Exploring the role of ubiquitination modifications in migraine headaches by Qian Zhu, Qian Zhu, Jin Yang, Jin Yang, Lei Shi, Lei Shi, Jieying Zhang, Jieying Zhang, Peng Zhang, Peng Zhang, Junlong Li, Junlong Li, Xiaoli Song, Xiaoli Song

“…Calcitonin gene-related peptide (CGRP) plays a dominant role and activation of MAPK and NF-κB signaling pathways regulates neuropeptide release, glial cell activation, and amplification of nociceptive signals. …”
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Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor by Bynthia M. Anose, Michel M. Sanders

“…These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways.…”
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IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells by Fadia R. Homaidan, Marwan E. El-Sabban, Iman Chakroun, Mirvat El-Sibai, Ghassan S. Dbaibo

“…We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.…”
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Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Lei Li, Wuping Yang, Yawei Xu, Jingcheng Zhou, Kaifang Ma, Kenan Zhang, Hongkai Zhuang, Yanqing Gong, Kan Gong

“…Functional enrichment analysis illustrated that TGF-β-SMAD2/3, Notch, and PI3K-Akt-mTOR signaling pathways may be potential signaling pathways of FXYD2 in ccRCC. …”
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Influence of flavonoids’ lipophilicity on platelet aggregation by Babić Ivana, Bojić Mirza, Maleš Željan, Zadro Renata, Gojčeta Koraljka, Duka Ivan, Rimac Hrvoje, Jukić Irena

“…As not all flavonoids have the same targets within signaling pathways, an assumption of a common non-specific mechanism related to lipophilicity is to be considered. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. First of all, they act as histone deacetylase (HDAC) inhibitors (HDIs), being involved in the epigenetic regulation of gene expression. …”
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Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies by Junko Okabe-Kado, Takashi Kasukabe, Yasuhiko Kaneko

“…The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways. Inhibitors specific for MAPK signaling pathways inhibit the growth/survival-promoting activity of NM23-H1. …”
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Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis by F. Morceau, M. Dicato, M. Diederich

“…This suggested that pro-inflammatory cytokine-mediated signaling pathways affect erythropoietin activity. They could interfere with erythropoietin-mediated signaling pathways, inducing early apoptosis and perturbing the expression and regulation of specific transcription factors involved in the control of erythroid differentiation. …”
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Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation by Jungwoon Lee, Young-Jun Park, Haiyoung Jung

“…In this review, we highlight the recent progress made in defining the roles of protein kinase signaling pathways and their small molecule modulators in regulating the pluripotent states, self-renewal, reprogramming process, and lineage differentiation of PSCs.…”
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DISTRIBUTED RESTful WEB SERVICES FOR RECONSTRUCTION AND ANALYSIS OF GENE NETWORKS by N. L. Podkolodnyy, A. V. Semenychev, D. A. Rasskazov, V. G. Borowsky, E. A. Ananko, E. V. Ignatieva, N. N. Podkolodnaya, O. A. Podkolodnaya, N. A. Kolchanov

“…This paper describes a RESTful Web service-based distributed software system, which focuses on the reconstruction of gene networks by integrating data from heterogeneous data sources, including databases of molecular-genetic interactions, metabolic and signaling pathways, gene networks, etc.…”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…Bioinformatics tools were employed to analyze gene expression patterns and signalling pathways.ResultsThe findings indicated that MVI-positive malignant cells activate multiple signalling pathways to facilitate invasion and metastasis. …”
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Systematic protein–protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

“…Abstract G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. …”
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Targeting TLR/IL-1R Signalling in Human Diseases by Maria Loiarro, Vito Ruggiero, Claudio Sette

“…These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. …”
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Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts by Tino Stauber, Greta Moschini, Amro A Hussien, Patrick Klaus Jaeger, Katrien De Bock, Jess G Snedeker

“…There is a need to deepen our understanding of the underlying cell signaling pathways to unlock effective treatments. In this work, we screen cell signaling pathways in human tendinopathies and find positively enriched IL-6/JAK/STAT signaling alongside signatures of cell populations typically activated by IL-6 in other tissues. …”
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…First, transcriptome analysis was used to guide notable signaling pathways mediated by lactate. Subsequently, biomolecular techniques, including immunoblotting, flow cytometry, and immunofluorescence imaging were performed to corroborate the changes in these key signaling pathways at the protein level. …”
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Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets by Soyoung Jeon, Yeram Jeon, Ji-Youn Lim, Yujeong Kim, Boksik Cha, Wantae Kim

“…Their ability to regulate cellular signaling pathways is particularly significant, as it requires a careful balance between flexibility and precision. …”
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Sargentgloryvine Stem Water Extract Mediated Nrf2 Pathway Activation and HO-1 Upregulation by Zhaorong CHEN, Xiaoping CHENG, Jianfeng CHU, Jun PENG, Wei LIN

“…Immunofluorescence images indicated that SSE treatment increased Nrf2 translocation into nuclear.Conclusion:SSE was able to activate Nrf2 signal pathway by increasing Nrf2 expression, and suppressing Keap1, which in turn increased Nrf2 translocation into nuclear and unregulated HO-1 expression.…”
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Early Head Specification in Xenopus laevis by Blue B. Lake, Kenneth R. Kao

“…Thus, development of the head, and indeed the body plan in general, requires precisely timed and spatially restricted activation and repression of these signaling pathways.…”
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The Role of Combining Probiotics in Preventing and Controlling Inflammation: A Focus on the Anti-Inflammatory and Immunomodulatory Effects of Probiotics in an In Vitro Model of IBD by Shadi Aghamohammad, Amin Sepehr, Seyedeh Tina Miri, Saeideh Najafi, Mohammad R. Pourshafie, Mahdi Rohani

“…The probiotic mixture of Lactobacillus spp. and Bifidobacterium spp. showed anti-inflammatory effects by modulating JAK/STAT and NF-kB signaling pathways. The use of probiotics could be considered as an appropriate complementary treatment for patients with inflammatory bowel disease.…”
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Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells by Hiroshi Tanaka, Tadaatsu Imaizumi

“…Based on our recent experimental studies using cultured normal human mesangial cells (MCs), we found that novel TLR3-mediated signaling pathways in MCs may be involved in the pathogenesis of glomerular diseases. …”
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