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  1. 41
    Artificial intelligence propels lung cancer screening: innovations and the challenges of explainability and reproducibility

    Artificial intelligence propels lung cancer screening: innovations and the challenges of explainability and reproducibility by Mario Mascalchi, Chiara Marzi, Stefano Diciotti

    Published 2025-01-01
    “…Signal Transduction and Targeted Therapy…”
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  2. 42
    Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8+T and tumor cells

    Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8+T and tumor cells by Gui-Qi Zhu, Zheng Tang, Tian-Hao Chu, Biao Wang, Shi-Ping Chen, Chen-Yang Tao, Jia-Liang Cai, Rui Yang, Wei-Feng Qu, Yi Wang, Qian-Fu Zhao, Run Huang, Meng-Xin Tian, Yuan Fang, Jun Gao, Xiao-Ling Wu, Jian Zhou, Wei-Ren Liu, Zhi Dai, Ying-Hong Shi, Jia Fan

    Published 2025-01-01
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  3. 43
    Tissue-resident immune cells: from defining characteristics to roles in diseases

    Tissue-resident immune cells: from defining characteristics to roles in diseases by Jia Li, Chu Xiao, Chunxiang Li, Jie He

    Published 2025-01-01
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  4. 44
    Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study

    Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

    Published 2025-01-01
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  5. 45
    Safety and efficacy of trifluridine/tipiracil +/− bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial

    Safety and efficacy of trifluridine/tipiracil +/− bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial by Marion Thibaudin, Nicolas Roussot, Chloé Burlot, Antonin Schmitt, Julie Vincent, Zoé Tharin, Leila Bengrine, Hélène Bellio, Aurélie Bertaut, Léa Hampe, Susy Daumoine, Emilie Rederstorff, Morgane Peroz, Titouan Huppe, Valentin Derangère, David Rageot, John Simard, Caroline Truntzer, Jean David Fumet, Francois Ghiringhelli

    Published 2025-01-01
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  6. 46
    Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use

    Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use by Yu Zhang, Ke Qiu, Jianjun Ren, Yu Zhao, Ping Cheng

    Published 2025-01-01
    “…Signal Transduction and Targeted Therapy…”
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  7. 47
    Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial

    Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

    Published 2025-02-01
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  8. 48
    Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis

    Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis by Benjamin Klein, J. Michelle Kahlenberg, Johann E. Gudjonsson

    Published 2025-02-01
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  9. 49
    Immunotherapy in ovarian cancer: spatial functional genomics to unravel resistance mechanisms

    Immunotherapy in ovarian cancer: spatial functional genomics to unravel resistance mechanisms by Martina Rausch, Karlotta Bartels, Josef Leibold

    Published 2025-01-01
    “…Signal Transduction and Targeted Therapy…”
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  10. 50
    Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, response-adapted study

    Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, resp... by Fei Wang, Yongjiu Wang, Bin Xiong, Zhenlin Yang, Jingfen Wang, Yumin Yao, Lixiang Yu, Qinye Fu, Liang Li, Qiang Zhang, Chao Zheng, Shuya Huang, Liyuan Liu, Chun Liu, Huaibo Sun, Beibei Mao, Dong-Xu Liu, Zhigang Yu

    Published 2025-01-01
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  11. 51
    Digestive cancers: mechanisms, therapeutics and management

    Digestive cancers: mechanisms, therapeutics and management by Tianzuo Zhan, Johannes Betge, Nadine Schulte, Lena Dreikhausen, Michael Hirth, Moying Li, Philip Weidner, Antonia Leipertz, Andreas Teufel, Matthias P. Ebert

    Published 2025-01-01
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  12. 52
    A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive-stage small cell lung cancer

    A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

    Published 2025-01-01
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  13. 53
    Beyond incretins: targeting neurokinin receptors for obesity treatment

    Beyond incretins: targeting neurokinin receptors for obesity treatment by Doreen Thor, Simone Prömel

    Published 2025-01-01
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  14. 54
    Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma

    Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma by Zhong Zheng, Jian-Biao Wang, Rui Sun, Nan Wang, Xiang-Qin Weng, Tian-Yuan Xu, Di Fu, Yan Feng, Peng-Peng Xu, Shu Cheng, Li Wang, Yan Zhao, Bin Qu, Chuan-Xin Huang, Wei-Li Zhao

    Published 2025-01-01
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  15. 55
    Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis

    Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis by Yuan Liu, Wacili Da, Ming-Jie Xu, Chao-Xin Xiao, Tao Deng, Sheng-Liang Zhou, Xiao-Ting Chen, Yao-Jia Zhou, Li Tang, Yong Nie, Yi Zeng, Hui-Qi Xie, Bin Shen

    Published 2025-02-01
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  16. 56
    Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

    Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

    Published 2025-02-01
    “…Signal Transduction and Targeted Therapy…”
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  17. 57
    Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis

    Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis by Lars Koch, Konrad Hoeft, Rafael Kramann

    Published 2025-01-01
    “…Signal Transduction and Targeted Therapy…”
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  18. 58
    Protecting cell cycle integrity: enhanced start-codon stringency in mitosis

    Protecting cell cycle integrity: enhanced start-codon stringency in mitosis by Omid Omrani, Kanstantsin Siniuk, Martin Fischer

    Published 2025-02-01
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  19. 59
    Cancer cell reprogramming: turning the enemy into an ally

    Cancer cell reprogramming: turning the enemy into an ally by Severin Guetter, Kaiji Fan, Hendrik Poeck

    Published 2025-01-01
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  20. 60
    Neutralizing antibody responses to three XBB protein vaccines in older adults

    Neutralizing antibody responses to three XBB protein vaccines in older adults by Guo-Jian Yang, Mei Lu, Rui-Rui Chen, Shuang-Qing Wang, Sheng Wan, Xue-Dong Song, Guo-Ping Cao, Lei Lv, Xue-Juan He, Bing-Dong Zhan, Mai-Juan Ma

    Published 2025-02-01
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