Nuclear Protein 1 Expression Is Associated with PPARG in Bladder Transitional Cell Carcinoma by Chao Lu, Shenglin Gao, Li Zhang, Xiaokai Shi, Yin Chen, Shuzhang Wei, Li Zuo, Lifeng Zhang

“…We further performed an Affymetrix microarray and Gene Set Enrichment Analysis (GSEA) to assess the genes and signaling pathways related to Nuclear protein 1. Results. …”
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Update on Myopia Risk Factors and Microenvironmental Changes by Valeria Coviltir, Miruna Burcel, Alina Popa Cherecheanu, Catalina Ionescu, Dana Dascalescu, Vasile Potop, Marian Burcea

“…This paper also covers current research aimed at elucidating the signaling pathways involved in the pathogenesis of myopia.…”
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Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention by Qiqi Zhang, Dandan Yang, Xingxing Han, Yu Ren, Yongqi Fan, Chao Zhang, Lei Sun, Tingting Ye, Qiushuang Wang, Youhao Ban, Yunxia Cao, Huijuan Zou, Zhiguo Zhang

“…By focusing on specific molecules in alarmins and their receptors and signaling pathways, we can more accurately conduct drug research and development. …”
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Comparative Transcriptome Analyses of Resistant and Susceptible Near-Isogenic Wheat Lines following Inoculation with Blumeria graminis f. sp. tritici by Piyi Xing, Xueying Zhang, Yinguang Bao, Yuhai Wang, Honggang Wang, Xingfeng Li

“…The results will aid in the identification of genes and signaling pathways involved in powdery mildew response in wheat.…”
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Exploration of the Potential Mechanisms of Wumei Pill for the Treatment of Ulcerative Colitis by Network Pharmacology by Jinke Huang, Yijun Zheng, Jinxin Ma, Jing Ma, Mengxiong Lu, Xiangxue Ma, Fengyun Wang, Xudong Tang

“…KEGG analysis revealed that the immune- and inflammation-related pathways, tumor-related signaling pathways, and microbial infection-related signaling pathways were the most significant. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…Here, we will discuss the interplay in GPCR-ERS linked to the EMT process of cancer cells, with a particular focus on oncogenes and molecular signaling pathways.…”
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Bioinformatics analysis of miR-2861 and miR-5011-5p that function as potential tumor suppressors in colorectal carcinogenesis by Alper Aytekin, Hikmet Kadakal, Deniz Mihcioglu, Turkan Gurer

“…It was also revealed that target genes of miRNAs can be found in signaling pathways such as TGF-beta, Rap1, Ras, cAMP, Wnt, mTOR and, PI3K-Akt signaling pathways. …”
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Bioinformatics analysis identifies key secretory protein-encoding differentially expressed genes in adipose tissue of metabolic syndrome by Jiandong Zhou, Yunshan Guo, Xuan Liu, Weijie Yuan

“…KEGG pathway analysis of the SP-DEGs were involved in the TGF-beta signalling pathway, cytokine‒cytokine receptor interactions, the hippo signalling pathway, Malaria. …”
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Exploring the mechanisms by which common inhalational anesthetics influence malignant tumor metastasis: A data mining study based on comparative toxicogenomic databases by Yiyu Chen, Wenlan Ouyang, Hu Lv, Wei Chen

“…Functional enrichment analysis revealed that these anesthetics could influence tumor cell migration by activating signaling pathways such as the IL-17 and tumor necrosis factor signaling pathways, thereby potentially inducing tumor metastasis. …”
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lncRNA PAPPA-AS1 Induces the Development of Hypertrophic Scar by Upregulating TLR4 through Interacting with TAF15 by Pengju Fan, Yongjie Wang, Jingjing Li, Man Fang

“…In the present study, the regulatory effect of lncRNA PAPPA-AS1 on the Toll-like receptor 4 (TLR4) signal pathway, as well as the molecular mechanism, was investigated. …”
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Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C by Sara Ullsten, Kine Østnes Hansen, Guillaume Axel Petit, Espen Holst Hansen, Jeanette Hammer Andersen

“…Abstract Pro-inflammatory cytokines, like interleukin-1 beta and interferon gamma, are known to activate signalling pathways causing pancreatic beta cell death and dysfunction, contributing to the onset of diabetes. …”
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Tensile Overload Injures Human Alveolar Epithelial Cells through YAP/F-Actin/MAPK Signaling by Shan He, Ruihan Liu, Qing Luo, Guanbin Song

“…Moreover, the inhibition of the JNK and ERK1/2 signaling pathways, as well as the expression of YAP, also reduced apoptosis caused by tensile overload. …”
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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…While the PI3K-Akt and MAPK signaling pathways were activated by both CRP and FFV PEVs, they differently upregulated the immunomodulatory TGF-β and type-I interferon signaling pathways, respectively. …”
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Network Pharmacology, Molecular Docking, and Molecular Dynamics Analysis of Honokiol against Triple-negative Breast Cancer by Hassan H. Alhassan

“…Through network pharmacology analysis, potential protein targets and signaling pathways were identified to be associated with the activity of honokiol. …”
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Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…Through bioinformatics analysis and in vitro experiments, the biological function and possibly associated signal pathways of SAE1 in BC were further analyzed. Methods. …”
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Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys by Yuhong Chen, Chao Xue

“…Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. …”
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Ferroptosis and its relationship with cancer by Chuanchao Su, Yiwen Xue, Siyu Fan, Xin Sun, Qian Si, Zhen Gu, Jingfei Wang, Runzhi Deng

“…The main molecular processes of ferroptosis discovered yet will be presented here, along with the approaches in which it interacts with tumour-associated signaling pathways and its uses in systemic therapy, radiation therapy, and immunotherapy managing tumors.…”
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Predictive and Prognostic Molecular Markers of Oral Cancers and Potential Therapeutic Agents Targeting These Markers by Shilpa Jain, Anil Goel, Arpita H Patel, Sarvatnida Shaikh

“…With the unveiling of various signaling pathways and molecular markers involved in oncogenesis, efforts are being made to develop therapeutic agents targeted at these molecular levels. …”
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Branched-Chain Amino Acids (BCAAs): Revisiting Their Role in Sport and Health by Aleksandra Kajtel, Anna Skowronek, Martyna Piekarska, Katarzyna Dąbek, Michał Ochwat, Maria Sudoł, Gabriela Mierzwa

“…This review explores the biochemistry, metabolism, and signaling pathways of BCAAs, emphasizing their potential therapeutic applications in conditions like sarcopenia, liver cirrhosis, and cachexia. …”
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SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection by Richard C. Crist, Samar N. Chehimi, Saurabh S. Divakaran, Michael J. Montague, Sébastien Tremblay, Noah Snyder-Mackler, Martin O. Bohlen, Kenneth L. Chiou, Trish M. Zintel, Cayo Biobank Research Unit, Michael L. Platt, Halvor Juul, Guido Silvestri, Matthew R. Hayes, Dennis L. Kolson, Benjamin C. Reiner

“…In silico predicted regulatory mechanisms and dysregulated neural signaling pathways are presented. Analysis of cell-cell interaction networks identify altered signal pathways in the frontal cortex that may represent regional alterations in cell-cell communications. …”
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