Comparative transcriptomic analysis of primary endometrial cancer and bone metastatic cancer: metastasis-associated genes and abnormal cell cycle regulation by Qinmin Wu, Feng Li, Yunlong Zhang, Siying Li, Chuan Xiang

“…The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicates significant changes in the Hippo signaling pathway, which regulates cell proliferation, and in the cell adhesion signaling pathway. …”
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MRP8/ABCC11 Expression Is Regulated by Dexamethasone in Breast Cancer Cells and Is Associated to Progesterone Receptor Status in Breast Tumors by Mylène Honorat, Aurélia Mesnier, Julie Vendrell, Attilio Di Pietro, Valérie Lin, Charles Dumontet, Pascale Cohen, Léa Payen

“…Thus, GR-signaling pathway involvement could not be excluded in ABCC11 regulation in MCF7 cells. …”
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Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway by Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng

“…The activation relationship between PHD2 and downstream signaling pathways was investigated through gene knockout and overexpression experiments. …”
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Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…The activity of the PI3K/Akt/mTOR signaling pathway was quantified using Western blot, and statistical significance was determined (P < 0.05). …”
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Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lance... by Xiaobo Yan, Simiao Pan, Xiangxiang Suo, Weibin Huang, Tao Li, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong

“…Transcriptomic and metabolomic analyses showed that squalene activated the Wnt/β-Catenin signaling pathway and PI3K-Akt signaling pathway. Western blot results showed that squalene ingestion significantly upregulated Wnt/β-Catenin protein expression and downregulated the Axin protein expression (P < 0.05). …”
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The Protective Role of PGC-1α in Cystitis Glandularis: Mitigating Mitochondrial Injury and Inflammation by Min Chen, Yongbo Tang, Yue Fu, Haiwei Hu, Ende Cui, Zhouliang Wen, Wei Zhong, Jimin Su, Bo Ge

“…Targeting the PGC-1α signaling pathway may offer an effective therapeutic intervention for the clinical management of CG.…”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Western blot and qRT-PCR were used to measure changes in pyrimidine metabolism-related markers and active molecules involved in the AMPK/mTOR signaling pathway. Results. Three AAMRGs, DNMT1, F2R, and GPX3, could independently predict the course of STAD. …”
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Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…Together, this study demonstrates that PAPP-A activates the macrophage signaling pathway (IGF-I/PI3K/Akt), which drives the expression and production of inflammatory cytokines known to contribute to the initiation and progression of ACS. …”
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circRNA Expression Profile in Dental Pulp Stem Cells during Odontogenic Differentiation by Ming Chen, Yeqing Yang, Junkai Zeng, Zilong Deng, Buling Wu

“…Bioinformatic analysis revealed that the Wnt signaling pathway and the TGF-β signaling pathway, as well as the other pathways associated with odontogenic differentiation, were correlated to the differentially expressed circRNAs. hsa_circRNA_104101 was proved to promote the odontogenic differentiation of hDPSCs. …”
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APOC1 knockdown induces apoptosis and decreases angiogenesis in diffuse large B-cell lymphoma cells through blocking the PI3K/AKT/mTOR pathway by Jing Gao, Xiaojuan Lu, Guanglei Wang, Tanling Huang, Zhongyu Tuo, Weiwei Meng

“…Advanced techniques, such as immunofluorescence, TUNEL assay, and immunohistochemical labeling were employed to analyze the effects of APOC1 knockdown on the PI3K/AKT/mTOR signaling pathway and tumor formation in nude mice. Results showed that APOC1 is overexpressed in DLBCL tissues and cells, with high APOC1 levels associated with poor patient prognosis. …”
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TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

“…Mechanistic studies revealed that high TMEM147 expression was linked to the B lymphocyte, antigen response, IL6 signaling pathway, cell cycle, Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling pathway, and myelocytomatosis oncogene (MYC) targets. …”
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Effects of Baicalin on Gout Based on Network Pharmacology, Molecular Docking, and in vitro Experiments by Liu C, Liu W, Lu H, Fan Y, Wang A

“…TNF, VEGFA, MMP9, PTGS2, and TLR4 might be the hub therapeutic target genes. The TLR4/NF-κB signaling pathway might be the foremost pathway in baicalin against gout. …”
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Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis by In-Woon Baek, Jung Woo Rhim, Kyung-Su Park, Ki-Jo Kim

“…Results Neutrophil degranulation and the IL-1 signaling pathway were the shared key processes for the three subgroups. …”
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MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/β-Cateninsignaling Pathway by Xiaohong Wu, Yong Zhang, Junping Guo, Xun Yan, Li Shen, Jianping Zhou, Jun Zhao, Min Zhuang, Zhihong Cao

“…Also, related protein expressions on Wnt/β-catenin signaling pathway were analyzed by Western blot method. …”
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model by Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu

“…Furthermore, the protective mechanisms involving neurogenesis, angiogenesis, and AKT-GSK3β-VEGF signaling pathway were analyzed. Human tissue kallikrein was injected through the tail vein daily starting at 8 h, 24 h, or 36 h after right middle cerebral artery occlusion (MCAO) until the 28th day. …”
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Mechanisms of breast cancer treatment using Gentiana robusta: evidence from comprehensive bioinformatics investigation by Bo Xiong, Xinxin Zhang, Dongzhi Sangji, Lianghong Ni, Mingjie Fan, Beibei Fan

“…Enrichment analysis highlighted the involvement of QJ in breast cancer treatment, primarily through the hsa05200 cancer signaling pathway and the hsa04066 HIF-1 signaling pathway. …”
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RNF138 contributes to cisplatin resistance in nasopharyngeal carcinoma cells by Hangyu Xu, Qing Yin, Linna Fan, Yating Zhao, Biying Song, Qifan Xu, Jie Zhu, Meifen Xu

“…We further indicated that in 5–8 F cells following RNF138 overexpression, some pathways such as PI3K-Akt signaling pathway, human papillomavirus infection and ErbB signaling pathway that have been reported to be associated with NPC progression and cisplatin resistance were significantly enriched. …”
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Transcriptome Analysis of the Effect of Acute Ammonia Stress on <i>Pseudobagrus ussuriensis</i> Liver Tissue by Shun Shi, Xiaohui Sun, Chunnuan Zhang, Chenran Lv, Yajuan Liu, Juan Du, Qian Qi

“…Especially, the phosphatidylinositol 3-kinase/protein kinase B (PI3K-Akt) signaling pathway had the maximum quantity of DEGs in all the three groups. …”
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Expression Profile of Long Noncoding RNAs and Circular RNAs in Mouse C3H10T1/2 Mesenchymal Stem Cells Undergoing Myogenic and Cardiomyogenic Differentiation by Mingshan Li, Zijie Pei, Hongtao Zhang, Jing Qu

“…Moreover, the differentially expressed mRNAs were enriched into 5 significant pathways, including those for focal adhesion, ECM-receptor interaction, PI3K-AKT signaling pathway, PPAR signaling pathway, and Tyrosine metabolism. …”
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A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis by Nasibeh Khayer, Samira Shabani, Maryam Jalessi, Mohammad Taghi Joghataei, Frouzandeh Mahjoubi

“…The results highlighted the “PI3K/AKT/mTOR (PAM) signaling pathway” as a disrupted pathway involved in the metastatic nature of HNSCC. …”
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