Myeloid-Related Protein Activity in Rheumatoid Arthritis by Charles J. Malemud

“…MRPs also activate the signal transduction pathway principally involving the stress-activated/mitogen-activated protein kinases. …”
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Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration by Yang Liu, Chenguang Wang, Guanfang Su

“…This review briefly provides the different signal transduction mechanisms which are underlying Müller cell-mediated neuroprotection and neuron regeneration and discusses recent advances about regeneration from Müller glia-derived progenitors.…”
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Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain by Edoardo Parrella, Valter D. Longo

“…We will focus on the role of yeast signal transduction proteins Ras, Tor, Sch9, Sir2, their homologs in higher organisms, and their association to oxidative stress and protective systems. …”
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Beta-adrenergic blocking agents in cutaneous and oral melanoma by Sivakamavalli Jeyachandran

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Systemic regulation of retinal medium-chain fatty acid oxidation repletes TCA cycle flux in oxygen-induced retinopathy by Almut Heinken, John M. Asara, Gopalan Gnanaguru, Charandeep Singh

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Implications of noncoding RNAs for cancer therapy: Are we aiming at the right targets? by Amil Shah

“…Over the past 30 years, many new drugs, which are primarily aimed at activated oncogenic proteins in signal transduction pathways involved in cell proliferation and survival, have been introduced in the clinic. …”
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Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model by Dimitrios Angelis, Maria Delivoria-Papadopoulos

“…Protein tyrosine phosphatases (PTPs) in conjunction with protein tyrosine kinases (PTKs) regulate cellular processes by posttranslational modifications of signal transduction proteins. PTP nonreceptor type 1B (PTP-1B) is an enzyme of the PTP family. …”
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The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants by Dala N. Daraghmeh, Rafik Karaman

“…The balance between pro-oxidants and antioxidants determines the oxidative status of cells, which affects signal transduction, differentiation, and proliferation. …”
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Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds by Khadijeh Khezri, Solmaz Maleki Dizaj, Yalda Rahbar Saadat, Simin Sharifi, Shahriar Shahi, Elham Ahmadian, Aziz Eftekhari, Elaheh Dalir Abdolahinia, Farzaneh Lotfipour

“…The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.…”
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Research Progress in Diseases Caused by STAT1 Gain-of-Function Mutations by LI Linpeng, MA Jing, GU Hao, SHU Zhou, MAO Huawei

“…Signal transduction and activator of transcription factor 1(STAT1), one of the important members of the STAT family, is a key cytoplasmic transcription factor and an important component of the JAK-STAT signaling pathway. …”
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Fine-tuning SLE treatment: the potential of selective TYK2 inhibition by Yoshiya Tanaka, Shingo Nakayamada, Yurie Satoh-Kanda

“…TYK2 inhibitors, which are involved in the signal transduction of type I interferon and interleukin-12/23 pathways and are linked to disease susceptibility genes in SLE, may have the potential to fine-tune the differentiation and function of immune cells, particularly CD4+ T cells.…”
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Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy by Tom Verfaillie, Maria Salazar, Guillermo Velasco, Patrizia Agostinis

“…ER stress activates a complex intracellular signal transduction pathway, called unfolded protein response (UPR). …”
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Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro by Claudia J. Labrador-Rached, Rebecca T. Browning, Laura K. Braydich-Stolle, Kristen K. Comfort

“…However, lower, subtoxic PtNP concentrations were able to elicit multiple stress responses, secretion of proinflammatory cytokines, and modulation of insulin-like growth factor-1 dependent signal transduction. Taken together, this work suggests that PtNPs would not be overtly toxic for acute exposures, but sustained cellular interactions might produce long term health consequences.…”
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Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation by Yoshikazu Nakaoka, Issei Komuro

“…In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules. …”
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SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…In conclusion, SLC1A4 promotes the malignant transformation of HCC through activating signal transduction mediated by AKT. The findings in this study suggested that SLC1A4 may be a diagnostic indicator for the early HCC and a therapeutic target for the advanced HCC.…”
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Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease by Sitong Yi, Qingwei Cong, Ying Zhu, Qiumin Xu

“…After entering the target cells, MSC-exosomes help regulate cell function and signal transduction; thus, it is expected to become an emerging treatment for MAFLD. …”
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High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period by W. Louis Cleveland, Robert L. DeLaPaz, Rashid A. Fawwaz, Roger S. Challop

“…This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). …”
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Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…One such effort is to identify the signal transduction deficits, for which previous studies have suggested that the central problems appear to be at the interface between G proteins and their coupled receptors. …”
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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment by Tian Z, Wang X, Chen S, Guo Z, Di J, Xiang C

“…Mitochondria, often referred to as the “power plants” of the cell, are essential organelles responsible for critical functions such as energy metabolism, material synthesis, and signal transduction. The functional state of mitochondria is closely linked to macrophage polarization, prompting interest in therapeutic strategies that target mitochondria to regulate this process. …”
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Substance P Increases Cell-Surface Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor): In Vivo Biotinylation of Urothelial Cell-Surface Proteins by Katherine L. Meyer-Siegler, Shen-Ling Xia, Pedro L. Vera

“…Macrophage migration inhibitory factor (MIF), an inflammatory cytokine, and its receptor CD74 are upregulated by bladder inflammation. MIF-mediated signal transduction involves binding to cell-surface CD74, this study documents, in vivo, MIF-CD74 interactions at the urothelial cell surface. …”
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