Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats by Yonglin Zhao, Yahui Zhao, Ming Zhang, Junjie Zhao, Xudong Ma, Tingqin Huang, Honggang Pang, Jiaxi Li, Jinning Song

“…The purpose of this study was to investigate the role of the TLR4 signalling pathway in secondary axonal injury in the cortices of DAI rats. …”
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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function. …”
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Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023 by Wang Junli, Hao Zhihong, Wang Lina, Ou Qiaoqun, Qu Jing, Hu Jiaqi, Shengyou Yu, Shengyou Yu, Shengyou Yu

“…Future research directions may include the identification of specific therapeutic targets, detailed exploration of podocyte signaling pathways, and the role of autophagy. This study provides a comprehensive overview of the major research areas, frontiers, and trends in podocyte endoplasmic reticulum research, which are pivotal for guiding future investigations.…”
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TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein by Zhenbin Bi, Wei Wang, Shanshen Gu, Yajing Zhou, Zhengchang Wu, Wenbin Bao, Haifei Wang

“…Transcriptomics analysis revealed that TRIM8 facilitates the expression of genes associated with several pathways, including the IL-17 signalling pathway, chemokine signalling pathway, and cytokine-cytokine receptor interaction. …”
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Nootkatone Derivative Nootkatone-(E)-2-iodobenzoyl hydrazone Promotes Megakaryocytic Differentiation in Erythroleukemia by Targeting JAK2 and Enhancing JAK2/STAT3 and PKCδ/MAPK Cro... by Yang Pan, Feng Xiao, Chaolan Pan, Hui Song, Peng Zhao, Meijun Chen, Liejun Huang, Jue Yang, Xiaojiang Hao

“…Mechanistically, N2 activated a crosstalk between the JAK2/STAT3 and PKCδ/MAPK signaling pathways, enhancing transcriptional regulation of key factors like <i>GATA1</i> and <i>FOS</i>. …”
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Gastrointestinal Stromal Tumours: Etiology, Pathology and Clinical Management by Martin E Blackstein, Pierre Dubé, Jonathan A Fletcher, Oliver R Keller, Margaret Knowling, Richard Létourneau, Donald Morris, Robert Riddell, Stewart Rorke, Carol J Swallow, Canadian Advisory Committee on GIST

“…Investigation of the regulation of cell growth, differentiation and death by signalling pathways has led to a greater understanding of how alterations in these pathways play a critical role in the development of some cancers, and has opened new opportunities for their treatment. …”
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The Response of the miRNA Profiles of the Thyroid Gland to the Artificial Photoperiod in Ovariectomized and Estradiol-Treated Ewes by Zizhen Ren, Wei Wang, Xiaoyun He, Mingxing Chu

“…Through GO and KEGG enrichment analysis, the results showed that the photoperiod response characteristics of Sunite ewes were affected by Olfactory transduction, Wnt signaling pathways, and Apelin signaling pathways. A different illumination time may have a certain influence on the downstream of these pathways, which leads to the change in animal estrus state. …”
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A Comparative Transcriptomic Analysis of Human Placental Trophoblasts in Response to Pathogenic and Probiotic Enterococcus faecalis Interaction by Qianglai Tan, Zhen Zeng, Feng Xu, Hua Wei

“…KEGG analysis showed that 6 and 9 signaling pathways were associated with interactions between Symbioflor 1 and V583. …”
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HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma by Katherine Julissa Palma Valladares, Karolyny Martins Balbinot, Antonia Taiane Lopes de Moraes, Maria Sueli da Silva Kataoka, Aline Maria Pereira Cruz Ramos, Rommel Thiago Jucá Ramos, Artur Luiz da Costa da Silva, Ricardo Alves Mesquita, David Normando, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro

“…Hypoxia increases HIF-1α levels, which triggers a number of signalling pathways. This paper aimed to present data in the study of hypoxia-activated signalling pathways that modulate proapoptotic and antiapoptotic events in AMB. …”
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Based on network pharmacology and molecular docking to study the mechanisms of active ingredients of ginseng in the treatment of atopic dermatitis by BU Jialiang, SHEN Lin, MENG Yuan, PIAO Yingshi

“…KEGG enrichment analysis identified 156 signaling pathways, including IL-17, TNF and other signaling pathways. …”
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Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution by Xuan Yu, Yongfu Shao, Haotian Dong, Jianing Yan, Xinjun Zhang, Guoliang Ye

“…Subsequently, significant differences were found in the tumor immune microenvironment, intratumoral microorganisms, gene expression, signaling pathways, and protein interaction networks between the two subtypes. …”
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The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities by Hajed Obaid A. Alharbi, Mohammad Alshebremi, Ali Yousif Babiker, Arshad Husain Rahmani

“…Additionally, numerous in vitro and in vivo studies have shown that quercetin’s efficacies in cancer management involve inhibiting cell signaling pathways, such as inflammation, cell cycle, and angiogenesis, activating cell signaling pathways including tumor suppressor genes, and inducing apoptosis. …”
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Explore the Mechanism of Astragalus mongholicus Bunge against Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Verification by Lili Fu, Zhongming Wu, Yanjun Chu, Wenbin Chen, Ling Gao, Shumin Mu, Jiajun Zhao

“…Network pharmacology predicted that quercetin may be the main active component in AMB, and the TNF and MAPK signaling pathways may be the key targets of AMB against NAFLD. …”
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Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…Finally, we found that sporoderm-removed Ganoderma lucidum spore powder decreased the expression of PI3K/AKT/mTOR and Erk signaling pathways. Taken together, these findings demonstrate that sporoderm-removed Ganoderma lucidum spore powder suppresses esophageal squamous cell carcinomas by involving MCP-1, regulated by PI3K/AKT/mTOR and Erk signal pathways.…”
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A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data by Xiaoqiong Li, Kejiang Wang, Jiaxin Liu, Yan Li

“…KEGG functional enrichment analysis only obtained two signaling pathways, thyroid hormone synthesis and mineral absorption. …”
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Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer by Takahiro Inoue, Osamu Ogawa

“…In this paper, we review mechanisms of CRPC development, with particular focus on recent advances in the understanding of specific intracellular signaling pathways participating in the proliferation of CRPC cells.…”
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Extracellular matrix stiffness regulates colorectal cancer progression via HSF4 by Kangtao Wang, Siyi Ning, Shuai Zhang, Mingming Jiang, Yan Huang, Haiping Pei, Ming Li, Fengbo Tan

“…High-stiffness matrices significantly regulated cell functions and signalling pathways. High HSF4 (heat shock transcriptional factor 4) expression was strongly associated with tumour stiffness and poor prognosis. …”
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Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis by Shang Wu, Xindi Ma, Xiangmei Zhang, Kaiye Du, Chao Shi, Ahmed Ali Almaamari, Boye Han, Suwen Su, Yunjiang Liu

“…Transcriptome analysis revealed 2,101 differentially expressed genes enriched in apoptosis and mitochondrial signaling pathways. Western blot results showed NDUFAF6 knockdown enhanced apoptosis. …”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Future research should focus on elucidating the precise mechanisms of putative salt tolerance genes like GaEXPA4 and evaluating the potential of signaling pathways, such as MAPK, for engineering enhanced salt resilience in cotton. …”
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Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway by Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu

“…Pathway enrichment analysis showed that the candidate targets were mostly related to the response to bacteria and immunity signalling pathways, which are known contributors to pharyngitis. …”
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