lncRNA HHIP-AS1 Promotes the Osteogenic Differentiation Potential and Inhibits the Migration Ability of Periodontal Ligament Stem Cells by Qianyi Qin, Haoqing Yang, Chen Zhang, Xiao Han, Jing Guo, Zhipeng Fan, Jie Guo

“…Bioinformatic analysis revealed several biological processes and signaling pathways related to HHIP-AS1 functions, including the PI3K-Akt signaling pathway and JAK-STAT signaling pathway. …”
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MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3 by Bin Wang, Ping Yu, Wei Lin, Zhaohui Zhai

“…Besides, miR-21-5p could restore the activation of the EGFR/PI3K/AKT signaling pathway inhibited by H/R treatment (all P<0.05). …”
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In vitro and in vivo studies on bioactive hydroxyapatite-coated magnesium for glaucoma drainage implant by Huanhuan Gao, Yi Chen, Xia Chen, Liandi Huang, Hao Yao, Xiaomin Zhu, Min Tang, Yong Wang, Xiangji Li, Lin Xie

“…In conclusion, the application of hydroxyapatite-coated Mg in the eye has good biocompatibility and has the potential to resist postoperative glaucoma filtration fibrosis, which may be mediated by the regulation of the TGFβ/Smad signaling pathway.…”
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Malignant phyllodes tumors with sarcomatous components: A histopathologic and molecular study by Ting Lei, Yunjie Song, Zhiyi Shen, Yongqiang Shi, Cunyan Xia, Xu Deng, Wenyue Da, Yan Peng, Qing Li

“…Furthermore, it typically facilitates tumor formation and progression via the NOTCH signaling pathway. These findings may offer valuable insights for clinical prognosis and identify potential therapeutic targets.…”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…The non-canonical STING-NF-κB pathway is the crucial signaling pathway that initiates and links apoptosis, pyroptosis, and immunogenic cell death.Conclusions Our study is the first to show that Clo, an FDA-approved drug, induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53-STING-NF-κB signaling pathway, providing a novel strategy for the clinical therapy of melanoma and lung cancer.…”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…The intestinal morphology, intestinal permeability, and inflammatory response activation signaling pathway were assessed using histological staining, western blots, quantitative-PCR, and enzyme-linked immunosorbent assays. …”
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RETRACTED ARTICLE: hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer by Olivia Crociani, Francesca Zanieri, Serena Pillozzi, Elena Lastraioli, Matteo Stefanini, Antonella Fiore, Angelo Fortunato, Massimo D'Amico, Marika Masselli, Emanuele De Lorenzo, Luca Gasparoli, Martina Chiu, Ovidio Bussolati, Andrea Becchetti, Annarosa Arcangeli

“…We identified a novel signaling pathway that sustains angiogenesis and progression in colorectal cancer (CRC). …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…The results of KEGG analysis suggested that the potential targets of Dracocephalum moldavica L. extract against pulmonary fibrosis mainly involved the PI3K-AKT, HIF-1 signaling pathway, TNF signaling pathway, and MAPK signaling pathway. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…This is attributed to its ability to regulate the LIMS1/ILK signaling pathway, which represents a common molecular mechanism in both heart and kidney tissues.…”
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Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward by David Munn, Maria Rain Jennings, John Blazeck

“…We hypothesize that prior lukewarm results may be attributed to redundancies in each metabolites’ synthesis or signaling pathway and highlight routes for how therapeutic development and patient stratification might proceed in the future.…”
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Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish by Hui Lv, Bo Liu, Yongwen Qin

“…We found that 6 drugs including isosorbide mononitrate, amlodipine, bisoprolol fumarate, carvedilol, irbesartan, and rosuvastatin calcium may affect angiogenesis by vascular endothelial growth factor (VEGF) signaling pathway. Conclusion. These new findings of some cardiovascular drugs should improve the treatment of cardiovascular diseases.…”
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The Role of Leukotriene Receptor Signaling in Inflammation and Cancer by Ramin Massoumi, Anita Sjölander

“…In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT1 receptor signaling pathway. In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.…”
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Plakoglobin: Role in Tumorigenesis and Metastasis by Zackie Aktary, Manijeh Pasdar

“…However, unlike β-catenin that has well-documented oncogenic potential through its involvement in the Wnt signaling pathway, plakoglobin generally acts as a tumor/metastasis suppressor. …”
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The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure by Lili Yu, Zhiwei Feng

“…More and more emerging data indicate that TLR signaling pathway molecules are involved in the progression of HF. …”
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How does chronic pain lead to memory loss? by Suelen Pereira, Ivan Tomsic, Robson da Costa, Mychael V Lourenco

“…A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.…”
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Stat92E Signaling Following Pre-exposure to Ethanol by Alexandria Wilson, Erica M Periandri, Mackenzie Sievers, Emily Petruccelli

“…Recent animal model research has implicated changes in the conserved JAK/STAT pathway, a signaling pathway classically associated with development and the innate immune system. …”
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Coupling Planar Cell Polarity Signaling to Morphogenesis by Jeffrey D. Axelrod, Helen McNeill

“…The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. …”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…The hERG1/β1 integrin complex in LRs can be dissociated and the downstream signaling pathway can be inhibited by either disrupting LRs through methyl-beta-cyclodextrin (MβCD) or inhibiting cholesterol synthesis by statins. …”
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Muscle metabolism in response to oxidized fish oil feed in juvenile Nile tilapia by Xinyuan Li, Lili Chen, Hua Wen, Xuan Wang, Di Peng, Jianmin Zhang, Yangyang Liu, Ming Jiang, Lixue Dong, Feng Huang, Juan Tian

“…The KEGG pathway enrichment analysis revealed that the major pathways of the differentially abundant proteins were the Wnt signaling pathway, TGF-beta signaling pathway, and proteoglycans in cancer. …”
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Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway by Shangman Xing, Yifan Ma, Bing Song, Bing Song, Min Bai, Kexin Wang, Wenjing Song, Tingting Cao, Chao Guo, Yanying Zhang, Zhandong Wang, Yongfeng Wang, Yongfeng Wang

“…Simultaneously, the Wnt signaling pathway might be a crucial mechanism through which irisin sustains the bone-fat balance in aging BMSCs and mitigates the decline in pluripotency. …”
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