Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans by Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri

“…Although it may regulate directly only a limited number of genes, these include elements of the signaling network, for example, members of the two-component signal transduction systems. AtfA acts in a stress-specific manner, which may increase further the number and diversity of AtfA-dependent genes. …”
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Transcriptomics and Physiological Analyses of Soybean Stay-Green Syndrome by Dagang Wang, Yanan Wang, Ruidong Sun, Yong Yang, Wei Zhao, Guoyi Yu, Yueying Wang, Feng Wang, Lin Zhou, Zhiping Huang

“…Further investigation revealed that SGS mainly affected the expression levels of key genes involved in the regulation of photosynthesis, starch and sucrose metabolism, and plant hormone signal transduction. To support this finding, the chlorophyll content of the pods was to be found increased by 320% for chlorophyll <i>a</i> and 260% for chlorophyll <i>b</i>. …”
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Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations by Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A. Arafa, Qingshan Sun

“…Aside from having a similar structure, these peptides have few overlapping biological activities and signal transduction action through related receptors. However, several other activities are also present that are peptide specific. …”
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Regulation of Chemokine Production via Oxidative Pathway in HeLa Cells by Shinichiro Kina, Toshiyuki Nakasone, Hiroyuki Takemoto, Akira Matayoshi, Shoko Makishi, Nao Sunagawa, Feixin Liang, Thongsavanh Phonaphonh, Hajime Sunakawa

“…Collectively, these results indicate that Fe2+-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells.…”
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Lipid-Derived Mediators in Endogenous Anti-Inflammation and Resolution: Lipoxins and Aspirin-Triggered 15-epi-Lipoxins by Charles N. Serhan, Nan Chiang

“…In this on-line update, LX and ATL biosynthesis and the LXA4 specific receptor, termed ALXR, are reviewed with a focus on their roles in inflammation and resolution with respect to pharmacology, molecular biology, and signal transduction in several cell types and animal models investigated thus far.…”
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Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

“…These subnetworks are related to antigen processing and presentation, chemokine-mediated signaling, immune response-signal transduction, rRNA processing, and mRNA splicing. …”
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Electrochemical properties of hydroxyapatite immobilization material for potential cytosensor fabrication by Dennis Adusei, Bernard O. Asimeng, Francis D. Krampa, Elvis K. Tiburu

“…Unique materials that enhance immobilisation of biorecognition molecules and improve electrochemical signal transduction are important in overcoming challenges based on the sensitivity of biosensors. …”
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Integrated omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by LP533401 by Yidan Ling, Ziyu Liu, Shuibing Han, Haiqin Wu, Chunlong Mu, Weiyun Zhu

“…., nucleotide metabolism, signal transduction, metabolism of cofactors and vitamins) suggested an impact on the colonic function. …”
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A Possible Involvement of Ion Transporter in Tumor Necrosis Factor α and Cycloheximide-Induced Apoptosis of Endothelial Cells by Hiroshi Fujita, Ikuo Morita, Sei-itsu Murota

“…That is to say, there is a possibility that chloride ions or bicarbonate (pH) may play an important role in signal transduction such as NF-κB and caspase activation in the apoptosis induced by TNFα and cycloheximide.…”
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A Transcriptomic Analysis Reveals Diverse Regulatory Networks That Respond to Cold Stress in Strawberry (Fragaria×ananassa) by Yong Zhang, Yunting Zhang, Yuanxiu Lin, Ya Luo, Xiaorong Wang, Qing Chen, Bo Sun, Yan Wang, Mengyao Li, Haoru Tang

“…Functional enrichment analysis showed that DEGs were significantly (adjusted P value < 0.05) overrepresented in six pathways including plant hormone signal transduction, flavonoid biosynthesis, mitogen-activated protein kinase (MAPK) signaling, starch and sucrose metabolism, circadian rhythm, and alpha-linolenic acid metabolism. …”
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Comparative transcriptomics analysis of Zygosaccharomyces mellis under high-glucose stress by Gongliang Liu, Xinyu Bi, Changli Tao, Yongtao Fei, Sujuan Gao, Jinglong Liang, Weidong Bai

“…The result revealed that transcriptional changes in multiple metabolic pathways occur in response to high-glucose stress. q-RT PCR analysis further confirmed that several stress response pathways, such as the high osmolarity glycerol mitogen-activated protein kinase (HOG-MAPK) signal transduction pathway, trehalose synthesis pathway and oxidative stress response are closely related to high-glucose tolerance in Z. mellis. …”
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Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

“…The mGlu receptors signal transduction can be allosterically potentiated by positive allosteric modulators (PAMs) binding to the 7TMs, which are of therapeutic interest in various neurological disorders. …”
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Proteomic analysis reveals the roles of silicon in mitigating glyphosate-induced toxicity in Brassica napus L. by Probir Kumar Mittra, Md Atikur Rahman, Swapan Kumar Roy, Soo-Jeong Kwon, Abhik Mojumdar, Sung Ho Yun, Kun Cho, Seong-Woo Cho, Meiliang Zhou, Tomoyuki Katsube-Tanaka, Sun-Hee Woo

“…These proteins are associated with diverse biological processes in B. napus, including energy metabolism, antioxidant activity, signal transduction, photosynthesis, sulfur assimilation, cell wall functions, herbicide tolerance, and plant development. …”
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BvBZR1 improves parenchyma cell development and sucrose accumulation in sugar beet (Beta vulgaris L.) taproot by Ningning Li, Wei Wang, Wei Wang, Xiaotong Guo, Yaqing Sun, Guolong Li, Shaoying Zhang

“…BRASSINAZOLE-RESISTANT (BZR) transcription factors, key elements of brassinolide (BR) signal transduction, play an important role in regulating plant growth and development. …”
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Genetic Characteristics of the Rat Fibroblast Cell Line Rat-1 by Thomas Liehr, Stefanie Kankel, Eva Miriam Buhl, Sarah K. Schröder-Lange, Ralf Weiskirchen

“…They are also crucial for investigating signal transduction pathways and play a key role in drug testing and pharmacological studies due to their rapid proliferation. …”
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JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease by Darya Farhoomand Aksoy, Rahime Aksoy, Sevim Gönen, Ümit Ölmez

“…Janus kinase-2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are intracellular signal transduction molecules that increase the risk of developing some autoimmune diseases. …”
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Genome-wide identification and expression analysis of CBF/DREB1 gene family in Medicago sativa L. and functional verification of MsCBF9 affecting flowering time by Jing Cui, Yajing Li, Hao Liu, Xu Jiang, Lili Zhang, Hongbo Dai, Xue Wang, Fei He, Mingna Li, Junmei Kang

“…Abstract Background The C-repeat binding factor (CBF)/dehydration-responsive element binding (DREB1) belongs to a subfamily of the AP2/ERF (APETALA2/ethylene-responsive factor) superfamily, which can regulate many physiological and biochemical processes in plants, such as plant growth and development, hormone signal transduction and response to abiotic stress. Although the CBF/DREB1 family has been identified in many plants, studies of the CBF/DREB1 family in alfalfa are insufficient. …”
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Free-caged rearing modes regulate chicken intestinal metabolism by influencing gut microbial homeostasis by Tao Li, Peng Wang, Zhuo Zhi, Tong Guo, Jie Zhou, Huiya Zhang, Chang Cao, Yingjie Cai, Yuxiao Li, Jianqin Zhang

“…Functional analysis revealed that rearing modes impact gut metabolites involved in gut metabolism as well as broader processes such as signal transduction, protein digestion, and autophagy. This study offers new insights into how rearing modes influence gut microbiota and metabolites, shedding light on the study of rearing mode-mediated muscle development and fat deposition.…”
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The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas by Li-Yun Chang, Li-Yu D. Liu, Don A. Roth, Wen-Hung Kuo, Hsiao-Lin Hwa, King-Jen Chang, Fon-Jou Hsieh

“…The clinical and cohort significance of NR5A2-mediated transcriptional activities indicates that it may have a significant role in attenuating grade development and cancer related signal transduction pathways. NR5A2 signature that conditions poor prognosis was identified based upon results from 15 distinct probes. …”
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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation by Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d’Azzo

“…Sialylated Trem2-FL (Sia-Trem2-FL) does not hinder Trem2-FL-DAP12-Syk complex assembly but impairs signal transduction through Syk, ultimately abolishing Trem2-dependent phagocytosis. …”
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