Multi-active phlorotannins boost antimicrobial peptide LL-37 to promote periodontal tissue regeneration in diabetic periodontitis by Cancan Li, Luowen Du, Yingying Xiao, Lei Fan, Quanli Li, Chris Ying Cao

“…Interestingly, it could downregulate the AGE-RAGE signaling pathway, exerting a protective effect against diabetes. …”
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The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity by Yujia Li, Max Xuezhong Ma, Bo Qin, Liang-Tzung Lin, Christopher D. Richardson, Jordan Feld, Ian D. McGilvray, Limin Chen

“…Overexpression of wild-type (USP18 WT) or catalytically inactive mutant (USP18 C64S) USP18 was examined for effects on HCV replication in the absence and presence of IFNα or IFNλ using both the HCV-infective model and replicon cells. The IFN signaling pathway was assessed via STAT1 phosphorylation (western blot) and downstream ISG expression (real-time PCR). …”
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Jiangzhi Granule Ameliorates JNK-Mediated Mitochondrial Dysfunction to Reduce Lipotoxic Liver Injury in NASH by Jiang Y, Xu J, Ding J, Liu T, Liu Y, Huang P, Wang Q, Zheng P, Song H, Yang L

“…The inhibition of the JNK signaling pathway may contribute to the underlying mechanism of JZG in preventing and reversing NASH development. …”
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ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis by Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang, Jinghua Jiang, Qiudong Zhao, Lixin Wei, Li Zhang, Zhipeng Han, Wenting Liu, Jianxin Qian

“…This differentiation is mediated by the activation of the MAPK signaling pathway and the downstream transcription factor ERG via the TLR4 receptor. …”
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The enriched gut commensal Faeciroseburia intestinalis contributes to the anti-metabolic disorders effects of the Ganoderma meroterpene derivative by Shanshan Qiao, Kai Wang, Chang Liu, Nan Zhou, Li Bao, Jun Wang, Shuangjiang Liu, Hongwei Liu

“…Treatment with F. intestinalis effectively enhanced the level of gut butyrate, which subsequently ameliorated the intestinal barrier function and activated epithelial PPAR-γ signaling pathway to regulate microbiome homeostasis in gut. …”
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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage by Shan Tian, Ruixue Li, Jiao Li, Jinhui Zou

“…Exposure to PS-NPs activated the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway both in the AOM/DSS mouse model and cellular model. …”
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Accumulation of advanced oxidative protein products exacerbate satellite glial cells activation and neuropathic pain by Chen Tu, Shi-Cheng Wang, Meng-Xuan Dai, Si-Qi Lai, Zhi-Wei Huang, Yong-Peng Yu, Yun-Biao Chen, Ji-Huan Zeng, Liang Wang, Zhao-Ming Zhong

“…The effects of AOPPs on the activation of satellite glial cells (SGCs) in the dorsal root ganglion (DRG), receptor for advanced glycation end-products (RAGE) expression, and NF-κB signaling pathway activation were also investigated using western blotting, immunofluorescence, and the Fluo4-AM fluorescence probe for calcium signaling. …”
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Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation by Lei Sun, Jinhao Zhang, Zhikai Xiahou, Zhenzhen Zhao, Yanchen Liang

“…Given the pivotal role of osteoclasts in OS progression, we speculated that these signaling pathways and transcription factors could emerge as novel therapeutic targets, offering innovative strategies for OS treatment.ConclusionThis study enhanced our understanding of OS and osteoclasts through scRNA-seq. …”
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Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…Conclusion In conclusion, Kuwanon H, Morusin, and Kuwanon G effectively protected HUVECs from ox-LDL-induced oxidative injury, with Kuwanon H showing the strongest protective effects via the Nrf-2/HO-1 signaling pathway. These compounds hold potential in treating atherosclerosis and related oxidative stress diseases. …”
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Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human u... by Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu

“…Furthermore, the primary receptor signaling pathways were identified using signaling pathway blockers: LY294002 (PI3K blocker), SP600125 (JNK blocker), and U0126 (ERK1/2 blocker).ResultsIn the DTT pretreatment group (0.8 mmol/L, for 8 h), the expressions of GRP78 and CHOP were significantly up regulated, indicating that an optimal ERS model was successfully established. …”
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Investigation of Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Gene Polymorphisms in Type 2 Diabetes Patients by Duygu Yolal Ertural, Ümit Çınkır, Nurcan Aras

“…Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) gene participates in insulin signaling pathway and is involved in insulin secretion. …”
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RETRACTED ARTICLE: CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer by Leilei Yang, Chengfeng Fang, Jiaju Han, Yufeng Ren, Zaiping Yang, Lingyan Shen, Dinghai Luo, Ruili Zhang, Yan Chen, Shenkang Zhou

“…Methods Bioinformatics and RNA-seq analyses were employed to study genes associated with the ferroptosis signaling pathway. CKS2 expression was evaluated using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot (WB). …”
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Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction by Irina Stavrovskaya, Bethany Kristi Morin, Stephen Madamba, Cliyahnelle Alexander, Alexis Romano, Samia Alam, Lucas Pavlov, Erna Mitaishvili, Pablo M. Peixoto

“…The absence of Wnt1/Wg release from synaptic boutons suggested involvement of alternative or non-canonical signaling pathway(s). However, in existing boutons we observed an increase in the active zone (AZ) marker Brp/Erc1, which serves as docking site for the neurotransmitter vesicle release pool. …”
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Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis by Yuan Liu, Wacili Da, Ming-Jie Xu, Chao-Xin Xiao, Tao Deng, Sheng-Liang Zhou, Xiao-Ting Chen, Yao-Jia Zhou, Li Tang, Yong Nie, Yi Zeng, Hui-Qi Xie, Bin Shen

“…In addition, the Angptl7 + chondrocytes promoted angiogenesis in the subchondral bone of KOA mice by interacting with endothelial cells via the FGF2-FGFR2 signaling pathway. The number of H-type vessels was increased in the subchondral bone, recruiting osteoprogenitor cells and facilitating osteogenesis in KOA mice. …”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…L-citrulline (L-CIT), a precursor to L-arginine (L-ARG), is a key contributor to the nitric oxide (NO) signaling pathway. Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of various neonatal conditions such as necrotizing enterocolitis (NEC) and bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH). …”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…Additionally, RNA-seq analysis revealed that the differentially expressed genes among HIIT, MOD, and MCAO groups were highly associated with signaling pathways involved in inflammatory response, more specifically the I-kappaB kinase/NF-kappaB signaling. …”
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TRIM26 exacerbates pathological cardiac hypertrophy by activating TAK1 by Xiaochuang Xia, Huajing Shan, Zhaoxia Jin, Tengfei Ma, Yemao Liu, Jianqing Zhang, Han Tian, Bizhen Dong, Chengsheng Xu, Shaoze Chen

“…The results showed that TRIM26 activated the transforming growth factor-beta activated kinase 1 (TAK1)-c-Jun N-terminal kinase/p38 signaling pathway in response to hypertrophic stress. Moreover, inhibition of TAK1 activation can reverse the promotion effect of TRIM26 overexpression on cardiomyocyte hypertrophy induced by PE stimulation in vitro. …”
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Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway by Mingming Xu, Jiyuan Chen, Lin Gao, Shaoxi Cai, Hangming Dong

“…Overall, these finding suggested that microplastics elicited inflammation via the PI3K-Akt-mTOR signaling pathway and stimulated the proliferation of ASMCs. …”
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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…The levels of plasma interleukin 6 and its soluble receptors were found to be elevated in subjects with cardiovascular diseases, which points to amplification of the IL-6-mediated trans-signaling pathway in cells and the development of chronic inflammation. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Results Gene expression levels of components of the activin signaling pathway were elevated within EOC when compared to a benign cohort, with differences in activin type I/II receptor gene profiles identified. …”
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