Marfan Syndrome and Autosomal Dominant Polycystic Kidney Disease: A Case of Rare Co-occurrence or Coincidence? by Arjun Sekar

“…Studies have shown that there could be a common signalling pathway for connective tissue disorders when both genes are affected simultaneously. …”
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Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications by Sonal Sharma, Geeta Pandey

“…The findings suggest that triazoles might negatively affect female fertility and embryonic development through multiple mechanisms including inhibition or interference with key enzymes such as CYP17A1 and CYP19A1 (aromatase) involved in steroid hormone synthesis, endocrine disruption, oxidative stress, disruption of signaling pathways, and apoptosis. This review consolidates current knowledge on the teratogenic and embryotoxic properties of triazole fungicides, providing a comprehensive understanding of their health implications and addressing critical research gaps.…”
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Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections by Vibhu Prasad

“…The cell-autonomous UPR is the immediate response of an infected cell to this stress, aiming to restore normal function by halting protein translation, degrading misfolded proteins, and activating signaling pathways that increase the production of molecular chaperones. …”
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TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells by L. Kui, G. C. Chan, P. P. W. Lee

“…Our findings suggest that TSG-6 and its downstream signalling pathway could potentially be targeted to modulate proinflammatory cytokine expression in pDCs.…”
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Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective by Jia-Jun Ju, Li-Hua Hang, Li-Hua Hang

“…Glial cells participate in brain iron metabolism through various mechanisms; meanwhile, iron accumulation exacerbates neuroinflammation by activating inflammatory signaling pathways modulating the functions of inflammatory cells, and so on. …”
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A Review on Colorectal Cancer and the Role of Traditional Chinese Herbal Medicine as Complementary Therapy by Jie Ji, Hiu Ching Phang, Xian Gu, Riyanto Teguh Widodo, Bey Hing Goh, Phei Er Kee, Siew-Keah Lee, Ashok Kumar Janakiraman, Long Chiau Ming, Kai Bin Liew

“…Furthermore, various signalling pathways of CRC and the possible mechanism of TCM intervening in these pathways are also discussed.  …”
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A Network Pharmacology Study on the Cervix Prescription for Treatment of Cervical Cancer by Yingping Zhu, Liangping Wang, Leilai Xu, Pian Ying

“…The CP contains 2 active ingredients, corresponding to 301 nonreactive targets; 10 GO biological process related items and 73 signal pathways were obtained. Cell experiments confirmed that the medicated serum of CP could effectively inhibit the proliferation and invasion ability of Hela cells. …”
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Ketamine-Induced Cystitis: A Comprehensive Review of the Urologic Effects of This Psychoactive Drug by Danyon J. Anderson, Jessica Zhou, David Cao, Matthew McDonald, Maya Guenther, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…The precise pathophysiology of KIC is still unknown but several theories exist, most of which highlight the inflammatory signaling pathways leading to bladder epithelium damage due to presence of ketamine in the urine. …”
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Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties by Varun Jaiswal, Hae-Jeung Lee

“…Mechanistic studies of trifolirhizin showed that it could act on important target genes and pathways such as the NF-κB-MAPK, EGFR-MAPK, AMPK/mTOR, and PI3K/Akt signaling pathways. These pathways are also implicated in various other diseases, suggesting the potential of trifolirhizin in therapeutic applications. …”
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Modulation of miRNAs in Pulmonary Hypertension by Sudhiranjan Gupta, Li Li

“…A single miRNA may influence several signaling pathways associated with cardiac remodeling by targeting multiple genes. …”
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Chain Gangs: New Aspects of Hyaluronan Metabolism by Michael Erickson, Robert Stern

“…Hyaluronan is recognized by membrane receptors that trigger intracellular signaling pathways regulating proliferation, migration, and differentiation. …”
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Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation by Jeeho Kim, Young Jin Jeon, In-Youb Chang, Jung-Hee Lee, Ho Jin You

“…This effect was mediated by the interaction of Ephexin1 with Axin1, a critical component of the β-catenin destruction complex, which in turn enhanced the stability and activity of β-catenin in signaling pathways critical for tumor development. Importantly, our findings also suggest that targeting Ephexin1 may increase the efficacy of Wnt/β-catenin pathway inhibitors in CRC treatment. …”
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Molecular mechanisms of mTOR-mediated cisplatin response in tumor cells by Amirhosein Maharati, Yasamin Rajabloo, Meysam Moghbeli

“…Although, mTOR is mainly activated by PI3K/AKT pathway, it can also be regulated by many other signaling pathways. PI3K/Akt/mTOR axis functions as a key modulator of drug resistance and unfavorable prognosis in different cancers. …”
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The Effect of Sleep Disruption on Cardiometabolic Health by SeokHyun Hong, Da-Been Lee, Dae-Wui Yoon, Seung-Lim Yoo, Jinkwan Kim

“…The NLRP3 inflammasome and NF-κB signaling pathways have been identified as crucial mediators linking sleep disruption to metabolic inflammation. …”
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Single-cell RNA sequencing elucidates cellular plasticity in esophageal small cell carcinoma following chemotherapy treatment by Qinkai Zhang, Qinkai Zhang, Qinkai Zhang, Ziyu Gao, Ru Qiu, Jizhao Cao, Chunxiao Zhang, Wei Qin, Wei Qin, Meiling Yang, Meiling Yang, Xinyue Wang, Ciqiu Yang, Jie Li, Jie Li, Dongyang Yang, Dongyang Yang

“…Further analysis highlighted dynamic interactions between tumor cells andimmune cells, with significant changes detected in key signaling pathways, suchas TIGIT-PVR and MDK-SDC4. This study elucidates the complex dynamics of cellplasticity in SCCE following chemotherapy, providing new insights and identifyingpotential therapeutic targets to enhance treatment efficacy.…”
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The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma by Tim Klüter, Stefanie Fitschen-Oestern, Sebastian Lippross, Matthias Weuster, Rolf Mentlein, Nadine Steubesand, Claudia Neunaber, Frank Hildebrand, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Beyer, Andreas Seekamp, Deike Varoga

“…In the present study we evaluated the lysozyme expression in serum of multiple injured patients and subsequently analyzed their possible sources and signaling pathways. Expression of lysozyme was examined in blood samples of multiple trauma patients from the day of trauma until 14 days after trauma by ELISA. …”
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Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway by Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa

“…However, recent evidence indicates that Ezetimibe inhibits several cancers indirectly by reducing circulating cholesterol or via specific signalling pathways. Methods and Results: Our in silico studies indicate that Ezetimibe binds to the Tp53 binding domain in Mdm2, forming a more thermodynamically stable complex than nutlin3a. …”
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Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product by Avanish Mishra, Shih-Bo Huang, Taronish Dubash, Risa Burr, Jon F. Edd, Ben S. Wittner, Quinn E. Cunneely, Victor R. Putaturo, Akansha Deshpande, Ezgi Antmen, Kaustav A. Gopinathan, Keisuke Otani, Yoshiyuki Miyazawa, Ji Eun Kwak, Sara Y. Guay, Justin Kelly, John Walsh, Linda T. Nieman, Isabella Galler, PuiYee Chan, Michael S. Lawrence, Ryan J. Sullivan, Aditya Bardia, Douglas S. Micalizzi, Lecia V. Sequist, Richard J. Lee, Joseph W. Franses, David T. Ting, Patricia A. R. Brunker, Shyamala Maheswaran, David T. Miyamoto, Daniel A. Haber, Mehmet Toner

“…Paired single-cell DNA and RNA sequencing identifies subclonal patterns of aneuploidy and distinct signaling pathways within CTCs. In prostate cancers, a subpopulation of small aneuploid cells lacking epithelial markers is enriched for neuroendocrine signatures. …”
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Research advances in Pimpinella thellungiana: Nutrients, bioactive compounds, and functional properties benefitting livestock by Shuxian Zhang, Minglu Yang, Tao Xu, Qiongxian Yan, Allan Degen, Xiaoling Zhou

“…The nutrition, metabolism, biological activities, and pharmacological effects of the principal compounds of P. thellungiana in livestock are reviewed, as well as their potential molecular targets and metabolic signaling pathways in which these compounds are involved. …”
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Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications by Gargi S. Sarode, Sachin C. Sarode, Urmi Ghone, Rahul Anand

“…These proteases drive tumor invasion, angiogenesis, and metastasis by degrading extracellular matrix components and modulating signaling pathways. Moreover, OSCC progression is exacerbated by the loss of protease inhibitors, notably membrane-bound serine protease inhibitor HAI-1. …”
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