Insights into mungbean defense response to Cercospora leaf spot based on transcriptome analysis by Sukanya Inthaisong, Pakpoom Boonchuen, Tana Jaichopsanthia, Pongpan Songwattana, Apinya Khairum, Witsarut Chueakhunthod, Akkawat Tharapreuksapong, Panlada Tittabutr, Neung Teaumroong, Piyada Alisha Tantasawat

“…KEGG pathway analysis showed that these genes were represented in plant-pathogen interaction, the MAPK signaling pathway, plant hormone signal transduction, and cell wall component biosynthesis in response to the CLS infection specifically in SUPER5. …”
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Crocin Alleviates Hippocampal Neuron Injury in Rats with Cerebral Ischemia-Reperfusion by Inhibiting JAK2/STAT3 Signaling Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, YAO Li, HU Ke, FENG Lina, WANG Xudong

“…The expression of Janus kinase 2/signal transduction and activator of transcription 3 (JAK2/STAT3) signaling pathway related proteins in hippocampal tissue were detected by Western blot.ResultsCompared with the sham group, the learning and memory ability of the rats in the CI/R group was significantly decreased, and the cerebral infarction rate was significantly increased (<italic>P</italic>&lt;0.05); the neurons in hippocampal CA1 and CA3 showed pathological changes, such as reduced neuron number, enlarged gaps, vacuolar degeneration, blurred nucleolar border, and inflammatory cell infiltration, and the apoptosis rate was significantly increased (<italic>P</italic>&lt;0.05); the levels of IL-1β, IL-8, TNF-α in hippocampal tissue were significantly increased (<italic>P</italic>&lt;0.05); the expression of p-JAK2, p-STAT3, high mobility group protein B1, Bcl-2 associated X protein (Bax), Cleaved Caspase-3 and the ratio of p-JAK2/JAK2, p-STAT3/STAT3, Bax/Bcl-2 were significantly increased, while the expression of Bcl-2 was significantly decreased (<italic>P</italic>&lt;0.05). …”
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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…BackgroundLactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial respiration. …”
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Ginkgetin Alleviates Inflammation and Senescence by Targeting STING by Yadan Liu, Jialin Ye, Zisheng Fan, Xiaolong Wu, Yinghui Zhang, Ruirui Yang, Bing Jiang, Yajie Wang, Min Wu, Jingyi Zhou, Jingyi Meng, Zhiming Ge, Guizhen Zhou, Yuan Zhu, Yichuan Xiao, Mingyue Zheng, Sulin Zhang

“…Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy‐terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. Furthermore, in vivo pharmacodynamic data showed that Ginkgetin effectively alleviates systemic inflammation in Trex1−/− mice and inhibits the abnormally activated STING signaling in aging mouse model. …”
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Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma by I. A. Goncharova, A. A. Zarubin, N. P. Babushkina, I. A. Koroleva, M. S. Nazarenko

“…Genes hypomethylated in liver tumor tissue in the setting of liver cirrhosis are related to olfactory signal transduction, neuroactive ligand-receptor interaction, keratinization, immune response, inhibition of serine proteases, and zinc metabolism. …”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…Phytochromes are essential photoreceptors in plants that sense red and far-red light, playing a vital role in regulating plant growth and development through light signal transduction. Despite extensive research on phytochromes in model plants like Arabidopsis and rice, they have received relatively little attention in wheat. …”
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Identification of Host–Protein Interaction Network of Canine Parvovirus Capsid Protein VP2 in F81 Cells by Hongzhuan Zhou, Huanhuan Zhang, Xia Su, Fuzhou Xu, Bing Xiao, Jin Zhang, Qi Qi, Lulu Lin, Kaidi Cui, Qinqin Li, Songping Li, Bing Yang

“…The results showed that CPV VP2 protein participated mainly in cell metabolism, cell biosynthesis, protein folding and various signal transduction processes. According to the results of proteomics analysis, we randomly selected seven proteins for co-immunoprecipitation verification, and the experimental results were consistent with the LC-MS/MS data. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…TCZ exerts a protective effect on the kidneys by specifically binding to the IL-6 receptor and blocking the signal transduction of IL-6. Additionally, the levels of IL-6 were detected by employing ELISA kits. …”
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Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsi... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…The transcription factors MYB, ERF, bHLH, zinc finger, and MADS-box may regulate the genes involved in hormone signal transduction and starch and sucrose metabolism, which are critical for regulating the transition from endo- to ecodormancy in AMM buds. …”
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Effects of Carbonate Alkalinity on Antioxidants, Immunity and Intestinal Flora of <i>Penaeus vannamei</i> by Chuang Gao, Zhonghong Li, Bo Ma, Rantao Zuo, Xudong Shen, Mingkang Chen, Chuanqi Ren, Wenjun Zheng, Zhonglu Cai, Jiaxing Li, Shuang Li

“…The functional abundance of signal transduction histidine kinase was lower than that of the control group. …”
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Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…Predictive analysis highlighted 15 common proteins, up- or downregulated in PBMCs from patients with T1DM and MS patients vs. healthy controls, involved in the immune system activity (BTF3, TTR, CD59, CSTB), diseases of the neuronal system (TTR), signal transduction (STMN1, LAMTOR5), metabolism of nucleotides (RPS21), proteins (TTR, ENAM, CD59, RPS21, SRP9) and RNA (SRSF10, RPS21). …”
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Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…The F. nucleatum genome harbors a conserved ethanolamine utilization (eut) locus with 21 genes that encode several putative BMC shell proteins and a two-component signal transduction system (TCS), in addition to the enzymes for ethanolamine transport and catabolism. …”
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Chromosome-level reference genome and annotation of the Arctic fish Anisarchus medius by Ruoyu Liu, Ziyu Meng, Yinan Mu, Ran Zhang, Hanhui Ma, Jingjing Hu, Yanan Wang, Yuxin Shi, Yanan Li, Chaofeng Wang, Weini Zhang, Longshan Lin, Ping Zheng, Xinhua Chen

“…Molecular pathway related to the endocrine system, carbohydrate metabolism, folding, sorting, and degradation, signal transduction, and transport and catabolism contribute to A. medius adaptation to extreme Arctic environments. …”
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Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway by Yihan Lai, Yihan Lai, Mingkang Li, Mingkang Li, Juan Zhan, Juan Zhan, Lin Jiang, Lin Jiang, Yuan Wu, Zhiyi Fang, Jianhan Zhou, Jianhan Zhou, Yujie Ma, Yisen Shao, Yisen Shao, Wei Wang, Wei Wang

“…WB and PCR proved that BJO could effectively reduce the expression levels of MTFR2 and SOD2/H2O2 related signal transduction pathways. At the same time, the expression of oxidative phosphorylation markers increased, the expression of glycolytic markers decreased, and glycolysis-mediated decomposition of reactive oxygen species decreased, and H2O2 and oxygen levels decreased.In addition, when MTFR2 expression increased or decreased, SOD2/H2O2 expression also increased or decreased.DiscussionIn this study, we concluded through in vitro and in vivo experiments that BJO may affect the SOD2/H2O2 signaling pathway by down-regulating MTFR2-mediated aerobic glycolysis, thereby inhibiting cell proliferation, Migration, and Invasion. …”
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Cloning, Characterization and Expression Regulation in Response to High-Temperature Stress of TRAF7 Gene in the Sea Cucumber Apostichopus japonicus by Yanfeng ZHAO, Meijie LIAO, Jianlong GE, Jinjin WANG, Yingeng WANG, Xiaojun RONG, Bin LI, Yanting TAN

“…As an intracellular protein, tumor necrosis factor receptor-associated factor 7 (TRAF7) is involved in signal transduction and regulates host stress defense. In a previous transcriptome sequencing analysis of the high-temperature-stressed sea cucumber body wall, TRAF7 was significantly differentially expressed between healthy sea cucumbers and ulcered skin in high-temperature-stressed sea cucumbers. …”
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Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells by Zhiwei Yuan, Taiyan Yu, Xu Wang, Kelin Meng, Tianlai Wang, Boyu Wang, Yu Xi, Congjian Wang, Chenxi Zeng, Shaojie Hu, Yitao Tian, Hui Xiong, Qi Wang, Wenbin Zou, Xue Wang, Yi Gao, Xiangning Fu, Lequn Li

“…Moreover, V9302 also increased Glut1 expression through the inhibition of lysosomal pathway-dependent degradation of Glut1 and consequently increased cancer cell glucose uptake, in turn retaining the levels of intracellular alpha-ketoglutarate (α-KG) and ATP, which are involved in maintaining IFN-γ signal transduction in cancer cells. In support of these findings, targeting lysosomal activity with chloroquine (CQ) also increased IFNGR1 expression and the IFN-γ-driven response in cancer cells. …”
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Spatial variations in the microbiota: comparative analysis of microbial composition and predicted functions across different intestinal segments and feces in donkeys by Yanwei Wang, Yanwei Wang, Yanwei Wang, Tong Hu, Tong Hu, Kaixuan Liang, Kaixuan Liang, Shinuo Li, Shinuo Li, Qiyue Zhang, Qiyue Zhang, Qiyue Zhang, Wenqiang Li, Honglei Qu, Honglei Qu, Boying Dong, Haihua Zhang, Qiugang Ma, Qiugang Ma, Ru Jia, Shimeng Huang, Shimeng Huang

“…A PICRUSt2 functional prediction analysis indicated that carbohydrate metabolism, prokaryotic cellular communities, antimicrobial drug resistance, immune diseases, membrane transport, signal transduction, and transcription exhibited significant differences among the different intestinal segments. …”
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Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway by GAO Dexing, JIA Peizhi, PENG Jun, LIN Wei

“…Compared with the control group, the expression of TLR4, p-p65 protein of the model group after intervention for 12 h was significantly increased, the expression of TLR4, p-p65 protein of the model + the high dose BBR group, the model group + the inhibitor group, the model group + the inhibitor group + the high dose BBR goup was significantly decreased. ⑥ Biochemical test results: compared with the control group, the content of MDA of the model group was significantly increased, SOD activity was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05), the content of MDA in the model group + the low, medium and high dose BBR group was significantly down-regulated, SOD activity was significantly increased, the difference was statistically significant (<italic>P</italic>&lt;0.05).ConclusionBBR can regulate TLR4 signaling pathway and inhibit the abnormal activation of TLR4 signaling pathway induced by Ang Ⅱ and NF-κB, MAPK signal transduction, and reduce the content of proinflammatory factors and regulate inflammatory response; in addition, BBR can also improve the lipid peroxidation and antioxidant ability of ANA-1 cells induced by Ang Ⅱ, reduce the oxidative stress damage caused by Ang Ⅱ, and protect ANA-1 cells.…”
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The Hyperactivation of JAK-STAT Signaling Connects Inborn Errors of Immunity and Autoimmune Diseases by JIANG Yi, AN Yunfei, ZHAO Xiaodong

“…JAK-STAT signaling pathway is an important cytokine signaling transduction pathway. Many monogenic loss-of-function or gain-of-function mutations in this pathway can cause inborn errors of immunity (IEI). …”
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Recent Status on Lactate Monitoring in Sweat Using Biosensors: Can This Approach Be an Alternative to Blood Detection? by Leonardo Messina, Maria Teresa Giardi

“…Recent studies have shown that lactate is a molecule that plays an indispensable role in various physiological cellular processes, such as energy metabolism and signal transductions related to immune and inflammatory processes. …”
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