Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models by Yang Mou, Yan Zhang, Yuxian Zheng, Guang He, Zhi‐Xiang Xu, Xiao Xiao, Yong Ping

Get full text

Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway by Yue He, Chao Huang, Jingjing Chen, Weizeng Shen

“…Aims of the study: To investigate the regulatory mechanism of Caesalpinia sappan L. ethyl acetate extract (CSEAE) on angiogenesis in atherosclerosis (AS) based on the miR-126/VEGF signalling pathway. Materials and methods: Our study first screened for differentially expressed microRNAs (miRNAs) associated with AS using the Gene Expression Omnibus (GEO) public database at the National Center for Biotechnology Information (NCBI) and R language software. …”
Get full text

Inhibition of growth of colorectal cancer patient-derived subcutaneous xenografts using combined Wnt signaling pathway inhibitor and 5‑fluorouracil by A. S. Goncharova, A. V. Galina, D. V. Khodakova, G. Yu. Egorov, A. Yu. Maksimov, E. N. Kolesnikov, E. F. Komarova, A. A. Kiblitskaya, E. V. Zaikina, L. Z. Kurbanova, M. V. Mindar

Subjects: Get full text

Melatonin improves endometrial receptivity and embryo implantation via MT2/PI3K/LIF signaling pathway in sows by Xue Qin, Menghao Yang, Yang Yu, Xiaolin Wang, Yi Zheng, Rui Cai, Weijun Pang

Get full text

Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…YAP knockdown via siRNA transfection reversed these effects, increasing IL-1β and TNF-α levels (P < 0.01) while significantly reducing HIF-1α expression (P < 0.05).Conclusion: This study demonstrated that DMOG reduces inflammatory cytokine expression in hPDLSCs by stabilizing HIF-1α and activating the YAP signaling pathway. These findings provide a mechanistic basis for targeting the HIF-1α/YAP axis to control periodontal inflammation and support the potential of PHD inhibitors as therapeutic agents for periodontitis.Keywords: periodontitis, HIF-1α, YAP, DMOG, inflammation…”
Get full text

Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis by Nan Zhang, Wenli Yue, Bihang Jiao, Duo Cheng, Jingjing Wang, Fang Liang, Yingnan Wang, Xiyue Liang, Kunkun Li, Junwei Liu, Yadong Li

“…This study aimed to explore JAK-STAT signaling pathway related genes in CRC and establish a new prognostic model. …”
Get full text

Polysaccharides of St. John’s Wort Herb Stimulate NHDF Proliferation and NEHK Differentiation via Influence on Extracellular Structures and Signal Pathways by S. Abakuks, A. M. Deters

Get full text

The involvement of CgCaspase-3 in regulating the expressions of proinflammatory cytokines through NF-κB/Rel signaling pathway in oysters by Zihan Wang, Xiaopeng Li, Jiejie Sun, Shuyi Mu, Wei Wu, Renle Chang, Lingling Wang, Linsheng Song

“…These results indicated that CgCaspase-3 was involved in regulating bacteria-induced inflammation through NF-κB/Rel signaling pathway.…”
Get full text

Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice by Hao Liu, Yiwen Li, Yujiao Zhu, Lei Ma, Haibo Xue

“…To investigate whether the Notch signaling pathway participates in the occurrence and development of experimental autoimmune thyroiditis (EAT) by affecting the differentiation and function of Th17 cells. …”
Get full text

Effect and Mechanism of Action of Pushing Method on Rats with Skeletal Muscle Overuse Injury based on Wnt/β-catenin Signaling Pathway by DUAN Miaomiao, HUANG Bo, RUAN Lei, MU Pangpang, CHEN Yiming, PENG Liang

“…ObjectiveTo observe the effect of pushing method on the repair and regeneration of rats with overuse injury of skeletal muscle, and to explore its mechanism of action based on Wnt/β-catenin signaling pathway.MethodsForty-two rats were selected and divided into blank group, model group and intervention group according to randomized table method, with 14 rats in each group. …”
Get full text

Constructing adverse outcome pathway for per- and polyfluoroalkyl substances and retinoblastoma based on PI3K-AKT/MAPK signaling pathway by Yuyan GUI, Tingji WANG, Minghao WANG, Yaqi XU, Yunhui ZHANG

Subjects: Get full text

Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…Conversely, TOCP stimulated the mTOR signaling pathway, enhancing phosphorylation of downstream proteins S6K, RHOA, and PKC, consequently promoting immune responses. …”
Get full text

Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI3K/mTOR Signaling Pathway by Dandan Chai, Guoyu Wang, Ziyu Zhou, Hanyan Yang, Zhiwen Yu

“…Taken together, our study suggests that insulin upregulates SESN2 content via the PI3K/mTOR signaling pathway and this effect is attributed to decreased SESN2 degradation. …”
Get full text

FKBP4 Accelerates Malignant Progression of Non-Small-Cell Lung Cancer by Activating the Akt/mTOR Signaling Pathway by Wen Meng, Jingfei Meng, Hong Jiang, Xing Feng, Dongshan Wei, Qingsong Ding

“…Furthermore, FKBP4 can promote Akt and mTOR phosphorylation and activate the Akt/mTOR signaling pathway and an mTOR inhibitor can neutralize the functions of FKBP4 in NSCLC cells. …”
Get full text

ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation by Marco Túlio R. Gomes, Erika S. Guimarães, Erika S. Guimarães, Sergio C. Oliveira, Sergio C. Oliveira, Sergio C. Oliveira

Get full text

Laxative Effect of Lacticaseibacillus rhamnosus Glory LG12: from the Perspective of the Stem Cell Factor/C-kit Signaling Pathway by XIANG Fangqin, LI Yuxing, LI Bailiang

Subjects: “…lacticaseibacillus rhamnosus glory lg12; constipation; laxative effect; inflammatory cytokines; gastrointestinal regulatory peptides; stem cell factor/c-kit signaling pathway…”
Get full text

Familial Exudative Vitreoretinopathy-Related Disease-Causing Genes and Norrin/β-Catenin Signal Pathway: Structure, Function, and Mutation Spectrums by Hongtao Xiao, Yuna Tong, Yuxuan Zhu, Min Peng

“…Four of the identified disease-causing genes of FEVR were NDP, FZD4, LRP5, and TSPAN12, the protein coded by which were the components of the Norrin/β-catenin signal pathway. In this review, we summarized and discussed the spectrum of mutations involving these four genes. …”
Get full text

Corrigendum to “Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways” by Rui Teng, Yanmeng Wang, Nan Lv, Dan Zhang, Ramone A. Williamson, Lei Lei, Ping Chen, Li Lei, Baiyan Wang, Jiaqi Fu, Xuna Liu, Aili He, Jinsong Hu, Michael O’Dwyer

Get full text

Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway by Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren

“…In conclusion, our data identify that GB could be a potential novel therapeutic agent to block vessel injury-associated vascular remodeling and further restenosis and show significant repression of Tgfβ1/Smad signaling pathway.…”
Get full text

Retracted: Rhein Inhibits NF-κB Signaling Pathway to Alleviate Inflammatory Response and Oxidative Stress of Rats with Chronic Glomerulonephritis by Applied Bionics and Biomechanics

Get full text