IL-21 Modulates Release of Proinflammatory Cytokines in LPS-Stimulated Macrophages through Distinct Signaling Pathways by Su-nan Li, Wei Wang, Shou-peng Fu, Jian-fa Wang, Hong-mei Liu, Shan-shan Xie, Bing-run Liu, Yang Li, Qing-kang Lv, Zhi-qiang Li, Wen-jing Xue, Bing-xu Huang, Wei Chen, Ju-xiong Liu

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The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway by Nana Wang, Tiegang Li, Ping Han

“…Area under the curve (AUC) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated, and PI3-K/AKT signal pathway-related genes and proteins were tested by reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis in muscle, adipose, and liver tissues, respectively. …”
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Spermatozoal Fractalkine Signaling Pathway Is Upregulated in Subclinical Varicocele Patients with Normal Seminogram and Low-Level Leucospermia by Salwa M. Abo El-khair, Mohammad A. Gaballah, Mamdouh M. Abdel-Gawad, Sherif Refaat M. Ismail, Ayman Z. Elsamanoudy

“…Subclinical varicocele induces seminal and spermatozoal subclinical inflammatory response in the form of low-level leucospermia and increased mRNA expression of the fractalkine signaling pathway, leading to increased spermatozoal ROS production, oxidative stress, and DNA fragmentation. …”
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Application and prospects of proteomic technology in inflammation: a review by Senye Wang, Yanhai Chu, Jiajia Yuan, Yiqi Li, Zhenhua Liu, Xiaoyu Chen, Wenyi Kang

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Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems by Chengyi He, Yunfei Chen, Jiao Xie, Miao Luo, David Fisher, Nguyen Thi Thu Hien, Erkin Musabaev, Yiping Dang, Lei Zhao, Yin Xia

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Ethanolic Extract of Red Okra Pods Induces Aberrant Spindle Segregation and Apoptotic Cell Death by Disrupting the Wnt Signaling Pathway in Colon Cancer Cells by Firli Rahmah Primula Dewi, Sri Puji Astuti Wahyuningsih, Vuanghao Lim, Lionel Lian Aun In, Alfiah Hayati

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Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway by Chenlong Wang, Chuangjiang Chen, MengYa Wang, Sajid Ur Rahman, Bin Wei, Hongyan Ding, Wanyue Huang, Xichun Wang

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ISG15 promotes M5-induced hacat cell proliferation through Wnt signaling in psoriasis by Sun Xianqi, Li Yuzhen, Yu Huiwen, Lin Jiaying, Wang Chen, Liu Quanlin, Bai Bingxue

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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

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Angesinenolide B, A Phthalide Dimeric Peroxide, Exerts Anti-Inflammatory Properties by Suppressing MAPK/STATs Signaling Pathways and ROS Production by Zhang L, Liu Y, Wang H, Guo S, Lv J

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NT5E Mediates Cisplatin Resistance in NSCLC Through the PI3K-AKT Signaling Pathway by Liangfeng Zheng, Jian Liu, Feiyue Ji, Chunxiang Li, Ye Qian, Lili Shao, Xiaomin Lu

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Effect of Electroacupuncture on Chondrocyte Apoptosis in Knee Osteoarthritis Rat Based on PI3K/Akt Signaling Pathway by Yuanyuan ZHANG, Xinyu JIANG, Xihai LI, Mingxia WU

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Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review by Yiting Ze, Yongyao Wu, Zhen Tan, Rui Li, Rong Li, Wenzhen Gao, Qing Zhao

“…Studies have shown that multiple signaling pathways are involved in the process of Bmal1 regulating bone and cartilage metabolism, but the exact regulatory mechanisms remain unclear. …”
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Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

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Whole-Genome Expression Analysis and Signal Pathway Screening of Synovium-Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis by Jingyi Hou, Yi Ouyang, Haiquan Deng, Zhong Chen, Bin Song, Zhongyu Xie, Peng Wang, Jinteng Li, Weiping Li, Rui Yang

“…Our study found that differentially expressed genes in the MAPK signaling, rheumatoid arthritis, and p53 signaling pathways may help to explain the pathogenic mechanism of RA and lead to therapeutic RA SMSC applications.…”
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Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway by Maoping Cai, Shengdong Ge, Yaying Hong, Yao Chen, Yang-Zi Ren, Dacai Zhong, Mingkun Chen, Yuan Liu, Zhe-Sheng Chen, Ninghan Feng, Zhanghui Chen, Shan-Chao Zhao

“…Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa.…”
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Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats by Shoujiao Ye, Zhenqiang Song, Jing Li, Chunshen Li, Juhong Yang, Bai Chang

“…In conclusion, the early use of DDD improves the permeability of vascular endothelial cells by regulating the MLCK signaling pathway.…”
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Corrigendum to “Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health” by Sen Yin, Xuemei Bai, Danqing Xin, Tingting Li, Xili Chu, Hongfei Ke, Min Han, Wenqiang Chen, Xingang Li, Zhen Wang

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Exploring the Analgesic Effect of Acupuncture on Knee Osteoarthritis Based on MLT/cAMP/PKA/CREB Signaling Pathway by Zhang C, Yu M, Zhang L, Zhou X, Han J, Fu B, Xue H, Zhang C

“…In addition, acupuncture significantly reduced the expression of the inflammatory factor MMP-3 in knee joint fluid and significantly increased the levels of MLT, AANAT, MT1, MT2, cAMP, PKA and CREB.Conclusion: By regulating sympathetic excitability, acupuncture may activate the MLT/cAMP/PKA/CREB signaling pathway, decrease inflammatory factor expression and slow down degradation of articular cartilage, resulting in the relief of knee pain.Keywords: acupuncture, knee osteoarthritis, MLT/cAMP/PKA/CREB pathway, melatonin…”
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Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

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