarty, M. Patrick Stagg

“…The increased bleeding tendency associated with ibrutinib is thought to be related to its effect on several platelet signaling pathways, which can be exacerbated in the setting of concurrent antiplatelet or anticoagulant therapy. …”
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Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy by Lili Zhang, Zhige Wen, Lin Han, Yujiao Zheng, Yu Wei, Xinmiao Wang, Qing Wang, Xinyi Fang, Linhua Zhao, Xiaolin Tong

“…More and more studies have shown that multiple signaling pathways play important roles in the progression of podocyte injury in DN. …”
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Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases by Eun Ji Lee, Jong Hoon Park

“…In this review, we summarize the signaling pathways regulated by RAGE and its ligands identified up to date and demonstrate the effects of hyper-activation of RAGE signals on human diseases, focused mainly on renal disorders. …”
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Dynamics of agonist-evoked opioid receptor activation revealed by FRET- and BRET-based opioid receptor conformation sensors by Sina B. Kirchhofer, Claudia Kurz, Lorenz Geier, Anna-Lena Krett, Cornelius Krasel, Moritz Bünemann

“…Moreover, our sensors offer an assay independent from other signaling pathways, thereby minimizing the potential for interfering influences or biases within the system.…”
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Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities by Ping Na Zhang, Meng Qi Zhou, Jing Guo, Hui Juan Zheng, Jingyi Tang, Chao Zhang, Yu Ning Liu, Wei Jing Liu, Yao Xian Wang

“…In this review, we have surveyed recent advances in elucidating the mitochondrial networking and signaling pathways in physiological and pathological contexts. …”
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