L-Borneol 7-O-[β-D-Apiofuranosyl-(1→6)]-β-D-Glucopyranoside Alleviates Myocardial Ischemia-Reperfusion Injury in Rats and Hypoxic/Reoxygenated Injured Myocardial Cells via Regulating the PI3K/AKT/mTOR Signaling Pathway by Ziyi Tong, Gaowen Li, Chengxiao Su, Liyan Zhou, Ling Zhang, Qun Chen, Qing Xia

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Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia/repe... by Rulin Mi, Huifeng Cheng, Rui Chen, Bo Bai, An Li, Fankai Gao, Guofang Xue

Subjects: “…nuclear factor kappa-light-chain-enhancer of activated b-cell signaling pathway…”
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Mechanosensitive molecular interactions in atherogenic regions of the arteries: development of atherosclerosis by E. L. Mishchenko, A. M. Mishchenko, V. A. Ivanisenko

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Exploring the inhibitory effect and mechanism of isorhamnetin therapy on oral squamous cell carcinoma based on network pharmacology and molecular docking by YU Fangfang, ZHOU Jingjing, YANG Jie, QU Huijuan, HUI Guangyan

Subjects: “…isorhamnetin|oral squamous cell carcinoma|pi3k/akt signaling pathway|src tyrosine kinase|estrogen receptor-1|network pharmacology|molecular docking|experimental verification <i>in vitro</i>…”
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Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with r... by Madhu Dyavaiah, Chella Perumal Palanisamy, Tewin Tencomnao, Siriporn Chuchawankul, Phaniendra Alugoju, Naga Venkata Anusha Anthikapalli, Anchalee Prasanskulab, Selvaraj Jayaraman

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PiERF1 regulates cold tolerance in Plumbago indica L. through ethylene signalling by Zi-An Zhao, Yi-Rui Li, Ting Lei, Cai-Lei Liu, Qing-Xiao Zeng, Xuan Liu, Li-Juan Yang, Jia-Ni Li, Su-Ping Gao

Subjects: “…Ethylene signalling pathway…”
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The transcription factor dFOXO controls the expression of insulin pathway genes and lipids content under heat stress in <i>Drosophila melanogaster</i> by M. A. Eremina, P. N. Menshanov, O. D. Shishkina, N. E. Gruntenko

Subjects: “…insulin/insulin-like growth factors signaling pathway…”
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Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis by Rongjie Zhang, Xin Zhang, Xuhui Zhu, Tao Li, Yansheng Li, Peng Zhang, Yuanhao Chen, Gao Li, Xiuwu Han

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Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Therapeutic Effects of Capsaicin on Lipopolysaccharide-Induced Acute Lung Injury by Peihui Liu, Jindou Hao, Jie Zhao, Rong Zou, Juan Han, Jia Tian, Wanqu Liu, Hao Wang

“…Thus, our findings demonstrated that Cap has the therapeutic effect on LPS-induced acute lung injury in neonatal rats via suppression of the TNF signaling pathway and IL-17 signaling pathway.…”
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Heme Oxygenase 1/Peroxisome Proliferator-Activated Receptor Gamma Pathway Protects Intimal Hyperplasia and Mitigates Arteriovenous Fistula Dysfunction by Regulating Oxidative Stres... by Tingfei Xie, Yunpeng Xu, Lecai Ji, Xiaolu Sui, Aisha Zhang, Yanzi Zhang, Jihong Chen

“…These DEmRNAs were significantly enriched in the PPAR signaling pathway, AMPK signaling pathway, glucagon signaling pathway, IL-17 signaling pathway, and Toll-like receptor signaling pathway. …”
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Bioinformatics Analysis for Identifying Differentially Expressed MicroRNAs Derived from Plasma Exosomes Associated with Radiotherapy Resistance in Non-Small-Cell Lung Cancer by Lirong Zeng, Guilin Zeng, Zhong Ye

“…KEGG enrichment analysis showed that target genes were significantly enriched in the Ras signaling pathway and associated with endocytosis. Among the 135 identified target genes of miR-92a-3p, 4 were involved in the PI3K-Akt signaling pathway (the downstream pathway of the Ras gene) and 3 in the cAMP signaling pathway (the upstream pathway of the Ras gene). …”
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Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking by Yongxiang Liu, Jinhai Luo, Maninder Meenu, Baojun Xu

“…The network pharmacology analysis revealed that the essential oil components may combat obesity through the Wnt signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, prolactin signaling pathway, and cAMP signaling pathway, etc. …”
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Effects of Ginsenoside Rg1 Regulating Wnt/β-Catenin Signaling on Neural Stem Cells to Delay Brain Senescence by Yue Xiang, Shun-he Wang, Lu Wang, Zi-ling Wang, Hui Yao, Lin-bo Chen, Ya-ping Wang

“…This is a study on the relationship between the protective effect of ginsenoside Rg1 on senescent neural stem cells and Wnt-β/catenin signaling pathway. Background. Recent studies have shown that overactivation of the Wnt/β-catenin signaling pathway is closely related to stem cell senescence. …”
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Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits by Jie Wu, Jiamin Zhai, Haofan Jia, Ifeanyi Solomon Ahamba, Xianggui Dong, Zhanjun Ren

“…Target genes of DEMs were mainly enriched in MAPK signaling pathway, Wnt signaling pathway, ECM-receptor interaction and Signaling pathways regulating pluripotency of stem cells. …”
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Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study by Shaozhe Cai, Bingxia Ming, Cong Ye, Shengyan Lin, Peng Hu, Jungen Tang, Fang Zheng, Lingli Dong

“…We also identified the potential regulatory effects of the WNT signaling pathway, the TGF-β signaling pathway, the FcεRI signaling pathway, and the ERBB signaling pathway on modifying the SFs’ functional state. …”
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VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis by Genxiang Rong, Zhenyu Zhang, Wenjing Zhan, Minnan Chen, Jingjing Ruan, Cailiang Shen

“…The mitogen-activated protein kinase (MAPK) signaling pathway plays an essential role in OA. To address the lack of studies focused on synovial cells in OA, we evaluated the expression patterns and roles of the MAPK signaling pathway components in OA synovial tissues using bioinformatics. …”
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NEIL3 and TOP2A as key drivers of esophageal cancer through WNT signaling by Hui Li, Panpan Wang, Huijuan Chen, Yanyan Shao, Hui Luo

“…Both NEIL3 and TOP2A acted through the WNT signaling pathway. In vivo, NEIL3 knockdown reduced tumor size and weight via WNT pathway modulation. …”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…Functional enrichment analysis highlighted several inflammation-related pathways, such as cytokine-mediated signaling pathway, CXCR chemokine receptor binding, NF-kappa B signaling pathway, TNF signaling pathway, and IL-17 signaling pathway. …”
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Mining Potential Drug Targets and Constructing Diagnostic Models for Heart Failure Based on miRNA-mRNA Networks by Xiangming Fang, Rensheng Song, Jiaxing Wei, Qin Liao, Zhenhong Zeng

“…The GEO dataset was used to screen 66 differentially expressed miRNAs, incorporating 56 downregulated miRNAs and 10 upregulated miRNAs. The JAK-STAT signaling pathway, MAPK signaling pathway, p53 signaling pathway, Prolactin signaling pathway, and TGF-beta signaling pathway were enriched, as shown by KEGG enrichment analysis on the target genes. …”
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Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…Furthermore, KEGG pathway enrichment analysis revealed significant enrichment in the p53 signaling pathway and several other pathways. Notably, the Wnt signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, and AMPK signaling pathway are implicated in the metabolic processes of glucose dysregulation and lipid homeostasis, as well as the pathogenesis of hypertension associated with OSAHS. …”
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