Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease by Wenhao Chen, Wanliang Yang, Bin Meng, Xingkun Wang, Heng Duan, Qian Xu, Hao Li

“…KEGG pathway analysis showed that these genes were mainly involved in Parkinson’s disease, oxytocin signaling pathway, calcium ion signaling pathway, AMPK signaling pathway, and glucagon signaling pathway. …”
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High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway by Deliang Xu, Jing Guo, Hongwei Xu

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that UPK3A was involved in the p53 signaling pathway. UPK3A suppressed the activation of p53 signaling pathway, and treatment with Pifithrin-α (an inhibitor of the p53 signaling pathway) or silencing of p53 significantly reversed the effect of UPK3A silencing on the expression of p53, KLF4, ZMAT3, MDM2, and SP1. …”
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Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons by Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba

“…To this end, 3’ mRNA-Seq transcriptome analysis was employed, unexpectedly revealing downregulation of key genes associated with the NOD-like receptor signaling pathway (Irf9, Mapk3, Stat2, Nfkbia, Ikbkg, Rela, Cxcl1, and Traf5), the C-type lectin receptor signaling pathway (Nfkb2, Irf9, Mapk3, Stat2, Nfkbia, Ikbkg, Rela, and Ptgs2), the NF kappa B signaling pathway (Nfkbia, Ikbkg, Nfkb2, Rela, Traf5, Cxcl1, and Ptgs2), and the IL 17 signaling pathway (Nfkbia, Ikbkg, Mapk3, Rela, Traf5, Cxcl1, and Ptgs2). …”
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Integrated transcriptome and metabolome analysis of liver reveals unsynchronized growth mechanisms in blunt-snout bream (Megalobrama amblycephala) by Qi Liu, Xue Zou, Ming Zhao, Qianqian Guan, Zhaoyang Xuan, Lusha Liu, Zexia Gao

“…KEGG and GO enrichment analysis indicated that the DEGs with higher expression level were significantly correlated with insulin signaling pathway, steroid hormone and lipid metabolism related pathway (PPAR signaling pathway and fatty acid degradation). …”
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Fermented Lentinus edodes extract containing α-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice by Xin Hu, Dan Cheng, Yingxia Zhang, Po Li, Xiaoping Wu, Junsheng Fu

“…Further research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling pathway. …”
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. …”
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Brain transcriptome analysis of snakehead (Channa argus) under starvation and satiation conditions and identification of differentially expressed gene response to feeding regulatio... by Xiao-yan Jin, Xiu-mei Chen, Gui-liang Guo, Li Sun, Xue-qin Wu, Yun-jie Lin, Xiao-tian Niu, Yi-di Kong, Min Li, Gui-qin Wang

“…Differential gene functional enrichment analysis revealed that several pathways were highlighted, including PI3K-Akt signaling pathway, adipocytokine signaling pathway, estrogen signaling pathway, melanogenesis, and cyclic adenosine monophosphate (cAMP) signaling pathway in the cultured starvation group and the cultured satiation group. …”
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A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy by Weie Zhou, Xuefeng Zhou, Yuan Zhang, Yuyang Wang, Wenjie Wu, Haojun Zhang, Tingting Zhao, Liang Peng, Hailing Zhao, Ping Li

“…The quercetin, naringenin, kaempferol, and isorhamnetin as key active compounds and the PI3K-Akt signaling pathway, TNF signaling pathway, nonalcoholic fatty liver disease (NAFLD), focal adhesion, rap1 signaling pathway, T cell receptor signaling pathway, MAPK signaling pathway, and insulin resistance as the key molecular mechanisms play important roles in TSF treating DN. …”
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Mechanisms of wogonoside in the treatment of atherosclerosis based on network pharmacology, molecular docking, and experimental validation by Zhaohui Gong, Haixin Yang, Li Gao, Yi Liu, Qingmin Chu, Chuanjin Luo, Liang Kang, Huiqi Zhai, Qiang Xu, Wei Wu, Nan Li, Rong Li

“…Results Predictions were obtained that wogonoside treatment of atherosclerosis has 31 core targets, which are mainly focused on pathways such as Toll-like receptor (TLR) signaling pathway and NF-kappa B (NF-κB ) signaling pathway. …”
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Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese by Jin Yu, Ichraf Mabrouk, Qiuyuan Liu, Yuxuan Zhou, Yupu Song, Jingyun Ma, Fengshuo Liu, Xiangman Hu, Zhiyi Yang, Yuxia Zeng, Jingtao Hu, Yongfeng Sun

“…These DEGs were enriched in Gene Ontology (GO) terms related to the microtubule cytoskeleton, cytoskeleton, cell adhesion, and biological adhesion and the KEGG enrichment analysis suggested that the DEGs were mainly enriched in “MAPK signaling pathway”, “Wnt signaling pathway”, “Calcium signaling pathway”, “Focal adhesion”, “Neuroactive ligand-receptor interaction”, “Melanogenesis”, “mTOR signaling pathway”, “ECM-receptor interaction”, and “TGF-beta signaling pathway” in the two comparison groups. …”
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TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis by Xiang Hu, Jing Zhou, Sha-sha Song, Wen Kong, Yan-Chuan Shi, Lu-Lu Chen, Tian-Shu Zeng

“…However, it is unclear whether AP1 signaling pathway mediates metabolic inflammation in the liver. …”
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The Systematic Analysis of Exercise Mechanism in Human Diseases by Lei Pu, Peng Sun

“…Through analysis, it was found that these DEGs-enriched pathways, such as the VEGF signaling pathway, the Wnt signaling pathway, and the insulin signaling pathway, were all involved in the regulation of various diseases. …”
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Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway by Jia Sun, Jinhua Luo, Yuting Ruan, Liangchang Xiu, Bimei Fang, Hua Zhang, Ming Wang, Hong Chen

“…Moreover, the activation of RAS in 3T3-L1 adipocytes was blocked when we blocked Toll-like receptor 4 (TLR4) signaling pathway using TAK242 or NF-κB signaling pathway using BAY117082. …”
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MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration. by Xingpeng Zhang, Guang Li, Fang Tan, Tao Yu, Chengping Xu, Kai Li, Feng Zhang, Meiyan Zhang, Jian Wang

“…Altering TGFBI levels modulated these effects and the NF-κB signaling pathway, influencing inflammatory cytokine concentrations. …”
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Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p by Biao Wang, Nianjie Zhang, Lin Dai, Yuanwei Zhang, Shuo Yin, Xuefeng Yang

“…Knockdown of FRK promoted NP-induced EMT in CRC cells and activated the WNT/β-catenin signaling pathway, while overexpression had the opposite effect. …”
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B-doped nano-hydroxyapatite facilitates proliferation and differentiation of osteoblasts by Qiao Kang, Wenhao Wang, Shengtao Wu, Ganggang Hu

“…B-nHAp boosted the activity of the Wnt/β-catenin signaling pathway. Conclusion B-nHAp modulates the Wnt/β-catenin signaling pathway to significantly enhance the proliferative and differential abilities of osteoblasts, potentially as an efficient material for bone repair.…”
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Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy by Qingchao Shang, Qingchao Shang, Pei Zhang, Xiao Lei, Lehui Du, Baolin Qu

“…Recently, the promising therapeutic potential of CSF-1/CSF-1R signaling pathway inhibition in cancer treatment is widely used. …”
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AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer by Guansong Zheng, Zhaojie Yan, Junrong Zou, Junrong Zou, Junrong Zou, Xiaofeng Zou, Keqiang Chai, Guoxi Zhang

“…Recent studies have identified alterations in the Hippo-YAP signaling pathway within prostate cancer, highlighting intricate crosstalk with the AR signaling pathway. …”
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Study on the role of activation of TGF-β pathway by ASPN in the occurrence and development of keloid and the underlying mechanisms by XU Xueyan, CHEN Junyi, YAO Liuyi, DENG Chengcheng

“…[Conclusion] ASPN promotes the development of keloid by activating TGF-β signaling pathway.…”
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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT... by Huizhen Xing, Xinwei Bai, Xiaoying Pei, Yuqi Zhang, Xueying Zhang, Shujun Chen, Dan Li, Bin Lv, Xiaoying Wang, Xiaoli Wu

“…In summary, CHSe NPs synergistically exert antioxidant and anti-inflammatory effects by regulating the MAPK signaling pathway and PI3K-Akt signaling pathway, showing enormous potential in the treatment of ALI. …”
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