Discovery of potent allosteric antibodies inhibiting EGFR by Léxane Fournier, Lukas Pekar, Birgitta Leuthner, Harald Kolmar, Lars Toleikis, Stefan Becker

“…Moreover, they are also able to inhibit EGF-induced downstream signaling pathways. In particular, we identified one clone that is more potent than the approved blocking antibody cetuximab in inhibiting both PI3K/AKT and MAPK/ERK pathways. …”
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Implication of protein post translational modifications in gastric cancer by Houji Song, Mingze Zhang, Chengwang Guo, Xi Guo, Yuqi Ma, Yuntao Ma, Yuntao Ma

“…Notably, this review also discusses the phenomenon of PTM crosstalk, highlighting the interactions among PTM and their roles in regulating signaling pathways and protein functions. Therefore, in-depth investigation into the mechanisms of PTM and the development of targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, and prognostic evaluation of GC, offering novel insights and future research directions.…”
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Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health by Liyun Jiang, Xia Song, Li Yan, Yali Liu, Xiumei Qiao, Wen Zhang

“…It focuses on how abnormalities in bone metabolism, autophagy, ferroptosis, and vitamin D receptor (VDR) gene polymorphisms contribute to osteoporosis in T2DM patients.ResultsOur analysis indicates that T2DM is associated with reduced bone formation and increased bone resorption, which are influenced by hormonal changes, inflammation, and disrupted cellular signaling pathways. Additionally, increased perirenal fat thickness worsens osteoporosis through local inflammation and altered adipokine levels. …”
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Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model by Wei Wang, Yunhao Wang, Tengfei Lou, Mingqian Ding, Juehong Li, Hao Xiong, Zhixiao Yao, Yingying Ma, Huajiang Chen, Shenghe Liu

“…It concluded that the CEL-loaded PCL membrane could reduce fibrosis and inflammation in a rat model of FBSS via COX-2/PGE2 signaling pathways.…”
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Switching to faricimab from the current anti-VEGF therapy: evidence-based expert recommendations by Sanjay Sharma, David T Wong, Shaheer Aboobaker, David Maberley, Pradeepa Yoganathan

“…Dual inhibition of the angiopoietin (Ang)/Tie and vascular endothelial growth factor (VEGF) signalling pathways in patients with retinal diseases, such as neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DME), may induce greater vascular stability and contribute to increased treatment efficacy and durability compared with treatments that only target the VEGF pathway. …”
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Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…Specifically, increased leptin and decreased adiponectin levels disrupt homeostatic signaling pathways involved in cell proliferation, survival, cell-cycle regulation, and angiogenesis. …”
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Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase by Yinhua Dong, Hongxin Wang, Zefeng Chen

“…In this study, we found that ALA could activate insulin receptor and PI3K/Akt signaling pathways, inhibit the expression and activity of NADPH oxidase, and subsequently suppress the generation of superoxide and the augment of oxidative stress indicators including MDA, protein carbonylation, and 8-OHdG. …”
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Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms by Jua Kim, Jeremy L. Gilbert, William W. Lv, Ping Du, Haobo Pan

“…Depending on the corrosion rate, Mg modulates HIF1α and many signaling pathways like PI3K/AKT/mTOR, mitophagy, cell cycle, and oxidative phosphorylation. …”
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How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? by Muhammad Babar Khawar, Fareeha Azam, Nadeem Sheikh, Khawaja Abdul Mujeeb

“…It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation. …”
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Engineering extracellular vesicles for ROS scavenging and tissue regeneration by Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim

“…Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. …”
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MicroRNAs in the DNA Damage/Repair Network and Cancer by Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

“…To preserve the genomic integrity, eukaryotic cells need a complex DNA damage/repair response network of signaling pathways, involving many proteins, able to induce cell cycle arrest, apoptosis, or DNA repair. …”
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Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. …”
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IL-18 biology in severe asthma by Sarita Thawanaphong, Sarita Thawanaphong, Sarita Thawanaphong, Aswathi Nair, Aswathi Nair, Emily Volfson, Emily Volfson, Parameswaran Nair, Parameswaran Nair, Manali Mukherjee, Manali Mukherjee

“…This review aims to provide an overview of the current understanding of IL-18 biology, the associated signaling pathways, and the involvement of inflammasome complexes in airway diseases. …”
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Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells by Ahmad Hamad, Zeyad Sahli, Maya El Sabban, Maha Mouteirik, Rihab Nasr

“…This review summarizes recent research done on alternative targeted therapies with a particular focus on some important signaling pathways (such as Alox5, Hedgehog, Wnt/b-catenin, autophagy, and PML) that have the potential to target CML stem cells and potentially provide cure for CML.…”
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Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis by Patrick Coulombe, Elisa Tomellini, Jalila Chagraoui, Nadine Mayotte, Guy Sauvageau

“…This differentiation bias can be driven by pro-inflammatory signaling pathways that are activated downstream of UM171 and results in an abundant mast cell population that can be transplanted as part of the graft to populate mice tissues in xenotransplantation studies.…”
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Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups by Helle Evi Simovart, Andres Arend, Jüri Lieberg, Marina Aunapuu

“…If increase in apoptosis during earlier stages of varicosities is probably regulated by intrinsic pathway, then in older patients other signaling pathways may be involved.…”
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Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis by Jingxue Han, Jingyi Hou, Yu Liu, Peng Liu, Tingting Zhao, Xinwei Wang

“…The mechanism of action may be related to AGE-RAGE, proteoglycans, and IL-17 signaling pathways. Five key targets (IL6, ALB, AKT1, TNF, and VEGFA) may be involved in the treatment of MF using Panax notoginseng. …”
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Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling by Ying Cheng, Man Zhang, Chenguang Li, Long Su, Lingli Fu, Shi Wu, Chaofei Xu, Bei Sun, Liming Chen

“…Additionally, we discover that sodium-glucose cotransporter 2 inhibitors (SGLT2i) could inhibit the AGGF1 signalling pathway early to achieve therapeutic effects. …”
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A Chemically Defined Culture for Tooth Reconstitution by Ziwei Zhang, Hong Hu, Zhiheng Xu, Ce Shan, Hanyi Chen, Kun Xie, Kun Wang, Yifu Wang, Qing Zhu, Yike Yin, Haoyang Cai, Yunqiu Zhang, Zhonghan Li

“…Here, a chemically defined culture system is established that supports tooth reconstitution, further development with normal anatomy, and prompt response to chemical interference in key developmental signaling pathways, termed as toothoids. By using such a system, it is discovered that, during reconstitution, instead of resetting the developmental clock, dental cells reorganized and restarted from the respective developmental stage where they are originally isolated. …”
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Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications by Soroush Fotouhi, Aida Yavari, Amir Reza Bagheri, Vahid Reza Askari, Yazdan Gholami, Vafa Baradaran Rahimi

“…They also possessed antioxidant and anti-inflammatory impacts through regulating mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-κB), and Nrf2 signaling pathways. The obtained data emphasizes their role in protecting against heart, neuropathy, nephropathy, gastrointestinal tract, testicles, and skin diabetic complications. …”
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