Comparative transcriptome analysis reveals the key role of photosynthetic traits in the formation of differences in photothermal sensitivity in tobacco by Yanfeng Zheng, Qiwei Yu, Anbin Lu, Xiue Chen, Kai Yang, Jingyao Zhang, Ying Huang, Renxiang Liu

“…In the photosynthesis and plant hormone signaling pathways, genes such as Lhcb, aldo, AUX/IAA, and SAUR were significantly upregulated. …”
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How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health by Ayazhan Akhatova, Celine Jones, Kevin Coward, Marc Yeste

“…DNA methylation is correlated with alterations in sperm quality and the ability to fertilise oocytes, possibly via a differentially regulated MAKP81IP3 signalling pathway. Paternal exposure to toxic endocrine-disrupting chemicals (EDCs) is also linked to the transgenerational transmission of increased predisposition to disease, infertility, testicular disorders, obesity, and polycystic ovarian syndrome (PCOS) in females through epigenetic changes during gametogenesis. …”
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RNA-Binding Proteins and Alternative Splicing Genes Are Coregulated in Human Retinal Endothelial Cells Treated with High Glucose by Hongran Zhao, Hui Kong, Bozhao Wang, Sihui Wu, Tianran Chen, Yan Cui

“…The regulatory network between identified RBPs and RASGs suggests the presence of several signaling pathways possibly involved in the pathogenesis of DR. …”
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Exploring the Mechanism of Antioxidant Action of Bitter Almond Based on Network Pharmacology and Molecular Docking Techniques by Xuehua Feng, Jingya Niu, Zurong Song, Ali Tao, Rumin Zong, Wenqing Pei, Panpan Gong

“…The targets regulated by their main active ingredients were intersected with oxidative targets, and 53 intersected targets were obtained by Venn diagram, with key targets involving NR3C2, NCOA2, MAOA, ADRA2A, and CHRM1; GO analysis yielded 3616 GO entries, including 2821 biological process (BP) entries, 316 cellular component (CC) entries, and 479 molecular function (MF) entries, and 184 signalling pathways were obtained from KEGG pathway enrichment screening. …”
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Transcriptome sequencing reveals jasmonate playing a key role in ALA-induced osmotic stress tolerance in strawberry by Yan Zhong, Xin Wei, Jianting Zhang, Liangju Wang

“…Transcriptome analysis showed that the differentially expressed genes (DEGs) stimulated by exogenous ALA were mostly associated with the secondary biosynthesis and hormones signaling pathways, especially jasmonates (JAs). The JA derivative (+)-7-iso-jasmonoyl-L-isoleucine (JA-Ile) was found to be elevated in the strawberry leaves and roots treated with ALA under PEG stress. …”
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Chromosome Numbers and Reproductive Life Cycles in Green Plants: A Phylotranscriptomic Perspective by Rijan R. Dhakal, Alex Harkess, Paul G. Wolf

“…We found expansions in gene families related to developmental regulation, signaling pathways, and stress responses across heterosporous groups. …”
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Analyzing exosomal miRNA profiles in tetralogy of fallot fetuses’ amniotic fluid by Hainan Yang, Yadan Li, Qiuyue Chen, Shangqing Li, Yiru Yang, Guorong Lyu

“…Notably, 25 of these miRNAs were previously reported to be regulated by both Notch and Wnt signaling pathways, which are critical to heart development. …”
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Role of Hyperbaric Oxygen Therapy in Prostate Tumor Microenvironment and Cancer Stem Cell Niche by Pranathi Konda, Merrel Holley, Vinoth Kumar Lakshmanan

“…We have succinctly captured the multifaceted role of HBOT in modifying the TME and comprehensive overview focuses on the advanced approaches to eliminate prostate cancer stem cells (PCSCs) and exploration of their role in anti-androgen resistance, as well as stemness-related signaling pathways and growing body of evidence supporting the potential benefits of HBOT in prostate cancer treatment. …”
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Evaluation of the Anti-Cancer Effect of TRAF2 and NCK In teracting Protein Kinase (TNIK) Inhibition in Breast Cancer Cells by Kaan Furkan Hamarat, Gamze Güney Eskiler, Selin Zeynep Özçelik, Süleyman Kaleli

“…Conclusion: The results demonstrate that NCB-0846 induces changes in the mRNA levels of the NFKB1 and TNFA genes, which are associated with inflammatory signalling pathways in MCF-7 cells. However, further molecular analyses are necessary to clarify the effect of NCB-0846 on inflammation in breast cancer and other cancer types.…”
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Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…Several previous studies mentioned that protein tyrosine phosphatase 1B (PTP1B) acted as a negative regulator of the insulin signal pathway and played a significant role in the inflammation process. …”
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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…KEGG analysis suggested that EERM's mechanism may involve signaling pathways such as PI3K-Akt, lipid and atherosclerosis, EGFR tyrosine kinase inhibitor resistance, and MAPK pathways. …”
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The interaction of Adipose Derived Stem Cells and Breast Cancer by Natasha Cunningham, Ava O'Meara, Cathy L. Brougham

“…MicroRNAs have been linked to gene regulation essential in oncogenic, and tumour suppression as well as cell signalling pathways in BC. Aim: To research the hypothesis of ADSCs and their therapeutic properties in BC patients. …”
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Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis by Zhang Q, Zhao YX, Li LF, Fan QQ, Huang BB, Du HZ, Li C, Li W

“…As key mediators of MetS, metabolic adipokines such as leptin, lipocalin, and resistin regulate inflammation and bone metabolism through distinct or synergistic signaling pathways. Their modulation of inflammatory responses and bone remodeling processes plays a critical role in the pathogenesis and progression of OA. …”
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Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice by Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo

“…These findings confirmed that conditional knockdown of hepatic PCSK9 attenuates liver inflammation following hyperlipidemia induction by modulating multiple signaling pathways; this suggests that targeting PCSK9 knockdown/inhibition with appropriate agents is useful not only for treating hyperlipidemia but also for ameliorating hyperlipidemia-induced liver inflammation.…”
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Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…Non-covalent protein-protein interactions are one of the most fundamental building blocks in cellular signalling pathways. Despite this, they have been historically hard to identify using conventional methods due to their often weak and transient nature. …”
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Machine learning-random forest model was used to construct gene signature associated with cuproptosis to predict the prognosis of gastric cancer by Xiaolong Liu, Pengxian Tao, He Su, Yulan Li

“…GSEA and GSVA results indicated that high risk patients with GC were mainly associated with the enrichment of ANGIOGENESIS and TGF_BETA_SIGNALING pathways. Finally, EFNA4 expression in GC was significantly higher than that in normal tissues, and patients with GC and high EFNA4 expression exhibited improved prognosis. …”
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Identifying Key Biomarkers Related to Immune Response in the Progression of Diabetic Kidney Disease: Mendelian Randomization Combined With Comprehensive Transcriptomics and Single-... by Hu M, Deng Y, Bai Y, Zhang J, Shen X, Shen L, Zhou L

“…In addition, we also conducted gene enrichment analysis to explore the complex network of potential signaling pathways that may regulate these key genes. Finally, we identified the effectiveness and reliability of these selected key genes through RT-qPCR in the DKD mice model.Conclusion: Our results indicated that the AKT2, IL2RB, NRXN3, SLIT3, and TBPL1 genes are closely related to DKD, which may be useful in the diagnosis and therapy of DKD.Keywords: Mendelian randomization analysis, diabetic kidney disease, clinical correlated genes, biomarker, immune cell infiltration…”
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Effects of IGF-1 on IK and IK1 Channels via PI3K/Akt Signaling in Neonatal Cardiac Myocytes by Richard M. Millis, Zikiar V. Alvin, Aiqiu Zhao, Georges E. Haddad

“…Failure of LY294002 to effectively antagonize IGF-1 induced decrements in IK1 suggests that a signal pathway adjunct to PI3K/Akt contributes to IGF-1 protection against arrhythmogenesis in these myocytes. …”
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Pyriproxyfen, villain or good guy? A brief review by Andressa Pereira Cabral, Fabrício Pereira dos Santos Maia, D’Angelo Carlo Magliano, Jones Bernardes Graceli, Paula Soares, Eduardo Andrés Rios Morris, Leandro Miranda-Alves

“…Amphibians, for instance, display altered reproductive physiology and developmental abnormalities due to disruptions in endocrine signaling pathways caused by PPF. The ecological ramifications of PPF extend beyond direct toxicity to non-target species. …”
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Review: cell mechanisms in the control of inflammatory foundations of obesity and secondary metabolic disorders by Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham

“…Curcumin is a promising therapeutic approach in regulating inflammatory disease through the modulation of key disease mediators, such as pro- and anti-inflammatory cytokines, microRNAs (miRNAs) responsible for gene expression, and intracellular signalling pathways. Although the potential therapeutic benefits of curcumin are significant, there are several unknowns and limitations to its activity that remain. …”
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