Perspectives on Adipose Tissue, Chagas Disease and Implications for the Metabolic Syndrome by Fnu Nagajyothi, Mahalia S. Desruisseaux, Linda A. Jelicks, Fabiana S. Machado, Streamson Chua, Philipp E. Scherer, Herbert B. Tanowitz

“…T. cruzi infection is associated with an upregulation of signaling pathways such as MAPKs, Notch and cyclin D, and reduced caveolin-1 expression. …”
Get full text

Excessive activation of JAK-STAT signaling contributes to inflammation induced by acute Vibrio infection in shrimp by Hongliang Zuo, Xiya Yang, Youxi Wang, Bangping Hu, Zhiming Zhu, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

“…Uncontrolled immune responses resulting from overactivated cellular signaling pathways, leading to inflammation and tissue injury, are a major cause of death in pathogen-infected individuals. …”
Get full text

Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotoci... by Huan Xiang, Dongxiao Sun-Waterhouse, Chun Cui

“…One mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling pathways. AP is cheaper than AA, thereby representing a favorable source of functional polysaccharides.…”
Get full text

Three anti-inflammatory polysaccharides from Lonicera japonica Thunb.: insights into the structure-function relationships by Yu Liu, Hongjing Dong, Dongxiao Sun-Waterhouse, Wenwen Li, Bin Zhang, Jinqian Yu, Zhichang Qiu, Zhenjia Zheng

“…They exhibited excellent protective effects (in a dose-dependent manner) in lipopolysaccharide-injured RAW264.7 macrophages and CuSO4-damaged zebrafish via reducing NO production and inhibiting the overexpressions of inflammation-related transcription factors, inflammatory proteins and cytokines in the NF-κB/MAPK signaling pathways. Their anti-inflammatory effects varied owing to their different molecular characteristics and chemical compositions. …”
Get full text

Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease by Sitong Yi, Qingwei Cong, Ying Zhu, Qiumin Xu

“…In this review, we comprehensively discussed the roles of MSCs in MAFLD, main signaling pathways of MSCs that affect MAFLD, and mechanisms of MSC-exosomes on MAFLD.…”
Get full text

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics. by Jaime Moreno, Lise Lotte Gluud, Elisabeth D Galsgaard, Henning Hvid, Gianluca Mazzoni, Vivek Das

“…A more comprehensive analysis of the cell-specific ligand-receptor (L-R) interactions could provide pivotal information about signaling pathways in CKD and MASH. To achieve this, we created an integrative analysis framework in CKD and MASH from two available human cohorts.…”
Get full text

Vascular Remodeling in Experimental Hypertension by Norma R. Risler, Montserrat C. Cruzado, Roberto M. Miatello

“…Research focused on new signaling pathways and molecules that can participate in the mechanisms of vascular remodeling has provided evidence showing that vascular structure is not only affected by blood pressure, but also by mechanisms that are independent of the increased pressure. …”
Get full text

Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity by Manfred Kunz, Saleh M. Ibrahim

“…In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been detected. …”
Get full text

Biological Effects of Culture Substrates on Human Pluripotent Stem Cells by Yohei Hayashi, Miho Kusuda Furue

“…We discuss the possible effect of integrin-mediated signaling pathways on maintaining hPSC self-renewal. Activation of integrin-linked kinase (ILK), which transmits ECM-integrin signaling to AKT (also known as protein kinase B), has been shown to be critical in maintaining hPSC self-renewal. …”
Get full text

The role of insulin signaling with FOXO and FOXK transcription factors by Masaji Sakaguchi

“…The insulin receptor depends on the tyrosine phosphatase feedback of insulin signaling to maintain adipocyte insulin responsiveness. α4, a regulatory subunit of protein phosphatase 2A (PP2A), has been shown to play a crucial role in modulating insulin signaling pathways by regulating the phosphorylation status of key proteins involved in these pathways. …”
Get full text

Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…In this study, we aimed to investigate the signaling pathways in TMT-induced microglial activation using BV-2 murine microglial cells. …”
Get full text

The Tao of Hematopoietic Stem Cells: Toward a Unified Theory of Tissue Regeneration by Kevin D. Bunting, Robert G. Hawley

“…Furthermore, characterization of the signaling pathways and molecular determinants regulating the remarkable transdifferentiation capacity of these stem cells may provide insight into novel approaches for modulating frequency of differentiative potential.…”
Get full text

Real-Time Analysis of Endogenous Wnt Signalling in 3D Mesenchymal Stromal Cells by Fatima Saleh, Alice Carstairs, S. Leah Etheridge, Paul Genever

“…The identification of the signalling pathways that regulate MSCs in a 3D in vivo-like environment will advance our understanding of the molecular mechanisms that control MSC fate.…”
Get full text

Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins. by Jessica R Thomas, Jinglang Sun, Juan De la Rosa Vazquez, Amy Lee

“…Our results highlight the complexity whereby Cav2.2 channels integrate G-protein signaling pathways, which may enrich the information encoding potential of chemical synapses in the nervous system.…”
Get full text

Advancing Platelet Research Through Live-Cell Imaging: Challenges, Techniques, and Insights by Yuping Yolanda Tan, Jinghan Liu, Qian Peter Su

“…They swiftly respond to vascular injury by adhering to damaged vessel surfaces, activating signalling pathways, and aggregating with each other to control bleeding. …”
Get full text

Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy by Saima Khatoon, Nida Kalam

“…Curcumin has the propensity to modulate signaling pathways involved in cell survival and manage oxidative stress, apoptosis, and inflammatory mechanisms. …”
Get full text

Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases by Van-Long Truong, Woo-Sik Jeong

“…Tea polyphenols also regulate signaling pathways such as nuclear factor-κB, activator protein 1, signal transducer and activator of transcriptions, and nuclear factor E2-related factor 2, which are associated with IBD development. …”
Get full text

Proteomic Analysis of Exudates from Chronic Ulcer of Diabetic Foot Treated with Scorpion Antimicrobial Peptide by Zhixiang Tan, Zhiguo Yu, Xiaobo Xu, Lanxia Meng, Mosheng Yu, Rui Tao, Yingliang Wu, Zhanyong Zhu

“…In addition, functional annotation, cluster analysis of effects and the analysis of signal pathway, transcription regulation, and protein-protein interaction network were carried out. …”
Get full text

Role of Myokines in Myositis Pathogenesis and Their Potential to be New Therapeutic Targets in Idiopathic Inflammatory Myopathies by Vlad Mageriu, Emilia Manole, Alexandra E. Bastian, Florica Staniceanu

“…Therefore, other signaling pathways that could contribute to the pathogenesis of myositis have been investigated, such as the expression of myokines in skeletal muscle in response to the inflammatory process. …”
Get full text

Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes by Guangxin Yuan, Yu Bai, Yuhang Zhang, Guangyu Xu

“…Using DAVID and KEGG, the functional analysis of differentially expressed genes (GO analysis) and the analysis of signaling pathways were performed. Based on the differentially expressed gene, the transcriptional regulatory element databases (TRED) were integrated to construct the M. tuberculosis pathogenic gene regulatory network, and the correlation of the network genes with disease was analyzed with the DAVID online annotation tool. …”
Get full text