Deer antler velvet (Cervus elaphus sibiricus) promotes fracture healing via partial BMP2-Smad mediated osteoblast differentiation by Ji Hyang Gu, Min-Young Chae, Jeong June Choi, Thanh Chu Duc, Chang Gue Son, Eun-Jung Lee

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Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

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Multi-omics reveals the mechanism of Trimethylamine N-oxide derived from gut microbiota inducing liver fatty of dairy cows by Chenlei Li, Feifei Wang, Yongxia Mao, Yanfen Ma, Yansheng Guo

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Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice by Qin Wang, Baijun Qin, Han Yu, Jiawei Zeng, Jingjing Fan, Qiong Wu, Rong Zeng, Haichun Yu, Xian Zhang, Mingfen Li, Yanying Zhou, Limei Diao

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Modeling extracellular matrix through histo-molecular gradient in NSCLC for clinical decisions by Camila Machado Baldavira, Tabatha Gutierrez Prieto, Juliana Machado-Rugolo, Juliana Machado-Rugolo, Jurandir Tomaz de Miranda, Lizandre Keren Ramos da Silveira, Ana Paula Pereira Velosa, Walcy Rosolia Teodoro, Alexandre Ab’Saber, Teresa Takagaki, Vera Luiza Capelozzi

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Bibliometric analysis of pyroptosis in pathogenesis and treatment of acute lung injury by Chun Wang, Na Liu

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LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers by Xin Hu, Yong Wang, Sijia Zhang, Xiaosi Gu, Xiaoyu Zhang, Lianlian Li, Lianlian Li

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Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway by Lina Zhao, Hongjuan Cao, Yao Yuan, Chunyan Liao, Dan Huang, Xiaoyi Li, Yueyao Zhao, Quanfeng Huang, Sha Li, Bei Zhang

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High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis by Yifei Song, Xiaoni Wang, Haoyu Zhang, Rui Ma, Yiting Kang, Xiaohui Di, Zeguo Feng, Can Ni, Fadong Zhao, Hongwei Zhuang, Jianbao Zhang

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Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

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RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway by Yufang Ni, Hongmin Zhang, Qianwen Xian, Wenjie Qin, Hongwei Su, Li Wang, Jianchun Li

“…In terms of mechanism, Circ1647 may mediate the PI3K/AKT Signaling Pathway as demonstrated by the balance of the phosphorylation of PI3K and AKT in vivo and the aggravated phosphorylation of PI3K and AKT in vitro. …”
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Sunitinib Reduced the Migration of Ectopic Endometrial Cells via p-VEGFR-PI3K-AKT-YBX1-Snail Signaling Pathway by Xiaodan Fan, Yanyan Tong, Yiting Chen, Yichen Chen

“…To confirm this signaling pathway, VEGF165 was added to the sunitinib group to upregulate the expression of VEGFR. …”
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Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway by Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi

“…This may be attributable to the specific ability of HA-CUR NPs to target the CD44 receptor and activate the Keap1/Nrf2/HO-1 signaling pathway, suggesting a potential mechanism. In summary, this study revealed that HA-CUR NPs, which are composed of a natural product and biomacromolecules with outstanding artificial antioxidant enzyme activities, may be novel agents for effectively and safely treating uveitis and other ROS-related diseases.…”
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Trim13‐induced ubiquitination of RPS27A inhibits the progression of lung cancer by depending on the inactivation of NF‐κB signaling pathway by Lailing Li, Hui Zhou, Yayun Cui, Ke Xu

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Group 2 Innate Lymphoid Cells Participate in Renal Fibrosis in Diabetic Kidney Disease Partly via TGF-β1 Signal Pathway by Cuiping Liu, Ludan Qin, Jingya Ding, Luping Zhou, Chenlin Gao, Ting Zhang, Man Guo, Wei Huang, Zongzhe Jiang, Yang Long, Yong Xu

“…ILC2s may participate in renal fibrosis in DKD partly via TGF-β1 signal pathway.…”
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Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway by Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen

“…In conclusion, our data firstly demonstrated that the anti-inflammatory effects of V. axillare against ALI were achieved through downregulation of the NF-κB signaling pathway, thereby reducing the production of inflammatory mediators.…”
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Bioinformatics Analysis of miRNAs Targeting TRAF5 in DLBCL Involving in NF-κB Signaling Pathway and Affecting the Apoptosis and Signal Transduction by Chunyao Li, Lanshan Huang, Yongqin Wen, Muhua Yi, Min Gao

“…Subsets of miRNAs may participate in the NF-κB signaling pathway by co-targeting TRAF5 and could be prospective biomarkers exploring the pathogenesis of DLBCL.…”
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Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway by Xiaokang Wang, Xiaokang Wang, Chunxiao Ye, Xixiao Yang, Maoxun Yang, Maoxun Yang, Maoxun Yang

“…Finally, in vitro findings in Caco-2 cells treated with OMVs from the ceftriaxone-associated dysbiotic group suggested that Nrf2 translocation into the nucleus induced high expression of P-gp.ConclusionOMVs from intestinal bacterial in the ceftriaxone-associated dysbiotic group induced high P-gp expression by regulating the Nrf2 signalling pathway, which led to an in vivo reduction in the bioavailability of voriconazole due to ceftriaxone-associated dysbiosis.…”
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RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel by Jialin Yuan, Cong Liu, Chengwei Jiang, Ning Liu, Zhaoying Yang, Hua Xing

“…Our research validated the synergistic effects of PTX and RSL3 both in vivo and in vitro, with RSL3 inducing ferroptosis by activating the NF-κB signalling pathway, thereby increasing the chemosensitivity of TNBC to PTX. …”
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Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis by Tian Yu, Feng Xiaojuan, Liu Jinxi, Miao Xinyan, Xu Jie, Tian Yuexin, Liu Qingjuan, Zhang Wei, Gu Cunyang, Huang Jie, Wu Lunbi, Zhao Hang, Liu Shuxia, Guo Huifang

“…These results suggested that extracellular HMGB1 might involve in GEC injury by activating the TLR4/MyD88 signaling pathway in LN, which provided novel insights and potential therapeutic target for the treatment of lupus nephritis.…”
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