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961
Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2)
Published 2025-01-01“…By acting as a competitive antagonist to ghrelin, LEAP-2 influences energy balance and metabolic processes via the ghrelin–GHSR1a signaling pathway. LEAP-2 alone or the LEAP-2/ghrelin molar ratio showed potential as therapeutic targets for obesity, diabetes, and metabolic disorders. …”
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962
When molecular biology transforms clinical oncology: the EGFR journey in colorectal cancer
Published 2025-02-01“…However, a better understanding of the biology of the EGFR signaling pathway in CRC, coupled with the development of liquid biopsy methodologies to study cancer evolution in real time, fostered the clinical refinement of anti‐EGFR treatment in CRC. …”
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963
Identification of a novel disulfidptosis-related gene signature in osteoarthritis using bioinformatics analysis and experimental validation
Published 2025-01-01“…The proportion of EC subgroups with high SLC3A2 expression increased, mainly enriching pathways related to inflammation, such as the IL-17 signaling pathway and TGF-beta signaling pathway. Using machine learning, we identified four characteristic DR-DEGs, which, in combination with the nomogram and ROC models, demonstrated promising performance in the diagnosis of OA. …”
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964
Role of calcium overload-mediated disruption of mitochondrial dynamics in offspring neurotoxicity due to methylmercury exposure during pregnancy and lactation
Published 2025-02-01“…In summary, our study suggests that MeHg-induced calcium overload may induce disturbed mitochondrial dynamics through activation of the CaM/CaMKII/DRP1 signaling pathway, resulting in neuronal apoptosis.…”
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965
Protein Level and Infantile Diarrhea in a Postweaning Piglet Model
Published 2020-01-01“…In addition, the Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway (P<0.01) was inhibited in the HP group. …”
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966
CSNK1E is involved in TGF-β1 induced epithelial mesenchymal transformationas and related to melanoma immune heterogeneity
Published 2025-01-01“…Identifying novel biomarkers and therapeutic targets is critical for improving the prognosis and treatment of MM.MethodsIn this study, we analyzed the expression patterns of WNT signaling pathway genes in MM and explored their potential mechanisms. …”
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967
Network pharmacology and experimental verification reveal the mechanism of Qingfei Tongluo mixture in treating pulmonary fibrosis
Published 2025-01-01“…Quercetin, a key active ingredient, was associated with the TGF-β1 signaling pathway. Gene Ontology and KEGG enrichment analyses identified 42 core genes, with a notable implication of the TGF-beta signaling pathway in PF. …”
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968
Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway
Published 2020-01-01“…EA increased the levels of tight junction proteins, inhibited the activation of the ERK1/2 signaling pathway, and reduced MMP9 overexpression induced by delayed rtPA thrombolysis. …”
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969
Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway
Published 2020-01-01“…The effects of 10 Hz EA at the GV20 and ST36 acupoints on the NLRP3/caspase-1 signaling pathway may be a mechanism by which this treatment relieves aging-related CI in mice.…”
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970
Ablation of IGFBP5 expression alleviates neurogenic erectile dysfunction by inducing neurovascular regeneration
Published 2025-01-01“…Finally, western blot analysis demonstrated that IGFBP5 ablation attenuated the JNK/c-Jun signaling pathway, activated the PI3K/AKT signaling pathway, and increased vascular endothelial growth factor and neurotrophic factor expression. …”
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971
GLP‐1 Receptor Agonists Alleviate Diabetic Kidney Injury via β‐Klotho‐Mediated Ferroptosis Inhibition
Published 2025-01-01“…Notably, Smg treatment significantly increases the mRNA expression of KLB through the activation of the cyclic adenosine monophosphate (cAMP) signaling pathway, specifically through the phosphorylation of protein kinase A (PKA) and cAMP‐response element‐binding protein (CREB). …”
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972
The Developing Human : clinically oriented embryology /
Published 2016Table of Contents: “…Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth : the fetal period -- Placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.…”
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973
The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury
Published 2025-11-01“…The mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults. …”
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974
Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound
Published 2021-01-01“…Consequently, the integrated bioinformatic analyses revealed the shared KEGG pathways between DEG-identified and diabetes-related pathways were functionally enriched in the MAPK signaling pathway, and the MAPKAPK3, HSPA2, TGFBR1, and p53 signaling pathways were involved. …”
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975
Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis
Published 2006-01-01“…These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-<mml:math> <mml:mi>α</mml:mi> </mml:math> signaling pathway to inhibit liver fibrosis.</p>…”
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976
The Heart-Placenta Axis in the First Month of Pregnancy: Induction and Prevention of Cardiovascular Birth Defects
Published 2013-01-01“…All three factors affected the important Wnt signaling pathway by suppressing Wnt-mediated gene expression in the heart fields, resulting in a delay of cardiomyocyte migration, cardiomyogenesis, and CHD. …”
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977
Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis
Published 2006-01-01“…These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-α signaling pathway to inhibit liver fibrosis.…”
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978
Exploring the Revolutionary Impact of YAP Pathways on Physical and Rehabilitation Medicine
Published 2025-01-01“…The review investigates the involvement of the Hippo/YAP signaling pathway in various diseases and considers how different rehabilitation techniques leverage this pathway to aid in healing. …”
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979
Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression
Published 2024-10-01“…Meibomian gland obstruction is a causative factor of MGD, which led to abnormal histological structure in MG, differential expression of PPAR signaling pathway and TRPV3.…”
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980
Exploring the molecular basis of efficient feed utilization in low residual feed intake slow-growing ducks based on breast muscle transcriptome
Published 2025-01-01“…There were significant differences in gene expression between LRFI and HRFI ducks, with 102 upregulated and 258 downregulated genes, which were enriched in the PPAR signaling pathway, adipocytokine signaling pathway, actin cytoskeleton regulation, ECM-receptor interaction, and focal adhesion. …”
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