A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…The two bsAbs were able to block the binding of CA125 to MSLN and stimulate 4-1BB signaling pathway, which was strictly dependent on MSLN expression. …”
Get full text

The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase by Dapeng Zhang, Yehong Wang, Ming Yi, Suli Zhang, Ye Wu

“…MPO might provoke vascular endothelial dysfunction in hypercholesterolemic rats by reducing the NO biological activity and impairing the NO/cGMP/cGK signaling pathway. PIO might inhibit vascular MPO activity and increase NO bioavailability with the net result of reversing endothelial dysfunction.…”
Get full text

Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS by Yicong Liu, Zhou Wu, Xinwen Zhang, Junjun Ni, Weixian Yu, Yanmin Zhou, Hiroshi Nakanishi

“…LPS-induced TNF-α and IL-1 β production by leptomeningeal cells through inhibiting the nuclear factor-κB signaling pathway. Together with the inhibitory effect on microglial activation, propolis may be beneficial in preventing neuroinflammation during chronic periodontitis.…”
Get full text

Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery by Song Zhang, ZongXiu Yin, WeiDong Qin, XiaoLi Ma, Yao Zhang, EnXiu Liu, YanBiao Chu

“…PFD reduced hypoxia-induced phosphorylation of p38 through the NOX4/reactive oxygen species (ROS) signaling pathway. Moreover, Rac1 also decreased hypoxia-induced phosphorylation of p38, without any cross-interaction with NOX4. …”
Get full text

Dietary Tryptophan Requirement of Juvenile Hybrid Grouper (<i>Epinephelus fuscoguttatus</i>♀ <i>× E. lanceolatus</i>♂) by Jiaxian Chen, Xiaohui Dong, Qihui Yang, Shuyan Chi, Shuang Zhang, Beiping Tan, Junming Deng

“…Dietary levels of 0.32–0.46% Trp activated the hepatic mammalian target of rapamycin pathway, while a dietary 0.46% Trp level inhibited the hepatic amino acid response signaling pathway. In summary, suitable dietary Trp levels enhanced intestinal digestive enzyme activities, facilitated both protein synthesis and catabolism, and ultimately improved growth performance in hybrid grouper. …”
Get full text

A Case Report of Clinical Features Analysis of a Novel IKBKG Variant Leading to Anhidrotic Ectodermal Dysplasia and Immunodeficiency by HUANG Xiaomei, LUO Ying, HE Tingyan, XU Yongbin, XIA Yu, YANG Zhi, ZHU Xiaona, HUANG Yanyan, WENG Ruohang, YANG Jun, WANG Linlin

“…IKBKG is the essential modulator for nuclear factor-κB(NF-κB) signaling pathway, and mutations within this gene can lead to anhidrotic ectodermal dysplasia and immunodeficiency (EDA-ID). …”
Get full text

P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury by Ruidong Cheng, Genying Zhu, Chengtao Ni, Rui Wang, Peng Sun, Liang Tian, Li Zhang, Jie Zhang, Xiangming Ye, Benyan Luo

“…The aim of this study was to investigate the effect of the P2Y2 receptor (P2Y2R) signaling pathway on neuronal regeneration and angiogenesis during spinal cord injury (SCI). …”
Get full text

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway by Wei Zhang, Hong He, Hujie Song, Junjie Zhao, Tao Li, Leitao Wu, Xiaojun Zhang, Jianzong Chen

“…These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3β pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD.…”
Get full text

New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite by Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

“…A population of pancreatic cancer stem cells with aberrantly active developmental signaling pathways has been identified in recent studies of human pancreatic tumors. …”
Get full text

The role of cholesterol in modifying the lipid-lowering effects of Fuzhuan brick-tea in Caenorhabditis elegans via SBP-1/SREBP by Lianyun Pan, Yan Lu, Shen Dai, Xiangyue Tang, Ligui Xiong, Zhonghua Liu, Yushun Gong

“…Moreover, this mechanism may involve the conserved sterol regulatory element-binding protein (SREBP)/mediator-15 (MDT-15) signaling pathway and the nuclear hormone receptor NHR-80. …”
Get full text

Odontogenic differentiation of dental pulp stem cells by glycogen synthase kinase-3β inhibitory peptides by Vidhyashree Rajasekar, Mohamed Mahmoud Abdalla, Mohammed S. Basbrain, Prasanna Neelakantan, Cynthia KY Yiu

“…Conclusions L803-mts, a peptide-based substrate competitive inhibitor of GSK-3β, enhanced the odontogenic differentiation of hDPSCs by activating the Wnt signaling pathway.…”
Get full text

Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE by Lihong Huo, Arati Naveen Kumar, Gantsetseg Tumurkhuu, Moumita Bose, Daniel S. Berman, Daniel J. Wallace, Janet Wei, Mariko Ishimori, C. Noel Bairey Merz, Caroline Jefferies

“…Using whole blood RNA samples, we asked whether gene signatures discriminate SLE patients with coronary microvascular dysfunction (CMD) on cardiac MRI (n = 4) from those without (n = 7) and whether any signaling pathway is linked to the underlying pathobiology of SLE CMD. …”
Get full text

Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-κB Pathway by Zige Liu, Yan Li, Fengying Guo, Chen Zhang, Guorui Song, Jiahao Yang, Desheng Chen

“…Mechanistic studies using Western blotting demonstrated that Tet inhibited the nuclear factor (NF)-κB signaling pathway by decreasing the phosphorylation of inhibitor of NF-κB α (IκBα) and p65, which play important roles in osteoclast formation. …”
Get full text

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

“…Previous studies implicated the AKT signaling pathway in α-Syn toxicity in cellular models of PD, suggesting AKT as a potential therapeutic target. …”
Get full text

IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical roles in mediating cell proliferation, growth, and survival. …”
Get full text

Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf-κb pathway by Yachen Si, Lulu Liu, Yinyin Zhang, Hongxia Li, Tingting Zhao, Su Liu, Xuejun Sun, Jin Cheng, Hongtao Lu

“…Collectively, this study indicated that MgH2 protects against APAP-AKI by alleviating oxidative stress, inflammation and apoptosis via inhibition of TXNIP/NLRP3/NF-κB signaling pathway.…”
Get full text

Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats by Ye Jiang, Jing Yang, Min Wei, Jiayin Shou, Shixiong Shen, Zhuoying Yu, Zixian Zhang, Jie Cai, Yanhan Lyu, Dongsheng Yang, Yongzheng Han, Jinpiao Zhu, Zhigang Liu, Daqing Ma, Guo-gang Xing, Min Li

“…Furthermore, probiotics treatment inhibited the activation of the TLR4/MyD88/NF-κB signaling pathway and reduced proinflammatory cytokines in the sciatic nerve of the PDN rats. …”
Get full text

Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB by Jeanne Durendale Chiadak, Tatjana Arsenijevic, Kevin Verstrepen, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Véronique Flamand, Jason Perret, Christine Delporte

“…The aim of this study was to determine the signaling pathway by which Forskolin (FK), a cyclic adenosine monophosphate- (cAMP-) promoting agent causing positive changes in body composition in overweight and obese adult men, affects MCP-1 and GPR120 expression during an inflammatory response induced by lipopolysaccharide (LPS) in adipocytes, such as in an obese state. 3T3-L1 cells differentiated into adipocytes (DC) were stimulated with LPS in the absence or presence of FK and inhibitors of TLR-4 and inhibitor of kappa B (IκBα). …”
Get full text

Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…Overall, miR-223-3p in LPS-EVs contributes to sepsis-induced ALI by priming AMs for autophagy and ferroptosis through the MEF2C/Hippo signaling pathway. These findings suggest a novel mechanism of plasma-AM interaction in sepsis-induced ALI, offering a plausible strategy for assessing septic progression and treating lung injury.…”
Get full text

PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/β-CATENIN Pathway in Testosterone-Treated Hypogonadal Men by Siresha Bathina, Mia Prado, Virginia Fuenmayor Lopez, Georgia Colleluori, Lina Aguirre, Rui Chen, Dennis T. Villareal, Reina Armamento-Villareal

“…Likewise, we evaluated changes in the WNT10b—β-CATENIN signaling pathway by gene expression and protein analyses. …”
Get full text